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Volumn 4, Issue 7, 2004, Pages 528-539

Hyaluronan: From extracellular glue to pericellular cue

Author keywords

[No Author keywords available]

Indexed keywords

HYALURONIC ACID; POLYSACCHARIDE;

EID: 3042697038     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1391     Document Type: Review
Times cited : (1817)

References (187)
  • 2
    • 0037085475 scopus 로고    scopus 로고
    • Hyaluronan and homeostasis: A balancing act
    • Tammi, M. I., Day, A. J. & Turley, E. A. Hyaluronan and homeostasis: a balancing act. J. Biol. Chem. 277, 4581-4584 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 4581-4584
    • Tammi, M.I.1    Day, A.J.2    Turley, E.A.3
  • 3
    • 0035202430 scopus 로고    scopus 로고
    • The six hyaluronidase-like genes in the human and mouse genomes
    • Csoka, A. B., Frost, G. I. & Stern, R. The six hyaluronidase-like genes in the human and mouse genomes. Matrix Biol. 20, 499-508 (2001).
    • (2001) Matrix Biol. , vol.20 , pp. 499-508
    • Csoka, A.B.1    Frost, G.I.2    Stern, R.3
  • 5
    • 0035783042 scopus 로고    scopus 로고
    • Hyaluronan in morphogenesis
    • Toole, B. P. Hyaluronan in morphogenesis. Semin. Cell. Dev. Biol. 12, 79-87 (2001).
    • (2001) Semin. Cell. Dev. Biol. , vol.12 , pp. 79-87
    • Toole, B.P.1
  • 6
    • 0032524104 scopus 로고    scopus 로고
    • Landscaping the cancer terrain
    • Kinzler, K. W. & Vogelstein, B. Landscaping the cancer terrain. Science 280, 1036-1037 (1998).
    • (1998) Science , vol.280 , pp. 1036-1037
    • Kinzler, K.W.1    Vogelstein, B.2
  • 7
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 8
    • 0037085254 scopus 로고    scopus 로고
    • Signaling properties of hyaluronan receptors
    • Turley, E. A., Noble, P. W. & Bourguignon, L. Y. Signaling properties of hyaluronan receptors. J. Biol. Chem. 277, 4589-4592 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 4589-4592
    • Turley, E.A.1    Noble, P.W.2    Bourguignon, L.Y.3
  • 10
    • 2342444724 scopus 로고    scopus 로고
    • Watch thy neighbor: Cancer is a communal affair
    • Weaver, V. M. & Gilbert, P. Watch thy neighbor: cancer is a communal affair. J. Cell Sci. 117, 1287-1290 (2004).
    • (2004) J. Cell Sci. , vol.117 , pp. 1287-1290
    • Weaver, V.M.1    Gilbert, P.2
  • 12
    • 0000913748 scopus 로고
    • Hyaluronate and Invasiveness of the rabbit V2 carcinoma
    • Toole, B. P., Biswas, C. & Gross, J. Hyaluronate and Invasiveness of the rabbit V2 carcinoma. Proc. Natl Acad. Sci. USA 76, 6299-6303 (1979). One of the earliest papers to show a relation between hyaluronan and invasive tumour growth. This and later papers (see also references 13-15) highlighted the stromal localization of hyaluronan and the effect of tumour-stroma interactions on hyaluronan production.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 6299-6303
    • Toole, B.P.1    Biswas, C.2    Gross, J.3
  • 13
    • 0026674857 scopus 로고
    • Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: Comparison between invasive and non-invasive areas
    • Bertrand, P. et al. Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: comparison between invasive and non-invasive areas. Int. J. Cancer 52, 1-6 (1992).
    • (1992) Int. J. Cancer , vol.52 , pp. 1-6
    • Bertrand, P.1
  • 14
    • 0006585248 scopus 로고
    • Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis
    • Knudson, W., Biswas, C. & Toole, B. P. Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis. Proc. Natl Acad. Sci. USA 81, 6767-6771 (1984).
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 6767-6771
    • Knudson, W.1    Biswas, C.2    Toole, B.P.3
  • 15
    • 0027473748 scopus 로고
    • Human mesothelioma cells produce factors that stimulate the production of hyaluronan by mesothelial cells and fibroblasts
    • Asplund, T., Versnel, M. A., Laurent, T. C. & Heldin, P. Human mesothelioma cells produce factors that stimulate the production of hyaluronan by mesothelial cells and fibroblasts. Cancer Res. 53, 388-392 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 388-392
    • Asplund, T.1    Versnel, M.A.2    Laurent, T.C.3    Heldin, P.4
  • 16
    • 0020660232 scopus 로고
    • Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants with high metastatic potential
    • Kimata, K. et al. Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants with high metastatic potential. Cancer Res. 43, 1347-1354 (1983).
    • (1983) Cancer Res. , vol.43 , pp. 1347-1354
    • Kimata, K.1
  • 17
    • 0028796676 scopus 로고
    • Hyaluronan on the surface of tumor cells is correlated with metastatic behavior
    • Zhang, L., Underhill, C. B. & Chen, L. Hyaluronan on the surface of tumor cells is correlated with metastatic behavior. Cancer Res. 55, 428-433 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 428-433
    • Zhang, L.1    Underhill, C.B.2    Chen, L.3
  • 18
    • 0036786339 scopus 로고    scopus 로고
    • Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: Predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients
    • Calabro, A., Oken, M. M., Hascall, V. C. & Masellis, A. M. Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients. Blood 100, 2578-2585 (2002).
    • (2002) Blood , vol.100 , pp. 2578-2585
    • Calabro, A.1    Oken, M.M.2    Hascall, V.C.3    Masellis, A.M.4
  • 19
    • 0037085376 scopus 로고    scopus 로고
    • Hyaluronan-cell interactions in cancer and vascular disease
    • Toole, B. P., Wight, T. N. & Tammi, M. Hyaluronan-cell interactions in cancer and vascular disease. J. Biol. Chem. 277, 4593-4596 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 4593-4596
    • Toole, B.P.1    Wight, T.N.2    Tammi, M.3
  • 20
    • 0033970911 scopus 로고    scopus 로고
    • High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer
    • Anttila, M. A. et al. High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer. Cancer Res. 60, 150-155 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 150-155
    • Anttila, M.A.1
  • 21
    • 0033889231 scopus 로고    scopus 로고
    • Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival
    • Auvinen, P. et al. Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival. Am. J. Pathol. 156, 529-536 (2000).
    • (2000) Am. J. Pathol. , vol.156 , pp. 529-536
    • Auvinen, P.1
  • 22
    • 0036233581 scopus 로고    scopus 로고
    • Sonographic morphology of infiltrating breast carcinoma: Relationship with the shape of the hyaluronan extracellular matrix
    • Vignal, P., Meslet, M. R., Romeo, J. M. & Feuilhade, F. Sonographic morphology of infiltrating breast carcinoma: relationship with the shape of the hyaluronan extracellular matrix. J. Ultrasound Med. 21, 532-538 (2002).
    • (2002) J. Ultrasound Med. , vol.21 , pp. 532-538
    • Vignal, P.1    Meslet, M.R.2    Romeo, J.M.3    Feuilhade, F.4
  • 23
    • 0035915774 scopus 로고    scopus 로고
    • Prognostic value of hyaluronan expression in non-small-cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarcinoma
    • Pirinen, R. et al. Prognostic value of hyaluronan expression in non-small-cell lung cancer: increased stromal expression indicates unfavorable outcome in patients with adenocarcinoma. Int. J. Cancer 95, 12-17 (2001).
    • (2001) Int. J. Cancer , vol.95 , pp. 12-17
    • Pirinen, R.1
  • 24
    • 0038180913 scopus 로고    scopus 로고
    • Evaluation of the prognostic potential of hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer
    • Posey, J. T. et al. Evaluation of the prognostic potential of hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer. Cancer Res. 63, 2638-2644 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 2638-2644
    • Posey, J.T.1
  • 25
    • 0035045589 scopus 로고    scopus 로고
    • High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer
    • Lipponen, P. et al. High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer. Eur. J. Cancer 37, 849-856 (2001).
    • (2001) Eur. J. Cancer , vol.37 , pp. 849-856
    • Lipponen, P.1
  • 26
    • 0035853711 scopus 로고    scopus 로고
    • Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer
    • Lokeshwar, V. B. et al. Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer. J. Biol. Chem. 276, 11922-11932 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 11922-11932
    • Lokeshwar, V.B.1
  • 27
    • 0031973883 scopus 로고    scopus 로고
    • Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer
    • Ropponen, K. et al. Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer. Cancer Res. 58, 342-347 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 342-347
    • Ropponen, K.1
  • 28
    • 0033052479 scopus 로고    scopus 로고
    • Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate
    • Setala, L. P. et al. Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate. Br. J. Cancer 79, 1133-1138 (1999).
    • (1999) Br. J. Cancer , vol.79 , pp. 1133-1138
    • Setala, L.P.1
  • 29
    • 0030045099 scopus 로고    scopus 로고
    • Hyaluronan-dependent motility of B cells and leukemic plasma cells in blood, but not of bone marrow plasma cells, in multiple myeloma: Alternate use of receptor for hyaluronan-mediated motility (RHAMM) and CD44
    • Masellis-Smith, A., Belch, A. R., Mant, M. J., Turley, E. A. & Pilarski, L. M. Hyaluronan-dependent motility of B cells and leukemic plasma cells in blood, but not of bone marrow plasma cells, in multiple myeloma: alternate use of receptor for hyaluronan-mediated motility (RHAMM) and CD44. Blood 87, 1891-1899 (1996).
    • (1996) Blood , vol.87 , pp. 1891-1899
    • Masellis-Smith, A.1    Belch, A.R.2    Mant, M.J.3    Turley, E.A.4    Pilarski, L.M.5
  • 30
    • 0033104710 scopus 로고    scopus 로고
    • Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: Identification of three distinct RHAMM variants
    • Crainie, M., Belch, A. R., Mant, M. J. & Pilarski, L. M. Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: identification of three distinct RHAMM variants. Blood 93, 1684-1696 (1999).
    • (1999) Blood , vol.93 , pp. 1684-1696
    • Crainie, M.1    Belch, A.R.2    Mant, M.J.3    Pilarski, L.M.4
  • 31
    • 0034332199 scopus 로고    scopus 로고
    • Involvement of CD44-hyaluronan interaction in malignant cell homing and fibronectin synthesis in hairy cell leukemia
    • Aziz, K. A., Till, K. J., Zuzel, M. & Cawley, J. C. Involvement of CD44-hyaluronan interaction in malignant cell homing and fibronectin synthesis in hairy cell leukemia. Blood 96, 3161-3167 (2000).
    • (2000) Blood , vol.96 , pp. 3161-3167
    • Aziz, K.A.1    Till, K.J.2    Zuzel, M.3    Cawley, J.C.4
  • 32
    • 0036644999 scopus 로고    scopus 로고
    • Bladder tumor markers for monitoring recurrence and screening comparison of hyaluronic acid-hyaluronidase and BTA-Stat tests
    • Lokeshwar, V. B. et al. Bladder tumor markers for monitoring recurrence and screening comparison of hyaluronic acid-hyaluronidase and BTA-Stat tests. Cancer 95, 61-72 (2002).
    • (2002) Cancer , vol.95 , pp. 61-72
    • Lokeshwar, V.B.1
  • 33
    • 0025120954 scopus 로고
    • Serum hyaluronan (hyaluronic acid) in breast cancer patients
    • Delpech, B. et al. Serum hyaluronan (hyaluronic acid) in breast cancer patients. Int. J. Cancer 46, 388-390 (1990).
    • (1990) Int. J. Cancer , vol.46 , pp. 388-390
    • Delpech, B.1
  • 34
    • 0037491618 scopus 로고    scopus 로고
    • Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors
    • Franzmann, E. J. et al. Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors. Int. J. Cancer 106, 438-445 (2003).
    • (2003) Int. J. Cancer , vol.106 , pp. 438-445
    • Franzmann, E.J.1
  • 35
    • 0034492932 scopus 로고    scopus 로고
    • Reduced level of CD44 and hyaluronan associated with unfavorable prognosis in clinical stage I cutaneous melanoma
    • Karjalainen, J. M. et al. Reduced level of CD44 and hyaluronan associated with unfavorable prognosis in clinical stage I cutaneous melanoma. Am. J. Pathol. 157, 957-965 (2000).
    • (2000) Am. J. Pathol. , vol.157 , pp. 957-965
    • Karjalainen, J.M.1
  • 36
    • 0037240613 scopus 로고    scopus 로고
    • Hyaluronan, CD44 and versican in epidermal keratinocyte tumours
    • Karvinen, S., Kosma, V. M., Tammi, M. I. & Tammi, R. Hyaluronan, CD44 and versican in epidermal keratinocyte tumours. Br. J. Dermatol. 148, 86-94 (2003).
    • (2003) Br. J. Dermatol. , vol.148 , pp. 86-94
    • Karvinen, S.1    Kosma, V.M.2    Tammi, M.I.3    Tammi, R.4
  • 37
    • 0033106004 scopus 로고    scopus 로고
    • Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity
    • Kosaki, R., Watanabe, K. & Yamaguchi, Y. Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity. Cancer Res. 59, 1141-1145 (1999). The first study showing that molecular manipulation of hyaluronan production affects tumour progression in an animal model. This study was followed by several important papers showing that upregulation of hyaluronan synthesis stimulates - and down-regulation inhibits - tumour progression (see also references 38-42).
    • (1999) Cancer Res. , vol.59 , pp. 1141-1145
    • Kosaki, R.1    Watanabe, K.2    Yamaguchi, Y.3
  • 38
    • 0033562998 scopus 로고    scopus 로고
    • Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells
    • Itano, N., Sawai, T., Miyaishi, O. & Kimata, K. Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells. Cancer Res. 59, 2499-2504 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 2499-2504
    • Itano, N.1    Sawai, T.2    Miyaishi, O.3    Kimata, K.4
  • 39
    • 0035393499 scopus 로고    scopus 로고
    • Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells
    • Liu, N. et al. Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. Cancer Res. 61, 5207-5214 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5207-5214
    • Liu, N.1
  • 40
    • 0037145745 scopus 로고    scopus 로고
    • Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors
    • Jacobson, A., Rahmanian, M., Rubin, K. & Heldin, P. Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors. Int. J. Cancer 102, 212-219 (2002).
    • (2002) Int. J. Cancer , vol.102 , pp. 212-219
    • Jacobson, A.1    Rahmanian, M.2    Rubin, K.3    Heldin, P.4
  • 41
    • 0036731865 scopus 로고    scopus 로고
    • Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice
    • Simpson, M. A., Wilson, C. M. & McCarthy, J. B. Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice. Am. J. Pathol. 161, 849-857 (2002).
    • (2002) Am. J. Pathol. , vol.161 , pp. 849-857
    • Simpson, M.A.1    Wilson, C.M.2    McCarthy, J.B.3
  • 42
    • 2442597186 scopus 로고    scopus 로고
    • Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation
    • Itano, N. et al. Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation. J. Biol. Chem. 279, 18679-18687 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 18679-18687
    • Itano, N.1
  • 43
    • 0037058318 scopus 로고    scopus 로고
    • Hyaluronidase reduces human breast cancer xenografts in SCID mice
    • Shuster, S., Frost, G. I., Csoka, A. B., Formby, B. & Stern, R. Hyaluronidase reduces human breast cancer xenografts in SCID mice. Int. J. Cancer 102, 192-197 (2002).
    • (2002) Int. J. Cancer , vol.102 , pp. 192-197
    • Shuster, S.1    Frost, G.I.2    Csoka, A.B.3    Formby, B.4    Stern, R.5
  • 44
    • 0034677379 scopus 로고    scopus 로고
    • HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA
    • Frost, G. I. et al. HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA. Oncogene 19, 870-877 (2000).
    • (2000) Oncogene , vol.19 , pp. 870-877
    • Frost, G.I.1
  • 45
    • 0033572449 scopus 로고    scopus 로고
    • Hyaluronidase-2 overexpression accelerates intracerebral but not subcutaneous tumor formation of murine astrocytoma cells
    • Novak, U., Stylli, S. S., Kaye, A. H. & Lepperdinger, G. Hyaluronidase-2 overexpression accelerates intracerebral but not subcutaneous tumor formation of murine astrocytoma cells. Cancer Res. 59, 6246-6250 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 6246-6250
    • Novak, U.1    Stylli, S.S.2    Kaye, A.H.3    Lepperdinger, G.4
  • 46
    • 0036466840 scopus 로고    scopus 로고
    • Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer
    • Patel, S. et al. Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer. Int. J. Cancer 97, 416-424 (2002).
    • (2002) Int. J. Cancer , vol.97 , pp. 416-424
    • Patel, S.1
  • 47
    • 0036626690 scopus 로고    scopus 로고
    • Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity
    • Enegd, B. et al. Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity. Neurosurgery 50, 1311-1318 (2002).
    • (2002) Neurosurgery , vol.50 , pp. 1311-1318
    • Enegd, B.1
  • 48
    • 0034981355 scopus 로고    scopus 로고
    • Elevated tissue expression of hyaluronic acid and hyaluronidase validates the HA-HAase urine test for bladder cancer
    • Hautmann, S. H. et al. Elevated tissue expression of hyaluronic acid and hyaluronidase validates the HA-HAase urine test for bladder cancer. J. Urol. 165, 2068-2074 (2001).
    • (2001) J. Urol. , vol.165 , pp. 2068-2074
    • Hautmann, S.H.1
  • 49
    • 0029817452 scopus 로고    scopus 로고
    • Expression of hyaluronidase by tumor cells induces angiogenesis in vivo
    • Liu, D. et al. Expression of hyaluronidase by tumor cells induces angiogenesis in vivo. Proc. Natl Acad. Sci. USA 93, 7832-7837 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7832-7837
    • Liu, D.1
  • 50
    • 0036332420 scopus 로고    scopus 로고
    • Hyaluronidase is more elevated in human brain metastases than in primary brain tumours
    • Delpech, B., Laquerriere, A., Maingonnat, C., Bertrand, P. & Freger, P. Hyaluronidase is more elevated in human brain metastases than in primary brain tumours. Anticancer Res. 22, 2423-2427 (2002).
    • (2002) Anticancer Res. , vol.22 , pp. 2423-2427
    • Delpech, B.1    Laquerriere, A.2    Maingonnat, C.3    Bertrand, P.4    Freger, P.5
  • 51
    • 0037085372 scopus 로고    scopus 로고
    • Hyaluronan-binding proteins: Tying up the giant
    • Day, A. J. & Prestwich, G. D. Hyaluronan-binding proteins: tying up the giant. J. Biol. Chem. 277, 4585-4588 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 4585-4588
    • Day, A.J.1    Prestwich, G.D.2
  • 52
    • 0024560984 scopus 로고
    • A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family
    • Stamenkovic, I., Amiot, M., Pesando, J. M. & Seed, B. A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell 56, 1057-1062 (1989).
    • (1989) Cell , vol.56 , pp. 1057-1062
    • Stamenkovic, I.1    Amiot, M.2    Pesando, J.M.3    Seed, B.4
  • 53
    • 0025282411 scopus 로고
    • CD44 is the principal cell surface receptor for hyaluronate
    • Aruffo, A., Stamenkovic, I., Melnick, M., Underhill, C. B. & Seed, B. CD44 is the principal cell surface receptor for hyaluronate. Cell 61, 1303-1313 (1990). Brings together past research on cell-surface receptors for hyaluronan and lymphocyte homing factors, identifying CD44 as an important hyaluronan receptor and part of the 'link module' family of hyaladherins.
    • (1990) Cell , vol.61 , pp. 1303-1313
    • Aruffo, A.1    Stamenkovic, I.2    Melnick, M.3    Underhill, C.B.4    Seed, B.5
  • 55
    • 0035404863 scopus 로고    scopus 로고
    • CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression
    • Bourguignon, L. Y. CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression. J. Mammary Gland Biol. Neoplasia 6, 287-297 (2001).
    • (2001) J. Mammary Gland Biol. Neoplasia , vol.6 , pp. 287-297
    • Bourguignon, L.Y.1
  • 56
    • 0842280615 scopus 로고    scopus 로고
    • The role of the CD44 transmembrane and cytoplasmic domains in coordinating adhesive and signalling events
    • Thome, R. F., Legg, J. W. & Isacke, C. M. The role of the CD44 transmembrane and cytoplasmic domains in coordinating adhesive and signalling events. J. Cell Sci. 117, 373-380 (2004).
    • (2004) J. Cell Sci. , vol.117 , pp. 373-380
    • Thome, R.F.1    Legg, J.W.2    Isacke, C.M.3
  • 57
    • 0030917306 scopus 로고    scopus 로고
    • Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation
    • Kaya, G., Rodriguez, I., Jorcano, J. L., Vassalli, P. & Stamenkovic, I. Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. Genes Dev. 11, 996-1007 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 996-1007
    • Kaya, G.1    Rodriguez, I.2    Jorcano, J.L.3    Vassalli, P.4    Stamenkovic, I.5
  • 58
    • 0037023364 scopus 로고    scopus 로고
    • Resolution of lung inflammation by CD44
    • Teder, P. et al. Resolution of lung inflammation by CD44. Science 296, 155-158 (2002).
    • (2002) Science , vol.296 , pp. 155-158
    • Teder, P.1
  • 59
    • 0028097742 scopus 로고
    • Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein
    • 7)B. This group was the first to clone and identify a major hyaluronan receptor, namely RHAMM.
    • (1994) EMBO J. , vol.13 , pp. 286-296
    • Yang, B.1    Yang, B.L.2    Savani, R.C.3    Turley, E.A.4
  • 61
    • 0032080068 scopus 로고    scopus 로고
    • The hyaluronan receptor RHAMM regulates extracellular-regulated kinase
    • Zhang, S. et al. The hyaluronan receptor RHAMM regulates extracellular-regulated kinase. J. Biol. Chem. 273, 11342-11348 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 11342-11348
    • Zhang, S.1
  • 63
    • 0035902816 scopus 로고    scopus 로고
    • Hyaluronan production increases the malignant properties of mesothelioma cells
    • Li, Y. & Heldin, P. Hyaluronan production increases the malignant properties of mesothelioma cells. Br. J. Cancer 85, 600-607 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 600-607
    • Li, Y.1    Heldin, P.2
  • 64
    • 0242412978 scopus 로고    scopus 로고
    • Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells
    • Zoltan-Jones, A., Huang, L., Ghatak, S. & Toole, B. P. Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells. J. Biol. Chem. 278, 45801-45810 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 45801-45810
    • Zoltan-Jones, A.1    Huang, L.2    Ghatak, S.3    Toole, B.P.4
  • 65
    • 0033895822 scopus 로고    scopus 로고
    • Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites
    • Peterson, R. M., Yu, Q., Stamenkovic, I. & Toole, B. P. Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites. Am. J. Pathol. 156, 2159-2167 (2000).
    • (2000) Am. J. Pathol. , vol.156 , pp. 2159-2167
    • Peterson, R.M.1    Yu, Q.2    Stamenkovic, I.3    Toole, B.P.4
  • 66
    • 0037063999 scopus 로고    scopus 로고
    • Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway
    • Ghatak, S., Misra, S. & Toole, B. P. Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway. J. Biol. Chem. 277, 38013-38020 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 38013-38020
    • Ghatak, S.1    Misra, S.2    Toole, B.P.3
  • 67
    • 0035157990 scopus 로고    scopus 로고
    • Hyaluronan activates cell motility of v-Src-transformed cells via Ras- mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner
    • Sohara, Y. et al. Hyaluronan activates cell motility of v-Src-transformed cells via Ras- mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner. Mol. Biol. Cell 12, 1859-1868 (2001).
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1859-1868
    • Sohara, Y.1
  • 68
    • 0037133564 scopus 로고    scopus 로고
    • Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration
    • Itano, N. et al. Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration. Proc. Natl Acad. Sci. USA 99, 3609-3614 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3609-3614
    • Itano, N.1
  • 69
    • 0037478612 scopus 로고    scopus 로고
    • Regulation of multi-drug resistance in cancer cells by hyaluronan
    • Misra, S., Ghatak, S., Zoltan-Jones, A. & Toole, B. P. Regulation of multi-drug resistance in cancer cells by hyaluronan. J. Biol. Chem. 278, 25285-25288 (2003). The first demonstration that hyaluronan and EMMPRIN are important for multidrug resistance.
    • (2003) J. Biol. Chem. , vol.278 , pp. 25285-25288
    • Misra, S.1    Ghatak, S.2    Zoltan-Jones, A.3    Toole, B.P.4
  • 70
    • 0028241389 scopus 로고
    • Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity
    • Hall, C. L., Wang, C., Lange, L. A. & Turley, E. A. Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity. J. Cell Biol. 126, 575-588 (1994). One of a series of papers that show the importance of hyaluronan-RHAMM interactions in cell signalling (see also references 60, 61 and 79).
    • (1994) J. Cell Biol. , vol.126 , pp. 575-588
    • Hall, C.L.1    Wang, C.2    Lange, L.A.3    Turley, E.A.4
  • 71
    • 18644363387 scopus 로고    scopus 로고
    • CD44 signaling through focal adhesion kinase and its anti-apoptotic effect
    • Fujita, Y. et al. CD44 signaling through focal adhesion kinase and its anti-apoptotic effect. FEBS Lett. 528, 101-108 (2002).
    • (2002) FEBS Lett. , vol.528 , pp. 101-108
    • Fujita, Y.1
  • 72
    • 0043032859 scopus 로고    scopus 로고
    • Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression
    • Bourguignon, L. Y., Singleton, P. A., Zhu, H. & Diedrich, F. Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. J. Biol. Chem. 278, 29420-29434 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 29420-29434
    • Bourguignon, L.Y.1    Singleton, P.A.2    Zhu, H.3    Diedrich, F.4
  • 73
    • 18544367200 scopus 로고    scopus 로고
    • Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel
    • Mabuchi, S. et al. Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel. J. Biol. Chem. 277, 33490-33500 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 33490-33500
    • Mabuchi, S.1
  • 74
  • 75
    • 0028216487 scopus 로고
    • Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development
    • Bartolazzi, A., Peach, R., Aruffo, A. & Stamenkovic, I. Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J. Exp. Med. 180, 53-66 (1994). One of the first papers in a series showing that soluble hyaluronan-binding decoys inhibit several aspects of tumour progression. Together, these papers convincingly showed the importance of hyaluronan-tumour-cell interactions in tumour progression (see also references 65, 76-81, 139 and 140)
    • (1994) J. Exp. Med. , vol.180 , pp. 53-66
    • Bartolazzi, A.1    Peach, R.2    Aruffo, A.3    Stamenkovic, I.4
  • 76
    • 0031453690 scopus 로고    scopus 로고
    • Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function
    • Yu, Q., Toole, B. P. & Stamenkovic, I. Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. J. Exp. Med. 186, 1985-1996 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 1985-1996
    • Yu, Q.1    Toole, B.P.2    Stamenkovic, I.3
  • 77
    • 0035821780 scopus 로고    scopus 로고
    • Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid
    • Ahrens, T. et al. Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Oncogene 20, 3399-3408 (2001).
    • (2001) Oncogene , vol.20 , pp. 3399-3408
    • Ahrens, T.1
  • 78
    • 0035114425 scopus 로고    scopus 로고
    • Metastatin: A hyaluronan-binding complex from cartilage that inhibits tumor growth
    • Liu, N. et al. Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumor growth. Cancer Res. 61, 1022-1028 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 1022-1028
    • Liu, N.1
  • 79
    • 0029935148 scopus 로고    scopus 로고
    • Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression
    • Mohapatra, S., Yang, X., Wright, J. A., Turley, E. A. & Greenberg, A. H. Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression. J. Exp. Med. 183, 1663-1668 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 1663-1668
    • Mohapatra, S.1    Yang, X.2    Wright, J.A.3    Turley, E.A.4    Greenberg, A.H.5
  • 80
    • 0242417533 scopus 로고    scopus 로고
    • Perturbation of hyaluronan interactions inhibits malignant properties of glioma cells
    • Ward, J. A., Huang, L., Guo, H., Ghatak, S. & Toole, B. P. Perturbation of hyaluronan interactions inhibits malignant properties of glioma cells. Am. J. Pathol. 162, 1403-1409 (2003).
    • (2003) Am. J. Pathol. , vol.162 , pp. 1403-1409
    • Ward, J.A.1    Huang, L.2    Guo, H.3    Ghatak, S.4    Toole, B.P.5
  • 81
    • 0742287882 scopus 로고    scopus 로고
    • Hyaluronan-binding peptide can inhibit tumor growth by interacting with Bcl-2
    • Liu, N. et al. Hyaluronan-binding peptide can inhibit tumor growth by interacting with Bcl-2. Int. J. Cancer 109, 49-57 (2004).
    • (2004) Int. J. Cancer , vol.109 , pp. 49-57
    • Liu, N.1
  • 82
    • 0032880880 scopus 로고    scopus 로고
    • Intracellular localization of hyaluronan in proliferating cells
    • Evanko, S. P. & Wight, T. N. Intracellular localization of hyaluronan in proliferating cells. J. Histochem. Cytochem. 47, 1331-1342 (1999).
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 1331-1342
    • Evanko, S.P.1    Wight, T.N.2
  • 83
    • 0032407701 scopus 로고    scopus 로고
    • Rapid hyaluronan uptake is associated with enhanced motility: Implications for an intracellular mode of action
    • Collis, L. et al. Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action. FEBS Lett. 440, 444-449 (1998).
    • (1998) FEBS Lett. , vol.440 , pp. 444-449
    • Collis, L.1
  • 84
    • 0033490051 scopus 로고    scopus 로고
    • The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments
    • Assmann, V., Jenkinson, D., Marshall, J. F. & Hart, I. R. The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments. J. Cell. Sci. 112, 3943-3954 (1999).
    • (1999) J. Cell. Sci. , vol.112 , pp. 3943-3954
    • Assmann, V.1    Jenkinson, D.2    Marshall, J.F.3    Hart, I.R.4
  • 85
    • 0037632929 scopus 로고    scopus 로고
    • RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability
    • Maxwell, C. A. et al. RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability. Mol. Biol. Cell 14, 2262-2276 (2003).
    • (2003) Mol. Biol. Cell , vol.14 , pp. 2262-2276
    • Maxwell, C.A.1
  • 86
    • 0029057403 scopus 로고
    • A novel glycosaminoglycan-binding protein is the vertebrate homologue of the cell cycle control protein, Cdc37
    • Grammatikakis, N. et al. A novel glycosaminoglycan-binding protein is the vertebrate homologue of the cell cycle control protein, Cdc37. J. Biol. Chem. 270, 16198-16205 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 16198-16205
    • Grammatikakis, N.1
  • 88
    • 85047695528 scopus 로고    scopus 로고
    • Hsp-90-associated oncoproteins: Multiple targets of geldanamycin and its analogs
    • Blagosklonny, M. V. Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. Leukemia 16, 455-462 (2002).
    • (2002) Leukemia , vol.16 , pp. 455-462
    • Blagosklonny, M.V.1
  • 89
    • 0034703020 scopus 로고    scopus 로고
    • Molecular characterization of a novel intracellular hyaluronan-binding protein
    • Huang, L., Grammatikakis, N., Yoneda, M., Banerjee, S. D. & Toole, B. P. Molecular characterization of a novel intracellular hyaluronan-binding protein. J. Biol. Chem. 275, 29829-29839 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 29829-29839
    • Huang, L.1    Grammatikakis, N.2    Yoneda, M.3    Banerjee, S.D.4    Toole, B.P.5
  • 90
    • 0037449857 scopus 로고    scopus 로고
    • Constitutive expression of hyaluronan binding protein 1 (HABP1/p32/gC1qR) in normal fibroblast cells perturbs its growth characteristics and induces apoptosis
    • Meenakshi, J., Anupama, Goswami, S. K. & Datta, K. Constitutive expression of hyaluronan binding protein 1 (HABP1/p32/gC1qR) in normal fibroblast cells perturbs its growth characteristics and induces apoptosis. Biochem. Biophys. Res. Commun. 300, 686-693 (2003).
    • (2003) Biochem. Biophys. Res. Commun. , vol.300 , pp. 686-693
    • Meenakshi, J.1    Anupama2    Goswami, S.K.3    Datta, K.4
  • 91
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: The biology of ErbB-2 and ErbB-3
    • Citri, A., Skaria, K. B. & Yarden, Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp. Cell Res. 284, 54-65 (2003).
    • (2003) Exp. Cell Res. , vol.284 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 92
    • 0036312252 scopus 로고    scopus 로고
    • HER (erbB) tyrosine kinase inhibitors in the treatment of breast cancer
    • Arteaga, C. L., Moulder, S. L. & Yakes, F. M. HER (erbB) tyrosine kinase inhibitors in the treatment of breast cancer. Semin. Oncol. 29, 4-10 (2002).
    • (2002) Semin. Oncol. , vol.29 , pp. 4-10
    • Arteaga, C.L.1    Moulder, S.L.2    Yakes, F.M.3
  • 93
    • 0033847008 scopus 로고    scopus 로고
    • Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme
    • Camenisch, T. D. et al. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J. Clin. Invest. 106, 349-360 (2000). Analysis of the Has2-null mouse, showing that hyaluronan is essential for EMT during endocardial-cushion development. This and reference 94 also showed that hyaluronan is required for ERBB2/ERBB3 and RAS signalling during this transition.
    • (2000) J. Clin. Invest. , vol.106 , pp. 349-360
    • Camenisch, T.D.1
  • 94
    • 0036344533 scopus 로고    scopus 로고
    • Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors
    • Camenisch, T. D., Schroeder, J. A., Bradley, J., Klewer, S. E. & McDonald, J. A. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nature Med. 8, 850-855 (2002).
    • (2002) Nature Med. , vol.8 , pp. 850-855
    • Camenisch, T.D.1    Schroeder, J.A.2    Bradley, J.3    Klewer, S.E.4    McDonald, J.A.5
  • 95
    • 0035966019 scopus 로고    scopus 로고
    • HER2 and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth
    • HER2 and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth. J. Biol. Chem. 276, 48679-48692 (2001). Showed that the hyaluronan-CD44 interaction promotes ERBB2 signalling. One of a series of papers from this laboratory showing the importance of this interaction in signal transduction (see also references 72, 98, 126, 144 and 181).
    • (2001) J. Biol. Chem. , vol.276 , pp. 48679-48692
    • Bourguignon, L.Y.1
  • 96
    • 0036176638 scopus 로고    scopus 로고
    • CD44 associates with EGFR and erbB2 in metastasizing mammary carcinoma cells
    • Wobus, M. et al. CD44 associates with EGFR and erbB2 in metastasizing mammary carcinoma cells. Appl. Immunohistochem. Mol. Morphol. 10, 34-39 (2002).
    • (2002) Appl. Immunohistochem. Mol. Morphol. , vol.10 , pp. 34-39
    • Wobus, M.1
  • 97
    • 0036342722 scopus 로고    scopus 로고
    • EGF receptor modifies cellular responses to hyaluronan in glioblastoma cell lines
    • Tsatas, D., Kanagasundaram, V., Kaye, A. & Novak, U. EGF receptor modifies cellular responses to hyaluronan in glioblastoma cell lines. J. Clin. Neurosci. 9, 282-288 (2002).
    • (2002) J. Clin. Neurosci. , vol.9 , pp. 282-288
    • Tsatas, D.1    Kanagasundaram, V.2    Kaye, A.3    Novak, U.4
  • 98
    • 0037131169 scopus 로고    scopus 로고
    • Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor-β receptor I in metastatic breast tumor cells
    • Bourguignon, L. Y., Singleton, P. A., Zhu, H. & Zhou, B. Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor-β receptor I in metastatic breast tumor cells. J. Biol. Chem. 277, 39703-39712 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 39703-39712
    • Bourguignon, L.Y.1    Singleton, P.A.2    Zhu, H.3    Zhou, B.4
  • 99
    • 0036896923 scopus 로고    scopus 로고
    • CD44 is required for two consecutive steps in HGF/c-Met signaling
    • Orian-Rousseau, V., Chen, L., Sleeman, J. P., Herrlich, P. & Ponta, H. CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev. 16, 3074-3086 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 3074-3086
    • Orian-Rousseau, V.1    Chen, L.2    Sleeman, J.P.3    Herrlich, P.4    Ponta, H.5
  • 100
    • 0034095213 scopus 로고    scopus 로고
    • Enhanced transformation by a plasma membrane-associated met oncoprotein: Activation of a phosphoinositide 3′-kinase-dependent autocrine loop involving hyaluronic acid and CD44
    • Kamikura, D. M., Khoury, H., Maroun, C., Naujokas, M. A. & Park, M. Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3′-kinase-dependent autocrine loop involving hyaluronic acid and CD44. Mol. Cell. Biol. 20, 3482-3496 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3482-3496
    • Kamikura, D.M.1    Khoury, H.2    Maroun, C.3    Naujokas, M.A.4    Park, M.5
  • 101
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman, M. M., Fojo, T. & Bates, S. E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Rev. Cancer 2, 48-58 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 102
    • 0035500410 scopus 로고    scopus 로고
    • Apoptosis and cancer chemotherapy
    • Makin, G. & Dive, C. Apoptosis and cancer chemotherapy. Trends Cell Biol. 11, S22-S26 (2001).
    • (2001) Trends Cell Biol. , vol.11
    • Makin, G.1    Dive, C.2
  • 103
    • 0035129120 scopus 로고    scopus 로고
    • Molecular signals in anti-apoptotic survival pathways
    • O'Gorman, D. M. & Cotter, T. G. Molecular signals in anti-apoptotic survival pathways. Leukemia 15, 21-34 (2001).
    • (2001) Leukemia , vol.15 , pp. 21-34
    • O'Gorman, D.M.1    Cotter, T.G.2
  • 104
    • 0031671794 scopus 로고    scopus 로고
    • The impact of extracellular matrix on the chemoresistance of solid tumors - Experimental and clinical results of hyaluronidase as additive to cytostatic chemotherapy
    • Baumgartner, G., Gomar-Hoss, C., Sakr, L., Ulsperger, E. & Wogritsch, C. The impact of extracellular matrix on the chemoresistance of solid tumors - experimental and clinical results of hyaluronidase as additive to cytostatic chemotherapy. Cancer Lett. 131, 85-99 (1998).
    • (1998) Cancer Lett. , vol.131 , pp. 85-99
    • Baumgartner, G.1    Gomar-Hoss, C.2    Sakr, L.3    Ulsperger, E.4    Wogritsch, C.5
  • 105
    • 0029783842 scopus 로고    scopus 로고
    • Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells
    • St. Croix, B. et al. Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells. J. Natl Cancer Inst. 88, 1285-1296 (1996).
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 1285-1296
    • St. Croix, B.1
  • 106
    • 0032508627 scopus 로고    scopus 로고
    • Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors
    • St. Croix, B., Man, S. & Kerbel, R. S. Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors. Cancer Lett. 131, 35-44 (1998).
    • (1998) Cancer Lett. , vol.131 , pp. 35-44
    • St. Croix, B.1    Man, S.2    Kerbel, R.S.3
  • 107
    • 0033800091 scopus 로고    scopus 로고
    • Multicellular resistance: A paradigm for clinical resistance?
    • Desoize, B. & Jardillier, J. Multicellular resistance: a paradigm for clinical resistance? Crit. Rev. Oncol. Hematol. 36, 193-207 (2000).
    • (2000) Crit. Rev. Oncol. Hematol. , vol.36 , pp. 193-207
    • Desoize, B.1    Jardillier, J.2
  • 108
    • 0037879594 scopus 로고    scopus 로고
    • Hyaluronan, a major non-protein glycosaminoglycan component of the extracellular matrix in human bone marrow, mediates dexamethasone resistance in multiple myeloma
    • Vincent, T., Molina, L., Espert, L. & Mechti, N. Hyaluronan, a major non-protein glycosaminoglycan component of the extracellular matrix in human bone marrow, mediates dexamethasone resistance in multiple myeloma. Br. J. Haematol. 121, 259-269 (2003).
    • (2003) Br. J. Haematol. , vol.121 , pp. 259-269
    • Vincent, T.1    Molina, L.2    Espert, L.3    Mechti, N.4
  • 109
    • 0019457297 scopus 로고
    • Receptors for hyaluronate on the surface of parent and virus-transformed cell lines: Binding and aggregation studies
    • Underhill, C. B. & Toole, B. P. Receptors for hyaluronate on the surface of parent and virus- transformed cell lines: binding and aggregation studies. Exp. Cell Res. 131, 419-423 (1981).
    • (1981) Exp. Cell Res. , vol.131 , pp. 419-423
    • Underhill, C.B.1    Toole, B.P.2
  • 110
    • 0033545984 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles
    • Misra, S., Ujhazy, P., Varticovski, L. & Arias, I. M. Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles. Proc. Natl Acad. Sci. USA 96, 5814-5819 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 5814-5819
    • Misra, S.1    Ujhazy, P.2    Varticovski, L.3    Arias, I.M.4
  • 111
    • 4444286327 scopus 로고    scopus 로고
    • Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters
    • in the press
    • Prehm, P. & Schumacher, U. Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters. Biochem. Pharmacol. (in the press).
    • Biochem. Pharmacol.
    • Prehm, P.1    Schumacher, U.2
  • 112
    • 0028795147 scopus 로고
    • The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily
    • Biswas, C. et al. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res. 55, 434-439 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 434-439
    • Biswas, C.1
  • 113
    • 1242338794 scopus 로고    scopus 로고
    • Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production
    • Marieb, E. et al. Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer Res. 64, 1229-1232 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 1229-1232
    • Marieb, E.1
  • 114
    • 0642277903 scopus 로고    scopus 로고
    • Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function
    • Toole, B. P. Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function. Curr. Top. Dev. Biol. 54, 371-389 (2003).
    • (2003) Curr. Top. Dev. Biol. , vol.54 , pp. 371-389
    • Toole, B.P.1
  • 115
    • 0037392052 scopus 로고    scopus 로고
    • Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells
    • Yang, J. M. et al. Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Mol. Cancer Res. 1, 420-427 (2003).
    • (2003) Mol. Cancer Res. , vol.1 , pp. 420-427
    • Yang, J.M.1
  • 116
    • 0034976637 scopus 로고    scopus 로고
    • Tumorigenic potential of extracellular matrix metalloproteinase inducer (EMMPRIN)
    • Zucker, S. et al. Tumorigenic potential of extracellular matrix metalloproteinase inducer (EMMPRIN). Am. J. Path. 158, 1921-1928 (2001).
    • (2001) Am. J. Path. , vol.158 , pp. 1921-1928
    • Zucker, S.1
  • 117
    • 18344382135 scopus 로고    scopus 로고
    • Combined transcriptome and genome analysis of single micrometastatic cells
    • Klein, C. A. et al. Combined transcriptome and genome analysis of single micrometastatic cells. Nature Biotechnol. 20, 387-392 (2002).
    • (2002) Nature Biotechnol. , vol.20 , pp. 387-392
    • Klein, C.A.1
  • 118
    • 0035199380 scopus 로고    scopus 로고
    • Introduction of antisense CD44S cDNA down-regulates expression of overall CD 44 isoforms and inhibits tumor growth and metastasis in highly metastatic colon carcinoma cells
    • Harada, N. et al. Introduction of antisense CD44S cDNA down-regulates expression of overall CD44 isoforms and inhibits tumor growth and metastasis in highly metastatic colon carcinoma cells. Int. J. Cancer 91, 67-75 (2001).
    • (2001) Int. J. Cancer , vol.91 , pp. 67-75
    • Harada, N.1
  • 119
    • 0037089521 scopus 로고    scopus 로고
    • Absence of the CD44 gene prevents sarcoma metastasis
    • Weber, G. F. et al. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res. 62, 2281-2286 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 2281-2286
    • Weber, G.F.1
  • 120
    • 0029891775 scopus 로고    scopus 로고
    • Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells
    • Sleeman, J. P. et al. Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells. Cancer Res. 56, 3134-3141 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 3134-3141
    • Sleeman, J.P.1
  • 121
    • 0032101137 scopus 로고    scopus 로고
    • Metastasis suppression by the standard CD 44 isoform does not require the binding of prostate cancer cells to hyaluronate
    • Gao, A. C., Lou, W., Sleeman, J. P. & Isaacs, J. T. Metastasis suppression by the standard CD44 isoform does not require the binding of prostate cancer cells to hyaluronate. Cancer Res. 58, 2350-2352 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 2350-2352
    • Gao, A.C.1    Lou, W.2    Sleeman, J.P.3    Isaacs, J.T.4
  • 122
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers, A. F., Groom, A. C. & MacDonald, I. C. Dissemination and growth of cancer cells in metastatic sites. Nature Rev. Cancer 2, 563-572 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 123
    • 0037155798 scopus 로고    scopus 로고
    • Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells
    • Simpson, M. A. et al. Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. J. Biol. Chem. 277, 10050-10057 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 10050-10057
    • Simpson, M.A.1
  • 124
    • 0034623223 scopus 로고    scopus 로고
    • Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells
    • Lokeshwar, V. B. & Selzer, M. G. Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells. J. Biol. Chem. 275, 27641-27649 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 27641-27649
    • Lokeshwar, V.B.1    Selzer, M.G.2
  • 125
    • 0035965301 scopus 로고    scopus 로고
    • Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis
    • Savani, R. C. et al. Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis. J. Biol. Chem. 276, 36770-36778 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 36770-36778
    • Savani, R.C.1
  • 126
    • 0036890218 scopus 로고    scopus 로고
    • 2+ signaling during hyaluronan (HA)-induced endothelial cell migration
    • 2+ signaling during hyaluronan (HA)-induced endothelial cell migration. Cell Motil. Cytoskeleton 53, 293-316 (2002).
    • (2002) Cell Motil. Cytoskeleton , vol.53 , pp. 293-316
    • Singleton, P.A.1    Bourguignon, L.Y.2
  • 127
    • 0037531791 scopus 로고    scopus 로고
    • Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer
    • Williams, C. S. et al. Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer. J. Pathol. 200, 195-206 (2003).
    • (2003) J. Pathol. , vol.200 , pp. 195-206
    • Williams, C.S.1
  • 128
    • 0032917384 scopus 로고    scopus 로고
    • Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells
    • Evanko, S. P., Angello, J. C. & Wight, T. N. Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 19, 1004-1013 (1999).
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 1004-1013
    • Evanko, S.P.1    Angello, J.C.2    Wight, T.N.3
  • 129
    • 0032820555 scopus 로고    scopus 로고
    • Hyaluronan stimulates tumor cell migration by modulating the fibrin fiber architecture
    • Hayen, W., Goebeler, M., Kumar, S., Riessen, R. & Nehls, V. Hyaluronan stimulates tumor cell migration by modulating the fibrin fiber architecture. J. Cell Sci. 112, 2241-2251 (1999).
    • (1999) J. Cell Sci. , vol.112 , pp. 2241-2251
    • Hayen, W.1    Goebeler, M.2    Kumar, S.3    Riessen, R.4    Nehls, V.5
  • 130
    • 0028858363 scopus 로고
    • Hyaluronic acid/CD 44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro
    • Koochekpour, S., Pilkington, G. J. & Merzak, A. Hyaluronic acid/CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro. Int. J. Cancer 63, 450-454 (1995).
    • (1995) Int. J. Cancer , vol.63 , pp. 450-454
    • Koochekpour, S.1    Pilkington, G.J.2    Merzak, A.3
  • 131
    • 0029889923 scopus 로고    scopus 로고
    • Suppression of CD44 expression decreases migration and invasion of human glioma cells
    • Okada, H., Yoshida, J., Sokabe, M., Wakabayashi, T. & Hagiwara, M. Suppression of CD44 expression decreases migration and invasion of human glioma cells. Int. J. Cancer 66, 255-260 (1996).
    • (1996) Int. J. Cancer , vol.66 , pp. 255-260
    • Okada, H.1    Yoshida, J.2    Sokabe, M.3    Wakabayashi, T.4    Hagiwara, M.5
  • 132
    • 0033673670 scopus 로고    scopus 로고
    • Epidermal growth factor up-regulates CD44-dependent astrocytoma invasion in vitro
    • Monaghan, M. et al. Epidermal growth factor up-regulates CD44-dependent astrocytoma invasion in vitro. J. Pathol. 192, 519-525 (2000).
    • (2000) J. Pathol. , vol.192 , pp. 519-525
    • Monaghan, M.1
  • 133
    • 0034758718 scopus 로고    scopus 로고
    • Hyaluronate receptors mediating glioma cell migration and proliferation
    • Akiyama, Y. et al. Hyaluronate receptors mediating glioma cell migration and proliferation. J. Neurooncol. 53, 115-127 (2001).
    • (2001) J. Neurooncol. , vol.53 , pp. 115-127
    • Akiyama, Y.1
  • 134
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • Chambers, A. F. & Matrisian, L. M. Changing views of the role of matrix metalloproteinases in metastasis. J. Natl Cancer Inst. 89, 1260-1270 (1997).
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.M.2
  • 135
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad, M. & Werb, Z. New functions for the matrix metalloproteinases in cancer progression. Nature Rev. Cancer 2, 161-174 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 136
    • 0036830240 scopus 로고    scopus 로고
    • PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation
    • Park, M. J. et al. PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation. Cancer Res. 62, 6318-6322 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6318-6322
    • Park, M.J.1
  • 137
    • 0037099514 scopus 로고    scopus 로고
    • Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90
    • Zhang, Y. et al. Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90. Cancer Res. 62, 3962-3965 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 3962-3965
    • Zhang, Y.1
  • 138
    • 0031808063 scopus 로고    scopus 로고
    • CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells
    • Bourguignon, L. Y. et al. CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells. J. Cell Physiol. 176, 206-215 (1998).
    • (1998) J. Cell Physiol. , vol.176 , pp. 206-215
    • Bourguignon, L.Y.1
  • 139
    • 0032926177 scopus 로고    scopus 로고
    • Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion
    • Yu, Q. & Stamenkovic, I. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev. 13, 35-48 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 35-48
    • Yu, Q.1    Stamenkovic, I.2
  • 140
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis
    • Yu, Q. & Stamenkovic, I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis. Genes Dev. 14, 163-176 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 141
    • 0036683241 scopus 로고    scopus 로고
    • CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain
    • Mori, H. et al. CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J. 21, 3949-3959 (2002).
    • (2002) EMBO J. , vol.21 , pp. 3949-3959
    • Mori, H.1
  • 142
    • 0033580237 scopus 로고    scopus 로고
    • CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration
    • Okamoto, I. et al. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration. Oncogene 18, 1435-1446 (1999).
    • (1999) Oncogene , vol.18 , pp. 1435-1446
    • Okamoto, I.1
  • 143
    • 0035947766 scopus 로고    scopus 로고
    • Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration
    • Kajita, M. et al. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J. Cell Biol. 153, 893-904 (2001).
    • (2001) J. Cell Biol. , vol.153 , pp. 893-904
    • Kajita, M.1
  • 144
    • 3042692979 scopus 로고    scopus 로고
    • + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion
    • April (doi:10.1074/jbc.m 311838200)
    • + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J. Biol. Chem. 16 April 2004 (doi:10.1074/jbc.m311838200).
    • (2004) J. Biol. Chem. , vol.16
    • Bourguignon, L.Y.1    Singleton, P.A.2    Diedrich, F.3    Stern, R.4    Gilad, E.5
  • 145
    • 0342906190 scopus 로고    scopus 로고
    • Interaction between CD44 and the repeat domain of ankyrin promotes hyaluronic acid-mediated ovarian tumor cell migration
    • Zhu, D. & Bourguignon, L. Y. Interaction between CD44 and the repeat domain of ankyrin promotes hyaluronic acid-mediated ovarian tumor cell migration. J. Cell Physiol. 183, 182-195 (2000).
    • (2000) J. Cell Physiol. , vol.183 , pp. 182-195
    • Zhu, D.1    Bourguignon, L.Y.2
  • 146
    • 0036303142 scopus 로고    scopus 로고
    • A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility
    • Legg, J. W., Lewis, C. A., Parsons, M., Ng, T. & Isacke, C. M. A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility. Nature Cell Biol. 4, 399-407 (2002). One of a series of papers showing the importance of ezrin-CD44 interactions in cell motility.
    • (2002) Nature Cell Biol. , vol.4 , pp. 399-407
    • Legg, J.W.1    Lewis, C.A.2    Parsons, M.3    Ng, T.4    Isacke, C.M.5
  • 147
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery, J. P. Epithelial-mesenchymal transitions in tumour progression. Nature Rev. Cancer 2, 442-454 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 148
    • 0037424511 scopus 로고    scopus 로고
    • E-cadherin negatively regulates CD44-hyaluronan interaction and CD44-mediated tumor invasion and branching morphogenesis
    • Xu, Y. & Yu, Q. E-cadherin negatively regulates CD44-hyaluronan interaction and CD44-mediated tumor invasion and branching morphogenesis. J. Biol. Chem. 278, 8661-8668 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 8661-8668
    • Xu, Y.1    Yu, Q.2
  • 149
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, β-catenin, and cadherin pathways
    • Nelson, W. J. & Nusse, R. Convergence of Wnt, β-catenin, and cadherin pathways. Science 303, 1483-1487 (2004).
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 150
    • 0242406727 scopus 로고    scopus 로고
    • Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor)
    • Tolg, C., Poon, R., Fodde, R., Turley, E. A. & Alman, B. A. Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). Oncogene 22, 6873-6882 (2003).
    • (2003) Oncogene , vol.22 , pp. 6873-6882
    • Tolg, C.1    Poon, R.2    Fodde, R.3    Turley, E.A.4    Alman, B.A.5
  • 151
    • 0024367374 scopus 로고
    • Hyaluronan and angiogenesis
    • West, D. C. & Kumar, S. Hyaluronan and angiogenesis. Ciba Found. Symp. 143, 187-201 (1989).
    • (1989) Ciba Found. Symp. , vol.143 , pp. 187-201
    • West, D.C.1    Kumar, S.2
  • 152
    • 0035571633 scopus 로고    scopus 로고
    • Hyaluronan digestion and synthesis in an experimental model of metastatic tumour
    • Delpech, B. et al. Hyaluronan digestion and synthesis in an experimental model of metastatic tumour. Histochem. J. 33, 553-558 (2001).
    • (2001) Histochem. J. , vol.33 , pp. 553-558
    • Delpech, B.1
  • 153
    • 0032005877 scopus 로고    scopus 로고
    • Free radical depolymerization of hyaluronan by Maillard reaction products: Role in liquefaction of aging vitreous
    • Deguine, V. et al. Free radical depolymerization of hyaluronan by Maillard reaction products: role in liquefaction of aging vitreous. Int. J. Biol. Macromol. 22, 17-22 (1998).
    • (1998) Int. J. Biol. Macromol. , vol.22 , pp. 17-22
    • Deguine, V.1
  • 154
    • 0142122582 scopus 로고    scopus 로고
    • Reactive oxygen species depolymerize hyaluronan: Involvement of the hydroxyl radical
    • Yamazaki, K. et al. Reactive oxygen species depolymerize hyaluronan: involvement of the hydroxyl radical. Pathophysiology 9, 215-220 (2003).
    • (2003) Pathophysiology , vol.9 , pp. 215-220
    • Yamazaki, K.1
  • 155
    • 0021834944 scopus 로고
    • Angiogenesis induced by degradation products of hyaluronic acid
    • West, D. C., Hampson, I. N., Arnold, F. & Kumar, S. Angiogenesis induced by degradation products of hyaluronic acid. Science 228, 1324-1326 (1985). The first of a series of papers showing that hyaluronan breakdown products stimulate angiogenesis (see also references 156-162).
    • (1985) Science , vol.228 , pp. 1324-1326
    • West, D.C.1    Hampson, I.N.2    Arnold, F.3    Kumar, S.4
  • 156
    • 0024381917 scopus 로고
    • The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity
    • West, D. C. & Kumar, S. The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity. Exp. Cell Res. 183, 179-196 (1989).
    • (1989) Exp. Cell Res. , vol.183 , pp. 179-196
    • West, D.C.1    Kumar, S.2
  • 157
    • 0028034363 scopus 로고
    • Application of angiogenic oligosaccharides of hyaluronan increases blood vessel numbers in rat skin
    • Sattar, A. et al. Application of angiogenic oligosaccharides of hyaluronan increases blood vessel numbers in rat skin. J. Invest. Dermatol. 103, 576-579 (1994).
    • (1994) J. Invest. Dermatol. , vol.103 , pp. 576-579
    • Sattar, A.1
  • 158
    • 0029143355 scopus 로고
    • Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan
    • Lees, V. C., Fan, T. P. & West, D. C. Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan. Lab. Invest. 73, 259-266 (1995).
    • (1995) Lab. Invest. , vol.73 , pp. 259-266
    • Lees, V.C.1    Fan, T.P.2    West, D.C.3
  • 159
    • 0029767043 scopus 로고    scopus 로고
    • Synergistic effect of hyaluronan oligosaccharides and vascular endothelial growth factor on angiogenesis in vitro
    • Montesano, R., Kumar, S., Orci, L. & Pepper, M. S. Synergistic effect of hyaluronan oligosaccharides and vascular endothelial growth factor on angiogenesis in vitro. Lab. Invest. 75, 249-262 (1996).
    • (1996) Lab. Invest. , vol.75 , pp. 249-262
    • Montesano, R.1    Kumar, S.2    Orci, L.3    Pepper, M.S.4
  • 160
    • 0037050721 scopus 로고    scopus 로고
    • Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44-mediated mechanism
    • Rahmanian, M. & Heldin, P. Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44-mediated mechanism. Int. J. Cancer 97, 601-607 (2002).
    • (2002) Int. J. Cancer , vol.97 , pp. 601-607
    • Rahmanian, M.1    Heldin, P.2
  • 161
    • 0037174957 scopus 로고    scopus 로고
    • Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses
    • Slevin, M., Kumar, S. & Gaffney, J. Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses. J. Biol. Chem. 277, 41046-41059 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 41046-41059
    • Slevin, M.1    Kumar, S.2    Gaffney, J.3
  • 162
    • 0029938495 scopus 로고    scopus 로고
    • Evidence of involvement of CD44 in endothelial cell proliferation, migration and angiogenesis in vitro
    • Trochon, V. et al. Evidence of involvement of CD44 in endothelial cell proliferation, migration and angiogenesis in vitro. Int. J. Cancer 66, 664-668 (1996).
    • (1996) Int. J. Cancer , vol.66 , pp. 664-668
    • Trochon, V.1
  • 163
    • 1042278148 scopus 로고    scopus 로고
    • Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration
    • Murai, T. et al. Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration. J. Biol. Chem. 279, 4541-4550 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 4541-4550
    • Murai, T.1
  • 165
    • 0842309884 scopus 로고    scopus 로고
    • Respect thy neighbor!
    • Radisky, D. C. & Bissell, M. J. Respect thy neighbor! Science 303, 775-777 (2004).
    • (2004) Science , vol.303 , pp. 775-777
    • Radisky, D.C.1    Bissell, M.J.2
  • 166
    • 0036596352 scopus 로고    scopus 로고
    • EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
    • Liu, D., Aguirre-Ghiso, J., Estrada, Y. & Ossowski, L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 1, 445-457 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 445-457
    • Liu, D.1    Aguirre-Ghiso, J.2    Estrada, Y.3    Ossowski, L.4
  • 167
    • 0347123435 scopus 로고    scopus 로고
    • Mucins in cancer: Protection and control of the cell surface
    • Hollingsworth, M. A. & Swanson, B. J. Mucins in cancer: protection and control of the cell surface. Nature Rev. Cancer 4, 45-60 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 45-60
    • Hollingsworth, M.A.1    Swanson, B.J.2
  • 168
    • 0033135255 scopus 로고    scopus 로고
    • Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells
    • Pilarski, L. M. et al. Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells. Blood 93, 2918-2927 (1999).
    • (1999) Blood , vol.93 , pp. 2918-2927
    • Pilarski, L.M.1
  • 169
    • 0037307373 scopus 로고    scopus 로고
    • Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro
    • Nilsson, S. K. et al. Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro. Blood 101, 856-862 (2003).
    • (2003) Blood , vol.101 , pp. 856-862
    • Nilsson, S.K.1
  • 171
    • 0015124266 scopus 로고
    • Hyaluronate production and removal during corneal development in the chick
    • Toole, B. P. & Trelstad, R. L. Hyaluronate production and removal during corneal development in the chick. Dev. Biol. 26, 28-35 (1971).
    • (1971) Dev. Biol. , vol.26 , pp. 28-35
    • Toole, B.P.1    Trelstad, R.L.2
  • 172
    • 0031036521 scopus 로고    scopus 로고
    • Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells
    • Guo, H., Zucker, S., Gordon, M. K., Toole, B. P. & Biswas, C. Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells. J. Biol. Chem. 272, 24-27 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 24-27
    • Guo, H.1    Zucker, S.2    Gordon, M.K.3    Toole, B.P.4    Biswas, C.5
  • 173
    • 0036943814 scopus 로고    scopus 로고
    • Emmprin-mediated MMP regulation in tumor and endothelial cells
    • Caudroy, S. et al. Emmprin-mediated MMP regulation in tumor and endothelial cells. Clin. Exp. Metastasis 19, 697-702 (2002).
    • (2002) Clin. Exp. Metastasis , vol.19 , pp. 697-702
    • Caudroy, S.1
  • 174
    • 0035266353 scopus 로고    scopus 로고
    • Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions
    • Sun, J. & Hemler, M. E. Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res. 61, 2276-2281 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 2276-2281
    • Sun, J.1    Hemler, M.E.2
  • 175
    • 1342322842 scopus 로고    scopus 로고
    • Tumor-stroma interaction: Positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN
    • Tang, Y., Kesavan, P., Nakada, M. T. & Yan, L. Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase- dependent generation of soluble EMMPRIN. Mol. Cancer Res. 2, 73-80 (2004).
    • (2004) Mol. Cancer Res. , vol.2 , pp. 73-80
    • Tang, Y.1    Kesavan, P.2    Nakada, M.T.3    Yan, L.4
  • 176
    • 0027204733 scopus 로고
    • Assembly of pericellular matrices by COS-7 cells transfected with CD44 lymphocyte-homing receptor genes
    • Knudson, W., Bartnik, E. & Knudson, C. B. Assembly of pericellular matrices by COS-7 cells transfected with CD44 lymphocyte-homing receptor genes. Proc. Natl Acad. Sci. USA 90, 4003-4007 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4003-4007
    • Knudson, W.1    Bartnik, E.2    Knudson, C.B.3
  • 177
    • 0027722083 scopus 로고
    • The dynamic structure of the pericellular matrix on living cells
    • Lee, G. M., Johnstone, B., Jacobson, K. & Caterson, B. The dynamic structure of the pericellular matrix on living cells. J. Cell Biol. 123, 1899-1907 (1993).
    • (1993) J. Cell Biol. , vol.123 , pp. 1899-1907
    • Lee, G.M.1    Johnstone, B.2    Jacobson, K.3    Caterson, B.4
  • 178
    • 0027494155 scopus 로고
    • Synthesis and assembly of the hyaluronan-containing coats around normal human mesothelial cells
    • Heldin, P. & Pertoft, H. Synthesis and assembly of the hyaluronan-containing coats around normal human mesothelial cells. Exp. Cell Res. 208, 422-429 (1993).
    • (1993) Exp. Cell Res. , vol.208 , pp. 422-429
    • Heldin, P.1    Pertoft, H.2
  • 179
    • 0031939945 scopus 로고    scopus 로고
    • Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family
    • Spicer, A. P. & McDonald, J. A. Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. J. Biol. Chem. 273, 1923-1932 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 1923-1932
    • Spicer, A.P.1    McDonald, J.A.2
  • 180
    • 0036606332 scopus 로고    scopus 로고
    • Degradation of HER2 by ansamycins induces growth arrest and apoptosis in
    • Munster, P. N., Marchion, D. C., Basso, A. D. & Rosen, N. Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3′-kinase-AKT-dependent pathway. Cancer Res. 62, 3132-3137 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 3132-3137
    • Munster, P.N.1    Marchion, D.C.2    Basso, A.D.3    Rosen, N.4
  • 181
    • 1642461424 scopus 로고    scopus 로고
    • 2- signaling leading to nitric oxide production and endothelial cell adhesion and proliferation
    • 2- signaling leading to nitric oxide production and endothelial cell adhesion and proliferation. Exp. Cell Res. 295, 102-118 (2004).
    • (2004) Exp. Cell Res. , vol.295 , pp. 102-118
    • Singleton, P.A.1    Bourguignon, L.Y.2
  • 182
    • 0034462121 scopus 로고    scopus 로고
    • Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
    • Nakamura, N. et al. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol. Cell. Biol. 20, 8969-8982 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8969-8982
    • Nakamura, N.1
  • 183
    • 0034921007 scopus 로고    scopus 로고
    • Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis
    • Yamada, K. M. & Araki, M. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J. Cell Sci. 114, 2375-2382 (2001).
    • (2001) J. Cell Sci. , vol.114 , pp. 2375-2382
    • Yamada, K.M.1    Araki, M.2
  • 184
    • 0344844479 scopus 로고    scopus 로고
    • Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells
    • Menashi, S. et al. Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells. Cancer Res. 63, 7575-7580 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 7575-7580
    • Menashi, S.1
  • 185
    • 33750937087 scopus 로고    scopus 로고
    • Hyaluronan: Structure and physical properties
    • Hascall, V. C. & Laurent, T. Hyaluronan: structure and physical properties. Science of hyaluronan today [online] 〈http://www.glycoforum.gr. jp/science/hyaluronan/HA01/HA01E.html〉 (1997).
    • (1997) Science of Hyaluronan Today [Online]
    • Hascall, V.C.1    Laurent, T.2
  • 187
    • 3042733797 scopus 로고    scopus 로고
    • Hyaluronan in morphogenesis and tissue remodelling
    • Toole, B. P. Hyaluronan in morphogenesis and tissue remodelling. Science of hyaluronan today [online] 〈http://www.glycoforum.gr.jp/science/ hyaluronan/HA08/HA08E.html〉 (1998).
    • (1998) Science of Hyaluronan Today [Online]
    • Toole, B.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.