A novel PKC-regulated mechanism controls CD44-ezrin association and directional cell motility

Nature Cell Biology

Volumn 4, Issue 6, 2002, Pages 399-407

  Legg, James W ^a,d   Lewis, Charlotte A ^a   Parsons, Maddy ^b   Ng, Tony ^b   Isacke, Clare M ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EZRIN; HERMES ANTIGEN; HYALURONIC ACID; PROTEIN KINASE C; SERINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL MOTILITY; CHEMOTAXIS; CONTROLLED STUDY; ENERGY TRANSFER; ENZYME ACTIVATION; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMAGING SYSTEM; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD44; CELL MOVEMENT; CYTOSKELETAL PROTEINS; HUMANS; MELANOMA; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PHORBOL ESTERS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; SERINE; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0036303142     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb797     Document Type: Article

References (50)

1. CD44 and its interaction with extracellular matrix
2. CD44: Structure, function and association with the malignant process
3. Molecular organization, structural features and ligand binding characteristics of CD44, a highly variable cell surface glycoprotein with multiple functions
4. Regulation of cortical structure by the ezrin-radixin-moesin protein family
5. ERM proteins in cell adhesion and membrane dynamics
6. Cortical actin organization: Lessons from ERM (ezrin/radixin/moesin) proteins
7. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
8. Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin Regulation by conformational change
9. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
10. 2-terminal domain of ezrin correlates with its altered cellular distribution
11. Rho- and Rac- dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: An essential role for ezrin/radixin/moesin proteins
12. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
13. Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane
14. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling
15. Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells
16. Essential functions of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts
17. Radixin is involved in lamellipodial stability during nerve growth cone motility
18. Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility
19. Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44
20. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43 and ICAM-2
21. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
22. Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325
23. 2+/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan
24. CD44 phosphorylation regulates melanoma cell and fibroblast migration on, but not attachment to, a hyaluronan substratum
25. Lymphoma protein kinase C is associated with the transmembrane glycoprotein GP85 and may function in GP85-ankyrin binding
26. Variations in the cytoskeletal interaction and post-translational modification of the CD44 homing receptor in macrophages
27. Phosphorylation of CD44 in vivo requires both Ser323 and Ser325, but does not regulate membrane localisation or cytoskeletal interaction in epithelial cells
28. PKCα regulates β1 integrin-dependent motility, through association and control of integrin traffic
29. Imaging protein kinase Cα activation in cells
30. Intracellular coupling of adhesion receptors: Molecular proximity measurements
31. Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons
32. Three dimensional image restoration in fluorescence lifetime imaging microscopy
33. Fluorescence lifetime imaging microscopy: Spatial resolution of biochemical processes in the cell
34. The renaissance of fluorescence resonance energy transfer
35. Activation of protein kinase C stimulates the dephosphorylation of natriuretic peptide receptor-B at a single serine residue
36. + channel Kv1.1/Kvβ1.1 via dephosphorylation of Kv1.1
37. Integrin ligation and PKC activation are required for migration of colon carcinoma cells
38. Migration of human melanoma cells on hyaluronate is related to CD44 expression
39. Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors
40. CD44 modulates Hs578T human breast cancer cell adhesion, migration, and invasiveness
41. CD44 interaction with tiam 1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
42. Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration
43. Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells
44. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP
45. β1-integrin and PTEN control the phosphorylation of protein kinase C
46. Fluorescence resonance energy transfer microscopy
47. The cytoplasmic tail of CD44 is required for basolateral localisation in epithelial MDCK cells but does not mediate association with the detergent insoluble cytoskeleton of fibroblasts
48. AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44
49. Monoclonal antibodies specific for under-phosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs
50. Analyzing chemotaxis using the Dunn direct-viewing chamber