Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells

Cancer Research

Volumn 56, Issue 13, 1996, Pages 3134-3141

  Sleeman, Jonathan P ^a   Arming, Sigrid ^b   Moll, Jürgen F ^a   Hekele, Armin ^a   Rudy, Wolfgang ^a   Sherman, Larry S ^a   Kreil, Günther ^b   Ponta, Helmut ^a   Herrlich, Peter ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; HYALURONIC ACID;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER INVASION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; METASTASIS; NONHUMAN; PANCREAS CARCINOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIGENS, CD44; EXONS; HYALURONIC ACID; ISOMERISM; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; PANCREATIC NEOPLASMS; RATS; RATS, INBRED STRAINS; TUMOR CELLS, CULTURED;

EID: 0029891775     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Herrlich, P., Zoller, M., Pals, S T , and Ponta, H. CD44 splice variants: metastases meet lymphocytes. Immunol. Today, 14, 395-399, 1993.
2. Lesley, J , Hyman, R , and Kincade, P. W. CD44 and its interaction with the cellular matrix. Adv Immunol., 54: 271-335, 1993.
3. Knudson, C. B., and Knudson, W. Hyaluronan-binding protein in development, tissue homeostasis, and disease. FASEB J., 7, 1233-1241, 1993
4. Screaton, G R., Bell, M. V , Jackson, D G , Cornelis, F B , Gerth, U., and Bell, J. I. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc. Natl. Acad. Sci USA, 89: 12160-12164, 1992
5. Tölg, C , Hofmann, M., Herrlich, P , and Ponta, H. Splicing choice from ten variant exons establishes CD44 variability. Nucleic Acids Res., 21: 1225-1229, 1993.
6. Sherman, L., Sleeman, J., Herrlich, P., and Ponta, H. Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression. Curr. Opin. Cell Biol., 6, 726-733, 1994.
7. Aruffo, A., Stamenkovic, I., Melnick, M., Underhill, C B , and Seed, B. CD44 is the principal cell surface receptor for hyaluronate. Cell, 61: 1303-1313, 1990
8. Lesley, J., and Hyman, R CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells. Eur. J Immunol., 22: 2719-2723, 1992.
9. Yang, B., Yang, B. L., Savani, R. C., and Turley, E. A. Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO J., 13: 286-296, 1994
10. Stamenkovic, I. Aruffo, A., Amiot, M , and Seed, B. The hematopoieuc and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells EMBO J., 10 343-348, 1991
11. Dougherty, G J., Cooper, D L , Memory, J. F., and Chiu, R. K. Ligand binding specificity of alternatively spliced CD44 isoforms Recognition and binding of hyaluronan by CD44R1 J Biol. Chem., 269, 9074-9078, 1994.
12. He, Q., Lesley, J , Hyman, R., Ishihara, K., and Kincade, P. W. Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J. Cell Biol., 119, 1711-1719, 1992
13. Gunthert, U., Hofmann, M., Rudy, W., Reber, S , Zoller, M., Hauβmann, I., Matzku, S , Wenzel, A., Ponta, H , and Herrlich, P A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell, 65, 13-24, 1991.
14. Sleeman, J., Moll, J., Sherman, L., Dall, P., Pals, S. T., Ponta, H., and Herrlich, P The role of CD44 splice variants in human metastatic cancer Ciba Found. Symp., 189: 142-156, 1995.
15. Sy, M S , Guo, Y-J., and Stamenkovic, I. Distinct effects of two CD44 isoforms on tumor growth in vivo. J Exp. Med , 174: 859-866, 1991
16. Bartolazzi, A , Peach, R., Aruffo, A , and Stamenkovic, I. Interaction between CD44 and hvaluronate is directly implicated in the regulation of tumor development. J. Exp. Med , 180 53-66, 1994
17. Rudy, W , Hofmann, M., Schwartz-Albiez, R , Zöller, M., Heider, K-H., Ponta, H., and Herrlich, P. The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior Cancer Res., 53: 1262-1268, 1993.
18. Kaneko, T , and LePage, G. A. Growth characteristics and drug responses of a murine lung carcinoma in vitro and in vivo Cancer Res., 38: 2084-2090, 1978.
19. Gorman, C High efficiency gene transfer into mammalian cells. In: D. M. Glover (ed), DNA Cloning. A Practical Approach, pp. 143-190. Oxford: IRL Press, 1985.
20. Smith, D B , and Johnson, K. S. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene, 67: 31-40, 1988.
21. Harlow, E. and Lane, D. Antibodies A Laboratory Manual Cold Cold Spring Harbor. NY: Spring Harbor Laboratory Press, 1988.
22. Matzku, S., Wenzel, A., Liu, S., and Zoller, M Antigenic differences between metastatic and nonmetastatic BSp73 rat tumor variants characterized by monoclonal antibodies. Cancer Res., 49, 1294-1299, 1989.
23. T detected only on CD4 positive T blasts. Mol. Immunol., 24: 1281-1290, 1987
24. Miyake, K., Underhill, C. B., Lesley, J , and Kincade, P W. Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J. Exp. Med., 172: 69-75, 1990.
25. Laemmli, U. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227, 680-685, 1970.
26. Towbin, H., Stachelin, T., and Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76 4350-4354, 1979
27. Sleeman, J P. Xenopus A-myb is expressed during early spermatogenesis. Oncogene, 8: 1931-1941, 1993.
28. Underhill, C. B., Chi-Rosso, G., and Toole, B. P. Effects of detergent solubilization on the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3 cells J. Biol. Chem , 258: 8086-8091, 1983
29. Gmachl, M., Sagan, S., Ketter, S., and Kreil, G. The human sperm protein PH-20 has hyaluronale activity. FEBS Lett., 336: 545-548, 1993.
30. Dorfman, A. Mucopolysaccharides. Methods Enzymol., 1, 166-173, 1955
31. Ossowski, L., and Reich, E. Experimental model for quantitative study of metastasis Cancer Res., 40: 2300-2309, 1980.
32. Peach, R. J , Hollenbaugh, D., Stamenkovic, I., and Aruffo, A. Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J. Cell Biol., 122: 257-264, 1993.
33. Reber, S., Matzku, S , Günthert, U., Ponta, H., Herrlich, P., and Zöller, M. Retardation of metastatic tumor growth after immunization with metastasis-specific monoclonal antibodies. Int. J. Cancer, 46: 919-927, 1990.
34. Seiter, S., Arch, R., Komitowski, D , Hofmann, M., Ponta, H., Herrlich, P., Matzku, S., and Zoller, M. Prevention of tumor metastasis formation by anti-variant CD44. J. Exp. Med., 177: 443-455, 1993.
35. Miyake, K., Medina, K., L., Hayashi, S , Ono, S., Hamaoka, T , and Kincade, P. W. Monoclonal antibodies to Pgp-1/CD44 block lymphohemopoiesis in long-term bone marrow cultures J. Exp. Med., 171: 477-488, 1990
36. Ponta, H., Sleeman, J., and Herrlich, P. Tumor metastasis formation. cell-surface proteins confer metastasis-promoting or -suppressing properties Biochim. Biophys. Acta, 1198: 1-10, 1994.
37. Knudson, W , Biswas, C., and Toole, B. P. Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis. Proc. Natl Acad. Sci. USA, 81: 6767-6771, 1984.
38. Thomas, L , Byers, H. R., Vink, J., and Stamenkovic, I. CD44H regulates tumor cell migration on hyaluronate-coated substrate. J. Cell Biol. 118: 971-977, 1992.
39. Guo, Y., Ma, J., Wang, J , Che, X., Narula, J., Bigby, M. Wu, M., and Sy, M. S. Inhibition of human melanoma growth and metastasis in vivo by anti-CD44 monoclonal antibody. Cancer Res , 54: 1561-1565, 1994
40. Took, B. P., Biswas, C., and Gross, J. Hyaluronate and invasiveness of the rabbit V2 carcinoma. Proc. Natl Acad. Sci USA, 76, 6299-6303, 1979.
41. Knudson, W., Biswas, C., Li, X. Q., Nemec, R E., and O'Toole, B. P. The role and regulation of tumor-associated hyaluronan The biology of hyaluronan. Ciba Found. Symp., 143: 150-169, 1989.
42. Turley, E. A., Austen, L., Moore, D., and Hoare, K. Ras-transformed cells express both CD44 and RHAMM hyaluronan receptors: only RHAMM is essential for hyaluronan-promoted locomotion Exp Cell Res., 207: 277-282, 1993.
43. Delpech, B., Chevallier, B., Reinhard, N , Julien, J P., Duval, C., Maingonnat, C., Bastit, P , and Asselain, B Serum hyaluronan (hyaluromc acid) in breast cancer patients. Int. J. Cancer. 46: 388-390, 1990.
44. Mahlbacher, V., Sewing, A., Elsasser, H-P., and Kem, H. F. Hyaluronan is a secretory product of human pancreatic adenocarcinoma cells. Eur. J. Cell Biol., 58: 28-34, 1992
45. Isaacs, J., Heston, W , Weissman, R., and Coffey, D. Animal models of the hormone sensitive and insensitive prostatic adenocarcinomas, Dunning R-3327-H, R-3327-HI, and R-3327-AT. Cancer Res , 38: 4353-4359, 1978
46. Isaacs, J., Isaacs, W., Feitz, W., and Scheres, J. Establishment and characterization of seven Dunning rat prostatic cancer cell lines and their use in developing methods for predicting metasratic abilities of prostatic cancers. Prostate, 9: 261-281, 1986.
47. Ichikawa, T., Ichilcawa, I , Dong, J, Hawkins, A., Griffin, C., Isaacs, W., Oshimura, M., Barrett, J., and Isaacs, J. Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. Cancer Res , 52: 3486-3490, 1992
48. Ichikawa, T , Ichikawa, I , and Isaacs, J. Genetic factors and suppression of metastatic ability of prostatic cancer. Cancer Res., 51: 3788-3792, 1991.
49. Hofmann, M., Rudy, W , Gunthert, U., Zimmer, S. G., Zawadzki, V., Zöller, M , Lichtner, R. B., Herrlich, P , and Ponta, H. A link between ras and metastatic behavior of tumor cells: ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells Cancer Res., 53: 1516-1521, 1993.
50. Dunnington, D., Kim, U., Hughes, C., Monaghan, P , Ormerod, E., and Rudland, P. Loss of myoepithelial cell characteristics in metastasizing rat mammary tumors relative to their nonmetastasizing counterparts. J. Natl. Cancer Inst., 72, 455-466, 1984.
51. Lichtner, R. B , and Nicolson, G. L Organization of cytoskeletal structures in 13762NF rat mammary adenocarcinorna cell lines and clones of different metastatic potentials. Invasion & Metastasis, 7: 73-82, 1987.
52. Neri, A , Ruoslahti, E., and Nicolson, G. L. The distribution of fibronectin on clonal cell lines of a rat mammary adenocarcinoma growing in vitro and in vivo at primary and metastatic sites Cancer Res., 41, 5082-5095, 1981.