Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression

Journal of Experimental Medicine

Volumn 183, Issue 4, 1996, Pages 1663-1668

  Mohapatra, Subhra ^a   Yang, Xuiwei ^a   Wright, Jim A ^a,b   Turley, Eva A ^a,b   Greenberg, Arnold H ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; GLUTATHIONE TRANSFERASE; HYALURONIC ACID; HYBRID PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL GROWTH; CONTROLLED STUDY; EMBRYO; FIBROBLAST CULTURE; FIBROSARCOMA; GENE EXPRESSION; GROWTH INHIBITION; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TUMOR VOLUME;

ANIMALS; ANTIGENS, CD44; CARCINOMA; CDC2 PROTEIN KINASE; CELL LINE; CYCLIN B; CYCLINS; EXTRACELLULAR MATRIX PROTEINS; FIBROSARCOMA; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; HYALURONIC ACID; LUNG NEOPLASMS; MAMMARY NEOPLASMS, ANIMAL; MICE; MITOSIS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SOLUBILITY; TUMOR CELLS, CULTURED;

EID: 0029935148     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.4.1663     Document Type: Article

References (28)

1. Laurent, T.C., and J.R.E. Fraser. 1992. Hyaluronan. FASEB (Fed. Am. Soc. Exp. Biol.) J. 6:2397-2404.
2. Hardwick, C., K. Hoare, R. Owens, H.P. Hohn, M. Hook, D. Moore, V. Cripps, L. Austen, D.M. Nance, and E.A. Turley. 1992. Molecular cloning of a novel hyalurorian receptor that mediates tumor cell motility. J. Cell Biol. 117: 1343-1350.
3. Turley E.A., A.R. Blech, S. Poppema, and L.M. Pilarsky. 1993. Expression and function of a receptor for hyaluronanmediated motility (RHAMM) on normal and malignant B lymphocytes. Blood. 81:446-453.
4. Pilarski, L.M., H. Miszta, and E.A. Turley. 1993. Regulated expression of a receptor for hyaluronan-mediated motility on human thymocytes and T cells. J. Immunol. 150:4292-4302.
5. Savani, R.C., C. Wang, B. Yang, S. Zhang, M.G. Kinsella, T.N. Wight, R. Stern, D.M. Nance, and E.A. Turley. 1995. Migration of bovine aortic smooth muscle cells after wounding injury. J. Clin. Invest. 95:1158-1168.
6. Samuel, S.K., R.A.R. Hurta, M.A. Sperman, J.A. Wright, E.A. Turley, and A.H. Greenberg. 1993. TGF-β1 stimulation of cell locomotion utilizes the hyaluronan receptor RHAMM and hyaluronan. J. Cell Biol. 133:749-758.
7. Hall, C.L., C. Wang, L.A. Lange, and E.A. Turley. 1994. Hyaluronan and hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity. J. Cell Biol. 126:575-588.
8. Hall, C.L., B. Yang, X. Yang, S. Zhang, M. Turley, S. Samuel, L. Lange, C. Wang, G.D. Curpen, R. Savani, et al. 1995. Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation. Cell. 82:19-28.
9. Yang, B., L. Zhang, and E.A. Turley. 1993. Identification of two hyaluronan-binding domains in the hyaluronan receptor RHAMM. J. Biol. Chem. 268:8617-8623.
10. Egan, S.E., J.A. Wright, L. Jarolim, K. Yanagihara, R.H. Bassin, and A.H. Greenberg. 1987. Transformation by oncogenes encoding protein kinases induces the metastaric phenotype. Science (Wash. DC). 238:202-205.
11. Th'ng, J.P., P.S. Wright, J. Hamaguchi, M.G. Lee, C.J. Norbury, P. Nurse, and E.M. Bradbury. 1990. The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive cdc2 gene product. Cell. 63:313-324.
12. cdc2 activation required for apoptosis. Science (Wash. DC). 263: 1143-1145.
13. Choczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
14. M.E. Greenberg, and E.B. Ziff. 1984. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (Lond.). 311:433-438.
15. Welch, P.J., and J.Y. Wang. 1992. Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle. Proc. Natl Acad. Sci. USA. 89:3093-3097.
16. Riabowol, K., G. Draetta, L. Brizuela, D. Vandre, and D. Beach. 1989. The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell. 57:393-401.
17. Lee, M.G., C.H. Norbury, N.K. Spurr, and P. Nurse. 1988. Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein. Nature (Lond.). 333:676-679.
18. Pine, J., and T. Hunter. 1989. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell. 58: 833-846.
19. McGowan, C.H., P. Russell, and S.I. Reed. 1990. Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle. Mol. Cell. Biol 7: 3847-3851.
20. Dalton, S. 1992. Cell cycle regulation of human cdc2 gene. EMBO (Eur. Mol. Biol. Organ.) J. 11:1797-1804.
21. Sy, M.S., Y.J. Guo, and I. Stamenkovic. 1992. Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein. J. Exp. Med. 176:623-627.
22. Bartolazzi, A., R. Peach, A. Aruffo, and I. Stamenkovic. 1994. Interaction between CD44 and hyluronate is directly implicated in the regulation of tumor development. J. Exp. Med. 180:53-66.
23. Brecht, M., U. Mayor, E. Schlosser, and P. Prehm. 1986. Increased hyluronate synthesis is required for fibroblast detachment and mitosis. Biochem. J. 239:445-450.
24. fak accompanies cell adhesion to the extracellular matrix: a role in cytoskeletal assembly. J. Cell Biol. 119:893-903.
25. 1, integrins. Proc. Natl. Acad. Sci. USA. 88:8392-8396.
26. Clark, E.A., and J.S. Brugge. 1995. Integrins and signal transduction pathways: the road taken. Science (Wash. DC). 268: 233-239.
27. Edward, K.H., T.M. Guadagno, S.L. Dalton, and R.K. Assoian. 1993. A cell cycle and mutational analysis of anchor-age-independent growth: cell adhesion and TGF-β1 control G1/S transit specifically. J. Cell Biol. 122:461-471.
28. Guadagno, T.M., M. Ohtsubo, J.M. Roberts, and R.K. Assoian. 1993. A link between cyclin A expression and adhesion-dependent cell cycle progression. Science (Wash. DC) 262:1572-1575.