Watch thy neighbor: Cancer is a communal affair

Journal of Cell Science

Volumn 117, Issue 8, 2004, Pages 1287-1290

  Weaver, Valerie M ^a   Gilbert, Penney ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; METALLOPROTEINASE; METHYLNITROSOUREA; TUMOR SUPPRESSOR PROTEIN;

ANGIOGENESIS; ARTICLE; CANCER INVASION; CARCINOGENESIS; CELL INTERACTION; CELL TYPE; DNA ADDUCT; EPIGENETICS; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENE MUTATION; HETEROZYGOSITY LOSS; HOMEOSTASIS; HUMAN; MALIGNANT TRANSFORMATION; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; STROMA; TUMOR SUPPRESSOR GENE;

ALKYLATING AGENTS; ANIMALS; CARCINOGENS; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FEMALE; GENES, RAS; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; MUTATION; NEOPLASM TRANSPLANTATION; RATS; RATS, INBRED WF; STROMAL CELLS;

EID: 2342444724     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01137     Document Type: Article

References (12)

1. Bissell, M. J. and Radisky, D. (2001). Putting tumours in context. Nat. Rev. Cancer 1, 46-54.
2. Deng, G., Lu, Y., Zlotnikov, G., Thor, A. D. and Smith, H. S. (1996). Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274, 2057-2059.
3. Haggie, J. A., Sellwood, R. A., Howell, A., Birch, J. M. and Schor, S. L. (1987). Fibroblasts from relatives of patients with hereditary breast cancer show fetal-like behaviour in vitro. Lancet 1, 1455-1457.
4. Holst, C. R., Nuovo, G. J., Esteller, M., Chew, K., Baylin, S. B., Herman, J. G. and Tisty, T. D. (2003). Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res. 63, 1596-1601.
5. Kenny, P. A. and Bissell, M. J. (2003). Tumor reversion: correction of malignant behavior by microenvironmental cues. Int. J. Cancer 107, 688-695.
6. Kinzler, K. W. and Vogelstein, B. (1996). Lessons from hereditary colorectal cancer. Cell 87, 159-170.
7. Maffini, M. V., Soto, A. M., Calabro, J. M., Ucci, A. A. and Sonnenschein, C. (2004) The stroma as a crucial target in rat mammary gland carcinogenesis. J. Cell Sci. 117, 1495-1502.
8. Moinfar, F., Man, Y. G., Arnould, L., Bratthauer, G. L., Ratschek, M. and Tavassoli, F. A. (2000). Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res. 60, 2562-2566.
9. Sonnenschein, C. and Soto, A. M. (2000). Somatic mutation theory of carcinogenesis: why it should be dropped and replaced. Mol. Carcinog. 29, 205-211.
10. Sternlicht, M. D., Lochter, A., Sympson, C. J., Huey, B., Rougier, J. P., Gray, J. W., Pinkel, D., Bissell, M. J. and Werb, Z. (1999). The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 98, 137-146.
11. Unger, M. and Weaver, V. M. (2003). The tissue microenvironment as an epigenetic tumor modifier. Methods Mol. Biol. 223, 315-347.
12. Zhu, Y., Ghosh, P., Charnay, P., Burns, D. K. and Parada, L. F. (2002). Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 296, 920-922.