CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain

EMBO Journal

Volumn 21, Issue 15, 2002, Pages 3949-3959

  Mori, Hidetoshi ^a   Tomari, Taizo ^a   Koshikawa, Naohiko ^a   Kajita, Masahiro ^a   Itoh, Yoshifumi ^a   Sato, Hiroshi ^a   Tojo, Hideaki ^a   Yana, Ikuo ^a   Seiki, Motoharu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Actin; CD44; Invasion; Lamellipodium; MT1 MMP

Indexed keywords

CD44H ANTIGEN; CD44V ANTIGEN; CYTOCHALASIN D; F ACTIN; HEMOPEXIN; HERMES ANTIGEN; MATRIX METALLOPROTEINASE 14; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CYTOPLASM; CYTOSKELETON; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LAMELLIPODIUM; MEMBRANE BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLARIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

ACTINS; ANIMALS; ANTIGENS, CD44; CELL MEMBRANE; CELL MOVEMENT; CERCOPITHECUS AETHIOPS; CHO CELLS; CRICETINAE; CRICETULUS; CYTOSKELETON; FIBROBLASTS; HEMOPEXIN; HUMANS; MACROMOLECULAR SUBSTANCES; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PSEUDOPODIA; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0036683241     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf411     Document Type: Article

References (50)

1. The phagokinetic tracks of 3T3 cells
2. Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells
3. Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes
4. Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan
5. A CD44-like endothelial cell transmembrane glycoprotein (GP116) interacts with extracellular matrix and ankyrin
6. Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
7. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin ανβ3
8. The C-terminal region of membrane type matrix metalloproteinase is a functional transmembrane domain required for pro-gelatinase A activation
9. Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: Associated activation of gelatinase A, gelatinase B and collagenase 3
10. Pro-collagenase-1 (matrix metalloproteinase-1) binds the α2β1 integrin upon release from keratinocytes migrating on type I collagen
11. New functions for the matrix metalloproteinases in cancer progression
12. Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling
13. Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors
14. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
15. CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix
16. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
17. Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2 and 3
18. Folding and characterization of the amino-terminal domain of human tissue inhibitor of metalloproteinases-1 (TIMP-1) expressed at high yield in E. coli
19. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase
20. Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
21. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration
22. Mouse T lymphoma cells contain a transmembrane glycoprotein (GP85) that binds ankyrin
23. TIMP-2 promotes activation of progelatinase A by membrane-type 1 matrix metalloproteinase immobilized on agarose beads
24. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase A (MMP-2) are able to generate active enzyme
25. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP
26. Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5
27. Function and expression of CD44 during spreading, migration and invasion of murine carcinoma cells
28. Cell migration: A physically integrated molecular process
29. Matrix metalloproteinases: Multifunctional contributors to tumor progression
30. Actin-based cell motility and cell locomotion
31. Cytochalasin D does not produce net depolymerization of actin filaments in HEp-2 cells
32. Proteolysis and cell migration: Creating a path?
33. Matrix metalloproteinases
34. CD44: Structure, function and association with the malignant process
35. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration
36. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
37. A matrix metalloproteinase expressed on the surface of invasive tumour cells
38. Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts
39. Membrane-type matrix metalloproteinases
40. Antibody-induced shedding of CD44 from adherent cells is linked to the assembly of the cytoskeleton
41. The normal structure and function of CD44 and its role in neoplasia
42. Tumor cell interactions with the extracellular matrix during invasion and metastasis
43. CD44H regulates tumor cell migration on hyaluronate-coated substrate
44. Migration of human melanoma cells on hyaluronate is related to CD44 expression
45. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons
46. Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity
47. Absence of the CD44 gene prevents sarcoma metastasis
48. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43 and ICAM-2
49. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion
50. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling