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Volumn 287, Issue 1 56-1, 2004, Pages

The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma

Author keywords

E3 ubiquitin ligase; Hypoxia inducible factor; Renal cell carcinoma

Indexed keywords

VON HIPPEL LINDAU PROTEIN;

EID: 2942689618     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00424.2003     Document Type: Review
Times cited : (60)

References (89)
  • 1
    • 0030602813 scopus 로고    scopus 로고
    • SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    • Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, and Elledge SJ. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86: 263-274, 1996.
    • (1996) Cell , vol.86 , pp. 263-274
    • Bai, C.1    Sen, P.2    Hofmann, K.3    Ma, L.4    Goebl, M.5    Harper, J.W.6    Elledge, S.J.7
  • 3
    • 0033602089 scopus 로고    scopus 로고
    • Alternate choice of initiation codon produces a biologically active product of the von Hippel-Lindau gene with tumor suppressor activity
    • Blankenship C, Naglich J, Whaley J, Seizinger B, and Kley N. Alternate choice of initiation codon produces a biologically active product of the von Hippel-Lindau gene with tumor suppressor activity. Oncogene 18: 1529-1535, 1999.
    • (1999) Oncogene , vol.18 , pp. 1529-1535
    • Blankenship, C.1    Naglich, J.2    Whaley, J.3    Seizinger, B.4    Kley, N.5
  • 4
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn HF and Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76: 839-885, 1996.
    • (1996) Physiol Rev , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 6
    • 0035339044 scopus 로고    scopus 로고
    • Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease
    • Clifford SC, Cockman ME, Smallwood AC, Mole DR, Woodward ER, Maxwell PH, Ratcliffe PJ, and Maher ER. Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Hum Mol Genet 10: 1029-1038, 2001.
    • (2001) Hum Mol Genet , vol.10 , pp. 1029-1038
    • Clifford, S.C.1    Cockman, M.E.2    Smallwood, A.C.3    Mole, D.R.4    Woodward, E.R.5    Maxwell, P.H.6    Ratcliffe, P.J.7    Maher, E.R.8
  • 9
    • 0030948396 scopus 로고    scopus 로고
    • Immunostaining of the von Hippel-Lindau gene oroduct (pVHL) in normal and neoplastic human tissues
    • Corless CL, Kibel A, Iliopoulos O, and Kaelin WGJ. Immunostaining of the von Hippel-Lindau gene oroduct (pVHL) in normal and neoplastic human tissues. Hum Pathol 28: 459-464, 1997.
    • (1997) Hum Pathol , vol.28 , pp. 459-464
    • Corless, C.L.1    Kibel, A.2    Iliopoulos, O.3    Kaelin, W.G.J.4
  • 12
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • Dang C and Semenza G. Oncogenic alterations of metabolism. Trends Biochem Sci 24: 68-72, 1999.
    • (1999) Trends Biochem Sci , vol.24 , pp. 68-72
    • Dang, C.1    Semenza, G.2
  • 18
    • 0035852668 scopus 로고    scopus 로고
    • Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
    • Haase VH, Glickman JN, Socolovsky M, and Jaenisch R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci USA 98: 1583-1588, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1583-1588
    • Haase, V.H.1    Glickman, J.N.2    Socolovsky, M.3    Jaenisch, R.4
  • 20
    • 0037223823 scopus 로고    scopus 로고
    • Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
    • Hergovich A, Lisztwan J, Barry R, Ballschmieter P, and Krek W. Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat Cell Biol 5: 64-70, 2003.
    • (2003) Nat Cell Biol , vol.5 , pp. 64-70
    • Hergovich, A.1    Lisztwan, J.2    Barry, R.3    Ballschmieter, P.4    Krek, W.5
  • 21
    • 0035336706 scopus 로고    scopus 로고
    • Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
    • Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, and Kaelin WG Jr. Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum Mol Genet 10: 1019-1027, 2001.
    • (2001) Hum Mol Genet , vol.10 , pp. 1019-1027
    • Hoffman, M.A.1    Ohh, M.2    Yang, H.3    Klco, J.M.4    Ivan, M.5    Kaelin Jr., W.G.6
  • 22
    • 0030887045 scopus 로고    scopus 로고
    • Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
    • Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, and Bradfield CA. Characterization of a subset of the basic-helix-loop- helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 272: 8581-8593, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 8581-8593
    • Hogenesch, J.B.1    Chan, W.K.2    Jackiw, V.H.3    Brown, R.C.4    Gu, Y.Z.5    Pray-Grant, M.6    Perdew, G.H.7    Bradfield, C.A.8
  • 25
    • 0029090338 scopus 로고
    • Tumor suppression by the human von Hippel-Lindau hene product
    • Iliopoulos O, Kibel A, Gray S, and Kaelin WG. Tumor suppression by the human von Hippel-Lindau hene product. Nat Med 1: 822-826, 1995.
    • (1995) Nat Med , vol.1 , pp. 822-826
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin, W.G.4
  • 26
    • 0032578357 scopus 로고    scopus 로고
    • pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation
    • Iliopoulos O, Ohh M, and Kaelin W. pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc Natl Acad Sci USA 95: 11661-11666, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11661-11666
    • Iliopoulos, O.1    Ohh, M.2    Kaelin, W.3
  • 28
    • 0032514685 scopus 로고    scopus 로고
    • Down-regulation of transmembrance carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    • Ivanov S, Kuzmin I, Wei MH, Pack S, Geil L, Johnson B, Stanbridge E, and Lerman M. Down-regulation of transmembrance carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc Natl Acad Sci USA 95: 12596-12601, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12596-12601
    • Ivanov, S.1    Kuzmin, I.2    Wei, M.H.3    Pack, S.4    Geil, L.5    Johnson, B.6    Stanbridge, E.7    Lerman, M.8
  • 32
    • 0029295649 scopus 로고
    • Expression of the von Hippel-Lindau tumor-suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis
    • Kessler P, Vasavada S, Rackley R, Stackhouse T, Duh F, Latif F, Lerman M, Zbar B, and Williams B. Expression of the von Hippel-Lindau tumor-suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis. Mol Med 1: 457-466, 1995.
    • (1995) Mol Med , vol.1 , pp. 457-466
    • Kessler, P.1    Vasavada, S.2    Rackley, R.3    Stackhouse, T.4    Duh, F.5    Latif, F.6    Lerman, M.7    Zbar, B.8    Williams, B.9
  • 33
    • 0032583530 scopus 로고    scopus 로고
    • Recombinant adenovirus expressing Von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1
    • Kim M, Katayose Y, Li Q, Rakkar A, Li Z, Hwang S, Katayose D, Trepel J, Cowan K, and Seth P. Recombinant adenovirus expressing Von Hippel-Lindau- mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1. Biochem Biophys Res Commun 253: 672-677, 1998.
    • (1998) Biochem Biophys Res Commun , vol.253 , pp. 672-677
    • Kim, M.1    Katayose, Y.2    Li, Q.3    Rakkar, A.4    Li, Z.5    Hwang, S.6    Katayose, D.7    Trepel, J.8    Cowan, K.9    Seth, P.10
  • 35
    • 0024517466 scopus 로고
    • Tissue-specific expression of a constitutional 3;6 translocation: Development of multiple bilateral renal-cell carcinomas
    • Kovacs G, Brusa P, and De Riese W. Tissue-specific expression of a constitutional 3;6 translocation: development of multiple bilateral renal-cell carcinomas. Int J Cancer 43: 422-427, 1989.
    • (1989) Int J Cancer , vol.43 , pp. 422-427
    • Kovacs, G.1    Brusa, P.2    De Riese, W.3
  • 37
    • 0032211161 scopus 로고    scopus 로고
    • Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function
    • Krieg M, Marti H, and Plate KH. Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function. Blood 92: 3388-3393, 1998.
    • (1998) Blood , vol.92 , pp. 3388-3393
    • Krieg, M.1    Marti, H.2    Plate, K.H.3
  • 39
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, and Bruick RK. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16: 1466-1471, 2002.
    • (2002) Genes Dev , vol.16 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3    Whelan, D.A.4    Whitelaw, M.L.5    Bruick, R.K.6
  • 40
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • Lando D, Peet DJ, Whelan DA, Gorman JJ, and Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295: 858-861, 2002.
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 42
    • 0344592621 scopus 로고    scopus 로고
    • Playing tag with HIF: The VHL story
    • Leung SK and Ohh M. Playing tag with HIF: the VHL story. J Biomed Biotechnol 2: 131-135, 2002.
    • (2002) J Biomed Biotechnol , vol.2 , pp. 131-135
    • Leung, S.K.1    Ohh, M.2
  • 43
    • 0037085456 scopus 로고    scopus 로고
    • Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein
    • Li Z, Na X, Wang D, Schoen SR, Messing EM, and Wu G. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 277: 4656-4662, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 4656-4662
    • Li, Z.1    Na, X.2    Wang, D.3    Schoen, S.R.4    Messing, E.M.5    Wu, G.6
  • 44
    • 0037446951 scopus 로고    scopus 로고
    • The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1α transcriptional activity
    • Li Z, Wang D, Na X, Schoen SR, Messing EM, and Wu G. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1α transcriptional activity. EMBO J 22: 1857-1867, 2003.
    • (2003) EMBO J , vol.22 , pp. 1857-1867
    • Li, Z.1    Wang, D.2    Na, X.3    Schoen, S.R.4    Messing, E.M.5    Wu, G.6
  • 45
    • 0242608613 scopus 로고    scopus 로고
    • The genetic basis of cancer of the kidney
    • Linehan WM, Walther MM, and Zbar B. The genetic basis of cancer of the kidney. J Urol 170: 2163-2172, 2003.
    • (2003) J Urol , vol.170 , pp. 2163-2172
    • Linehan, W.M.1    Walther, M.M.2    Zbar, B.3
  • 46
    • 0031907152 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau protein requires binding to complexes containing elongins B/C and Cul2
    • Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, and Kaelin WG. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau protein requires binding to complexes containing elongins B/C and Cul2. Mol Cell Biol 18: 732-741, 1998.
    • (1998) Mol Cell Biol , vol.18 , pp. 732-741
    • Lonergan, K.M.1    Iliopoulos, O.2    Ohh, M.3    Kamura, T.4    Conaway, R.C.5    Conaway, J.W.6    Kaelin, W.G.7
  • 48
    • 0029847090 scopus 로고    scopus 로고
    • Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients
    • Lubensky IA, Gnarra JR, Bertheau P, Walther MM, Linehan WM, and Zhuang Z. Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients. Am J Pathol 149: 2089-2094, 1996.
    • (1996) Am J Pathol , vol.149 , pp. 2089-2094
    • Lubensky, I.A.1    Gnarra, J.R.2    Bertheau, P.3    Walther, M.M.4    Linehan, W.M.5    Zhuang, Z.6
  • 49
    • 0031445126 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • Maher E and Kaelin WG. Von Hippel-Lindau disease. Medicine 76: 381-391, 1997.
    • (1997) Medicine , vol.76 , pp. 381-391
    • Maher, E.1    Kaelin, W.G.2
  • 50
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon PC, Hirota K, and Semenza GL. FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686, 2001.
    • (2001) Genes Dev , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 51
    • 0036527785 scopus 로고    scopus 로고
    • The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
    • Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, and Klausner RD. The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1: 247-255, 2002.
    • (2002) Cancer Cell , vol.1 , pp. 247-255
    • Maranchie, J.K.1    Vasselli, J.R.2    Riss, J.3    Bonifacino, J.S.4    Linehan, W.M.5    Klausner, R.D.6
  • 53
    • 0033587146 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor α subunits
    • Maxwell P, Weisner M, Chang GW, Clifford S, Vaux E, Pugh C, Maher E, and Ratcliffe P. The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor α subunits. Nature 399: 271-275, 1999.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.1    Weisner, M.2    Chang, G.W.3    Clifford, S.4    Vaux, E.5    Pugh, C.6    Maher, E.7    Ratcliffe, P.8
  • 54
  • 56
    • 0036195134 scopus 로고    scopus 로고
    • An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
    • Ohh M, Kim WY, Moslehi JJ, Chen Y, Chau V, Read MA, and Kaelin WG. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. EMBO Rep 3: 177-182, 2002.
    • (2002) EMBO Rep , vol.3 , pp. 177-182
    • Ohh, M.1    Kim, W.Y.2    Moslehi, J.J.3    Chen, Y.4    Chau, V.5    Read, M.A.6    Kaelin, W.G.7
  • 59
    • 0033120027 scopus 로고    scopus 로고
    • ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
    • Ohta T, Michel JJ, Schottelius AJ, and Xiaong Y. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell 3: 535-541, 1999.
    • (1999) Mol Cell , vol.3 , pp. 535-541
    • Ohta, T.1    Michel, J.J.2    Schottelius, A.J.3    Xiaong, Y.4
  • 61
    • 0019998262 scopus 로고
    • Familial renal cell carcinoma with a 3; 11 chromosome translocation limited to tumor cells
    • Pathak S, Strong LC, Ferrell RE, and Trindade A. Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells. Science 217: 939-941, 1982.
    • (1982) Science , vol.217 , pp. 939-941
    • Pathak, S.1    Strong, L.C.2    Ferrell, R.E.3    Trindade, A.4
  • 62
    • 0032477788 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
    • Pause A, Lee S, Lonergan KM, and Klausner RD. The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proc Natl Acad Sci USA 95: 993-998, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 993-998
    • Pause, A.1    Lee, S.2    Lonergan, K.M.3    Klausner, R.D.4
  • 63
    • 0030953635 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
    • Pause A, Lee S, Worrell RA, Chen DYT, Burgess WH, Linehan WM, and Klausner RD. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci USA 94: 2156-2161, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2156-2161
    • Pause, A.1    Lee, S.2    Worrell, R.A.3    Chen, D.Y.T.4    Burgess, W.H.5    Linehan, W.M.6    Klausner, R.D.7
  • 65
    • 0029926989 scopus 로고    scopus 로고
    • Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis
    • Richards F, Schofield P, Fleming S, and Maher E. Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis. Hum Mol Genet 5: 639-644, 1996.
    • (1996) Hum Mol Genet , vol.5 , pp. 639-644
    • Richards, F.1    Schofield, P.2    Fleming, S.3    Maher, E.4
  • 67
    • 0032555217 scopus 로고    scopus 로고
    • A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor
    • Schoenfeld A, Davidowitz EJ, and Burk RD. A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc Natl Acad Sci USA 95: 8817-8822, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8817-8822
    • Schoenfeld, A.1    Davidowitz, E.J.2    Burk, R.D.3
  • 69
    • 0033529656 scopus 로고    scopus 로고
    • Perspectives on oxygen sensing
    • Semenza G. Perspectives on oxygen sensing. Cell 98: 281-284, 1999.
    • (1999) Cell , vol.98 , pp. 281-284
    • Semenza, G.1
  • 70
    • 0033233243 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1
    • 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15: 551-578, 1999.
    • (1999) Annu Rev Cell Dev Biol , vol.15 , pp. 551-578
    • Semenza, G.1
  • 71
    • 0029920054 scopus 로고    scopus 로고
    • Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein
    • Siemeister G, Weindel K, Mohrs K, Barleon B, Martiny-Baron G, and Marme D. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res 56: 2299-2301, 1996.
    • (1996) Cancer Res , vol.56 , pp. 2299-2301
    • Siemeister, G.1    Weindel, K.2    Mohrs, K.3    Barleon, B.4    Martiny-Baron, G.5    Marme, D.6
  • 73
    • 0029057703 scopus 로고
    • Human carbonic anhydrases and carbonic anhydrase deficiencies
    • Sly WS and Hu PY. Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem 64: 375-401, 1995.
    • (1995) Annu Rev Biochem , vol.64 , pp. 375-401
    • Sly, W.S.1    Hu, P.Y.2
  • 74
    • 0033526781 scopus 로고    scopus 로고
    • Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor α (HIF-α) proteins
    • Srinivas V, Zhang L, Zhu X, and Caro J. Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor α (HIF-α) proteins. Biochem Biophys Res Commun 260: 557-561, 1999.
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 557-561
    • Srinivas, V.1    Zhang, L.2    Zhu, X.3    Caro, J.4
  • 75
    • 0033574737 scopus 로고    scopus 로고
    • Structure of the VHL-elongin C-elonginB complex: Implications for VHL tumor suppressor function
    • Stebbins CE, Kaelin WG, and Pavletich NP. Structure of the VHL-elongin C-elonginB complex: implications for VHL tumor suppressor function. Science 284: 455-461, 1999.
    • (1999) Science , vol.284 , pp. 455-461
    • Stebbins, C.E.1    Kaelin, W.G.2    Pavletich, N.P.3
  • 76
    • 0030831655 scopus 로고    scopus 로고
    • Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene
    • Stratmann R, Krieg M, Haas R, and Plate K. Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene. J Neuropath Exp Neurol 56: 1242-1252, 1997.
    • (1997) J Neuropath Exp Neurol , vol.56 , pp. 1242-1252
    • Stratmann, R.1    Krieg, M.2    Haas, R.3    Plate, K.4
  • 77
    • 0033120593 scopus 로고    scopus 로고
    • Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of 1κBα
    • Tan P, Fuchs SY, Chen A, Wu K, Gomez C, Ronai Z, and Pan ZQ. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of 1κBα. Mol Cell 3: 527-533, 1999.
    • (1999) Mol Cell , vol.3 , pp. 527-533
    • Tan, P.1    Fuchs, S.Y.2    Chen, A.3    Wu, K.4    Gomez, C.5    Ronai, Z.6    Pan, Z.Q.7
  • 78
    • 0034663894 scopus 로고    scopus 로고
    • Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
    • Tanimoto K, Makino Y, Pereira T, and Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein. EMBO J 19: 4298-4309, 2000.
    • (2000) EMBO J , vol.19 , pp. 4298-4309
    • Tanimoto, K.1    Makino, Y.2    Pereira, T.3    Poellinger, L.4
  • 81
    • 0034107952 scopus 로고    scopus 로고
    • Mammalian oxygen sensing, signalling and gene regulation
    • Wenger R. Mammalian oxygen sensing, signalling and gene regulation. J Exp Biol 203: 1253-1263, 2000.
    • (2000) J Exp Biol , vol.203 , pp. 1253-1263
    • Wenger, R.1
  • 82
    • 0030583293 scopus 로고    scopus 로고
    • In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    • Wiener CM, Booth G, and Semenza GL. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem Biophys Res Commun 225: 485-488, 1996.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 485-488
    • Wiener, C.M.1    Booth, G.2    Semenza, G.L.3
  • 83
    • 0028929991 scopus 로고
    • Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas
    • Wizigmann-Voos S, Breier G, Risau W, and Plate K. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res 55: 1358-1364, 1995.
    • (1995) Cancer Res , vol.55 , pp. 1358-1364
    • Wizigmann-Voos, S.1    Breier, G.2    Risau, W.3    Plate, K.4
  • 85
    • 0036645091 scopus 로고    scopus 로고
    • Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease
    • Zatyka M, da Silva NF, Clifford SC, Morris MR, Wiesener MS, Eckardt KU, Houlston RS, Richards FM, Latif F, and Maher ER. Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease. Cancer Res 62: 3803-3811, 2002.
    • (2002) Cancer Res , vol.62 , pp. 3803-3811
    • Zatyka, M.1    Da Silva, N.F.2    Clifford, S.C.3    Morris, M.R.4    Wiesener, M.S.5    Eckardt, K.U.6    Houlston, R.S.7    Richards, F.M.8    Latif, F.9    Maher, E.R.10
  • 87
    • 0023181644 scopus 로고
    • Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
    • Zbar B, Brauch H, Talmadge C, and Linehan M. Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327: 721-724, 1987.
    • (1987) Nature , vol.327 , pp. 721-724
    • Zbar, B.1    Brauch, H.2    Talmadge, C.3    Linehan, M.4
  • 89
    • 0033007795 scopus 로고    scopus 로고
    • Oxygen sensing and signaling: Impact on the regulation of physiologically important genes
    • Zhu H and Bunn F. Oxygen sensing and signaling: impact on the regulation of physiologically important genes. Respir Physiol 115: 239-247, 1999.
    • (1999) Respir Physiol , vol.115 , pp. 239-247
    • Zhu, H.1    Bunn, F.2


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