Hypoxia-selective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine

Journal of Medicinal Chemistry

Volumn 44, Issue 21, 2001, Pages 3511-3522

  Tercel, M ^a   Lee, A E ^a   Hogg, A ^a   Anderson, R F ^a   Lee, H H ^a   Siim, B G ^a   Denny, W A ^a   Wilson, W R ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMOETHYLAMINO) 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 1,4 BIS[[2 (DIMETHYLAMINO N OXIDE)ETHYL]AMINO] 5,8 DIHYDROXYANTHRAQUINONE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CHLORMETHINE; CHLORMETHINE DERIVATIVE; CISPLATIN; DNA; IMIDAZOLE DERIVATIVE; N,N BIS(2 CHLOROETHYL) N METHYL N [(1 METHYL 4 NITRO 5 IMIDAZOLYL)METHYL]AMMONIUM CHLORIDE; NITROBENZENE DERIVATIVE; PORFIROMYCIN; PRODRUG; PYRAZOLE DERIVATIVE; PYRROLE DERIVATIVE; THIOPHENE DERIVATIVE; TIRAPAZAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; DNA CROSS LINKING; DRUG CYTOTOXICITY; DRUG RELEASE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON; HUMAN; HUMAN CELL; HYPOXIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; REDUCTION; TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; COMET ASSAY; CRICETINAE; CROSS-LINKING REAGENTS; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDAZOLES; MAXIMUM TOLERATED DOSE; MICE; NEOPLASM TRANSPLANTATION; NITRO COMPOUNDS; NITROGEN MUSTARD COMPOUNDS; OXIDATION-REDUCTION; PRODRUGS; QUATERNARY AMMONIUM COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 0035846072     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010202l     Document Type: Article

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