The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-I knockout mice

British Journal of Cancer

Volumn 87, Issue 4, 2002, Pages 465-470

  Zhao, L ^a   Ching, L M ^a   Kestell, P ^a   Baguley, B C ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Antivascular; Serotonin; Tumour necrosis factor

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; 5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; ANTINEOPLASTIC AGENT; SEROTONIN; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATTENUATION; COLON CARCINOMA; CONTROLLED STUDY; DOSE RESPONSE; KNOCKOUT MOUSE; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; WILD TYPE;

ANIMALS; ANTIGENS, CD; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NECROSIS; NEOPLASM TRANSPLANTATION; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SEROTONIN; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; XANTHENES; XANTHONES;

EID: 0037068317     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600479     Document Type: Article

References (41)

1. Tumour necrosis factors: Developments during the last decade
2. Small-molecule cytokine inducers causing tumor necrosis
3. Comparison of the effects of flavone acetic acid, fostriecin, homo-harringtonine and tumour necrosis factor alpha on Colon 38 tumors in mice
4. Serotonin involvement in the antitumour and host effects of flavone-8-acetic acid and 5,6-dimethyl-xanthenone-4-acetic acid
5. Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicine - Relation to vascular effects
6. Tumour vasculature - A potential therapeutic target
7. Tumour necrosis factor
8. Suppression of serum tumour necrosis factor-alpha by thalidomide does not lead to reversal of tumour vascular collapse and anti-tumour activity of 5,6-dimethylxanthenone-4-acetic acid
9. Thalidomide increases both intra-tumoural tumour necrosis factor-alpha production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid
10. Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
11. Effect of thalidomide on tumour necrosis factor production and anti-tumour activity induced by 5,6-dimethylxanthenone-4-acetic acid
12. Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice
13. Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
14. Microvascular injury in pathogenesis of interferon-induced necrosis of subcutaneous tumors in mice
15. Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions
16. Phase I pharmacokinetic and pharmacodynamic study of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent
17. Acute hemorrhagic necrosis of tumors induced by interleukin-1alpha - Effects independent of tumor necrosis factor
18. Stimulation of tumors to synthesize tumor necrosis factor-alpha in situ using 5,6-dimethylxanthenone-4-acetic acid: A novel approach to cancer therapy
19. Flavone acetic acid - Preclinical and clinical activity
20. Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice by thalidomide
21. Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents
22. Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs
23. Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict dose dependency and therapeutic efficacy against murine renal cancer
24. Important role of serotonin in the antitumor effects of tumor necrosis factor-alpha in mice
25. Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells
26. Antitumour activity of the novel immune modulator 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice lacking the interferon-gamma receptor
27. Induction of tumour necrosis factor-alpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid
28. Induction of endothelial cell apoptosis by TNF alpha: Modulation by inhibitors of protein synthesis
29. Light-induced breakdown of flavone acetic acid and xanthenone analogues in solution
30. Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids
31. Tumor necrosis factor and interleukin 1-alpha increase vascular endothelial permeability
32. Evidence for the involvement of endothelial cell integrin áVâ3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma
33. Impact on tumour perfusion measured by dynamic magnetic resonance imaging (MRI), in the phase 1 trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
34. Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo
35. Tumor necrosis factor activates human endothelial cells through the p55-tumor necrosis factor receptor but the p75-receptor contributes to activation at low tumor necrosis factor concentration
36. Tumor necrosis factor induces tumor necrosis via tumor necrosis factor receptor type 1-expressing endothelial cells of the tumor vasculature
37. Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice
38. Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
39. Oral activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice
40. Necrosis in non-tumour tissues caused by flavone acetic acid and 5,6-dimethyl xanthenone acetic acid
41. Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents