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Volumn 51, Issue 1, 2005, Pages 61-76

Killer genes in pancreatic cancer therapy

Author keywords

Cytotoxic bacterial toxins; Killer genes; Pancreatic cancer; Viral and non viral delivery systems

Indexed keywords

ADENOVIRUS VECTOR; BACTERIAL TOXIN; CYTOKINE; CYTOSINE DEAMINASE; DNA POLYMERASE; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROURACIL; GANCICLOVIR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; K RAS PROTEIN; LIPOSOME; PROTEIN P53; SMAD4 PROTEIN; SOMATOSTATIN RECEPTOR; THYMIDINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 29144508009     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (129)
  • 1
    • 0346455774 scopus 로고    scopus 로고
    • Activated K-ras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • Aguirre, A.J., Bardeesy, N., Sinha, M., Lopez, L., Tuveson, D.A., Horner, J., Redston, M.S. and DePinho, R.A., Activated K-ras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 2003, 17: 3112-3126.
    • (2003) Genes Dev. , vol.17 , pp. 3112-3126
    • Aguirre, A.J.1    Bardeesy, N.2    Sinha, M.3    Lopez, L.4    Tuveson, D.A.5    Horner, J.6    Redston, M.S.7    DePinho, R.A.8
  • 2
    • 0042835658 scopus 로고    scopus 로고
    • Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreas
    • Ammori, J.B., Colletti, L.M., Zalupski, M.M., Eckhauser, F.E., Greenson J.K., Dimick, J., Lawrence, T.S. and McGinn, C.J., Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreas. J. Gastrointest. Surg. 2003, 7: 766-772.
    • (2003) J. Gastrointest. Surg. , vol.7 , pp. 766-772
    • Ammori, J.B.1    Colletti, L.M.2    Zalupski, M.M.3    Eckhauser, F.E.4    Greenson, J.K.5    Dimick, J.6    Lawrence, T.S.7    McGinn, C.J.8
  • 3
    • 0030757856 scopus 로고    scopus 로고
    • Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene
    • Aoki, K., Yoshida, T., Matsumoto, N., Ide, H., Hosokawa, K., Sugimura, T. and Terada, M., Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene. Hum. Gene Ther. 1997, 8: 1105-1113.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 1105-1113
    • Aoki, K.1    Yoshida, T.2    Matsumoto, N.3    Ide, H.4    Hosokawa, K.5    Sugimura, T.6    Terada, M.7
  • 4
    • 0030710098 scopus 로고    scopus 로고
    • Suppresion of ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with ki-ras mutation but not those without ki-ras mutation
    • Aoki, K., Yoshida, T., Matsumoto, N., Ide, H., Sugimura, T. and Terada, M., Suppresion of ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with ki-ras mutation but not those without ki-ras mutation. Mol. Carcinogen 1997, 20: 251-258.
    • (1997) Mol. Carcinogen , vol.20 , pp. 251-258
    • Aoki, K.1    Yoshida, T.2    Matsumoto, N.3    Ide, H.4    Sugimura, T.5    Terada, M.6
  • 5
    • 0037010076 scopus 로고    scopus 로고
    • Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia
    • Arteaga, C.L., Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia. Sem. Oncol. 2002, 29: 3-9.
    • (2002) Sem. Oncol. , vol.29 , pp. 3-9
    • Arteaga, C.L.1
  • 6
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • Bardeesy, N. and DePinho, R.A., Pancreatic cancer biology and genetics. Nat. Rev. Cancer 2002, 2: 897-909.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    DePinho, R.A.2
  • 7
    • 0028953137 scopus 로고
    • Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression
    • Barton, C.M. and Lemoine, N.R., Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression. Br. J. Cancer 1995, 71: 429-437.
    • (1995) Br. J. Cancer , vol.71 , pp. 429-437
    • Barton, C.M.1    Lemoine, N.R.2
  • 8
    • 0001388461 scopus 로고    scopus 로고
    • Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents
    • Bauerschmitz, G.J., Barker, S.D. and Hemminki, A., Adenoviral gene therapy for cancer: from vectors to targeted and replication competent agents. Int. J. Oncol 2002, 21: 1161-1174 (review).
    • (2002) Int. J. Oncol , vol.21 , pp. 1161-1174
    • Bauerschmitz, G.J.1    Barker, S.D.2    Hemminki, A.3
  • 9
    • 0042303768 scopus 로고    scopus 로고
    • Overview of therapeutic vaccination approaches for cancer
    • Berinstein, N., Overview of therapeutic vaccination approaches for cancer. Sem. Oncol. 2003, 30: 1-8.
    • (2003) Sem. Oncol. , vol.30 , pp. 1-8
    • Berinstein, N.1
  • 10
    • 0031666927 scopus 로고    scopus 로고
    • K-ras mutations in stools and tissue samples from patients with malignant and non-malignant pancreatic diseases
    • Berndt, C., Haubold, K., Wenger, F., Brux, B., Muller, J., Bendzko, P., Hillebrand, T., Kottgen, E. and Zanow, J., K-ras mutations in stools and tissue samples from patients with malignant and non-malignant pancreatic diseases. Clin. Chem. 1998, 44: 2103-2107.
    • (1998) Clin. Chem. , vol.44 , pp. 2103-2107
    • Berndt, C.1    Haubold, K.2    Wenger, F.3    Brux, B.4    Muller, J.5    Bendzko, P.6    Hillebrand, T.7    Kottgen, E.8    Zanow, J.9
  • 13
    • 0030686481 scopus 로고    scopus 로고
    • Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: Regression of hepatic metastasis of pancreatic tumors
    • Block, A., Chen, S.-H., Kosai, K.-I., Finegold, M. and Woo, S.L.C., Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors. Pancreas 1997, 15: 25-34.
    • (1997) Pancreas , vol.15 , pp. 25-34
    • Block, A.1    Chen, S.-H.2    Kosai, K.-I.3    Finegold, M.4    Woo, S.L.C.5
  • 16
    • 0034774666 scopus 로고    scopus 로고
    • Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer
    • Calbò, J., Marotta, M., Cascallo, M., Roig, J.M., Gelpi, J.L., Fueyo, J. and Mazo, A., Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer. Cancer Gene Ther. 2001, 8: 740-750.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 740-750
    • Calbò, J.1    Marotta, M.2    Cascallo, M.3    Roig, J.M.4    Gelpi, J.L.5    Fueyo, J.6    Mazo, A.7
  • 17
    • 0035479932 scopus 로고    scopus 로고
    • Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells. Results in variable efficiency on the bystander killing: Implications for gene therapy
    • Carriò, M., Mazo, A., López-Iglesias, C., Estivill, X. and Fillat, C., Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells. Results in variable efficiency on the bystander killing: implications for gene therapy. Int. J. Cancer 2001, 94: 81-88.
    • (2001) Int. J. Cancer , vol.94 , pp. 81-88
    • Carriò, M.1    Mazo, A.2    López-Iglesias, C.3    Estivill, X.4    Fillat, C.5
  • 18
    • 0032959726 scopus 로고    scopus 로고
    • Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of herpes simplex virus thymidine kinase gene
    • Carriò, M., Romagosa, A., Mercadè, E., Mazo, A., Nadal, M., Gomez-Foix, A.-M. and Filial, C., Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of herpes simplex virus thymidine kinase gene. Gene Ther. 1999, 6: 547-553.
    • (1999) Gene Ther. , vol.6 , pp. 547-553
    • Carriò, M.1    Romagosa, A.2    Mercadè, E.3    Mazo, A.4    Nadal, M.5    Gomez-Foix, A.-M.6    Filial, C.7
  • 19
    • 0033190986 scopus 로고    scopus 로고
    • Genetic background determines the response to adenovirus-mediated wild-type p53 expression in pancreatic tumor cells
    • Cascallo, M., Mercade, E., Capella, G., Lluis, F., Fillat, C., Gomez-Foix, A.M. and Mazo, A., Genetic background determines the response to adenovirus-mediated wild-type p53 expression in pancreatic tumor cells. Cancer Gene Ther. 1999, 6: 428-436.
    • (1999) Cancer Gene Ther. , vol.6 , pp. 428-436
    • Cascallo, M.1    Mercade, E.2    Capella, G.3    Lluis, F.4    Fillat, C.5    Gomez-Foix, A.M.6    Mazo, A.7
  • 20
    • 0142218032 scopus 로고    scopus 로고
    • Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografis
    • Celinski, S.A., Fisher, W.E., Amaya, F., Wu, Y.Q., Yao, Q., Youker, K.A. and Li, M., Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografis. J. Surg. Res. 2003, 115: 41-47.
    • (2003) J. Surg. Res. , vol.115 , pp. 41-47
    • Celinski, S.A.1    Fisher, W.E.2    Amaya, F.3    Wu, Y.Q.4    Yao, Q.5    Youker, K.A.6    Li, M.7
  • 22
    • 0037183984 scopus 로고    scopus 로고
    • Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells
    • Chen, W.B., Lenschow, W., Tiede, K., Fischer, J.W., Kalthoff, H., and Ungefroren, H. Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. J. Biol. Chem. 2002, 277: 36118-36128.
    • (2002) J. Biol. Chem. , vol.277 , pp. 36118-36128
    • Chen, W.B.1    Lenschow, W.2    Tiede, K.3    Fischer, J.W.4    Kalthoff, H.5    Ungefroren, H.6
  • 23
    • 0015217337 scopus 로고
    • Structure and activity of diphteria toxin. I. Thiol dependent dissociation of a fraction of toxin into enzymatically active and inactive fragments
    • Collier, R.J. and Kandel, J., Structure and activity of diphteria toxin. I. Thiol dependent dissociation of a fraction of toxin into enzymatically active and inactive fragments. J. Biol. Chem. 1971, 246: 1496-1503.
    • (1971) J. Biol. Chem. , vol.246 , pp. 1496-1503
    • Collier, R.J.1    Kandel, J.2
  • 24
    • 0034003075 scopus 로고    scopus 로고
    • TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growth
    • Cook, T. and Urrutia, R., TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growth. Am. J. Physiol. Gastrointest. Liver Physiol. 2000, 278: G513-G521.
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.278
    • Cook, T.1    Urrutia, R.2
  • 25
    • 0141724605 scopus 로고    scopus 로고
    • The genetics of pancreatic cancer
    • Cowgill, S.M. and Muscarella, P., The genetics of pancreatic cancer. Am. J. Surg. 2003, 186: 279-286.
    • (2003) Am. J. Surg. , vol.186 , pp. 279-286
    • Cowgill, S.M.1    Muscarella, P.2
  • 27
    • 0347302952 scopus 로고    scopus 로고
    • Cytokines in cancer pathogenesis and cancer therapy
    • Dranoff, G., Cytokines in cancer pathogenesis and cancer therapy. Nature Rev. 2004, 4: 11-22.
    • (2004) Nature Rev. , vol.4 , pp. 11-22
    • Dranoff, G.1
  • 29
    • 0037280222 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer: Emerging strategies in chemotherapy and palliative care
    • El Kamar, F.G., Grossbard, M.L. and Kozuch, P.S., Metastatic pancreatic cancer: emerging strategies in chemotherapy and palliative care. The Oncologist 2003, 8: 18-34.
    • (2003) The Oncologist , vol.8 , pp. 18-34
    • El Kamar, F.G.1    Grossbard, M.L.2    Kozuch, P.S.3
  • 31
    • 0034660858 scopus 로고    scopus 로고
    • In vivo cancer gene therapy by adenovirus-mediated transfer of bifunctional yeast cytosine deaminasi/uracil phosphoribosyltransferase fusion gene
    • Erbs, P., Regulier, E., Kintz, J., Leroy P., Poitevin, Y., Exinger, F., Jund, R. and Mehtali, M., In vivo cancer gene therapy by adenovirus-mediated transfer of bifunctional yeast cytosine deaminasi/uracil phosphoribosyltransferase fusion gene. Cancer Res. 2000, 60: 3813-3822.
    • (2000) Cancer Res. , vol.60 , pp. 3813-3822
    • Erbs, P.1    Regulier, E.2    Kintz, J.3    Leroy, P.4    Poitevin, Y.5    Exinger, F.6    Jund, R.7    Mehtali, M.8
  • 33
    • 0025233918 scopus 로고
    • Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infection
    • Faulds, D. and Rennie, C.H., Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infection. Drugs 1990, 39: 567-638.
    • (1990) Drugs , vol.39 , pp. 567-638
    • Faulds, D.1    Rennie, C.H.2
  • 34
    • 0036290018 scopus 로고    scopus 로고
    • Somatostatin receptor subtype 2 gene therapy inhibits pancreatic cancer in vitro
    • Fisher, W.E., Wu, Y.Q., Amaya, F. and Berger, D.H., Somatostatin receptor subtype 2 gene therapy inhibits pancreatic cancer in vitro. J. Surg. Res. 2002, 105: 58-64.
    • (2002) J. Surg. Res. , vol.105 , pp. 58-64
    • Fisher, W.E.1    Wu, Y.Q.2    Amaya, F.3    Berger, D.H.4
  • 36
    • 0036840044 scopus 로고    scopus 로고
    • Malignant progenitors from patients with CD87+ acute myelogenous leucemia are sensitive to a diphtheria toxin-urokinase fusion protein
    • Frankel, A.E., Beran, M., Hogge, D.E., Powell, B.L., Thorburn, A., Chen, Y.Q. and Vallera, D.A., Malignant progenitors from patients with CD87+ acute myelogenous leucemia are sensitive to a diphtheria toxin-urokinase fusion protein. Exp. Hematol. 2002, 30: 1316-1323.
    • (2002) Exp. Hematol. , vol.30 , pp. 1316-1323
    • Frankel, A.E.1    Beran, M.2    Hogge, D.E.3    Powell, B.L.4    Thorburn, A.5    Chen, Y.Q.6    Vallera, D.A.7
  • 39
    • 0035114253 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo
    • Ghaneh, P., Greenhalf, W., Humphreys, M., Wilson, D., Zumstein, L., Lemoine, N.R. and Neoptolemos, J.P., Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo. Gene Ther. 2001, 8: 199-208.
    • (2001) Gene Ther. , vol.8 , pp. 199-208
    • Ghaneh, P.1    Greenhalf, W.2    Humphreys, M.3    Wilson, D.4    Zumstein, L.5    Lemoine, N.R.6    Neoptolemos, J.P.7
  • 40
    • 0033168564 scopus 로고    scopus 로고
    • Enzymatic and antisense effects of a specific anti ki-ras ribozyme in vitro and in cell culture
    • Giannini, C.D., Roth, W.K., Piiper, A. and Zeuzem, S., Enzymatic and antisense effects of a specific anti ki-ras ribozyme in vitro and in cell culture. Nucl. Acids Res. 1999, 13: 2737-2744.
    • (1999) Nucl. Acids Res. , vol.13 , pp. 2737-2744
    • Giannini, C.D.1    Roth, W.K.2    Piiper, A.3    Zeuzem, S.4
  • 41
    • 0036620226 scopus 로고    scopus 로고
    • Emerginge biological therapies for pancreatic carcinoma
    • Gilliam, A.D. and Watson, S.A., Emerginge biological therapies for pancreatic carcinoma. Eur. J. Surg. Oncol. 2002, 28: 370-378.
    • (2002) Eur. J. Surg. Oncol. , vol.28 , pp. 370-378
    • Gilliam, A.D.1    Watson, S.A.2
  • 46
    • 0041335589 scopus 로고    scopus 로고
    • New perspectives in the management of pancreas cancer
    • Haller, D.G., New perspectives in the management of pancreas cancer. Sem. Oncol. 2003, 30(11): 3-10.
    • (2003) Sem. Oncol. , vol.30 , Issue.11 , pp. 3-10
    • Haller, D.G.1
  • 48
    • 0037314610 scopus 로고    scopus 로고
    • A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma
    • Hecht, J.R., Bedford, R., Abbruzzese, J.L., Lahoti; S., Reid, T.R., Soetikno, R.M., Kim, D.H. and Freeman, S.M., A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin. Cancer Res. 2003, 9: 555-561.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 555-561
    • Hecht, J.R.1    Bedford, R.2    Abbruzzese, J.L.3    Lahoti, S.4    Reid, T.R.5    Soetikno, R.M.6    Kim, D.H.7    Freeman, S.M.8
  • 49
    • 19044367102 scopus 로고    scopus 로고
    • Specific targeting of tumor vasculature by diphtheria toxin-vascular endothelial growth factor fusion protein reduces angiogenesis and growth of pancreatic cancer
    • Hotz, H.G., Gill, P.S., Masood, R., Hotz, B., Buhr, H.J,, Foitzik, T., Hines, O.J. and Reber, H.A., Specific targeting of tumor vasculature by diphtheria toxin-vascular endothelial growth factor fusion protein reduces angiogenesis and growth of pancreatic cancer. J. Gastrointest. Surg. 2002, 6: 159-166.
    • (2002) J. Gastrointest. Surg. , vol.6 , pp. 159-166
    • Hotz, H.G.1    Gill, P.S.2    Masood, R.3    Hotz, B.4    Buhr, H.J.5    Foitzik, T.6    Hines, O.J.7    Reber, H.A.8
  • 50
    • 0032813205 scopus 로고    scopus 로고
    • Enhanced retroviral transduction efficiency of pancreatic tumor cell lines using different envelope glycoproteins
    • Howard, B.D., Boenicke, L., Schneider-Brachert, W. and Kalthoff, H., Enhanced retroviral transduction efficiency of pancreatic tumor cell lines using different envelope glycoproteins. Ann. N.Y. Acad. Sci. USA 1999, 880: 366-370.
    • (1999) Ann. N.Y. Acad. Sci. USA , vol.880 , pp. 366-370
    • Howard, B.D.1    Boenicke, L.2    Schneider-Brachert, W.3    Kalthoff, H.4
  • 52
    • 0035328523 scopus 로고    scopus 로고
    • Cancer immunotherapy using a DNA vaccine encoding the translocation domain of a bacterial toxin linked to a tumor antigen
    • Hung, C.-F., Cheng, W.-F., Hsu, K.-F., Chai, C.-Y., He, L., Ling, M. and Wu, T.-C., Cancer immunotherapy using a DNA vaccine encoding the translocation domain of a bacterial toxin linked to a tumor antigen. Cancer Res. 2001, 61: 3698-3703.
    • (2001) Cancer Res. , vol.61 , pp. 3698-3703
    • Hung, C.-F.1    Cheng, W.-F.2    Hsu, K.-F.3    Chai, C.-Y.4    He, L.5    Ling, M.6    Wu, T.-C.7
  • 53
    • 0031830091 scopus 로고    scopus 로고
    • Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene
    • Hwang, R.F., Gordon, E.M., Anderson, W.F. and Parekh, D., Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene. Surgery 1998, 124: 143-150.
    • (1998) Surgery , vol.124 , pp. 143-150
    • Hwang, R.F.1    Gordon, E.M.2    Anderson, W.F.3    Parekh, D.4
  • 54
    • 0030996607 scopus 로고    scopus 로고
    • Mechanism of 'bystander effect' killing in the herpes simplex thimidine kinase gene therapy model of cancer treatment
    • Ishii-Morita, H., Mechanism of 'bystander effect' killing in the herpes simplex thimidine kinase gene therapy model of cancer treatment. Gene Ther. 1997, 4: 244-251.
    • (1997) Gene Ther. , vol.4 , pp. 244-251
    • Ishii-Morita, H.1
  • 55
    • 0038805302 scopus 로고    scopus 로고
    • Immunity to adenovirus and adeno-associated viral vectors: Implications for gene therapy
    • Jooss, K. and Chirmule, N., Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy. Gene Ther. 2003, 10: 955-963.
    • (2003) Gene Ther. , vol.10 , pp. 955-963
    • Jooss, K.1    Chirmule, N.2
  • 57
    • 1542677822 scopus 로고    scopus 로고
    • Novel gene therapy approaches to pancreatic cancer
    • Katz, M.H. and Bouvet, M., Novel gene therapy approaches to pancreatic cancer. Int. J. Gastrointestinal Cancer 2003, 33: 89-97.
    • (2003) Int. J. Gastrointestinal Cancer , vol.33 , pp. 89-97
    • Katz, M.H.1    Bouvet, M.2
  • 60
    • 0032486226 scopus 로고    scopus 로고
    • Loss of tumorigenicity of human pancreatic carcinoma cells engineered to produce interleukin-2 or interleukin-4 in nude mice: A potentiality for cancer gene therapy
    • Kimura, M., Tagawa, M., Takenaga, K., Kondo, F., Yamaguchi, T., Saisho, H., Nakagawara, A. and Sakiyama, S., Loss of tumorigenicity of human pancreatic carcinoma cells engineered to produce interleukin-2 or interleukin-4 in nude mice: a potentiality for cancer gene therapy. Cancer Let. 1998, 128: 47-53.
    • (1998) Cancer Let. , vol.128 , pp. 47-53
    • Kimura, M.1    Tagawa, M.2    Takenaga, K.3    Kondo, F.4    Yamaguchi, T.5    Saisho, H.6    Nakagawara, A.7    Sakiyama, S.8
  • 61
    • 0032817103 scopus 로고    scopus 로고
    • Acquired immunity in nude mice induced by expression of the IL-2 or IL-4 gene in human pancreatic carcinoma cells and anti-tumor effect generated by in vivo gene transfer using retrovirus
    • Kimura, M., Yoshida, Y., Narita, M., Takenaga, K., Takenouchi, T., Yamaguchi, T., Saisho, H., Sakiyama, S. and Tagawa, M., Acquired immunity in nude mice induced by expression of the IL-2 or IL-4 gene in human pancreatic carcinoma cells and anti-tumor effect generated by in vivo gene transfer using retrovirus. Int. J. Cancer 1999, 82: 549-555.
    • (1999) Int. J. Cancer , vol.82 , pp. 549-555
    • Kimura, M.1    Yoshida, Y.2    Narita, M.3    Takenaga, K.4    Takenouchi, T.5    Yamaguchi, T.6    Saisho, H.7    Sakiyama, S.8    Tagawa, M.9
  • 62
    • 10744230081 scopus 로고    scopus 로고
    • Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma
    • Kishida, T., Asada, H., Itokawa, Y., Cui, F.-D., Shin-Ya, M., Gojo, S., Yasutomi, K., Ueda, Y., Yamagishi, H., Imanishi, J. and Mazda, O., Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma. Mol. Ther. 2003, 8: 552-558.
    • (2003) Mol. Ther. , vol.8 , pp. 552-558
    • Kishida, T.1    Asada, H.2    Itokawa, Y.3    Cui, F.-D.4    Shin-Ya, M.5    Gojo, S.6    Yasutomi, K.7    Ueda, Y.8    Yamagishi, H.9    Imanishi, J.10    Mazda, O.11
  • 63
    • 0033521860 scopus 로고    scopus 로고
    • Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes
    • Kita, K., Saito, S., Morioka, C.Y. and Watanabe, A., Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes. Int. J. Cancer 1999, 80: 553-558.
    • (1999) Int. J. Cancer , vol.80 , pp. 553-558
    • Kita, K.1    Saito, S.2    Morioka, C.Y.3    Watanabe, A.4
  • 65
    • 0037299714 scopus 로고    scopus 로고
    • Recombinant toxins for the treatment of cancer
    • Kreitman, R.J., Recombinant toxins for the treatment of cancer. Curr. Opin. Mol. Ther. 2003, 5: 44-51.
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 44-51
    • Kreitman, R.J.1
  • 67
    • 0030028301 scopus 로고    scopus 로고
    • The gap junction communication channel
    • Kumar, N.M. and Gilula, N.B., The gap junction communication channel. Cell 1996, 84: 381-388.
    • (1996) Cell , vol.84 , pp. 381-388
    • Kumar, N.M.1    Gilula, N.B.2
  • 68
    • 0032930673 scopus 로고    scopus 로고
    • Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice
    • Kuriyama, S., Kikukawa, M., Masui, K., Okuda, H., Nakatani, T., Sakamoto, T., Yoshiji, H., Fukui, H., Ikenaka, K., Mullen, C.A. and Tsujii, T., Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice. Int. J. Cancer 1999, 81: 592-597.
    • (1999) Int. J. Cancer , vol.81 , pp. 592-597
    • Kuriyama, S.1    Kikukawa, M.2    Masui, K.3    Okuda, H.4    Nakatani, T.5    Sakamoto, T.6    Yoshiji, H.7    Fukui, H.8    Ikenaka, K.9    Mullen, C.A.10    Tsujii, T.11
  • 69
    • 0032717286 scopus 로고    scopus 로고
    • Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma
    • Kuriyama, S., Minoro, A., Yamazaki, M., Tsujinoue, H., Nakatani, T., Akahane, T., Toyokawa, Y., Kojima, H., Okamoto, S. and Fukui, H., Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma. Scand. J. Gastroenterol. 1999, 34: 1033-1041.
    • (1999) Scand. J. Gastroenterol. , vol.34 , pp. 1033-1041
    • Kuriyama, S.1    Minoro, A.2    Yamazaki, M.3    Tsujinoue, H.4    Nakatani, T.5    Akahane, T.6    Toyokawa, Y.7    Kojima, H.8    Okamoto, S.9    Fukui, H.10
  • 72
    • 0036570316 scopus 로고    scopus 로고
    • Prostate-specific expression of the diphtheria toxin Achain (DT-A): Studies of inducibility and specificity of expression of prostate-specific antigen promoter-driven DT-A adenoviral-mediated gene transfer
    • Li, Y., McCadden, J., Ferrer, F., Kniszewski, M., Carducci, M., Simons, J. and Rodriguez, R., Prostate-specific expression of the diphtheria toxin Achain (DT-A): studies of inducibility and specificity of expression of prostate-specific antigen promoter-driven DT-A adenoviral-mediated gene transfer. Cancer Res. 2002, 62: 2576-2582.
    • (2002) Cancer Res. , vol.62 , pp. 2576-2582
    • Li, Y.1    McCadden, J.2    Ferrer, F.3    Kniszewski, M.4    Carducci, M.5    Simons, J.6    Rodriguez, R.7
  • 73
    • 0030690337 scopus 로고    scopus 로고
    • Dual role of the Smad4/DPC4 tumor suppressor in TGF -inducible transcriptional complexes
    • Liu, F., Pouponnot, C. and Massaguè, J., Dual role of the Smad4/DPC4 tumor suppressor in TGF -inducible transcriptional complexes. Genes Dev. 1997, 11: 3157-3167.
    • (1997) Genes Dev. , vol.11 , pp. 3157-3167
    • Liu, F.1    Pouponnot, C.2    Massaguè, J.3
  • 75
    • 0035947634 scopus 로고    scopus 로고
    • Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent antral toxin
    • Liu, S., Bugge, T.H. and Leppla, S.H., Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent antral toxin. J. Biol. Chem. 2001, 276: 17976-17984.
    • (2001) J. Biol. Chem. , vol.276 , pp. 17976-17984
    • Liu, S.1    Bugge, T.H.2    Leppla, S.H.3
  • 76
    • 0037447150 scopus 로고    scopus 로고
    • A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cells
    • Liu, T.F., Cohen, K.A., Ramage, J.G., Willingham, M.C., Thorburn, A.M. and Frankel, A.E., A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cells. Cancer Res. 2003, 63: 1834-1837.
    • (2003) Cancer Res. , vol.63 , pp. 1834-1837
    • Liu, T.F.1    Cohen, K.A.2    Ramage, J.G.3    Willingham, M.C.4    Thorburn, A.M.5    Frankel, A.E.6
  • 78
    • 7344268645 scopus 로고    scopus 로고
    • Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450
    • Lohr, M., Muller, P., Karle, P., Stange, J., Mitzner, S., Jesnowski, R., Nizze, H., Nebe, B., Liebe, S., Salmons, B. and Gunzburg, W.H., Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. Gene Ther. 1998; 5: 1070-1078.
    • (1998) Gene Ther. , vol.5 , pp. 1070-1078
    • Lohr, M.1    Muller, P.2    Karle, P.3    Stange, J.4    Mitzner, S.5    Jesnowski, R.6    Nizze, H.7    Nebe, B.8    Liebe, S.9    Salmons, B.10    Gunzburg, W.H.11
  • 79
    • 0038387494 scopus 로고    scopus 로고
    • 5-fluorouracil: Mechanisms of action and clinical strategies
    • Longley D.B., Harkin, D.P. and Johnston, P.G., 5-fluorouracil: mechanisms of action and clinical strategies. Nat. Rev. Cancer 2003, 3: 330-338.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 80
    • 0344061528 scopus 로고    scopus 로고
    • The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium
    • Luttges, J., Schlehe, B., Menke, M.A., Vogel, I., Henne-Bruns, D. and Kloppel, G., The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium. Cancer 1999, 85: 1703-1710.
    • (1999) Cancer , vol.85 , pp. 1703-1710
    • Luttges, J.1    Schlehe, B.2    Menke, M.A.3    Vogel, I.4    Henne-Bruns, D.5    Kloppel, G.6
  • 81
    • 0034279164 scopus 로고    scopus 로고
    • Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer
    • Makinen, K., Loimas, S., Wahlfors, J., Alhava, E. and Janne, J., Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer. J. Gene Med. 2000, 2: 361-367.
    • (2000) J. Gene Med. , vol.2 , pp. 361-367
    • Makinen, K.1    Loimas, S.2    Wahlfors, J.3    Alhava, E.4    Janne, J.5
  • 82
    • 0034988184 scopus 로고    scopus 로고
    • The epidermal growth factor receptor as a target for cancer therapy
    • Mendelsohn, J., The epidermal growth factor receptor as a target for cancer therapy. Endocrine-Rel. Cancer 2001, 8: 3-9.
    • (2001) Endocrine-Rel. Cancer , vol.8 , pp. 3-9
    • Mendelsohn, J.1
  • 83
    • 0033900009 scopus 로고    scopus 로고
    • Bystander effects in herpes simplex virus-thimidine kinase/ganciclovir cancer gene therapy: Role of gap-junctional intercellular communication
    • Mesnil, M. and Yamasaki, H., Bystander effects in herpes simplex virus-thimidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res. 2000, 60: 3989-3999.
    • (2000) Cancer Res. , vol.60 , pp. 3989-3999
    • Mesnil, M.1    Yamasaki, H.2
  • 84
    • 0142119195 scopus 로고    scopus 로고
    • Recombinant toxin DAB(389)EGF is cytotoxic to human pancreatic cancer cells
    • Mishra, G., Liu, T.F. and Frankel, A.E., Recombinant toxin DAB(389)EGF is cytotoxic to human pancreatic cancer cells. Export. Opin. Biol. Ther. 2003, 3: 1173-1180.
    • (2003) Export. Opin. Biol. Ther. , vol.3 , pp. 1173-1180
    • Mishra, G.1    Liu, T.F.2    Frankel, A.E.3
  • 86
    • 0033038501 scopus 로고    scopus 로고
    • Cationic lipid-mediated transfection of cells in culture requires mitotic activity
    • Mortimer, I., Tam, P., MacLachlan, I., Graham, R.W., Saravolac, E.G. and Joshi, P.B., Cationic lipid-mediated transfection of cells in culture requires mitotic activity. Gene Ther. 1999, 6: 403-411.
    • (1999) Gene Ther. , vol.6 , pp. 403-411
    • Mortimer, I.1    Tam, P.2    MacLachlan, I.3    Graham, R.W.4    Saravolac, E.G.5    Joshi, P.B.6
  • 87
    • 0035076823 scopus 로고    scopus 로고
    • Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovinis (ONYX-015) into primary carcinomas of the pancreas: A phase I trial
    • Mulvihill, S., Warren, R., Venook, A., Adler, A., Randlev, B., Heise, C. and Kirn, D., Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovinis (ONYX-015) into primary carcinomas of the pancreas: a phase I trial. Gene Ther. 2001, 8: 308-315.
    • (2001) Gene Ther. , vol.8 , pp. 308-315
    • Mulvihill, S.1    Warren, R.2    Venook, A.3    Adler, A.4    Randlev, B.5    Heise, C.6    Kirn, D.7
  • 88
    • 0035553610 scopus 로고    scopus 로고
    • Antisense oligonucleotides specific to mutated k-ras genes inhibit invasiveness of human pancreatic cancer cell lines
    • Nakada, Y., Saito, S., Ohzawa, K., Morioka, C.Y., Kita, K., Minemura, M., Takahara, T. and Watanabe, A., Antisense oligonucleotides specific to mutated k-ras genes inhibit invasiveness of human pancreatic cancer cell lines. Pancreatology 2001, 1: 314-319.
    • (2001) Pancreatology , vol.1 , pp. 314-319
    • Nakada, Y.1    Saito, S.2    Ohzawa, K.3    Morioka, C.Y.4    Kita, K.5    Minemura, M.6    Takahara, T.7    Watanabe, A.8
  • 89
    • 0000421475 scopus 로고    scopus 로고
    • Factors limiting adenovirus-mediated gene transfer into human lung and pancreatic cancer cell lines
    • Pearson, S.A., Koch, P.E., Atkinson, N., Xiong, M., Finberg, R.W., Roth, J.A. and Fang, B., Factors limiting adenovirus-mediated gene transfer into human lung and pancreatic cancer cell lines. Clin. Cancer Res. 1999, 5: 4208-4213.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 4208-4213
    • Pearson, S.A.1    Koch, P.E.2    Atkinson, N.3    Xiong, M.4    Finberg, R.W.5    Roth, J.A.6    Fang, B.7
  • 91
    • 0036798893 scopus 로고    scopus 로고
    • Regulated expression of diphtheria toxin in prostate cancer cells
    • Peng, W., Vverbitsky, A., Bao, Y. and Sawicki, J.A., Regulated expression of diphtheria toxin in prostate cancer cells. Mol. Ther. 2002, 6: 527-545.
    • (2002) Mol. Ther. , vol.6 , pp. 527-545
    • Peng, W.1    Vverbitsky, A.2    Bao, Y.3    Sawicki, J.A.4
  • 92
    • 0036631908 scopus 로고    scopus 로고
    • PG13 packaging cells produce recombinant retroviruses carrying a diphtheria toxin mutant which kills cancer cells
    • Qiao, J. and Caruso, M., PG13 packaging cells produce recombinant retroviruses carrying a diphtheria toxin mutant which kills cancer cells. J. Virol. 2002, 76: 7343-7348.
    • (2002) J. Virol. , vol.76 , pp. 7343-7348
    • Qiao, J.1    Caruso, M.2
  • 94
    • 0032806082 scopus 로고    scopus 로고
    • Genetic prodrug activation therapy for pancreatic cancer
    • Rigg, A.S. and Lemoine, N.R., Genetic prodrug activation therapy for pancreatic cancer. Ann. N.Y. Acad. Sci. USA 1999, 880: 319-325.
    • (1999) Ann. N.Y. Acad. Sci. USA , vol.880 , pp. 319-325
    • Rigg, A.S.1    Lemoine, N.R.2
  • 95
    • 0037296357 scopus 로고    scopus 로고
    • The epidermal growth factor receptor-tyrosine kinase: A promising therapeutic target in solid tumors
    • Ritter, C.A. and Arteaga, C.L., The epidermal growth factor receptor-tyrosine kinase: a promising therapeutic target in solid tumors. Sem. Oncol. 2003, 30: 3-11.
    • (2003) Sem. Oncol. , vol.30 , pp. 3-11
    • Ritter, C.A.1    Arteaga, C.L.2
  • 96
    • 0033541523 scopus 로고    scopus 로고
    • Gene therapy for pancreatic carcinoma: Local and distant antitumor effects after somatostatin receptor sst2 gene transfer
    • Rochaix, P., Delesque, N., Estève, J.-P., Saint-Laurent, N., Voigt, J.-J., Vaysse, N., Susini, C. and Buscail, L., Gene therapy for pancreatic carcinoma: local and distant antitumor effects after somatostatin receptor sst2 gene transfer. Hum. Gene Ther. 1999, 10: 995-1008.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 995-1008
    • Rochaix, P.1    Delesque, N.2    Estève, J.-P.3    Saint-Laurent, N.4    Voigt, J.-J.5    Vaysse, N.6    Susini, C.7    Buscail, L.8
  • 97
    • 0038277091 scopus 로고    scopus 로고
    • pP73 is effective in p53-null pancreatic cancer cells resistant to wild-type XP53 gene replacement
    • Rodicker, F. and Putzer, B.M., pP73 is effective in p53-null pancreatic cancer cells resistant to wild-type XP53 gene replacement. Cancer Res. 2003, 63: 2737-2741.
    • (2003) Cancer Res. , vol.63 , pp. 2737-2741
    • Rodicker, F.1    Putzer, B.M.2
  • 98
    • 0031424456 scopus 로고    scopus 로고
    • Pancreatic carcinoma cell killing via adenoviral mediated delivery of herpes simplex virus thymidine kinase gene
    • Rosenfeld, M.E., Vickers, S.M., Raben, D., Wang, M., Sampson, L., Feng, M., Jaffee, E. and Curiel, D.T., Pancreatic carcinoma cell killing via adenoviral mediated delivery of herpes simplex virus thymidine kinase gene. Ann. Surg. 1997, 5: 609-620.
    • (1997) Ann. Surg. , vol.5 , pp. 609-620
    • Rosenfeld, M.E.1    Vickers, S.M.2    Raben, D.3    Wang, M.4    Sampson, L.5    Feng, M.6    Jaffee, E.7    Curiel, D.T.8
  • 100
    • 0034915984 scopus 로고    scopus 로고
    • The future of human gene therapy
    • Rubanyi, G.M., The future of human gene therapy. Mol Aspects Med. 2001, 22: 113-142.
    • (2001) Mol Aspects Med. , vol.22 , pp. 113-142
    • Rubanyi, G.M.1
  • 102
    • 1642312315 scopus 로고    scopus 로고
    • Genetic alterations in pancreatic carcinoma
    • Schneider, G. and Schmid, R.M., Genetic alterations in pancreatic carcinoma. Mol. Cancer 2003, 2: 15.
    • (2003) Mol. Cancer , vol.2 , pp. 15
    • Schneider, G.1    Schmid, R.M.2
  • 105
    • 0036057585 scopus 로고    scopus 로고
    • Acquired resistance of pancreatic cancer towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes
    • Shi, X., Liu, S., Kleeff, J., Friess, H. and Buchler, M.W., Acquired resistance of pancreatic cancer towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes. Oncology 2002, 62: 354-362.
    • (2002) Oncology , vol.62 , pp. 354-362
    • Shi, X.1    Liu, S.2    Kleeff, J.3    Friess, H.4    Buchler, M.W.5
  • 106
    • 0032851547 scopus 로고    scopus 로고
    • Cytotoxicity of adenoviral-mediated cytosine deaminasei plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model
    • Shirakawa, T., Gardner, T.A., Ko, S.-C., Bander, N., Woo, S., Gotoh, A., Kamidono, S., Chung, L.W.K. and Kao, C., Cytotoxicity of adenoviral-mediated cytosine deaminasei plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model. J. Urol. 1999, 162: 949-954.
    • (1999) J. Urol. , vol.162 , pp. 949-954
    • Shirakawa, T.1    Gardner, T.A.2    Ko, S.-C.3    Bander, N.4    Woo, S.5    Gotoh, A.6    Kamidono, S.7    Chung, L.W.K.8    Kao, C.9
  • 107
    • 0031027559 scopus 로고    scopus 로고
    • Recurrence after resection for ductal adenocarcinoma of the pancreas
    • Sperti, C., Pasquali, C., Piccoli, A. and Pedrazzoli, S., Recurrence after resection for ductal adenocarcinoma of the pancreas. World J. Surg. 1997, 21: 195-200.
    • (1997) World J. Surg. , vol.21 , pp. 195-200
    • Sperti, C.1    Pasquali, C.2    Piccoli, A.3    Pedrazzoli, S.4
  • 111
    • 0032693659 scopus 로고    scopus 로고
    • High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions
    • Tateishi, K., Tada, M., Yamagata, M., Isayama, H., Komatsu, Y., Kawabe, T., Shiratori, Y. and Omata, M., High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions. Gut 1999, 45: 737-740.
    • (1999) Gut , vol.45 , pp. 737-740
    • Tateishi, K.1    Tada, M.2    Yamagata, M.3    Isayama, H.4    Komatsu, Y.5    Kawabe, T.6    Shiratori, Y.7    Omata, M.8
  • 114
    • 12444328351 scopus 로고    scopus 로고
    • Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and independent antitumor effects
    • Ugai, S.-I., Shimozato, O., Yu, L., Wang, Y.-Q., Kawamura, K., Yamamoto, H., Yamaguchi, T., Saisho, H., Sakiyama, S. and Tagawa, M., Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and independent antitumor effects. Cancer Gene Ther. 2003, 10: 771-778.
    • (2003) Cancer Gene Ther. , vol.10 , pp. 771-778
    • Ugai, S.-I.1    Shimozato, O.2    Yu, L.3    Wang, Y.-Q.4    Kawamura, K.5    Yamamoto, H.6    Yamaguchi, T.7    Saisho, H.8    Sakiyama, S.9    Tagawa, M.10
  • 115
    • 0033869563 scopus 로고    scopus 로고
    • Flucytosine: A review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions
    • Vermes, A., Guchelaar, H.-J. and Dankert, J., Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. JAC 2000, 46: 171-179.
    • (2000) JAC , vol.46 , pp. 171-179
    • Vermes, A.1    Guchelaar, H.-J.2    Dankert, J.3
  • 116
    • 0036828266 scopus 로고    scopus 로고
    • Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models
    • Vernejoul, F., Faure, P., Benali, N., Calise, D., Tiraby, G., Pradayrol, L., Susini, C. and Buscail, L., Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models. Cancer Res. 2002, 62: 6124-6131.
    • (2002) Cancer Res. , vol.62 , pp. 6124-6131
    • Vernejoul, F.1    Faure, P.2    Benali, N.3    Calise, D.4    Tiraby, G.5    Pradayrol, L.6    Susini, C.7    Buscail, L.8
  • 117
    • 1142263304 scopus 로고    scopus 로고
    • herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer
    • Wang, J., Xiao-Xuan, L., Dao-Zhen, C., Shu-Feng, L. and Li-Shan, Z., herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer. World J. Gastroenterol. 2004, 10: 400-403.
    • (2004) World J. Gastroenterol. , vol.10 , pp. 400-403
    • Wang, J.1    Xiao-Xuan, L.2    Dao-Zhen, C.3    Shu-Feng, L.4    Li-Shan, Z.5
  • 118
    • 1642423482 scopus 로고    scopus 로고
    • Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter
    • Wang, X.-P., Yazawa, K., Yang, J., Kohn, D., Fisher, W.E. and Brunicardi, C., Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter. J. Gastrointest. Surg. 2004, 8: 98-108.
    • (2004) J. Gastrointest. Surg. , vol.8 , pp. 98-108
    • Wang, X.-P.1    Yazawa, K.2    Yang, J.3    Kohn, D.4    Fisher, W.E.5    Brunicardi, C.6
  • 119
    • 0032937404 scopus 로고    scopus 로고
    • Modulation of the immune response and tumor growth by activated Ras.
    • Weijzen, S., Velders, M.P. and Kast, W.M., Modulation of the immune response and tumor growth by activated Ras. Leukemia 1999, 13: 502-513.
    • (1999) Leukemia , vol.13 , pp. 502-513
    • Weijzen, S.1    Velders, M.P.2    Kast, W.M.3
  • 121
    • 0026609066 scopus 로고
    • Diphteria toxin and pseudomonas aeruginosa exotoxin A: Active-site, structure and enzymatic mechanism
    • Wilson, B.A. and Collier, R.J., Diphteria toxin and pseudomonas aeruginosa exotoxin A: Active-site, structure and enzymatic mechanism. Curr Top. Microbiol. Immunol. 1992, 175: 27-41.
    • (1992) Curr Top. Microbiol. Immunol. , vol.175 , pp. 27-41
    • Wilson, B.A.1    Collier, R.J.2
  • 122
    • 0037182756 scopus 로고    scopus 로고
    • Mdm2 inhibition of p53 induces E2F1 transactivation via p21
    • Wunderlich, M. and Berberich, S.J., Mdm2 inhibition of p53 induces E2F1 transactivation via p21. Oncogene 2002, 21: 4414-4421.
    • (2002) Oncogene , vol.21 , pp. 4414-4421
    • Wunderlich, M.1    Berberich, S.J.2
  • 123
    • 0037010091 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted therapy for pancreatic cancer
    • Xiong, H.Q. and Abbruzzese, J.L., Epidermal growth factor receptor-targeted therapy for pancreatic cancer. Sem. Oncol. 2002, 29: 31-37.
    • (2002) Sem. Oncol. , vol.29 , pp. 31-37
    • Xiong, H.Q.1    Abbruzzese, J.L.2
  • 124
    • 0026544424 scopus 로고
    • Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney
    • Yamada, Y., Post, S.R., Wang, K., Tager, H.S., Bell, G.I. and Seino, S., Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. PNAS 1992, 89: 251-255.
    • (1992) PNAS , vol.89 , pp. 251-255
    • Yamada, Y.1    Post, S.R.2    Wang, K.3    Tager, H.S.4    Bell, G.I.5    Seino, S.6
  • 125
    • 0029794390 scopus 로고    scopus 로고
    • Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir
    • Yang, L., Hwang, R., Pandit, L., Gordon, E.M., Anderson, W.F. and Parekh, D., Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir. Ann. Surg. 1996, 224: 405-417.
    • (1996) Ann. Surg. , vol.224 , pp. 405-417
    • Yang, L.1    Hwang, R.2    Pandit, L.3    Gordon, E.M.4    Anderson, W.F.5    Parekh, D.6
  • 126
    • 0032549688 scopus 로고    scopus 로고
    • Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ ganciclovir-based gene therapy of human gastrointestinal tumor cells
    • Yiang, L., Chiang, Y., Lenz, H.-J., Danenberg, K.D., Spears, C.P., Gordon, E.M., Anderson, W.F. and Parekh, D., Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ ganciclovir-based gene therapy of human gastrointestinal tumor cells. Hum. Gene Ther. 1998, 9: 719-728.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 719-728
    • Yiang, L.1    Chiang, Y.2    Lenz, H.-J.3    Danenberg, K.D.4    Spears, C.P.5    Gordon, E.M.6    Anderson, W.F.7    Parekh, D.8
  • 127
    • 0031949646 scopus 로고    scopus 로고
    • Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex virus thymidine kinase gene
    • Yiang, L., Hwang, R., Chiang, Y., Gordon, E.M., Anderson, W.F. and Parekh, D., Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex virus thymidine kinase gene. Clin. Cancer Res. 1998, 4: 731-741.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 731-741
    • Yiang, L.1    Hwang, R.2    Chiang, Y.3    Gordon, E.M.4    Anderson, W.F.5    Parekh, D.6
  • 129
    • 0034508245 scopus 로고    scopus 로고
    • Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice
    • Zhang, Y.A., Nemunaitis, J., Scanlon, K.J. and Tong, A.W., Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice. Gene Ther. 2000, 7: 2041-2050.
    • (2000) Gene Ther. , vol.7 , pp. 2041-2050
    • Zhang, Y.A.1    Nemunaitis, J.2    Scanlon, K.J.3    Tong, A.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.