p73 is effective in p53-null pancreatic cancer cells resistant to wild-type TP53 gene replacement

Cancer Research

Volumn 63, Issue 11, 2003, Pages 2737-2741

  Rödicker, Florian ^a   Pützer, Brigitte M ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN P73; SERINE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GRAFT; CANCER THERAPY; CONTROLLED STUDY; GENE; GENE OVEREXPRESSION; GENE REPLACEMENT THERAPY; GENE THERAPY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TP53 GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WILD TYPE;

ADENOCARCINOMA; ADENOVIRIDAE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; HUMANS; NUCLEAR PROTEINS; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEINS; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0038277091     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Landis, S. H., Murray, T., Bolden, S., and Wingo, P. A. Cancer statistics. CA Cancer J. Clin., 48: 6-29, 1998.
2. Rosewicz, S., and Wiedenmann, B. Pancreatic carcinoma. Lancet, 349: 485-489, 1997.
3. Vogelstein, B., Lane, D., and Levine, A. J. Surfing the p53 network. Nature (Lond.), 408: 307-310, 2000.
4. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. p53 mutations in human cancers. Science (Wash. DC), 253: 49-53, 1991.
5. Pellegata, N. S., Sessa, F., Renault, B., Bonato, M., Leone, B. E., Solcia, E., and Ranzani, G. N. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res., 54: 1556-1560, 1994.
6. Roemer, K., and Friedmann, T. Mechanisms of action of the p53 tumor suppressor and prospects for cancer gene therapy by reconstitution of p53 function. Ann. N. Y. Acad. Sci., 716: 265-280, 1994.
7. Polyak, K., Waldman, T., He, T. C., Kinzler, K. W., and Vogelstein, B. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev., 10: 1945-1952, 1996.
8. Stiewe, T., and Putzer, B. M. p73 in apoptosis. Apoptosis, 6: 447-452, 2001.
9. Sasaki, Y., Morimoto, I., Ishida, S., Yamashita, T., Imai, K., and Tokino, T. Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63, induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer. Gene Ther., 8: 1401-1408, 2001.
10. He, T. C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA, 95; 2509-2514, 1998.
11. Stiewe, T., Theseling, C. C., and Pützer, B. M. Transactivation-deficient Δ TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis. J. Biol. Chem., 277: 14177-14185, 2002.
12. Rodicker, F., Stiewe, T., Zimmermann, S., and Putzer, B. M. Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction. Cancer Res., 61: 7052-7055, 2001.
13. Kimura, M., Tagawa, M., Takenaga, K., Yamaguchi, T., Saisho, H., Nakagawara, A., and Sakiyama, S. Inability to induce the alteration of tumorigenicity and chemosensitivity of p53-null human pancreatic carcinoma cells after the transduction of wild-type p53 gene. Anticancer Res., 17: 879-883, 1997.
14. Shinoura, N., Muramatsu, Y., Asai, A., Han, S., Horii, A., Kirino, T., and Hamada, H. Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73α depends on the p53 status of glioma cells. Cancer Lett., 160: 67-73, 2000.
15. Berrozpe, G., Schaeffer, J., Peinado, M. A., Real, F. X., and Perucho, M. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer. Int. J. Cancer, 58: 185-191, 1994.
16. Kusumoto, M., Ogawa, T., Mizumoto, K., Ueno, H., Niiyama, H., Sato, N., Nakamura, M., and Tanaka, M. Adenovirus-mediated p53 gene transduction inhibits telomerase activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cancer cells. Clin. Cancer Res., 5: 2140-2147, 1999.
17. Vousden, K. H., and Lu, X. Live or let die: the cell's response to p53. Nat. Rev. Cancer, 2: 594-604, 2002.
18. Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., and Taya, Y. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell, 102: 849-862, 2000.
19. Shieh, S. Y., Ikeda, M., Taya, Y., and Prives, C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell, 91: 325-334, 1997.
20. Constanzo, A., Merlo, P., Pediconi, N., Fulco, M., Sartorelly, V., Cole, P. A., Fontemaggi, G., Fanciulli, M., Schlitz, L., Blandino, G., Balsano, C., and Levrero, M. DNA damage-dependent acetylation of p73 dictates the selective activation of proapoptotic target genes. Mol. Cell, 9: 175-186, 2002.
21. Prabhu, N. S., Somasundaram, K., Satyamoorthy, K., Herlyn, M., and El-Deiry, W. S. p73β, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells. Int. J. Oncol., 13: 5-9, 1998.