Potent antitumor activity of a urokinase-activated engineered anthrax toxin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 2, 2003, Pages 657-662

  Liu, Shihui ^a   Aaronson, Hannah ^a   Mitola, David J ^a   Leppla, Stephen H ^a,b   Bugge, Thomas H ^a,b  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; CELL RECEPTOR; CHIMERIC PROTEIN; FURIN; HYBRID PROTEIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR RECEPTOR; PSEUDOMONAS EXOTOXIN; UNCLASSIFIED DRUG; UROKINASE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG ACTIVATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE MUTATION; IN VIVO STUDY; LETHAL GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN FUNCTION; TOXIN ANALYSIS; TUMOR CELL;

ANIMALS; ANTIGENS, BACTERIAL; ANTINEOPLASTIC AGENTS; BACTERIAL TOXINS; DRUG DELIVERY SYSTEMS; FURIN; MICE; NEOPLASMS, EXPERIMENTAL; PLASMINOGEN; PROTEIN ENGINEERING; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SUBTILISINS; URINARY PLASMINOGEN ACTIVATOR;

ANIMALIA; ANTHRAX; POSIBACTERIA; PSEUDOMONAS;

EID: 0037457895     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0236849100     Document Type: Article

References (41)

1. Andreasen, P. A., Kjoller, L., Christensen, L. & Duffy, M. J. (1997) Int. J. Cancer 72, 1-22.
2. Dano, K., Romer, J., Nielsen, B. S., Bjorn, S., Pyke, C., Rygaard, J. & Lund, L. R. (1999) Acta Pathol. Microbiol. Immunol. Scand. 107, 120-127.
3. Andreasen, P. A., Egelund, R. & Petersen, H. H. (2000) Cell Mol. Life Sci. 57, 25-40.
4. Romer, J., Bugge, T. H., Pyke, C., Lund, L. R., Flick, M. J., Degen, J. L. & Dano, K. (1996) Nat. Med. 2, 287-292.
5. Lund, L. R., Bjorn, S. F., Sternlicht, M. D., Nielsen, B. S., Solberg, H., Usher, P. A., Osterby, R., Christensen, I. J., Stephens, R. W., Bugge, T. H., et al. (2000) Development (Cambridge, U.K.) 127, 4481-4492.
6. Heymans, S., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E., Moons, L., Dyspersin, G. D., Cleutjens, J. P., Shipley, M., Angellilo, A., et al. (1999) Nat. Med. 5, 1135-1142.
7. Nielsen, L. S., Hansen, J. G., Skriver, L., Wilson, E. L., Kaltoft, K., Zeuthen, J. & Dano, K. (1982) Biochemistry 21, 6410-6415.
8. Bugge, T. H., Suh, T. T., Flick, M. J., Daugherty, C. C., Romer, J., Solberg, H., Ellis, V., Dano, K. & Degen, J. L. (1995) J. Biol. Chem. 270, 16886-16894.
9. Bugge, T. H., Flick, M. J., Danton, M. J., Daugherty, C. C., Romer, J., Dano, K., Carmeliet, P., Collen, D. & Degen, J. L. (1996) Proc. Natl. Acad. Sci. USA 93, 5899-5904.
10. Carmeliet, P., Moons, L., Dewerchin, M., Rosenberg, S., Herbert, J. M., Lupu, F. & Collen, D. (1998) J. Cell Biol. 140, 233-245.
11. Longstaff, C., Merton, R. E., Fabregas, P. & Felez, J. (1999) Blood 93, 3839-3846.
12. Smith, H. & Stanley, J. L. (1962) J. Gen. Microbiol. 29, 517-521.
13. Leppla, S. H. (1995) in Bacterial Toxins and Virulence Factors in Disease. Handbook of Natural Toxins, eds. Moss, J., Iglewski, B., Vaughan, M. & Tu, A. (Dekker, New York), Vol. 8, pp. 543-572.
14. Leppla, S. H. (1999) in Comprehensive Sourcebook of Bacterial Protein Toxins, eds. Alouf, J. E. & Freer, J. H, (Academic, London), pp. 243-263.
15. Bradley, K. A., Mogridge, J., Mourez, M., Collier, R. J. & Young, J. A. (2001) Nature 414, 225-229.
16. Molloy, S. S., Bresnahan, P. A., Leppla, S. H., Klimpel, K. R. & Thomas, G. (1992) J. Biol. Chem. 267, 16396-16402.
17. Klimpel, K. R., Molloy, S. S., Thomas, G. & Leppla, S. H. (1992) Proc. Natl. Acad. Sci. USA 89, 10277-10281.
18. Mogridge, J., Cunningham, K. & Collier, R. J. (2002) Biochemistry 41, 1079-1082.
19. Arora, N. & Leppla, S. H. (1993) J. Biol. Chem. 268, 3334-3341.
20. Liu, S., Netzel-Arnett, S., Birkedal-Hansen, H. & Leppla, S. H. (2000) Cancer Res. 60, 6061-6067.
21. Carmeliet, P., Schoonjans, L., Kieckens, L., Ream, B., Degen, J., Bronson, R., De Vos, R., van den Oord, J. J., Collen, D. & Mulligan, R. C. (1994) Nature 368, 419-424.
22. Bugge, T. H., Flick, M. J., Daugherty, C. C. & Degen, J. L. (1995) Genes Dev. 9, 794-807.
23. Carmeliet, P., Kieckens, L., Schoonjans, L., Ream, B., van Nuffelen, A., Prendergast, G., Cole, M., Bronson, R., Collen, D. & Mulligan, R. C. (1993) J. Clin. Invest. 92, 2746-2755.
24. Bugge, T. H., Kombrinck, K. W., Flick, M. J., Daugherty, C. C., Danton, M. J. & Degen, J. L. (1996) Cell 87, 709-719.
25. Gordon, V. M., Benz, R., Fujii, K., Leppla, S. H. & Tweten, R. K. (1997) Infect. Immunol. 65, 4130-4134.
26. Liu, S., Bugge, T. H. & Leppla, S. H. (2001) J. Biol. Chem. 276, 17976-17984.
27. Hart, I. R. (1979) Am. J. Pathol. 97, 587-600.
28. Liotta, L. A., Tryggvason, K., Garbisa, S., Hart, I., Foltz, C. M. & Shafie, S. (1980) Nature 284, 67-68.
29. Geran, R. I., Greenberg, N. H., MacDonald, M. M., Schumacher, A. M. & Abbot, B. J. (1972) Cancer Chemother. Rep. 3, 1-103.
30. Sugiura, K. & Stock, C. C. (1955) Cancer Res. 15, 38-51.
31. Bugge, T. H., Kombrinck, K. W., Xiao, Q., Holmback, K., Daugherty, C. C., Witte, D. P. & Degen, J. L. (1997) Blood 90, 4522-4531.
32. Varughese, M., Chi, A., Teixeira, A. V., Nicholls, P. J., Keith, J. M, & Leppla, S. H. (1998) Mol. Med. 4, 87-95.
33. Arora, N. & Leppla, S. H. (1994) Infect. Immunol. 62, 4955-4961.
34. Duesbery, N. S., Resau, J., Webb, C. P., Koochekpour, S., Koo, H. M., Leppla, S. H. & Vande Woude, G. F. (2001) Proc. Natl. Acad. Sci. USA 98, 4089-4094.
35. Koo, H. M., VanBrocklin, M., McWilliams, M. J., Leppla, S. H., Duesbery, N. S. & Vande Woude, G. F. (2002) Proc. Natl. Acad. Sci. USA 99, 3052-3057.
36. Ichinose, M., Liu, X. H., Hagihara, N. & Youle, R. J. (2002) Cancer Res. 62, 1433-1438.
37. Frankel, A. E., Powell, B. L., Hall, P. D., Case, L. D. & Kreitman, R. J. (2002) Clin. Cancer Res. 8, 1004-1013.
38. Lee, S. L., Dickson, R. B. & Lin, C. Y. (2000) J. Biol. Chem. 275, 36720-36725.
39. List, K., Jensen, O. N., Bugge, T. H., Lund, L. R., Ploug, M., Dano, K. & Behrendt, N. (2000) Biochemistry 39, 508-515.
40. Romisch, J., Vermohlen, S., Feussner, A. & Stohr, H. (1999) Haemostasis 29, 292-299.
41. Takeuchi, T., Harris, J. L., Huang, W., Yan, K. W., Coughlin, S. R. & Craik, C. S. (2000) J. Biol. Chem. 275, 26333-26342.