Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma

Lancet

Volumn 357, Issue 9268, 2001, Pages 1591-1592

  Löhr, Matthias ^a   Hoffmeyer, Anne ^a,c   Kröger, Jens Christian ^b   Freund, Mathias ^a   Hain, Johannes ^c   Holle, Albrecht ^a   Karle, Peter ^e   Knöfel, Wolfram T ^f   Liebe, Stefan ^a   Müller, Petra ^a,c   Nizze, Horst ^a   Renner, Matthias ^c,e   Saller, Robert M ^c   Wagner, Thomas ^d   Hauenstein, Karlheinz ^b   Günzburg, Walter H ^e   Salmons, Brian ^c  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b Dept Diagn Interventional R ^*  (Germany)

^c Bavarian Nordic GmbH   (Germany)

^d UNIVERSITY OF LÜBECK   (Germany)

^e UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^f UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULOSE SULFATE; CYTOCHROME P450; IFOSFAMIDE;

ADULT; AGED; ANGIOGRAPHY; ARTICLE; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA MODIFICATION; DRUG ACTIVATION; FEMALE; HUMAN; HUMAN CELL; INOPERABLE CANCER; MALE; MICROENCAPSULATION; PANCREAS CARCINOMA; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; TREATMENT OUTCOME; TUMOR REGRESSION; TUMOR VASCULARIZATION;

EID: 0342467852     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(00)04749-8     Document Type: Article

References (5)

1. Günzburg W.H., Salmons B. Novel clinical strategies for the treatment of pancreatic carcinoma. Trends Mol Med. 7:2001;30-37.
2. Lohr M., Muller P., Karle P., et al. Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. Gene Ther. 5:1998;1070-1078.
3. Kröger J.C., Bergmeister H., Hoffmeyer A., et al. Intra-arterial instillation of microencapsulated cells in the pancreatic arteries in pig. Ann N Y Acad Sci. 880:1999;374-378.
4. Löhr J.M., Bago Z.T., Bergmeister H., et al. Cell therapy using microencapsulated 293 cells transfected with a gene contruct expressing CYP2B1, an ifosfamide converting enzyme, instilled intra-arterially in patients with advanced-stage pancreatic carcinoma: a phase I/II study. J Mol Med. 77:1999;393-398.
5. A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med. 332:1995;1256-1261.