Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects

Cancer Gene Therapy

Volumn 10, Issue 10, 2003, Pages 771-778

  Ugai, Shin Ichi ^a,b   Shimozato, Osamu ^a   Yu, Ling ^a   Wang, Yan Qing ^a,c   Kawamura, Kiyoko ^a   Yamamoto, Hiroshi ^d   Yamaguchi, Taketo ^b   Saisho, Hiromitsu ^b   Sakiyama, Shigeru ^a   Tagawa, Masatoshi ^a  

^a CHIBA CANCER CENTER   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c FUDAN UNIVERSITY   (China)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Gene therapy; IL 21; IL 23; Natural killer cells; Pancreatic cancer

Indexed keywords

CYTOKINE; GANGLIOSIDE ANTIBODY; GANGLIOTETRAOSYLCERAMIDE ANTIBODY; INTERLEUKIN 21; INTERLEUKIN 23; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOMA CELL; CELL REGENERATION; CONTROLLED STUDY; GENETIC TRANSDUCTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUDE MOUSE; PANCREAS CARCINOMA; PRIORITY JOURNAL; SCID MOUSE;

ANIMALS; CELL LINE, TUMOR; DISEASE PROGRESSION; GENE THERAPY; HUMANS; IMMUNOTHERAPY; INTERFERON TYPE II; INTERLEUKIN-23; INTERLEUKIN-23 SUBUNIT P19; INTERLEUKINS; KILLER CELLS, NATURAL; MICE; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; SPLEEN;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 12444328351     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700630     Document Type: Article

References (22)

1. Ridwelski K, Meyer F, Ebert M, et al. Prognostic parameters determining survival in pancreatic carcinoma and, in particular, after palliative treatment. Dig Dis. 2001;19:85-92.
2. Kimura M, Yoshida Y, Narita M, et al. Acquired immunity in nude mice induced by expression of the IL-2 or IL-4 gene in human pancreatic carcinoma cells and anti-tumor effect generated by in vivo gene transfer using retrovirus. Int J Cancer. 1999;82:549-555.
3. Yoshida Y, Tasaki K, Miyauchi M, et al. Impaired tumorigenicity of human pancreatic cancer cells retrovirally transduced with interleukin-12 or interleukin-15 gene. Cancer Gene Ther. 2000;7:324-331.
4. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-793.
5. Parrish-Novok J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000; 408:57-63.
6. Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13:715-725.
7. c-dependent network? Curr Biol. 2001;11:R175-177.
8. Asao H, Okuyama C, Kumaki S, et al. The common γ-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167:1-5.
9. Kasaian MT, Whitters MJ, Carter LL, et al. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity. 2002;16:559-569.
10. Wurster AL, Rodgers VL, Satoskar AR, et al. Interleukin-21 is a T helper (Th) cells 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon γ-producing Th1 cells. J Exp Med. 2002;7:967-977.
11. Parham C, Chirica M, Timans J, et al. A receptor for the heterdimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002;168:5699-5708.
12. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. BioTechniques. 1989;7:980-990.
13. Duke GM, Hoffman MA, Palmenberg AC. Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation. J Virol. 1992;66:1602-1609.
14. Kato K, Shimozato O, Hoshi K, et al. Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. Proc Natl Acad Sci USA. 1996;93:9085-9089.
15. Ugai S, Shimozato O, Kawamura K, et al. Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts. Cancer Gene Ther. 2003;10:187-192.
16. Ling P, Gately MK, Gubler U, et al. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol. 1995;154:116-127.
17. Gillessen S, Carvajal D, Ling P, et al. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol. 1995;25:200-206.
18. + T cells on experimental haematogenous tumour metastases in the liver and lungs of mice. Immunol. 1997;92:561-566.
19. Li Y, Newby SA, Johnston JV, et al. Protective immunity induced by B7/CD28-costimulated γδ T cells to the EL-4 lymphoma in allogenic athymic mice. J Immunol. 1995;155:5705-5710.
20. Cui J, Shin T, Kawano T, et al. Requirement of Vα14NKT cells in IL-12-mediated rejection of tumors. Science. 1997;278:1623-1626.
21. Schnurr M, Scholz C, Rothenfusser S, et al. Apoptotic pancreatic tumor cells are superior to cell lysates in promoting cross-priming of cytotoxic T cells and activated NK and γδ T cells. Cancer Res. 2002;62:2347-2352.
22. Jaffee EM, Hruban RH, Biedrzycki B, et al. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J Clin Oncol. 2001;19:145-156.