Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models

Cancer Research

Volumn 62, Issue 21, 2002, Pages 6124-6131

  Vernejoul, Fabienne ^a   Faure, Patrick ^a   Benali, Naoual ^a   Calise, Denis ^a   Tiraby, Gérard ^b   Pradayrol, Lucien ^a   Susini, Christiane ^a   Buscail, Louis ^a  

^a CHU RANGUEIL   (France)

^b Société Cayla   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYETHYLENEIMINE; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TRANSFER; HAMSTER; LIVER METASTASIS; MALE; METASTASIS; NONHUMAN; NUDE MOUSE; PANCREAS CANCER; PRIORITY JOURNAL; REPORTER GENE; TRANSGENE; TUMOR GROWTH;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CARCINOMA, PANCREATIC DUCTAL; CELL DIVISION; CRICETINAE; DISEASE MODELS, ANIMAL; GENE THERAPY; GENE TRANSFER TECHNIQUES; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MESOCRICETUS; MICE; PANCREATIC NEOPLASMS; POLYETHYLENEIMINE; RECEPTORS, SOMATOSTATIN; TRANSGENES;

EID: 0036828266     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Warshaw, A. L., and Fernandez-del Castillo, C. Pancreatic carcinoma. N. Engl. J. Med., 326: 455-465, 1992.
2. Carrio, M., Mazo, A., Lopez-Iglesias, C., Estivill, X., and Fillat, C. Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells results in variable efficiency on the bystander killing: Implications for gene therapy. Int. J. Cancer, 94: 81-88, 2001.
3. Makinen, K., Loimas, S., Wahlfors, J., Alhava, E., and Janne, J. Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer. J. Gene Med., 2: 361-367, 2000.
4. Evoy, D., Hirschowitz, E. A., Naama, H. A., Li, X. K., Crystal, R. G., Daly, J. M., and Lieberman, M. D. In vivo adenoviral-mediated gene transfer in the treatment of pancreatic cancer. J. Surg. Res., 69: 226-231, 1997.
5. Kanai, F., Kawakami, T., Hamada, H., Sadata, A., Yoshida, Y., Tanaka, T., Ohashi, M., Tateishi, K., Shiratori, Y., and Omata, M. Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fiuorouracil. Cancer Res., 58: 1946-1951, 1998.
6. INK4a results in pancreatic cancer regression in vitro and in vivo. Gene Ther., 8: 199-208, 2001.
7. Motoi, F., Sunamura, M., Ding, L., Duda, D. G., Yoshida, Y., Zhang, W. W., Matsuno, S., and Hamada, H. Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus. Hum. Gene Ther., 11: 223-235, 2000.
8. Pollak, M. N., and Schally, A. V. Mechanisms of antineoplastic action of somatostatin analogs. Proc. Soc. Exp. Biol. Med., 217: 143-152, 1998.
9. Hoyer, D., Bell, G. I., Berelowitz, M., Epelbaum, J., Feniuk, W., Humphrey, P. P., O’Carroll, A. M., Patel, Y. C., Schonbrunn, A., Taylor, J. E., et al. Classification and nomenclature of somatostatin receptors. Trends Pharmacol. Sci. 16: 86-88, 1995.
10. Buscail, L., Delesque, N., Estève, J. P., Saint-Laurent, N., Prats, H., Clerc, P., Robberecht, P., Bell, G. L., Liebow, C., Schally, A. V., et al. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: Mediation by human somatostatin receptor subtypes SSTR1 and SSTR2. Proc. Natl. Acad. Sci. USA. 91: 2315-2319, 1994.
11. Buscail, L., Esteve, J. P., Saint-Laurent, N., Bertrand, V., Reisine, T., O’Carroll, A. M., Bell, G. I., Schally, A. V., Vaysse, N., and Susini, C. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms. Proc. Natl. Acad. Sci. USA, 92: 1580-1584, 1995.
12. Buscail, L., Saint-Laurent, N., Chastre, E., Vaillant, J. C., Gespach, C., Capella, G., Kalthoff, H., Lluis, F., Vaysse, N., and Susini, C. Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer. Cancer Res., 56: 1823- 1827, 1996.
13. Lamberts, S. W., Krenning, E. P., and Reubi, J. C. The role of somatostatin and its analogs in the diagnosis and treatment of tumors. Endocr. Rev., 12: 450-482, 1991.
14. Reubi, J. C., Kappeler A., Waser B., Laissue J., Hipkin R. W., and Schonbrunn A. Immunohistochemical localization of somatostatin receptors sst2A in human tumors. Am. J. Pathol., 153: 233-245, 1998.
15. Delesque, N., Buscail, L., Estève, J. P., Saint-Laurent, N., Muller, C., Weckbecker, G., Bruns, C., Vaysse, N., and Susini, C. sst2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells. Cancer Res., 57: 956-962, 1997.
16. Rochaix, P., Delesque, N., Estève, J. P., Saint-Laurent, N., Voigt, J. J., Vaysse, N., Susini, C., and Buscail, L. Gene therapy for pancreatic carcinoma: Local and distant antitumor effects after somatostatin receptor sst2 gene transfer. Hum. Gene Ther., 10: 995-1008, 1999.
17. Benali, N., Cordelier, P., Calise, D., Pagès, P., Rochaix, P., Nagy, A., Estève, J. P., Pour, P. M., Schally, A. V., Vaysse, N., Susini, C., and Buscail, L. Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238. Proc. Natl. Acad. Sci. USA, 97: 9180-9185, 2000.
18. He, T. C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA, 95: 2509-2514, 1998.
19. Goula, D., Benoist, C., Mantero, S., Merlo, G., Levi, G., and Demeneix, B. A. Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther., 5: 1291-1295, 1998.
20. Coll, J. L., Chollet, P., Brambilla, E., Desplanques, D., Behr, J. P., and Favrot, M. In vivo delivery to tumors of DNA complexed with linear polyethylenimine. Hum. Gene Ther., 10: 1659-1666, 1999.
21. KIP1. Evidence for the role of SHP-1. J. Biol. Chem., 274: 15186-15193, 1999.
22. Freeman, S. M., Whartenby, K. A., Freeman, J. L., Abboud, C. N., and Marrogi, A. J. In situ use of suicide genes for cancer therapy. Semin. Oncol., 23: 31-45, 1996.
23. Aoki, K., Furuhata, S., Hatanaka, K., Maeda, M., Remy, J. S., Behr, J. P., Terada, M., and Yoshida, T. Polyethylenimine-mediated gene transfer into pancreatic tumor dissemination in the murine peritoneal cavity. Gene Ther., 8: 508-514, 2001.
24. Demeneix, B., Behr, J., Boussif, O., Zanta, M. A., Abdallah, B., and Remy, J. Gene transfer with lipospermines and polyethylenimines. Adv. Drug Deliv. Rev., 30: 85-95, 1998.
25. Behr, J. P., Demeneix, B., Loeffler, J. P., and Perez-Mutul, J. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc. Natl. Acad. Sci. USA. 86: 6982-6986, 1989.
26. McClane, S.J., Chirmule, N., Burke, C. V., and Raper, S. E. Characterization of the immune response after local delivery of recombinant adenovirus in murine pancreas and successful strategies for readministration. Hum. Gene Ther., 8: 2207-2216, 1997.