Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene

Annals of Surgery

Volumn 225, Issue 5, 1997, Pages 609-620

  Rosenfeld, Maryland E ^a   Vickers, Selwyn M ^b   Raben, David ^c   Wang, Minghui ^a   Sampson, Lorenzo ^b   Feng, Meizhen ^a   Jaffee, Elizabeth ^d   Curiel, David T ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Kentucky   (United States)

^c The University of Alabama at Birmingham   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; GENE THERAPY; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; PANCREAS CARCINOMA; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; GANCICLOVIR; GENE THERAPY; GENES, VIRAL; HUMANS; MICE; MICE, INBRED BALB C; PANCREATIC NEOPLASMS; SIMPLEXVIRUS; THYMIDINE KINASE; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0031424456     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199705000-00017     Document Type: Article

References (42)

1. Moolten F. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46:5276-5281.
2. Abe A, Takeo T, Emi N, et al. Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector. Proc Natl Acad Exp Biol Med Sci USA 1993; 203:354-359.
3. Mullen CA, Killstrup M. Blaese RM. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system, Proc Natl Acad Sci U S A 1992; 89:33-37.
4. Elion GB, Furman PA, Fyfe JA, et al. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci U S A 1977; 74:5716-5721.
5. Furman PA, McGujirt PV, Keller PM, et al. Inhibition by acyclovir of cell growth and DMA synthesis of transformed with herpesvirus genetic information. Virology 1980; 102:420-430.
6. Culver KW, Ram Z, Walbridge S, et al. In vivo with retroviral vector producer cells for treatment of experimental brain tumors. Science 1992; 256:1550-1552.
7. Bi WL, Parysek LM, Warnick R, et al. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. Hum Gene Her 1993; 4:725-731.
8. Freeman SM, Abboud CN, Whartenby KA, et al. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53:5274-5283.
9. Smythe WR, Hwang HC, Elshami AA, et al. Treatment of experimental human mesothelioma using adenovirus transfer of die herpes simplex thymidine kinase gene. Ann Surg 1995; 222:78-86.
10. Hwang HC, Smythe WR, Elshami AA, et al. Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to teat in vivo models of human malignant mesothelioma and lung cancer. Am J Respir Cell Mol Biol 1995; 13:7-16.
11. Herz J, Gerard RD, Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci U S A 1993; 90:2812-2816.
12. Becker TC, Noel RJ, Coats WS, et al. Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods Cell Biol 1994; 43:161-189.
13. Rosenfeld ME, Feng M, Michael SI, et al. Adenoviral-mediated delivery of the herpes simplex virus thymidine kinase gene selectively sensitizes human ovarian carcinoma cells to ganciclovir. Clinical Cancer Research 1995; 1:1571-1580.
14. Feng M, Cabrera G, Deshane J, et al. Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an antiras ribozyme. Cancer Res 1995; 55:2024-2028.
15. Simon RH, Engelhardt JF, Yang Y, et al. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study. Hum Gene Ther 1993; 4:771-780.
16. Jaffe H, Danel C, Longenecker G, et al. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nature Genetics 1992; 1:372-378.
17. Yang Y, Raper SE, Cohn JA, et al. An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. Proc Natl Acad Sci U S A 1993; 90:4601-4605.
18. Quantin B, Perricaudet LD, Tajbakhsh S, et al. Adenovirus as an expression vector in muscle cells in vivo. Proc Natl Acad Sci U S A 1992; 89:2581-2584.
19. Bass C, Cabrera G, Elgavish A, et al. Recombinant adenovirus-mediated gene transfer to genito-urinary epithelium in vitro and in vivo. Cancer Gene Ther 1995; 2:97-104.
20. Smythe WR, Kaiser LR, Hwang HC, et al. Successful adenovirus-mediated gene transfer in an in vivo model of human malignant mesothelioma. Ann Thorac Surg 1994; 57:1395-1401.
21. Boring CC, Squires TS, Tong T. Cancer statistics. CA Cancer J Clin 1993; 43:7.
22. Caldas C, Hahn SA, da Costa LT, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nature Genetics 1994; 8:27-32.
23. Jin X, Nguyen D, Zang WW, et al. Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector. Cancer Res 1995; 55:3250-3253.
24. Fueyo J, Gomez-Manzano C, Yung WKA, et al. Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 1996; 12:103-110.
25. Aoki K, Yoshida T, Sugimura T, et al. Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity. Cancer Res 1995; 55:3810-3816.
26. Mukhopadhyay T, Tainsky M. Cavender AC, et al. Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Res 1991; 51:1744-1748.
27. Jaskulski D, DeRiel JK, Mercer WE, et al. Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science 1988; 240:1544-1546.
28. Laird AD, Brown PI, Fausto N. Inhibition of tumor growth in liver epithelial cells transfected with a transforming growth factor α antisense gene. Cancer Res 1994; 54:4224-4232.
29. Georges RN, Mukhopadhyay T, Zhang Y, et al. Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct Cancer Res 1993; 53:1743-1746.
30. Ratajczak MZ, Kant JA, Luger SM, et al. In vivo treatment of human leukemia in a SCID mouse model with c-myb antisense oligodeoxynucleotides. Proc Natl Acad Sci U S A 1992; 89:11823-11827.
31. Sobol RE, Scanlon KJ. Clinical protocols. In: Sobol RE, Scanlon KJ, eds. Cancer Gene Therapy. Connecticut: Appleton and Lange; 1995; 2:225-234.
32. Oldfleld EH, Ram Z, Culver KW, et al. Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 1993; 4:39-69.
33. Freeman SM, McCune C, Angel C, et al. Treatment of ovarian carcinoma using HSV-TK gene modified vaccine - regulatory issues. Hum Gene Ther 1992; 3:342-349.
34. DiMaio JM, Clary BM, Via DF, et al. Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. Surgery 1994; 116:205-213.
35. Garver RI, Goldsmith K, Rodu B, et al. Strategy for achieving selective killing of carcinomas. Gene Ther 1994; 1:46-50.
36. Ido A, Nakata K, Kato Y, et al. Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under control of human α-fetoprotein gene promoter. Cancer Res 1995; 55:3105-3109.
37. Kaneko S, Hallenbeck P, Kotani T, et al. Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res 1995; 55:5283-5287.
38. Manome Y, Abe M, Hagen MF, et al. Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer selective sensitivity of human breast cancer cells to ganciclovir. Cancer Res 1994; 54:5408-5413.
39. Osaki T, Tanio Y, Tachibana I, et al. Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene. Cancer Res 1994; 54:5258-5261.
40. Tanaka T, Kanai F, Okabe S, et al. Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro. Cancer Res 1996; 56:1341-1345.
41. Vile RG, Hart IR. Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. Cancer Res 1993; 53:3860-3864.
42. Lemoine NR. Genetic intervention for therapy and prevention of pancreatic cancer. Dig Surg 1994; 11:170-177.