Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer

Journal of Gene Medicine

Volumn 2, Issue 5, 2000, Pages 361-367

  Mäkinen, Kimmo ^a   Loimas, Sami ^a,b   Wahlfors, Jarmo ^a,b   Alhava, Esko ^a   Jänne, Juhani ^a,b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Adenovirus; Gene therapy; Pancreatic cancer; Retrovirus; Thymidine kinase

Indexed keywords

ADENOVIRIDAE; ANIMALIA; HERPES; SIMPLEXVIRUS; UNIDENTIFIED RETROVIRUS;

ANTIVIRUS AGENT; GANCICLOVIR; THYMIDINE KINASE;

ADENOVIRUS; ANIMAL; ARTICLE; CELL CULTURE; ENZYMOLOGY; EVALUATION; GENE THERAPY; GENETIC TRANSDUCTION; GENETICS; HERPES SIMPLEX VIRUS; HUMAN; LEWIS RAT; MALE; METHODOLOGY; MULTIMODALITY CANCER THERAPY; PANCREAS TUMOR; PATHOLOGY; RAT;

ADENOVIRIDAE; ANIMALS; ANTIVIRAL AGENTS; COMBINED MODALITY THERAPY; GANCICLOVIR; GENE THERAPY; HUMANS; MALE; PANCREATIC NEOPLASMS; RATS; RATS, INBRED LEW; SIMPLEXVIRUS; THYMIDINE KINASE; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0034279164     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-2254(200009/10)2:5<361::aid-jgm125>3.0.co;2-7     Document Type: Article

References (36)

1. Gudjonsson B. Cancer of the pancreas: 50 years of surgery. Cancer 1987; 60: 2284-2303.
2. Alanen KA, Joensuu H. Long-term survival after pancreatic adenocarcinoma - often a misdiagnosis? Br J Cancer 1993; 68: 1004-1005.
3. Bramhall SR, Allum WH, Jones AG, Allwood A, Cummins C, Neoptolemos JP. Treatment and survival in 13560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br J Surg 1995; 82: 111-115.
4. Hedberg M, Borgström A, Genell S, Janzon L. Survival following pancreatic carcinoma: a follow-up study of all cases recorded in Malmö, Sweden, 1977-1991. Br J Surg 1998; 85: 1641-1644.
5. Bakkevold K, Kambestad B. Morbidity and mortality after radical and palliative pancreatic cancer surgery. Ann Surg 1993; 217: 356-368.
6. Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 1993; 165: 68-73.
7. Cameron JL, Crist DW, Sitzmann JV, et al. Factors influencing survival after pancreaticoduodenectomy for pancreatic cancer. Am J Surg 1991; 161: 120-125.
8. Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy for cancer of the head of the pancreas. Ann Surg 1995; 221: 721-733.
9. Trede M, Saeger HD, Schwall G, Rumstadt B. Resection of pancreatic cancer - surgical achievements. Langenbecks Arch Surg 1998; 383: 121-128.
10. Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46: 5276-5281.
11. Aoki K, Yoshida T, Sugimura T, Terada M. Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity. Cancer Res 1995; 55: 3810-3816.
12. Shichinohe T, Senmaru N, Furuuchi K, et al. Suppression of pancreatic cancer by dominant negative ras mutant, N116Y. J Surg Res 1996; 66: 125-130.
13. Evoy D, Hirschowitz EA, Naama HA, et al. In vivo adenoviral-mediated gene transfer in the treatment of pancreatic cancer. J Surg Res 1997; 69: 226-231.
14. Simeone DM, Cascarelli A, Logsdon CD. Adenoviral-mediated gene transfer of a constitutively active retinoblastoma gene inhibits human pancreatic tumour cell proliferation. Surgery 1997; 122: 428-434.
15. Bouvet M, Bold RJ, Lee J, et al. Adenovirus-mediated wild-type p53 tumour suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer. Ann Surg Oncol 1998; 5: 681-688.
16. DiMaio JM, Clary B, Via DF, Conveney E, Pappas TN, Lyerly HK. Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. Surgery 1994; 116: 205-213.
17. Aoki K, Yoshida T, Matsumoto N, et al. Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene. Hum Gene Ther 1997; 8: 1105-1113.
18. Yang L, Hwang R, Pandit L, Gordon EM, Anderson WF, Parekh D. Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir. Ann Surg 1996; 224: 405-417.
19. Rosenfeld ME, Vickers SM, Raben D et al. Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene. 1997; 225: 609-620.
20. Hwang RF, Gordon EM, Anderson WF, Parekh D. Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene. Surgery 1998; 124: 143-151.
21. Pettengill OS, Faris RA, Bell RH Jr, Kühlmann ET, Longnecker DS. Derivation of ductlike cell lines from a transplantable acinar cell carcinoma of the rat pancreas. Am J Pathol 1993; 143: 292-303.
22. Mäkinen K, Loimas S, Kosma VM, et al. Azaserine-induced rat pancreas tumor model with transplantable cultured cells. Pancreas 1998; 16: 160-164.
23. Mäkinen K, Loimas S, Nuutinen P, Eskelinen M, Alhava E. The growth pattern and microvasculature of pancreatic tumours induced with cultured carcinoma cells. Br J Cancer 2000; 82: 900-904.
24. Sandmair AM, Loimas S, Poptani H, et al. Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment. Acta Neurochir 1999; 141: 867-872.
25. Miller AD, Buttimore C. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol 1986; 6: 2895-2902.
26. Barr E, Carroll J, Kalynych AM, et al. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther 1994; 1: 51-58.
27. McClane SJ, Hamilton TE, Burke CV, Raper SE. Functional consequences of adenovirus-mediated murine pancreatic gene transfer. Hum Gene Ther 1997; 8: 739-746.
28. Graham FL, van der Erb AJ. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973; 52: 456-467.
29. Ausubel FM, Brent R, Kingston RE, et al. (eds). Current Protocols in Molecular Biology. Greene Publishing Associates/John Wiley & Sons: New York, NY, 1991.
30. Horwitz MS. Adenoviruses. In Fields Virology, vol 2, Fields BN, Knipe DN (eds). Raven Press: New York, NY, 1990; 1723-1742.
31. Block A, Chen S-H, Kosai K-I, Finegold M, Woo SLC. Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors. Pancreas 1997; 15: 25-34.
32. Okada H, Giezeman-Smits KM, Tahara H, et al. Effective cytokine gene therapy against an intracranial glioma using a retrovirally transduced IL-4 plus HSVtk tumor vaccine. Gene Ther 1999; 6: 219-226.
33. Pour PM, Runge RG, Birt D, et al. Current knowledge of pancreatic carcinogenesis in the hamster and its relevance to the human disease. Cancer 1981; 47: 1573-1587.
34. Hall PA, Lemoine NR. Models of pancreatic cancer. Cancer Surv 1993; 16: 135-155.
35. Longnecker DS, Roebuck BD, Yager JD, Lilja HS, Siegmund B. Pancreatic carcinoma in azaserine-treated rats: induction, classification and dietary modulation of incidence. Cancer 1981; 47: 1562-1572.
36. Mäkinen K, Loimas S, Kosma VM, et al. Adenovirus-mediated gene transfer into experimental pancreatic tumour. Ann Chir Gynaecol 2000 (in press).