A γ-secretase-independent mechanism of signal transduction by the amyloid precursor protein

Journal of Biological Chemistry

Volumn 280, Issue 44, 2005, Pages 36895-36904

  Hass, Matthew R ^a   Yankner, Bruce A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELLS; ENZYMES; MUTAGENESIS; SIGNALING;

AMYLOID PRECURSOR PROTEIN (APP); CYCLIN-DEPENDENT KINASE; IMMUNOFLUORESCENCE; INTRACELLULAR DOMAIN;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYCLIN DEPENDENT KINASE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; HISTONE ACETYLTRANSFERASE; PRESENILIN 1; PRESENILIN 2; PROTEIN FE65; PROTEIN TIP60; ROSCOVITINE; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CELL NUCLEUS; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL MEMBRANE; CELL NUCLEUS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASES; ENDOPEPTIDASES; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; HISTONE ACETYLTRANSFERASES; HUMANS; KIDNEY; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHOSPHORYLATION; PRESENILIN-1; PRESENILIN-2; PROTEIN STRUCTURE, TERTIARY; PURINES; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STEM CELLS; SUBCELLULAR FRACTIONS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 27744587358     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502861200     Document Type: Article

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