In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes

Circulation Research

Volumn 78, Issue 6, 1996, Pages 1083-1089

  Brahmajothi, Mulugu V ^a   Morales, Michael J ^a   Liu, Shuguang ^a   Rasmusson, Randall L ^b   Campbell, Donald L ^a   Strauss, Harold C ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Duke University   (United States)

Author keywords

gene expression; heart; K+ channel; localization; SA node

Indexed keywords

GENE PRODUCT; MESSENGER RNA; POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FERRET; GENE EXPRESSION; HEART MUSCLE CELL; HEART REPOLARIZATION; IN SITU HYBRIDIZATION; LONG QT SYNDROME; MALE; NONHUMAN; OLIGONUCLEOTIDE PROBE; POTASSIUM CURRENT; PRIORITY JOURNAL; SINUS NODE;

EID: 0029902646     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.78.6.1083     Document Type: Article

References (69)

1. Schuessler RB, Boineau JP, Bromberg BI, Hand DE, Yamauchi S, Cox JL. Normal and abnormal activation of the atrium. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1995:543-562.
2. Allessie MA. Reentrant mechanisms underlying atrial fibrillation. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1995:562-566.
3. Jackman WM, Nakagawa H, Heidbüchel H, Beckman K, McClelland J, Lazzara R. Three forms of atrioventricular nodal (junctional) reentrant tachycardia: differential diagnosis, electrophysiological characteristics, and implications for anatomy of the reentrant circuit. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1995:620-637.
4. Waldo AL. Atrial flutter: mechanisms, clinical features, and management. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1995:666-681.
5. Anumonwo JMB, Jalife J. Cellular and subcellular mechanisms of pacemaker activity initiation and synchronization in the heart. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1995:151-163.
6. Members of the Sicilian Gambit. Antiarrhythmic Therapy: A Pathophysiologic Approach. Armonk, NY: Futura Publishing Co; 1994.
7. Campbell DL, Rasmusson RL, Comer MB, Strauss HC. The cardiac calcium-independent transient outward potassium current: kinetics, molecular properties, and role in ventricular repolarization. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1995:83-96.
8. Balser JR, Bennett PB, Roden DM. Time-dependent outward current in guinea pig ventricular myocytes. J Gen Physiol. 1990;96:835-863.
9. + current: differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol. 1990;96:195-215.
10. K and screens membrane surface charge in cardiac cells. Am J Physiol. 1990;259:H1881-H1889.
11. + current is composed of two currents in guinea pig atrial cells. Am J Physiol. 1991;260:H393-H399.
12. Kass RS. Delayed potassium channels in the heart: cellular, molecular, and regulatory properties. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1995:74-82.
13. Wang Z, Fermini B, Nattel S. Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc Res. 1994;28:1540-1546.
14. + channel current. Circ Res. 1993;73:210-216.
15. + current similar to Kv1.5 cloned channel currents. Circ Res. 1993;73:1061-1076.
16. Chandy KG, Gutman GA. Voltage-gated potassium channel genes. In: North RA, ed. Handbook of Receptors and Channels: Ligand and Voltage-Gated Ion Channels. Boca Raton, Fla: CRC Press; 1995:1-71.
17. to-like potassium channel from ferret ventricle. Am J Physiol. 1994;267:H1383-H1395.
18. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res. 1993;73:379-385.
19. Näbauer M, Beuckelmann DJ, Erdmann E. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res. 1993;73:386-394.
20. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell. 1995;80:795-803.
21. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Towbin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT. Positional cloning of a novel potassium channel gene: KvLQT1 mutations cause cardiac arrhythmias. Nat Genet. 1996;12:17-23.
22. Warmke JW, Ganetzky B. A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A. 1994;91:3438-3442.
23. Kr potassium channel. Cell. 1995;81:299-307.
24. Trudeau MC, Warmke JW, Ganetzky B, Robertson GA. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science. 1995;269:92-95.
25. Kubo Y, Baldwin TJ, Jan YN, Jan LY. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 1993;362:127-133.
26. Takumi T, Ohkubo H, Nakanishi S. Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science. 1988;242:1042-1045.
27. + channel protein in mammalian cells and immunolocalization in guinea pig heart. Circ Res. 1993;73:968-973.
28. Ks and mediates species-specific responses to protein kinase C. Proc Natl Acad Sci U S A. 1993;90:11528-11532.
29. Dixon JE, McKinnon D. Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circ Res. 1994;75:252-260.
30. Jacobson SL, Piper HM. Cell cultures of adult cardiomyocytes as models of the myocardium. J Mol Cell Cardiol. 1986;18:661-678.
31. Campbell DL, Rasmusson RL, Ou Y, Strauss HC. The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes, I: basic characterization and kinetic analysis. J Gen Physiol. 1993;101:571-601.
32. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol. 1990;215:403-410.
33. Pearson WR. Rapid and sensitive sequence comparison with FASTP and FASTA. Methods Enzymol. 1990;183:63-98.
34. + channel from human atrium. Circ Res. 1995;76:343-350.
35. Koyama H, Morishige KI, Takahashi N, Zanelli JS, Fass DN, Kurachi Y. Molecular cloning, functional expression and localization of a novel inward rectifier potassium channel in the rat brain. FEBS Lett. 1994;341:303-307.
36. Wilkinson DG, ed. In Situ Hybridization: A Practical Approach. 2nd ed. Oxford, England: IRL Press; 1992.
37. NIAID Manual of Tissue Typing Techniques. Washington, DC: National Institutes of Health; 1979.
38. Gorza L, Ausoni S, Merciai N, Hastings KEM, Schiaffino S. Regional differences in troponin I isoform switching during rat heart development. Dev Biol. 1993;156:253-264.
39. Noma A, Nakayama T, Kurachi Y, Irisawa H. Resting K conductances in pacemaker and non-pacemaker heart cells of the rabbit. Jpn J Physiol. 1984;34:245-254.
40. + current. Circ Res. 1995;77:1246-1253.
41. + channels? Circ Res. 1994;77:361-369.
42. + channels detected in vivo. Nature. 1993;365:72-75.
43. + channels in terminal and juxtaparanodal regions of neurons. Nature. 1993;365:75-79.
44. Morales MJ, Castellino RC, Crews AL, Rasmusson RL, Strauss HC. A novel β subunit increases rate of inactivation of specific voltage-gated potassium channel α subunits. J Biol Chem. 1995;270:6272-6277.
45. + channel α-subunit from human atrium. FEBS Lett. 1995;361:13-16.
46. + channel β-subunit (hKvβ1.3) is produced via alternative mRNA splicing. J Biol Chem. 1995;270:28531-28534.
47. Bennett PB, Po S, Snyders DJ, Tamkun MM. Molecular and functional diversity of cloned cardiac potassium channels. Cardiovasc Drugs Ther. 1993;7:585-592.
48. Antzelevitch C, Sicouri S, Lukas A, Nesterenko VV, Liu D-W, Di Diego JM. Regional differences in the electrophysiology of ventricular cells: physiological and clinical implications. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1995:228-245.
49. Wang Z, Fermini B, Nattel S. Delayed rectifier outward current and repolarization in human atrial myocytes. Circ Res. 1993;73:276-285.
50. Giles W, van Ginneken A, Shibata EF. Ionic currents underlying cardiac pacemaker activity: a summary of voltage-clamp data from single cells. In: Nathan RD, ed. Cardiac Muscle: The Regulation of Excitation and Contraction. Orlando, Fla: Academic Press Inc; 1986:1-27.
51. Giles W, Imaizumi Y. Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol (Lond). 1988;405:123-145.
52. Näbauer M, Beuckelmann DJ, Überfuhr P, Steinbeck G. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation. 1996;93:168-177.
53. Vallins WJ, Brand NJ, Dabhade N, Butler-Browne G, Yacoub MH, Barton PJ. Molecular cloning of human cardiac troponin I using polymerase chain reaction. FEBS Lett. 1990;270:55-61.
54. Wade R, Eddy R, Shows TB, Kedes L. cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I. Genomics. 1990;7:346-357.
55. Ramashwami M, Gautam M, Kamb AA, Rudy B, Tanouye MA, Mathew MK. Human potassium channel genes: molecular cloning and functional expression. Mol Cell Neurosci. 1990;1:214-223.
56. + channels in human T lymphocytes. J Biol Chem. 1992;267:8650-8657.
57. + channel cDNAs from human ventricle. FASEB J. 1991;5:331-337.
58. Grupe A, Schroter KH, Ruppersberg JP, Stocker M, Drewes T, Beckh S, Pongs O. Cloning and expression of a human voltage-gated potassium channel: a novel member of the RCK potassium channel family. EMBO J. 1990;9:1749-1756.
59. Albrecht B, Lorra C, Stocker M, Pongs O. Cloning and characterization of a human delayed rectifier potassium channel gene. Recept Chan. 1993;1:99-110.
60. Hwang PM, Glatt CE, Bredt DS, Yellen G, Snyder SH. A novel potassium channel with unique localization in mammalian brain: molecular cloning and characterization. Neuron. 1992;8:473-481.
61. Ried T, Rudy B, Vega-Saenz de Miera E, Lau D, Ward DC, Sen K. Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15. Genomics. 1993;15:405-411.
62. + channel genes in mammals. Proc Natl Acad Sci U S A. 1990;87:5227-5231.
63. Lee JE, Garbutt JH, Phillips KL, Garbutt JH, Roses AD. H. sapiens chromosome 19 potassium channel gene (partial). GenBank accession Z11585.
64. + channel. Proc R Soc Lond B Biol Sci. 1992;248:9-18.
65. Lennon GG, Auffray C, Polymeropoulos M, Soares MB. The I.M.A.G.E. consortium: an integrated molecular analysis of genomes and their expression. Genomics. In press.
66. Baldwin TJ, Tsaur ML, Lopez GA, Jan YN, Jan LY. Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel. Neuron. 1991;7:471-483.
67. Serodio P, Rudy B. Cloning, expression and distribution of Kv4.3, a new mammalian subunit of the A-type, low voltage-activating potassium channels. J Neurophysiol. In press.
68. + channel mRNAs from different subfamilies. J Neurosci. 1992;12:538-548.
69. Murai T, Kakizuka A, Takumi T, Ohkubo H, Nakanishi S. Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity. Biochem Biophys Res Commun. 1989;161:176-181.