Direct physical measure of conformational rearrangement underlying potassium channel gating

Science

Volumn 271, Issue 5246, 1996, Pages 213-216

  Mannuzzu, Lidia M ^b   Moronne, Mario M ^b   Isacoff, Ehud Y ^b  

^a University of California Berkeley   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIPOLE; FLUORESCENCE; MEMBRANE DEPOLARIZATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0030059224     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5246.213     Document Type: Article

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37. We thank L Y. Jan, H. Lecar, J. Ngai, E. Reuveni, O. Baker, R. Harris, H. P. Larsson, and K. Zito for valuable discussion; A, Glazer for advice about fluorescence; G. Westheimer for advice on optical filters; and Technical Instruments Corporation for loan of fluorescence microscopy equipment. ShH4 (W434F/ △6-46) was provided by L Toro, and the antibody for the immunoprecipitation was provided by L. Y. Jan. Supported by American Heart Association-California Affiliate grant 94-216, by a McKnight Scholar Award to E.Y I., and by U.S. Department of Energy contract DE-AC03-76SF00098 to M.M M.