Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization

Cell

Volumn 100, Issue 4, 2000, Pages 399-409

  Yu, Fengwei ^a   Morin, Xavier ^a   Cai, Yu ^a   Yang, Xiaohang ^a   Chia, William ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN; HYBRID PROTEIN; POLYPEPTIDE; RNA;

AMINO ACID SEQUENCE; ARTICLE; CELL DIVISION; DNA BINDING; DROSOPHILA; MITOSIS SPINDLE; NEUROBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 0034681261     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80676-5     Document Type: Article

References (56)

1. The embryonic CNS lineages of Drosophila melanogaster: I. Neuroblast lineages derived from the ventral half of the neuroectoderm
2. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
3. Staufen-dependent localisation of prospero mRNA contributes to neuroblast daughter-cell fate
4. Functional Drosophila cDNA libraries from Drosophila embryos
5. Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are non-stochastic and require inscuteable mediated asymmetry of ganglion mother cells
6. Numb diverts Notch pathway off the Tramtrack
7. Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis
8. Asymmetric cell divisions and neurogenesis
9. The prospero gene specifies cell fate in the Drosophila central nervous system
10. The Drosophila sanpodo gene controls sibling cell fate encodes a Tropomodulin homolog, an actin/tropomyosin associated protein
11. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos
12. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
13. The TPR snap helix: A novel protein repeat motif from mitosis to transcription
14. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo
15. Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch
16. Asymmetric segregation of a homeoprotein, prospero, during cell division in neural and endodermal development
17. Mechanisms of asymmetric cell divisions: Two Bs or not two Bs, that is the question
18. Par-6 is a conserved PDZ domain-containing protein that colocalises with Par-3 in Caenorhabditis elegans embryos
19. Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions
20. An atypical PKC directly associates and colocalises at the epithelial tight junction with ASIP, a mammalian homolog of Caenorhabditis elegans polarity protein Par-3
21. Asymmetric cell division
22. Localisation of numb and prospero reveals a novel mechanism for asymmetric protein segregation during mitosis
23. Deletion analysis of the Drosophila inscuteable protein reveals domains for cortical localization and asymmetric localization
24. Inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein
25. Role of inscuteable in orienting asymmetric cell divisions in Drosophila
26. Control of spindle orientation by the Par-3-related PDZ-domain protein Bazooka
27. Inscuteable and Staufen mediate asymmetric localization and segregation of prospero RNA during Drosophila neuroblast cell divisions
28. Partner of Numb, a novel protein that colocalises with Numb during mitosis, directs Numb asymmetric localization in Drosophila neural and muscle progenitors
29. Asymmetric cell division: Lessons from flies and worms
30. A new visible light DNA fluorochrome for confocal microscopy
31. Cloning of the Drosophila prospero gene and its expression in ganglion mother cells
32. Miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis
33. Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2
34. Armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila
35. Asymmetric distribution of Numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
36. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
37. Segregation of myogenic lineages in Drosophila requires Numb
38. The embryonic central nervous system lineages of Drosophila melanogaster. II. Neuroblast lineages derived from the dorsal part of the neuroectoderm
39. Bazooka recruits inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts
40. Miranda mediates asymmetric protein and RNA localisation in the developing nervous system
41. Protein localization and cell fate in bacteria
42. Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila
43. Miranda as a multidomain adapter linking apically localised inscuteable and basally localised Staufen and Prospero during asymmetric cell division in Drosophila
44. Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fate in the Drosophila CNS
45. The prospero transcription factor is asymmetrically localised to the cell cortex during neuroblast mitosis in Drosophila
46. Numb antagonises Notch signaling to specify sibling neuron cell fate
47. Asymmetric localisation of Numb autonomously determines sibling neuron identity in the Drosophila CNS
48. P-element mediated transformation
49. Atypical protein kinase C cooperates with Par-3 to establish embryonic polarity in Caenorhabditis elegans
50. A functional analyses of inscuteable and its roles during Drosophila asymmetric cell divisions
51. Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
52. Prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila
53. Mammalian numb is an evolutionarily conserved signaling adapter protein that specifies cell fate
54. Numb localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to Notch-1
55. Bazooka provides an apical cue for inscuteable localization in Drosophila neuroblasts
56. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis