Gαz inhibits serum response factor-dependent transcription by inhibiting Rho signaling

Molecular Pharmacology

Volumn 66, Issue 6, 2004, Pages 1508-1516

  Dutt, Parmesh ^a,c   Jaffe, Aron B ^b   Merdek, Keith D ^a   Hall, Alan ^b   Toksoz, Deniz ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADENYLATE CYCLASE; CYTOSKELETON PROTEIN; FATTY ACID; G ALPHA 12 PROTEIN; G ALPHA 13 PROTEIN; G ALPHA Q PROTEIN; G ALPHA Z PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; PROTEIN; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA188 PROTEIN; RHOAL63 PROTEIN; SERINE; SERUM RESPONSE FACTOR; UNCLASSIFIED DRUG; GNAZ PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; RECOMBINANT PROTEIN;

ACYLATION; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; AMINO ACID SUBSTITUTION; CELL LINE; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; KIDNEY; METABOLISM; PHYSIOLOGY; PLASMID; REPORTER GENE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; CELL LINE; GENE EXPRESSION REGULATION; GENES, REPORTER; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; KIDNEY; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; RECOMBINANT PROTEINS; RHO FACTOR; SERUM RESPONSE FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 9444245314     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.002949     Document Type: Article

References (42)

1. Alberts A and Treisman E (1998) Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1. EMBO (Eur Mol Biol Organ) J 17:4075-4085.
2. Arsenian S, Weinhold B, Oelgeschlager M, Ruther U, and Nordheim A (1998) Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO (Eur Mol Biol Organ) J 17:6289-6299.
3. Bishop AL and Hall A (2000) Rho GTPases and their effector proteins. Biochem J 348:241-255.
4. Blumer JB and Lanier SM (2003) Accessory proteins for G protein-signaling systems: activators of G protein signaling and other nonreceptor proteins influencing the activation state of G proteins. Recept Channels 9:195-204.
5. Boettner B and Van Aelst L (2002) The role of Rho GTPases in disease development. Gene 286:155-174.
6. Buchan AM, Lin CY, Choi J, and Barber DL (2002) Somatostatin, acting at receptor subtype 1, inhibits Rho activity, the assembly of actin stress fibers and cell migration. J Biol Chem 277:28431-28438.
7. Busca R, Bertolotto C, Abbe P, Englaro W, Ishizaki T, Narumiya S, Boquet P, Ortonne JP, and Ballotti R (1998) Inhibition of Rho is required for cAMP-induced melanoma cell differentiation. Mol Biol Cell 6:1367-1378.
8. Chen LT, Gilman AG, and Kozasa T (1999) A candidate target for G protein action in brain. J Biol Chem 274:26931-26938.
9. Dutt P, Kjoller L, Giel M, Hall A, and Toksoz D (2002) Activated Galphaq family members induce Rho GTPase activation and Rho-dependent actin filament assembly. FEBS Lett 531:565-569.
10. Dutt P, Nguyen N, and Toksoz D (2004) Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase. Cell Signal 16:201-209.
11. Ellerbroek SM, Wennerberg K, and Burridge K (2003) Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem 278:19023-19031.
12. Gudi T, Chen JC, Casteel DE, Seasholtz TM, Boss GR, and Pilz RB (2002) cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting Rho activation and functions. J Biol Chem 277:37382-37393.
13. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science (Wash DC) 279:509-514.
14. Hendry IA, Kelleher KL, Bartlett SE, Leck KJ, Reynolds AJ, Heydon K, Mellick A, Megirian D, and Matthaei KI (2000) Hypertolerance to morphine in Gz-deficient mice. Brain Res 870:10-19.
15. Hill CS, Wynne J, and Treisman R (1995) The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRP. Cell 81:1159-1170.
16. Ho MK and Wong YH (2001) G(z) signaling: emerging divergence from G(i) signaling. Oncogene 2013:1615-1625.
17. Jaffe AB, Aspenstrom P, and Hall A (2004) Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Mol Cell Biol 24:1736-1746.
18. Jalink K, van Corven EJ, Hengeveld T, Morii N, Narumiya S, and Moolenaar WH (1994) Inhibition of lysophosphatidate- and thrombin-induced neunte retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J Cell Biol 126:801-810.
19. Kjoller L and Hall A (1999) Signaling to Rho GTPases. Exp Cell Res 253:166-179.
20. Klussmann E, Tamma G, Lorenz D, Wiesner B, Maric K, Hofmann F, Aktories K, Valenti G, and Rosenthal W (2001) An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells. J Biol Chem 276:20451-20457.
21. Lang P, Gesbert F, Delespine-Carmagnat M, Stancou R, Pouchelet M, and Bertoglio J (1996) Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. EMBO (Eur Mol Biol Organ) J 15:510-519.
22. Lehmann M, Fournier A, Selles-Navarro I, Dergham P, Sebok A, Leclerc N, Tigyi G, and McKerracher L (1999) Inactivation of Rho signaling pathway promotes CNS axon regeneration. J Neurosci 19:7537-7547.
23. Li X, Saint-Cyr-Proulx E, Aktories K, and Lamarche-Vane N (2002) Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neunte outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. J Biol Chem 277:15207-15214.
24. Mao J, Yuan H, Xie W, and Wu D (1998) Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum responses factor by the G protein alpha subunit Galpha13. Proc Natl Acad Sci USA 95:12973-12976.
25. Meng J, Glick JL, Polakis P, and Casey PJ (1999) Functional interaction between Gz and Rap1GAP suggests a novel form of cellular cross-talk. J Biol Chem 274:36663-36669.
26. Miralles F, Posern G, Zaromytidou AI, and Treisman R (2003) Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113:329-342.
27. Morales J, Fishburn CS, Wilson PT, and Bourne HR (1998) Plasma membrane localization of G alpha z requires two signals. Mol Biol Cell 9:1-14.
28. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, and Kinzler KW (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (Wash DC) 275:1787-1790.
29. Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, and Tagaya M (2002) Inactivation of Galpha(z) causes disassembly of the Golgi apparatus. J Cell Sci 115:4483-4493.
30. Nobes CD and Hall A (1995) Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 81:53-62.
31. Ren XD, Kiosses WB, and Schwartz MA (1999) Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO (Eur Mol Biol Organ) J 18:578-585.
32. Ridley AJ and Hall A (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399.
33. Ross EM and Wilkie TM (2000) GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69:795-827.
34. Schmidt A and Hall A (2002) Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 16:1587-1609.
35. Seasholtz TM, Majumdar M, and Brown JH (1999) The role of Rho in G protein-coupled receptor signal transduction. Mol Pharmacol 6:949-956.
36. Simon MI, Strathmann MP, and Gautam N (1991) Diversity of G proteins in signal transduction. Science (Wash DC) 252:802-808.
37. Sotiropoulos A, Gineitis D, Copeland J, and Treisman R (1999) Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell 98:159-169.
38. Sterpetti P, Hack AA, Bashar MP, Park B, Cheng SD, Knoll JH, Urano T, Feig LA, and Toksoz D (1999) Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting. Mol Cell Biol 2:1334-1345.
39. Toksoz D and Merdek KD (2002) The Rho small GTPase: functions in health and disease. Histol Histopathol 17:915-927.
40. Wong YH, Conklin BR, and Bourne HR (1992) Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science (Wash DC) 255:339-342.
41. Woulfe D, Jiang H, Mortensen R, Yang J, and Brass LF (2002) Activation of Rap1B by G(i) family members in platelets. J Biol Chem 277:23382-23390.
42. Yang J, Wu J, Jiang H, Mortensen R, Austin S, Manning DR, Woulfe D, and Brass LF (2002) Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem 277:46035-46042.