G Protein-Coupled Receptor-Dependent Development of Human Frontal Cortex

Science

Volumn 303, Issue 5666, 2004, Pages 2033-2036

  Piao, Xianhua ^a   Hill, Sean ^a   Bodell, Adria ^a   Chang, Bernard S ^a   Basel Vanagaite, Lina ^b   Straussberg, Rachel ^c   Dobyns, William B ^d   Qasrawi, Bassam ^e   Winter, Robin M ^f   Innes, A Micheil ^g   Voit, Thomas ^h   Ross, M Elizabeth ⁱ   Michaud, Jacques L ^j   Déscarie, Jean Claude ^j   Barkovich, A James ^k   Walsh, Christopher A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b RABIN MEDICAL CENTER   (Israel)

^c SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^d UNIVERSITY OF CHICAGO   (United States)

^e Ministry of Social Affairs and Labor   (Kuwait)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF CALGARY   (Canada)

^h UNIVERSITY OF DUISBURG ESSEN   (Germany)

ⁱ Department of Molecular Biology and Genetics   (United States)

^j UNIVERSITY OF MONTREAL   (Canada)

^k UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; MUTAGENESIS; NEUROLOGY; SIGNALING;

CEREBRAL CORTEX; MUTATIONS;

PROTEINS;

G PROTEIN COUPLED RECEPTOR;

BIOLOGY;

ARTICLE; BILATERAL FRONTOPARIETAL POLYMICROGYRIA; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN MALFORMATION; CLINICAL ARTICLE; FRONTAL CORTEX; GENE; GENE LOCUS; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; GPR56 GENE; HUMAN; HUMAN TISSUE; NEUROANATOMY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTISENSE ELEMENTS (GENETICS); BODY PATTERNING; CEREBRAL CORTEX; CEREBRAL VENTRICLES; EVOLUTION; FEMALE; FRAMESHIFT MUTATION; FRONTAL LOBE; GENE ORDER; HUMANS; LIGANDS; MALE; MICE; MUTATION, MISSENSE; NEURONS; PARIETAL LOBE; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; STEM CELLS;

MAMMALIA;

EID: 12144286654     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092780     Document Type: Article

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35. We are deeply grateful to the patients and their families for their participation in this study, and to other clinical collaborators who provided information and patient samples not directly involved in this study. Supported by NIH program grant HD07466 (X.P.), National Institute of Neurological Disorders and Stroke grants K08 NS045762-01A1 (X.P.) and R37 NS35129 (C.A.W.), the March of Dimes, and the McKnight Foundation. C.A.W. is an Investigator of the Howard Hughes Medical Institute. We thank N. D. Dwyer, E. C. Olson, and the rest of the members of the Walsh lab for comments on the manuscript. This paper is dedicated to the memory of Dr. Robin Winter for his contributions to the teaching and practice of human genetics.