A protein complex containing inscuteable and the Gα-binding protein pins orients asymmetric cell divisions in Drosophila

Current Biology

Volumn 10, Issue 7, 2000, Pages 353-362

  Schaefer, Matthias ^a   Shevchenko, Anna ^b   Shevchenko, Andrej ^b   Knoblich, Juergen A ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; DROSOPHILA MELANOGASTER; INSECTA; PROSPERO;

EID: 0034611690     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00401-2     Document Type: Article

References (54)

1. Knoblich J.A., Jan L.Y., Jan Y.N. Asymmetric segregation of Numb and Prospero during cell division. Nature. 377:1995;624-627.
2. Spana E.P., Kopczynski C., Goodman C.S., Doe C.Q. Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. Development. 121:1995;3489-3494.
3. Uemura T., Shepherd S., Ackerman L., Jan L.Y., Jan Y.N. numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell. 58:1989;349-360.
4. Rhyu M.S., Jan L.Y., Jan Y.N. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell. 76:1994;477-491.
5. Hirata J., Nakagoshi H., Nabeshima Y., Matsuzaki F. Asymmetric segregation of the homeodomain protein Prospero during Drosophila development. Nature. 377:1995;627-630.
6. Spana E.P., Doe C.Q. The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development. 121:1995;3187-3195.
7. Lu B., Rothenberg M., Jan L.Y., Jan Y.N. Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors. Cell. 95:1998;225-235.
8. Li P., Yang X., Wasser M., Cai Y., Chia W. Inscuteable and Staufen mediate asymmetric localization and segregation of prospero RNA during Drosophila neuroblast cell divisions. Cell. 90:1997;437-447.
9. Broadus J., Fuerstenberg S., Doe C.Q. Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate. Nature. 391:1998;792-795.
10. Shen C.P., Jan L.Y., Jan Y.N. Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila. Cell. 90:1997;449-458.
11. Ikeshima-Kataoka H., Skeath J.B., Nabeshima Y., Doe C.Q., Matsuzaki F. Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions. Nature. 390:1997;625-629.
12. Kraut R., Campos-Ortega J.A. Inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein. Dev Biol. 174:1996;65-81.
13. Kraut R., Chia W., Jan L.Y., Jan Y.N., Knoblich J.A. Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature. 383:1996;50-55.
14. Kaltschmidt J.A., Davidson C.M., Brown N.H., Brand A.H. Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system. Nat Cell Biol. 2:2000;7-12.
15. Tio M., Zavortink M., Yang X., Chia W. A functional analysis of inscuteable and its roles during Drosophila asymmetric cell divisions. J Cell Sci. 112:1999;1541-1551.
16. Knoblich J.A., Jan L.Y., Jan Y.N. Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization. Curr Biol. 9:1999;155-158.
17. Schober M., Schaefer M., Knoblich J.A. Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature. 402:1999;548-551.
18. Wodarz A., Ramrath A., Kuchinke U., Knust E. Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature. 402:1999;544-547.
19. Kuchinke U., Grawe F., Knust E. Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka. Curr Biol. 8:1998;1357-1365.
20. Muller H.A., Wieschaus E. armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila. J Cell Biol. 134:1996;149-163.
21. Siderovski D.P., Diverse-Pierluissi M., De Vries L. The GoLoco motif. a Galphai/o binding motif and potential guanine-nucleotide exchange factor Trends Biochem Sci. 24:1999;340-341.
22. Brand A.H., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 118:1993;401-415.
23. Shevchenko A., Wilm M., Vorm O., Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem. 68:1996;850-858.
24. Schultz J., Milpetz F., Bork P., Ponting C.P. SMART, a simple modular architecture research tool. identification of signaling domains Proc Natl Acad Sci USA. 95:1998;5857-5864.
25. Sikorski R.S., Boguski M.S., Goebl M., Hieter P. A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis. Cell. 60:1990;307-317.
26. Mochizuki N., Cho G., Wen B., Insel P.A. Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with Gαi2. Gene. 181:1996;39-43.
27. Luo Y., Denker B.M. Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor. J Biol Chem. 274:1999;10685-10688.
28. Guillen A., Semeriva M., Bockaert J., Homburger V. The transduction signalling protein Go during embryonic development of Drosophila melanogaster. Cell Signal. 3:1991;341-352.
29. Wolfgang W.J., Quan F., Goldsmith P., Unson C., Spiegel A., Forte M. Immunolocalization of G protein alpha-subunits in the Drosophila CNS. J Neurosci. 10:1990;1014-1024.
30. Bhat M.A., Izaddoost S., Lu Y., Cho K.O., Choi K.W., Bellen H.J. Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell. 96:1999;833-845.
31. Tepass U. Epithelial differentiation in Drosophila. Bioessays. 19:1997;673-682.
32. Spiegel A.M. G proteins in cellular control. Curr Opin Cell Biol. 4:1992;203-211.
33. de Sousa S.M., Hoveland L.L., Yarfitz S., Hurley J.B. The Drosophila Go α-like G protein gene produces multiple transcripts and is expressed in the nervous system and in ovaries. J Biol Chem. 264:1989;18544-18551.
34. Thambi N.C., Quan F., Wolfgang W.J., Spiegel A., Forte M. Immunological and molecular characterization of Go α-like proteins in the Drosophila central nervous system. J Biol Chem. 264:1989;18552-18560.
35. Provost N.M., Somers D.E., Hurley J.B. A Drosophila melanogaster G protein α subunit gene is expressed primarily in embryos and pupae. J Biol Chem. 263:1988;12070-12076.
36. Wolfgang W.J., Quan F., Thambi N., Forte M. Restricted spatial and temporal expression of G-protein α subunits during Drosophila embryogenesis. Development. 113:1991;527-538.
37. Fremion F., Astier M., Zaffran S., Guillen A., Homburger V., Semeriva M. The heterotrimeric protein Go is required for the formation of heart epithelium in Drosophila. J Cell Biol. 145:1999;1063-1076.
38. Neer E.J. Heterotrimeric G proteins. organizers of transmembrane signals Cell. 80:1995;249-257.
39. Hamm H.E. The many faces of G protein signaling. J Biol Chem. 273:1998;669-672.
40. Broadus J., Doe C.Q. Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts. Curr Biol. 7:1997;827-835.
41. Leberer E., Thomas D.Y., Whiteway M. Pheromone signalling and polarized morphogenesis in yeast. Curr Opin Genet Dev. 7:1997;59-66.
42. Luo L., Liao Y.J., Jan L.Y., Jan Y.N. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8:1994;1787-1802.
43. Devreotes P.N., Zigmond S.H. Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium. Annu Rev Cell Biol. 4:1988;649-686.
44. Parent C.A., Devreotes P.N. Molecular genetics of signal transduction in Dictyostelium. Annu Rev Biochem. 65:1996;411-440.
45. Zwaal R.R., Ahringer J., van Luenen H.G., Rushforth A., Anderson P., Plasterk R.H. G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos. Cell. 86:1996;619-629.
46. Hyman A.A. Centrosome movement in the early divisions of Caenorhabditis elegans: a cortical site determining centrosome position. J Cell Biol. 109:1989;1185-1193.
47. Hyman A.A., White J.G. Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans. J Cell Biol. 105:1987;2123-2135.
48. Goldstein B. Cell contacts orient some cell division axes in the Caenorhabditis elegans embryo. J Cell Biol. 129:1995;1071-1080.
49. Jansen G., Thijssen K.L., Werner P., van der Horst M., Hazendonk E., Plasterk R.H. The complete family of genes encoding G proteins of Caenorhabditis elegans. Nat Genet. 21:1999;414-419.
50. Yu F., Morin X., Cai Y., Yang X., Chia W. Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell. 100:2000;399-409.
51. Wilm M., Shevchenko A., Houthaeve T., Breit S., Schweigerer L., Fotsis T.et al. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature. 379:1996;466-469.
52. Mann M., Wilm M. Error-tolerant identification of peptides in sequence databases by peptide sequence tags. Anal Chem. 66:1994;4390-4399.
53. Knoblich J.A., Jan L.Y., Jan Y.N. The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization. Proc Natl Acad Sci USA. 94:1997;13005-13010.
54. Burchard S., Paululat A., Hinz U., Renkawitz-Pohl R. The mutant not enough muscles (nem) reveals reduction of the Drosophila embryonic muscle pattern. J Cell Sci. 108:1995;1443-1454.