CD8+ T cells in autoimmunity

Current Opinion in Immunology

Volumn 17, Issue 6, 2005, Pages 624-631

  Walter, Ulrich ^a   Santamaria, Pere ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; CYTOKINE RELEASE; CYTOTOXICITY; DISEASE COURSE; DOWN REGULATION; GENE TARGETING; HUMAN; MOLECULAR RECOGNITION; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 27144498189     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.09.014     Document Type: Review

References (102)

1. P. Santamaria Effector lymphocytes in islet cell autoimmunity Rev Endocr Metab Disord 4 2003 271 280
2. C. Kurts, R.M. Sutherland, G. Davey, M. Li, A.M. Lew, E. Blanas, F.R. Carbone, J.F. Miller, and W.R. Heath CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose Proc Natl Acad Sci USA 96 1999 12703 12707
3. + T cell depends on the functional avidity of its TCR.
4. B. Han, P. Serra, A. Amrani, J. Yamanouchi, A.F. Maree, L. Edelstein-Keshet, and P. Santamaria Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide Nat Med 11 2005 645 652 This study shows that altered peptide ligands can disrupt the dominance hierarchy of high- versus low-avidity and dominant versus subdominant epitope-specific autoreactive T cells, and that therapeutic manipulation of this hierarchy has the potential to both blunt and promote disease progression.
5. Y. Shi, J.E. Evans, and K.L. Rock Molecular identification of a danger signal that alerts the immune system to dying cells Nature 425 2003 516 521
6. D.G. Millar, K.M. Garza, B. Odermatt, A.R. Elford, N. Ono, Z. Li, and P.S. Ohashi Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo Nat Med 9 2003 1469 1476
7. P. Serra, A. Amrani, J. Yamanouchi, B. Han, S. Thiessen, T. Utsugi, J. Verdaguer, and P. Santamaria CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells Immunity 19 2003 877 889
8. J. Hernandez, S. Aung, K. Marquardt, and L.A. Sherman Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens J Exp Med 196 2002 323 333
9. A.Y. Savinov, F.S. Wong, A.C. Stonebraker, and A.V. Chervonsky Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells J Exp Med 197 2003 643 656
10. P. Santamaria Kinetic evolution of a diabetogenic CD8+ T cell response Ann N Y Acad Sci 1005 2003 88 97
11. S.M. Lieberman, A.M. Evans, B. Han, T. Takaki, Y. Vinnitskaya, J.A. Caldwell, D.V. Serreze, J. Shabanowitz, D.F. Hunt, and S.G. Nathenson Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes Proc Natl Acad Sci USA 100 2003 8384 8388
12. A. Amrani, J. Verdaguer, P. Serra, S. Tafuro, R. Tan, and P. Santamaria Progression of autoimmune diabetes driven by avidity maturation of a T-cell population Nature 406 2000 739 742
13. J.D. Trudeau, C. Kelly-Smith, C.B. Verchere, J.F. Elliott, J.P. Dutz, D.T. Finegood, P. Santamaria, and R. Tan Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood J Clin Invest 111 2003 217 223
14. + T cells to the initiation of autoimmunity. In the absence of adequate peripheral regulation, however, these high-avidity clonotypes progressively accumulate in inflamed islets and kill β cells.
15. R.M. Kedl, W.A. Rees, D.A. Hildeman, B. Schaefer, T. Mitchell, J. Kappler, and P. Marrack T cells compete for access to antigen-bearing antigen-presenting cells J Exp Med 192 2000 1105 1113
16. R.M. Kedl, B.C. Schaefer, J.W. Kappler, and P. Marrack T cells down-modulate peptide-MHC complexes on APCs in vivo Nat Immunol 3 2002 27 32
17. S. Kim, K. Kim, D. Hwang, T. Lee, N. Kayagaki, H. Yagita, and M. Lee Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved J Immunol 164 2000 2931 2936
18. J. Allison, H.E. Thomas, T. Catterall, T.W. Kay, and A. Strasser Transgenic Expression of Dominant-Negative Fas-Associated Death Domain Protein in β Cells Protects against Fas Ligand-Induced Apoptosis and Reduces Spontaneous Diabetes in Nonobese Diabetic Mice J Immunol 175 2005 293 301
19. D. Kagi, B. Odermatt, P. Seiler, R. Zinkernagel, T. Mak, and H. Hengartner Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice J Exp Med 186 1997 989 997
20. H. Qin, J.D. Trudeau, G.S. Reid, I.F. Lee, J.P. Dutz, P. Santamaria, C.B. Verchere, and R. Tan Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL Int Immunol 16 2004 1657 1662
21. J. Yamanouchi, J. Verdaguer, B. Han, A. Amrani, P. Serra, and P. Santamaria Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens J Immunol 171 2003 6900 6909
22. E.E. Hamilton-Williams, S.E. Palmer, B. Charlton, and R.M. Slattery Beta cell MHC class I is a late requirement for diabetes Proc Natl Acad Sci USA 100 2003 6688 6693
23. + T cell responses.
24. V. Groh, A. Bruhl, H. El-Gabalawy, J. Nelson, and T. Spies Stimulation of T cell autoreactivity by anomalous expression of NKGD2 and its MIC ligands in rheumatoid arthritis Proc Natl Acad Sci USA 100 2003 9452 9457
25. P. Blanco, A. Palucka, M. Gill, V. Pacual, and J. Banchereau Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus Science 294 2001 1540 1543
26. E.C. Baechler, P.K. Gregersen, and T.W. Behrens The emerging role of interferon in human systemic lupus erythematosus Curr Opin Immunol 16 2004 801 807
27. P. Blanco, V. Pitard, J.F. Viallard, J.L. Taupin, J.L. Pellegrin, and J.F. Moreau Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus Arthritis Rheum 52 2005 201 211
28. R. Scott, E. McMahon, S. Pop, E. Reap, R. Caricchio, P. Cohen, H. Earp, and G. Matsushima Phagocytosis and clearance of apoptotic cells is mediated by MER Nature 411 2001 207 211
29. M.L. Santiago-Raber, R. Baccala, K.M. Haraldsson, D. Choubey, T.A. Stewart, D.H. Kono, and A.N. Theofilopoulos Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice J Exp Med 197 2003 777 788
30. E.S. Huseby, D. Liggitt, T. Brabb, B. Schnabel, C. Ohlen, and J. Goverman A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis J Exp Med 194 2001 669 676
31. H. Babbe, A. Roers, A. Waisman, H. Lassmann, N. Goebels, R. Hohlfeld, M. Friese, R. Schroder, M. Deckert, and S. Schmidt Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction J Exp Med 192 2000 393 404
32. C. Skulina, S. Schmidt, K. Dornmair, H. Babbe, A. Roers, K. Rajewsky, H. Wekerle, R. Hohlfeld, and N. Goebels Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood Proc Natl Acad Sci USA 101 2004 2428 2433
33. A. Perchellet, I. Stromnes, J.M. Pang, and J. Goverman CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft' Nat Immunol 5 2004 606 614
34. M.P. Crawford, S.X. Yan, S.B. Ortega, R.S. Mehta, R.E. Hewitt, D.A. Price, P. Stastny, D.C. Douek, R.A. Koup, and M.K. Racke High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay Blood 103 2004 4222 4231
35. A.E. Karlsen, S.G. Ronn, K. Lindberg, J. Johannesen, E.D. Galsgaard, F. Pociot, J.H. Nielsen, T. Mandrup-Poulsen, J. Nerup, and N. Billestrup Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1β and interferon-gamma -mediated toxicity Proc Natl Acad Sci USA 98 2001 12191 12196
36. H.E. Thomas, W. Irawaty, R. Darwiche, T.C. Brodnicki, P. Santamaria, J. Allison, and T.W. Kay IL-1 receptor deficiency slows progression to diabetes in the NOD mouse Diabetes 53 2004 113 121
37. M.M. Chong, Y. Chen, R. Darwiche, N.L. Dudek, W. Irawaty, P. Santamaria, J. Allison, T.W. Kay, and H.E. Thomas Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction J Immunol 172 2004 5714 5721
38. K.S. Lang, M. Recher, T. Junt, A.A. Navarini, N.L. Harris, S. Freigang, B. Odermatt, C. Conrad, L.M. Ittner, and S. Bauer Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease Nat Med 11 2005 138 145
39. P. Santamaria Effector lymphocytes in autoimmunity Curr Opin Immunol 13 2001 663 669
40. E.S. Cohen, and H.C. Bodmer Cytotoxic T lymphocytes recognize and lyse chondrocytes under inflammatory, but not non-inflammatory conditions Immunology 109 2003 8 14
41. A.K. Palucka, J.P. Blanck, L. Bennett, V. Pascual, and J. Banchereau Cross-regulation of TNF and IFN-alpha in autoimmune diseases Proc Natl Acad Sci USA 102 2005 3372 3377
42. + T-cell-derived cytokine, in the recruitment of additional immune cells to the islets of Langerhans in autoimmune diabetes.
43. A. Matejuk, J. Dwyer, A. Ito, Z. Bruender, A.A. Vandenbark, and H. Offner Effects of cytokine deficiency on chemokine expression in CNS of mice with EAE J Neurosci Res 67 2002 680 688
44. Y.M. Kang, X. Zhang, U.G. Wagner, H. Yang, R.D. Beckenbaugh, P.J. Kurtin, J.J. Goronzy, and C.M. Weyand CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis J Exp Med 195 2002 1325 1336
45. H. Jiang, R. Ware, A. Stall, L. Flaherty, L. Chess, and B. Pernis Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing V beta 8 TCR: a role of the Qa-1 molecule Immunity 2 1995 185 194
46. H. Jiang, H. Kashleva, L.X. Xu, J. Forman, L. Flaherty, B. Pernis, N.S. Braunstein, and L. Chess T cell vaccination induces T cell receptor Vβ-specific Qa-1-restricted regulatory CD8(+) T cells Proc Natl Acad Sci USA 95 1998 4533 4537
47. + T cells in vivo.
48. S. Sarantopoulos, L. Lu, and H. Cantor Qa-1 restriction of CD8+ suppressor T cells J Clin Invest 114 2004 1218 1221
49. H. Jiang, S. Curran, E. Ruiz-Vazquez, B. Liang, R. Winchester, and L. Chess Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis Proc Natl Acad Sci USA 100 2003 8378 8383
50. V. Panoutsakopoulou, K.M. Huster, N. McCarty, E. Feinberg, R. Wang, K.W. Wucherpfennig, and H. Cantor Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes J Clin Invest 113 2004 1218 1224
51. B.A. Sullivan, P. Kraj, D.A. Weber, L. Ignatowicz, and P.E. Jensen Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin Immunity 17 2002 95 105
52. + T cells maintain peripheral tolerance to self and, at the same time, promote immune responses to pathogens by selectively targeting intermediate avidity T-cell clones.
53. W.F. Lo, A.S. Woods, A. DeCloux, R.J. Cotter, E.S. Metcalf, and M.J. Soloski Molecular mimicry mediated by MHC class Ib molecules after infection with gram-negative pathogens Nat Med 6 2000 215 218
54. N. Najafian, T. Chitnis, A.D. Salama, B. Zhu, C. Benou, X. Yuan, M.R. Clarkson, M.H. Sayegh, and S.J. Khoury Regulatory functions of CD8+CD28- T cells in an autoimmune disease model J Clin Invest 112 2003 1037 1048
55. E. Davila, Y.M. Kang, Y.W. Park, H. Sawai, X. He, S. Pryshchep, J.J. Goronzy, and C.M. Weyand Cell-Based Immunotherapy with Suppressor CD8+ T Cells in Rheumatoid Arthritis J Immunol 174 2005 7292 7301
56. C.C. Chang, R. Ciubotariu, J.S. Manavalan, J. Yuan, A.I. Colovai, F. Piazza, S. Lederman, M. Colonna, R. Cortesini, and R. Dalla-Favera Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4 Nat Immunol 3 2002 237 243
57. J. Brimnes, M. Allez, I. Dotan, L. Shao, A. Nakazawa, and L. Mayer Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease J Immunol 174 2005 5814 5822
58. S.K. Seo, J.H. Choi, Y.H. Kim, W.J. Kang, H.Y. Park, J.H. Suh, B.K. Choi, D.S. Vinay, and B.S. Kwon 4-1BB-mediated immunotherapy of rheumatoid arthritis Nat Med 10 2004 1088 1094
59. L. Myers, C. Takahashi, R.S. Mittler, R.J. Rossi, and A.T. Vella Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering Proc Natl Acad Sci USA 100 2003 5348 5353
60. S.W. Lee, A.T. Vella, B.S. Kwon, and M. Croft Enhanced CD4 T Cell Responsiveness in the Absence of 4-1BB J Immunol 174 2005 6803 6808
61. K.J. McElwee, P. Freyschmidt-Paul, R. Hoffmann, S. Kissling, S. Hummel, M. Vitacolonna, and M. Zoller Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model J Invest Dermatol 124 2005 947 957
62. K.J. McElwee, E.M. Spiers, and R.F. Oliver In vivo depletion of CD8+ T cells restores hair growth in the DEBR model for alopecia areata Br J Dermatol 135 1996 211 217
63. A.M. Risitano, J.P. Maciejewski, S. Green, M. Plasilova, W. Zeng, and N. Young In vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing Lancet 364 2004 355 364
64. Y. Ichiki, C.A. Aoki, C.L. Bowlus, S. Shimoda, H. Ishibashi, and M.E. Gershwin T cell immunity in autoimmune hepatitis Autoimmun Rev 4 2005 315 321
65. M. Afanasyeva, D. Georgakopoulos, and N.R. Rose Autoimmune myocarditis: cellular mediators of cardiac dysfunction Autoimmun Rev 3 2004 476 486
66. N. Grabie, M.W. Delfs, J.R. Westrich, V.A. Love, G. Stavrakis, F. Ahmad, C.E. Seidman, J.G. Seidman, and A.H. Lichtman IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis J Clin Invest 111 2003 671 680
67. J.M. Penninger, N. Neu, E. Timms, V.A. Wallace, D.R. Koh, K. Kishihara, C. Pummerer, and T.W. Mak The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules J Exp Med 178 1993 1837 1842
68. Y. Tada, A. Ho, D.R. Koh, and T.W. Mak Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis J Immunol 156 1996 4520 4526
69. J. Reynolds, V.A. Norgan, U. Bhambra, J. Smith, H.T. Cook, and C.D. Pusey Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis J Am Soc Nephrol 13 2002 359 369
70. G.X. Zhang, B.G. Xiao, M. Bakhiet, P. van der Meide, H. Wigzell, H. Link, and T. Olsson Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis J Exp Med 184 1996 349 356
71. G.X. Zhang, C.G. Ma, B.G. Xiao, M. Bakhiet, H. Link, and T. Olsson Depletion of CD8+ T cells suppresses the development of experimental autoimmune myasthenia gravis in Lewis rats Eur J Immunol 25 1995 1191 1198
72. K. Strigard, T. Olsson, P. Larsson, R. Holmdahl, and L. Klareskog Modulation of experimental allergic neuritis in rats by in vivo treatment with monoclonal anti T cell antibodies J Neurol Sci 83 1988 283 291
73. A. Mukasa, C. Hiramine, and K. Hojo Generation and characterization of a continuous line of CD8+ suppressively regulatory T lymphocytes which down-regulates experimental autoimmune orchitis (EAO) in mice Clin Exp Immunol 96 1994 138 145
74. A. Mukasa, M. Itoh, Y. Tokunaga, C. Hiramine, and K. Hojo Inhibition of a novel model of murine experimental autoimmune orchitis by intravenous administration with a soluble testicular antigen: participation of CD8+ regulatory T cells Clin Immunol Immunopathol 62 1992 210 219
75. Y. Mizukawa, Y. Yamazaki, Y. Teraki, J. Hayakawa, K. Hayakawa, H. Nuriya, M. Kohara, and T. Shiohara Direct evidence for interferon-gamma production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption Am J Pathol 161 2002 1337 1347
76. Y. Teraki, and T. Shiohara IFN-gamma-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption J Allergy Clin Immunol 112 2003 609 615
77. K. Chen, Y. Wei, G.C. Sharp, and H. Braley-Mullen Mechanisms of spontaneous resolution versus fibrosis in granulomatous experimental autoimmune thyroiditis J Immunol 171 2003 6236 6243
78. K. Uchimura, M. Itoh, K. Yamamoto, S. Imamura, M. Makino, T. Kato, K. Fujiwara, and Y. Sawai The effects of CD40- and interleukin (IL-4)-activated CD23+ cells on the production of IL-10 by mononuclear cells in Graves' disease: the role of CD8+ cells Clin Exp Immunol 128 2002 308 312
79. B. Grubeck-Loebenstein, K. Trieb, A. Sztankay, W. Holter, H. Anderl, and G. Wick Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts J Clin Invest 93 1994 2738 2743
80. M. Watanabe, N. Yamamoto, H. Maruoka, H. Tamai, F. Matsuzuka, A. Miyauchi, and Y. Iwatani Independent involvement of CD8+ CD25+ cells and thyroid autoantibodies in disease severity of Hashimoto's disease Thyroid 12 2002 801 808
81. S. Sugihara, H. Fujiwara, H. Niimi, and G.M. Shearer Self-thyroid epithelial cell (TEC)-reactive CD8+ T cell lines/clones derived from autoimmune thyroiditis lesions. They recognize self-thyroid antigens directly on TEC to exhibit T helper cell 1-type lymphokine production and cytotoxicity against TEC J Immunol 155 1995 1619 1628
82. M.J. Penny, R.A. Boyd, and B.M. Hall Permanent CD8(+) T cell depletion prevents proteinuria in active Heymann nephritis J Exp Med 188 1998 1775 1784
83. S.T. Spicer, H. Ha, R.A. Boyd, X.Y. He, N. Carter, G. Tran, M.J. Penny, S.J. Hodgkinson, and B.M. Hall IL-4 therapy prevents the development of proteinuria in active Heymann nephritis by inhibition of Tc1 cells J Immunol 167 2001 3725 3733
84. V. Vezys, S. Olson, and L. Lefrancois Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction Immunity 12 2000 505 514
85. U. Steinhoff, V. Brinkmann, U. Klemm, P. Aichele, P. Seiler, U. Brandt, P.W. Bland, I. Prinz, U. Zugel, and S.H. Kaufmann Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells Immunity 11 1999 349 358
86. A. Cornet, T.C. Savidge, J. Cabarrocas, W.L. Deng, J.F. Colombel, H. Lassmann, P. Desreumaux, and R.S. Liblau Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease? Proc Natl Acad Sci USA 98 2001 13306 13311
87. M.C. Dalakas, and R. Hohlfeld Polymyositis and dermatomyositis Lancet 362 2003 971 982
88. M. Hofbauer, S. Wiesener, H. Babbe, A. Roers, H. Wekerle, K. Dornmair, R. Hohlfeld, and N. Goebels Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis Proc Natl Acad Sci USA 100 2003 4090 4095
89. H. Kita, M. Imawari, and M.E. Gershwin Cellular immune response in primary biliary cirrhosis Hepatol Res 28 2004 12 17
90. H. Kita, Z.X. Lian, J. Van de Water, X.S. He, S. Matsumura, M. Kaplan, V. Luketic, R.L. Coppel, A.A. Ansari, and M.E. Gershwin Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells J Exp Med 195 2002 113 123
91. A. Gutenberg, R. Buslei, R. Fahlbusch, M. Buchfelder, and W. Bruck Immunopathology of primary hypophysitis: implications for pathogenesis Am J Surg Pathol 29 2005 329 338
92. J. de Jersey, D. Carmignac, T. Barthlott, I. Robinson, and B. Stockinger Activation of CD8 T cells by antigen expressed in the pituitary gland J Immunol 169 2002 6753 6759
93. J.E. Gudjonsson, A. Johnston, H. Sigmundsdottir, and H. Valdimarsson Immunopathogenic mechanisms in psoriasis Clin Exp Immunol 135 2004 1 8
94. T. Fujihara, H. Fujita, K. Tsubota, K. Saito, K. Tsuzaka, T. Abe, and T. Takeuchi Preferential localization of CD8+ alpha E beta 7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogren's syndrome J Immunol 163 1999 2226 2235
95. L. Kong, N. Ogawa, T. Nakabayashi, G.T. Liu, E. D'Souza, H.S. McGuff, D. Guerrero, N. Talal, and H. Dang Fas and Fas ligand expression in the salivary glands of patients with primary Sjogren's syndrome Arthritis Rheum 40 1997 87 97
96. E. Hermann, D.T. Yu, K.H. Meyer zum Buschenfelde, and B. Fleischer HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis Lancet 342 1993 646 650
97. M.A. Trevino, E. Teixeiro, and R. Bragado CD8+ T cells oligoclonally expanded in synovial fluid at onset of spondyloarthropathy selectively proliferate in response to self-antigens: characterization of cell specificities in nonclonal populations J Rheumatol 31 2004 1962 1972
98. E.S. Cohen, and H.C. Bodmer Cytotoxic T lymphocytes recognize and lyse chondrocytes under inflammatory, but not non-inflammatory conditions Immunology 109 2003 8 14
99. E. Mozes, L.D. Kohn, F. Hakim, and D.S. Singer Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus Science 261 1993 91 93
100. J. Steitz, J. Wenzel, E. Gaffal, and T. Tuting Initiation and regulation of CD8+T cells recognizing melanocytic antigens in the epidermis: implications for the pathophysiology of vitiligo Eur J Cell Biol 83 2004 797 803
101. B. Palermo, R. Campanelli, S. Garbelli, S. Mantovani, E. Lantelme, V. Brazzelli, M. Ardigo, G. Borroni, M. Martinetti, and C. Badulli Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo J Invest Dermatol 117 2001 326 332
102. S. Sugita, K. Sagawa, M. Mochizuki, S. Shichijo, and K. Itoh Melanocyte lysis by cytotoxic T lymphocytes recognizing the MART-1 melanoma antigen in HLA-A2 patients with Vogt-Koyanagi-Harada disease Int Immunol 8 1996 799 803