Uncoupling of proliferative potential and gain of effector function by CD8+ T cells responding to self-antigens

Journal of Experimental Medicine

Volumn 196, Issue 3, 2002, Pages 323-333

  Hernández, Javier ^a   Aung, Sandra ^a   Marquardt, Kristi ^a   Sherman, Linda A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

B7; CD40; Cytotoxic T lympbocytes; Peripheral tolerance; T cell activation

Indexed keywords

CD40 ANTIGEN; CD8 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; EFFECTOR CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; INFLAMMATION; LYMPH NODE; LYMPHOCYTE ACTIVATION; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD40; ANTIGENS, CD80; AUTOANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; RECEPTORS, ANTIGEN, T-CELL;

EID: 0037025944     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011612     Document Type: Article

References (54)

1. T lymphocyte tolerance: From thymic deletion to peripheral control mechanisms
2. Cross-presentation, dendritic cells, tolerance and immunity
3. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
4. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
5. Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo
6. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay
7. Cross-tolerance: A pathway for inducing tolerance to peripheral tissue antigens
8. Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells
9. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
10. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis
11. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production
12. Mobilizing dendritic cells for tolerance, printing, and chronic inflammation
13. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
14. The induction of tolerance by dendritic cells that have captured apoptotic cells
15. + helper cell and T-killer cell
16. Help for cytotoxic T-cell responses is mediated by CD40 signalling
17. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
18. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
19. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
20. CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes
21. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
22. Role of antigen-presenting cells in mediating tolerance and autoimmunity
23. + T cell- and IL-2-dependent mechanism
24. + T cells
25. Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity
26. + T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas
27. + cell-mediated spontaneous diabetes in neonatal mice
28. Ontogeny of T cell tolerance to peripherally-expressed antigens
29. + T cell tolerance to peripherally expressed antigens
30. + T cells undergoing peripheral deletion in response to cross-presentation of self-antigen
31. Antigen-presenting cell in adoptively transferred and spontaneous autoimmune diabetes
32. A fail-safe mechanism for maintaining self-tolerance
33. + cells after a transient response to antigen
34. + T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity
35. lo thymocytes in vivo
36. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
37. CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40
38. - dendritic cells cross-prime cytotoxic T cells in vivo
39. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
40. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice
41. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
42. CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose
43. + T cells
44. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial printing signal
45. + T cells in the absence of tumor-antigen vaccination
46. IL-12 acts directly on DC to promote nuclear localization of NF-κB and primes DC for IL-12 production
47. + T cells
48. + T cells in vivo
49. Recombinant IL-12 administration induces tumor regression in association with IFN-γ production
50. Differentiation of naive CTL to effector and memory CTL: Correlation of effector function with phenotype and cell division
51. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: Effector function is linked to proliferative capacity
52. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
53. + T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells
54. + T-cell responses