T cells compete for access to antigen-bearing antigen-presenting cells

Journal of Experimental Medicine

Volumn 192, Issue 8, 2000, Pages 1105-1113

  Kedl, Ross M ^a   Rees, William A ^a   Hildeman, David A ^b   Schaefer, Brian ^b   Mitchell, Tom ^a   Kappler, John ^a,b,c   Marrack, Philippa ^a,b,c  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Antigen presenting cell; Competition; Dendritic cell; T cell; Tetramer

Indexed keywords

CD8 ANTIGEN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ANTIGENICITY; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TRANSGENE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN-PRESENTING CELLS; CD8-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELLS, CULTURED; DENDRITIC CELLS; EPITOPES; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, TRANSGENIC; OVALBUMIN; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0034675848     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.8.1105     Document Type: Article

References (35)

1. Untersuchungen uber Eiweissprazipitine
2. Weitere Untersuchungen uber Eiweissprazipitine
3. Antigenic competition
4. Specialization, tolerance, memory, competition, latency, and strife among T cells
5. Clonal selection and learning in the antibody system
6. Signaling thresholds and interclonal competition in preimmune B-cell selection
7. Dissecting the multifactoriai causes of immunodominance in class I-restricted T cell responses to viruses
8. Lowering the tone: Mechanisms of immunodominance among epitopes with low affinity for MHC
9. MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL
10. Immunodominance in the CTL response against minor histocompatibility antigens: Interference between responding T cells, rather than with presentation of epitopes
11. T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens
12. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues
13. T cell affinity maturation by selective expansion during infection
14. A kinetic basis for T cell receptor repertoire selection during an immune response
15. + T cell responses in vivo and in vitro
16. Progress in understanding the mechanism and consequences of somatic hypermutation
17. T cell receptor antagonist peptides induce positive selection
18. Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant
19. Soluble class I MHC with β2-microglobulin covalently linked peptides: Specific binding to a T cell hybridoma
20. Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone
21. Bystander virus infection prolongs activated T cell survival
22. Antigen processing in vivo and the elicitation of primary CTL responses
23. In vivo priming of two distinct antitumor effector populations: The role of MHC class I expression
24. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody
25. + T cells
26. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
27. T cell memory. Long-term persistence of virus-specific cytotoxic T cells
28. The response to H-2-different virus-infected cells is mediated by long-lived T lymphocytes and is diminished by prior virus priming in a syngeneic environment
29. Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands
30. T-cell-receptor affinity and thymocyte positive selection
31. Antigenspecific development of primary and memory T cells in vivo
32. TCR-mediated internalization of peptide-MHC complexes acquired by T cells
33. Antigen-specific suppressor factor: Missing pieces in the puzzle
34. Revisiting and revising suppressor T cells
35. Infectious tolerance