Qa-1 restriction of CD8+ suppressor T cells

Journal of Clinical Investigation

Volumn 114, Issue 9, 2004, Pages 1218-1221

  Sarantopoulos, Stefanie ^a,b   Lu, Linrong ^a,c   Cantor, Harvey ^a,c  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HLA E ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN; QA 1 ANTIGEN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; HLA ANTIGEN; HLA ANTIGEN CLASS 1; HLA-E ANTIGEN; INTERLEUKIN 2 RECEPTOR; PEPTIDE; Q SURFACE ANTIGENS;

ALLERGIC ENCEPHALOMYELITIS; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; CYTOTOXIC T LYMPHOCYTE; DISEASE EXACERBATION; IMMUNOLOGICAL TOLERANCE; MOUSE; MULTIPLE SCLEROSIS; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECURRENT DISEASE; REVIEW; SUPPRESSOR CELL; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHEMISTRY; HUMAN; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

ANIMALS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; IMMUNE TOLERANCE; MICE; MODELS, BIOLOGICAL; PEPTIDES; RECEPTORS, INTERLEUKIN-2;

EID: 85047690562     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI23152     Document Type: Review

References (55)

1. Cantor, H. 2000. T-cell receptor crossreactivity and autoimmune disease. Adv. Immunol. 75:209-233.
2. Goldrath, A.W., and Bevan, M.J. 1999. Selecting and maintaining a diverse T-cell repertoire. Nature. 402:255-262.
3. Bouneaud, C., Kourilsky, P., and Bousso, P. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity. 13:829-840.
4. Slifka, M.K., et al. 2003. Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy. J. Immunol. 170:1231-1239.
5. Kearney, E.R., Pape, K.A., Loh, D.Y., and Jenkins, M.K. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1:327-339.
6. Martin, D.A., et al. 1999. Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type 1a. Proc. Natl. Acad. Sci. U. S. A. 96:4552-4557.
7. Anderton, S.M., Radu, C.G., Lowrey, P.A., Ward, E.S., and Wraith, D.C. 2001. Negative selection during the peripheral immune response to antigen. J. Exp. Med. 193:1-11.
8. Panoutsakopoulou, V., et al. 2001. Analysis of the relationship between viral infection and autoimmune disease. Immunity. 15:137-147.
9. Wood, K.J., and Sakaguchi, S. 2003. Regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 3:199-210.
10. Shevach, E.M. 2002. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389-400.
11. Sakaguchi, S., et al. 2001. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18-32.
12. Apostolou, I., Sarukhan, A., Klein, L., and von Boehmer, H. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756-763.
13. Gavin, M., and Rudensky, A. 2003. Control of immune homeostasis by naturally arising regulatory CD4(+) T cells. Curr. Opin. Immunol 15:690-696.
14. Ben-Nun, A., Wekerle, H., and Cohen, I.R. 1981. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature. 292:60-61.
15. Cohen, I.R., and Weiner, H.L. 1988. T cell vaccination. Immunol Today. 9:332-335.
16. Jiang, H., et al. 1998. T cell vaccination induces TCR Vβ specific, Qa-1 restricted regulatory CD8+ T cells. Proc. Natl. Acad. Sci. U. S. A. 95:4533-4537.
17. Jiang, H., Braunstein, N.S., Yu, B., Winchester, R., and Chess, L. 2001. CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. Proc. Natl. Acad. Sci. U. S. A. 98:6301-6306.
18. Panoutsakopoulou, V., et al. 2004. Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. J. Clin. Invest. 113:1218-1224. doi: 10.1172/JCI200420772.
19. Noble, A., Zhao, Z.-S., and Cantor, H. 1998. Suppression of immune responses by CD8 cells: II. Qa-1 on activated B-cells stimulates CD8 cell suppression of Th2-dependent antibody responses. J. Immunol. 160:566-571.
20. Jiang, H., and Chess, L. 2000. The specific regulation of immune responses by CD8+ T cells restricted by the MHC class Ib molecule, Qa-1. Annu. Rev. Immunol. 18:185-216.
21. Cantor, H., et al. 1978. Immunoregulatory circuits among T cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition. J. Exp. Med. 148:871-877.
22. Stanton, T.H., and Boyse, E.A. 1976. A new serologically defined locus, Qa-1, in the Tla-region of the mouse. Immunogenetics. 3:525-531.
23. Lalanne, J.L., et al. 1985. Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver. Cell. 41:469-478.
24. Connolly, D.J., et al. 1993. A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site. J. Immunol. 151:6089-6098.
25. Aldrich, C.J., et al. 1992. T cell recognition of QA-1b antigens on cells lacking a functional Tap-2 transporter. J. Immunol. 149:3773-3777.
26. Lo, W.F., Ong, H., Metcalf, E.S., and Soloski, M.J. 1999. T cell responses to gram-negative intracellular bacterial pathogens: a role for CD8+ T cells in immunity to Salmonella infection and the involvement of MHC class Ib molecules. J. Immunol. 162:5398-5406.
27. Lo, W.F., et al. 2000. Molecular mimicry mediated by MHC class 1b molecules after infection with gram-negative pathogens. Nat. Med. 6:215-218.
28. Sullivan, B.A., Kraj, P., Weber, D.A., Ignatowicz, L., and Jensen, P.E. 2002. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity. 17:95-105.
29. Transy, C., et al. 1987. A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types. J. Exp. Med. 166:341-361.
30. Soloski, M.J., DeCloux, A., Aldrich, C.J., and Forman, J. 1995. Structural and functional characteristics of the class IB molecule, Qa-1. Immunol. Ref. 147:67-89.
31. Moser, J.M., Gibbs, J., Jensen, P.E., and Lukacher, A.E. 2002. CD94-NKG2A receptors regulate antiviral CD8(+) T cell responses. Nat. Immunol. 3:189-195.
32. Davies, A., et al. 2003. A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class Ia leader sequence peptide Qdm. J. Immunol. 170:5027-5033.
33. Tompkins, S.M., Kraft, J.R., Dao, C.T., Soloski, M.J., and Jensen, P.E. 1998. Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class 1b gene product, Qa-1(b). J. Exp. Med. 188:961-971.
34. Seaman, M.S., Perarnau, B., Lindahl, K.F., Lemonnier, F.A., and Forman, J. 1999. Response to Listeria monocytogenes in mice lacking MHC class Ia molecules. J. Immunol. 162:5429-5436.
35. Jiang, H., et al. 2003. Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. U. S. A. 100:8378-8383.
36. Jiang, H., Zhang, S.-L., and Pernis, B. 1992. Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science. 256:1213-1215.
37. Koh, D.R., et al. 1992. Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science. 256:1210-1213.
38. Hu, D., et al. 2004. Analysis of regulatory CD8 cells in mice deficient in the Qa-1 class Ib molecule. Nat. Immunol. 5:516-523.
39. Jiang, H., and Chess, L. 2004. An integrated model of immunoregulation mediated by regulatory T cell subsets. Adv. Immunol. 83:253-288.
40. Valitutti, S., Muller, S., Salio, M., and Lanzavecchia, A. 1997. Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation. J. Exp. Med. 185:1859-1864.
41. Liu, H., Rhodes, M., Wiest, D.L., and Vignali, D.A. 2000. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity. 13:665-675.
42. Urdahl, K.B., Sun, J.C., and Bevan, M.J. 2002. Positive selection of MHC class Ib-rescricted CD8(+) T cells on hematopoietic cells. Nat. Immunol. 3:772-779.
43. Speiser, D.E., et al. 1999. CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients. Eur. J. Immunol. 29:1990-1999.
44. Mingari, M.C., et al. 1998. HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activaced CD8+ T cells. Proc. Natl. Acad. Sci. U. S. A. 95:1172-1177.
45. Bertone, S., et al. 1999. Transforming growth factor-beta-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes. Eur. J. Immunol. 29:23-29.
46. Lohwasser, S., Kubota, A., Salcedo, M., Lian, R.H., and Takei, F. 2001. The non-classical MHC class I molecule Qa-1(b) inhibits classical MHC class 1-restricted cytotoxicity of cytotoxic T lymphocytes. Int. Immunol. 13:321-327.
47. Jia, S.H., Kurepa, Z., Bai, A., and Forman, J. 2000. Comparative ability of Qdm/Qa-1b, kb, and Db to protect class Ilow cells from NK-mediated lysis in vivo. J. Immunol. 165:6142-6147.
48. Anderton, S.M., van der, Z.R., Noordzij, A., and van Eden, W. 1994. Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols. J. Immunol. 152:3656-3664.
49. van Roon, J.A., van Eden, W., van Roy, J.L., Lafeber, F.J., and Bijlsma, J.W. 1997. Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis. J. Clin. Invest. 100:459-463.
50. Quintana, F.J., Carmi, P., Mor, F., and Cohen, I.R. 2002. Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J. Immunol. 169:3422-3428.
51. Quintana, F.J., Carmi, P., and Cohen, I.R. 2002. DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes. J. Immunol. 169:6030-6035.
52. Rees, M.A., Rosenberg, A.S., Munitz, T.I., and Singer, A. 1990. In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help. Proc. Natl. Acad. Sci. U. S. A. 87:2765-2769.
53. Huston, D.P., Tavana, G., Rich, R.R., and Gressens, S. E. 1986. Regulation of primary cytotoxic T lymphocyte responses generated during mixed leukocyte culture with H-2d identical Qa-1-disparate cells. J. Immunol. 137:1776-1781.
54. Huston, D.P., and Tavana, G. 1987. Suppression of 1a-unrestricted primary anti-Qa-1 cytotoxic T lymphocyte responses by class II major histocompatibility complex-restricted cellular interactions. J. Immunol. 138:2753-2759.
55. Douillard, P., et al. 1999. Reassessment of the role of CD8+ T cells in the induction of allograft tolerance by donor-specific blood transfusion. Eur. J. Immunol. 29:1919-1924.