The antiapoptotic effect of guanosine is mediated by the activation of the PI 3-kinase/AKT/PKB pathway in cultured rat astrocytes

GLIA

Volumn 46, Issue 4, 2004, Pages 356-368

  Di Iorio, Patrizia ^a   Ballerini, Patrizia ^a   Traversa, Ugo ^b   Nicoletti, Ferdinando ^c   D'Alimonte, Iolanda ^a   Kleywegt, Sonya ^a,d   Werstiuk, Eva S ^d   Rathbone, Michel P ^d   Caciagli, Francesco ^a   Ciccarelli, Renata ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d MCMASTER UNIVERSITY   (Canada)

Author keywords

AKT PKB; Antiapoptosis; Astrocytes; Cell survival; Guanosine; PI 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; CASPASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIC FACTOR; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROPENTOFYLLINE; PROTEIN BCL 2; PROTEIN KINASE B; PURINERGIC RECEPTOR BLOCKING AGENT; STAUROSPORINE; SURAMIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL DEATH; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IC 50; NERVE CELL CULTURE; NEWBORN; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; CASPASE 3; CASPASES; CELLS, CULTURED; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; GUANOSINE; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECEPTORS, PURINERGIC; RECEPTORS, PURINERGIC P1; RNA, MESSENGER; UP-REGULATION;

EID: 2542442420     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.20002     Document Type: Article

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