Modulation of apoptosis by adenosine in the central nervous system: A possible role for the A3 receptor. Pathophysiological significance and therapeutic implications for neurodegenerative disorders

Annals of the New York Academy of Sciences

Volumn 825, Issue , 1997, Pages 11-22

  Abbracchio, Maria P ^a   Ceruti, Stefania ^a   Brambilla, Roberta ^a   Franceschi, Claudio ^b,c   Malorni, Walter ^d   Jacobson, Kenneth A ^e   Von Lubitz, Dag K J E ^e   Cattabeni, Flaminio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Institute of General Pathology   (Italy)

^c INRCA   (Italy)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ASTROCYTE; BRAIN ISCHEMIA; CELL DEATH; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DEGENERATIVE DISEASE; ETIOLOGY; HUMAN; HUMAN CELL; NEUROTRANSMISSION; NONHUMAN; PATHOPHYSIOLOGY; RAT;

ANIMALIA;

EID: 0030708513     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48410.x     Document Type: Conference Paper

References (52)

1. RUDOLPHI, K. & P. SCHUBERT. 1996. Purinergic interventions in traumatic and ischemic injury. In Novel Therapies for CNS Injuries. Rationales and Results. P. L. Peterson & J. W. Phillis, Eds. 327-344. CRC Press. Boca Raton, FL.
2. FREDHOLM, B. B., M. P. ABBRACCHIO, G. BURNSTOCK, J. W. DALY, T. K. HARDEN, K. A. JACOBSON, P. LEFF & M. WILLIAMS. 1994. Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46: 143-156.
3. VAN RHEE, A. M. & K. A. JACOBSON. 1996. Molecular architecture of G protein-coupled receptors. Drug Dev. Res. 37: 1-38.
4. NICOLL, R. A. 1988. The coupling of neurotransmitter receptors to ion channels in the brain. Science 241: 545-551.
5. 1 receptors in rat brain synaptosomes: transductional mechanisms, effects on glutamate release, and preservation after metabolic inhibition. Drug Dev. Res. 35: 119-129.
6. ABBRACCHIO, M. P., A. M. PAOLETTI, A. LUINI, F. CATTABENI & M. A. DE MATTEIS. 1992. Adenosine receptors in rat basophilic leukaemia cells: transductional mechanisms and effects on 5-hydroxytriptamine release. Br. J. Pharmacol. 105: 405-411.
7. 3H]acetylcholine release from rat hippocampus. J. Neurochem. 63: 207-214.
8. 2B receptors mediate an increase in IL-6 mRNA and IL-6 protein synthesis in human astroglioma cells. Drug Dev. Res. 37(3): 174.
9. 3 adenosine receptors: design of selective ligands and therapeutic prospects. Drugs Future 20: 689-699.
10. 3 receptors: pharmacological properties, species-differences and receptor functions. Trends Pharmacol. Sci. 15: 298-306.
11. 3 receptors in rat brain. Mol. Pharmacol. 48: 1038-1045.
12. 3-adenosine receptors. Drug Dev. Res. 33: 51-59.
13. 6-p-sulfophenylalkyl- derivatives of adenosine: water soluble and peripherally selective adenosine agonists. J. Med. Chem. 35: 4143-4149.
14. 3-selective adenosine agonists. J. Med. Chem. 37: 636-646.
15. 3-adenosine receptors. Mediation of behavioral depressant effects. FEBS Lett. 336: 57-60.
16. PHILLIS, J. W. & P. H. WU. 1981. The role of adenosine and its nucleotides in central synaptic transmission. Prog. Neurobiol. 16: 187-193.
17. VON LUBITZ, D. K. J. E., M. F. CARTER, M. BEENHAKKER, R. C.-S. LIN & K. A. JACOBSON. 1995. Adenosine: a prototherapeutic concept in neurodegeneration. Ann. N. Y. Acad. Sci. 765: 163-178.
18. Choi, D. W. 1991. Methods for antagonizing glutamate neurotoxicity. Cerebrovasc. Brain Metab. Rev. 2: 105-121.
19. 3 receptor stimulation and cerebral ischemia. Eur. J. Pharmacol. 163: 59-67.
20. 3 receptor stimulation on seizures in mice. Eur. J. Pharmacol. 275: 23-29.
21. ABBRACCHIO, M. P., S. CERUTI, G. BURNSTOCK & F. CATTABENI. 1995. Purinoceptors on glial cells of the central nervous system: functional and pathological implications. In Adenosine and Adenine Nucleotides: from Molecular Biology to Integrative Physiology. L. Belardinelli & A. Pelleg, Eds. 271-280. Kluwer Academic Publishers. Boston.
22. NEARY, J. T., M. P. RATHBONE, F. CATTABENI M. P. ABBRACCHIO & G. BURNSTOCK. 1996. Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci. 19: 13-18.
23. WEINSTEIN, D. E., M. L. SHELANSKI & R. LIEM. 1991. Suppression by antisense mRNA demonstrates a requirement for the glial fibrillary acid protein in the formation of stable astrocytic processes in response to neurons. J. Cell. Biol. 112: 1205-1213.
24. ABBRACCHIO, M. P., M. J. SAFFREY, V. HOPKER & G. BURNSTOCK. 1994. Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum. Neurosci. 59: 67-76.
25. COLOMBEL, M., C. A. OLSSON, P.-Y. NG & R. BUTTYAN. 1992. Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle. Cancer Res. 52: 4313-4319.
26. BUTTYAN, R., Z. ZAKERI, R. LOCKSHIN & D. WOLGEMUTH. 1988. Cascade induction of c-fos, c-myc and heat shock 70K transcripts during regression of the rat ventral prostate gland. Mol. Endocrinol. 2: 650-657.
27. THOMPSON, N. L., J. E. MEADE, L. BRAUN, M. BOYETTER, P. R. SHANK & N. FAUSTO. 1986. Sequential protooncogene expression during rat liver regeneration. Cancer Res. 46: 3111-3117.
28. GRASSILLI, E., A. CARCERERI DE PRATI, D. MONTI, L. TROIANO, M. MENEGAZZI, D. BARBIERI, C. FRANCESCHI & H. SUZUKI. 1992. Studies of the relationship between cell proliferation and cell death. II. Early gene expression during concanavalin A-induced proliferation or dexamethasone-induced apoptosis of rat thymocytes. Biochem. Biophys. Res. Commun. 188: 1261-1266.
29. PANDEY, S. & E. WANG. 1995. Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse. J. Cell. Biochem. 58: 135-150.
30. CARSON, D. A. & J. M. RIBEIRO. 1993. Apoptosis and disease. Lancet 341: 1251-1254.
31. ABBRACCHIO, M. P., S. CERUTI, D. BARBIERI, C. FRANCESCHI, M. MALORNI, L. BIONDO, G. BURNSTOCK & F. CATTABENI. 1995. A novel action for adenosine: apoptosis of astroglial cells in rat brain primary cultures. Biochem. Biophys. Res. Commun. 213: 908-915.
32. 3-adenosine receptors. J. Med. Chem. 37: 3614-3621.
33. 3 receptor agonists on astrocytes: induction of cell protection at low and cell death at high concentrations. Drug Dev. Res. 37(3): 177.
34. MALORNI, W., G. RAINALDI, R. RIVABENE & M. T. SANTINI. 1994. Different susceptibilities to cell death induced by t-butylhydroperoxide could depend upon cell histotype-associated growth features. Cell. Biol. Toxicol. 10: 207-218.
35. KITAGAWA, K., M. MATSUMOTO, M. TAGAYA, R. HATA, H. UEDA, M. NIINOBE, N. HANDA, R. FUKUNAGA, K. KIMURA, K. MIKOSHIBA & T. KAMADA. 1990. "Ischemic tolerance" phenomenon found in the brain. Brain Res. 528: 21-24.
36. HENTOSH, P. & P. GRIPPO. 1994. Template 2-chloro-2′-deoxyadenosine monophosphate inhibits in vitro DNA synthesis. Mol. Pharmacol. 45: 955-961.
37. CARSON, D. A., B. WASSON, R. TAETLE & A. YU. 1983. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. Blood 62: 737-743.
38. GRIFFAG, J., R. KOOB & R. L. BLAKLEY. 1989. Mechanisms of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells. Cancer Res. 49: 6923-6928.
39. CARRERA, C. J., C. TERAI, M. LOTZ, J. G. CURD, L. D. PIRO, E. BEUTLER & D. A. CARSON. 1990. Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. J. Clin. Invest. 86: 1480-1488.
40. GAO, X., T. B. KNUDSEN, M. M. IBRAHIM & S. HALDAR. 1995. Bcl-2 relieves deoxyadenylate stress and suppresses apoptosis in pre-B leukemia cells. Death Differentiation 2: 69-78.
41. WAKADE, T. D., K. C. PALMER, R. MCCAULEY, D. A. PRZYWARA & A. R. WAKADE. 1995. Adenosine-induced apoptosis in chick embryonic sympathetic neurons: a new physiological role for adenosine. J. Physiol. 488: 123-138.
42. 2+-mediated mechanisms. Biochem. J. 364: 877-885.
43. SZONDY, Z. 1995. The 2-chlorodeoxyadenosine-induced cell death signalling pathway in human thymocytes is different from that induced by 2-chloroadenosine. Biochem. J. 311: 585-588.
44. 3 receptor agonists. Biochem. Biophys. Res. Commun. 219: 904-910.
45. GIBLETT, E. T., J. R. ANDERSON, F. COHEN, B. POLLARA & H. J. MEUWISSEN. 1972. Adenosine deaminase deficiency in two patients with severely impaired cellular immunity. Lancet 2: 1067-1069.
46. COHEN, A., R. HIRSCHHORN, S. D. HOROWITZ, A. RUBINSTEIN, S. H. PALMAR, R. HONG & D. W. MARTIN, JR. 1978. Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency. Proc. Natl. Acad. Sci. USA 75: 472-476.
47. OPPENHEIM, R. W. 1991. Cell death during development of the nervous system. Annu. Rev. Neurosci. 14: 453-501.
48. BONFOCO, E., D. KRAINC, M. ANKARCRONA, P. NICOTERA & S. A. LIPTON. 1995. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 92: 7162-7166.
49. CHARRIAUT-MARLANGUE, C., D. AGGOUN-ZOUAOUI, A. REPRESA & Y. BEN-ARI. 1996. Apoptotic features of selective neuronal death in ischemia, epilepsy and gp 120 toxicity. Trends Neurosci. 19: 109-114.
50. ELLIS, R., J. YUAN & H. HORVITZ. 1991. Mechanisms and functions of cell death. Annu. Rev. Cell. Biol. 7: 663-698.
51. ARENDS, M. & A. WYLLIEM. 1991. Apoptosis: mechanisms and role in pathology. Int. Rev. Exp. Pathol. 32: 223-254.
52. THOMPSON C. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462.