The trophic effects of purines and purinergic signaling in pathologic reactions of astrocytes

Alzheimer Disease and Associated Disorders

Volumn 12, Issue SUPPL. 2, 1998, Pages

  Rathbone, Michel P ^a   Middlemiss, Pamela ^a   Andrew, Craig ^a   Caciagli, Francesco ^b   Ciccarelli, Renata ^b   Di Iorio, Patrizia ^b   Huang, Rong ^c  

^a MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

^b UNIVERSITY OF CHIETI   (Italy)

^c NeoTherapeutics Inc   (United States)

Author keywords

Adenosine; Astrocytes; ATP; GTP; Guanosine; Neurotrophic effects

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; CELL SURFACE RECEPTOR; GROWTH FACTOR; GUANOSINE; GUANOSINE TRIPHOSPHATE; NUCLEOSIDE; NUCLEOTIDE; PURINE DERIVATIVE; PURINE RECEPTOR;

APOPTOSIS; ASTROCYTE; BRAIN INJURY; CELL MEMBRANE; CONFERENCE PAPER; MITOSIS; MORPHOGENESIS; NERVE CELL DIFFERENTIATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINAL CORD INJURY;

EID: 0032450346     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-199803001-00006     Document Type: Conference Paper

References (89)

1. Abbracchio MP, Cattabeni F, Clementi F, Sher E. Adenosine receptors linked to adenylate cyclase activity in human neuroblastoma cells: Modulation during cell differentiation. Neuroscience 1989;30:819-25.
2. Abbracchio MP, Ceruti S, Barbieri D, et al. A novel action for adenosine: apoptosis of astroglial cells in rat brain primary cultures. Biochem Biophys Res Commun 1995;213:908-15.
3. Abbracchio MP, Rainaldi G, Giammarioli AM, et al. The A3 adenosine receptor mediates cell spreading reorganization of actin cytoskeleton, and distribution of Bcl-xL: studies in human astroglioma cells. Biochem Biophys Res Commun 1997;241:297-304.
4. Abbracchio MP, Saffrey MJ, Hopker V, Burnstock G. Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum. Neuroscience 1994;59:67-76.
5. Abraham EH, Prat AG, Gerweck L, et al. The multidrug resistance (mdr1) gene product functions as an ATP channel. Proc Natl Acad Sci USA 1993;90:312-6.
6. Aruffo C, Ferszt R, Hildebrandt AG, Cervos-Navarro J. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro. Dev Neurosci 1987;9:228-39.
7. Balazas R, Hack N, Jorgensen OS. Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells. Neurosci Lett 1988a;87:80-6.
8. Balazas R, Jorgensen OS, Hack N. N-methyl-D-aspartate promotes the survival of cerebellar granule cells in culture. Neuroscience 1988b;27:437-51.
9. Beal MF. Mechanisms of excitotoxicity in neurologic diseases. FASEB J 1992;6:3338-43.
10. Bender AS, Hertz L. Similarities of adenosine uptake systems in astrocytes and neurons in primary cultures. Neurochem Res 1986; 11:1507-24.
11. Bender AS, Woodbury DM, White HS. Ionic dependence of adenosine uptake into cultured astrocytes. Brain Res 1994;661:1-8.
12. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
13. Brewer GJ, Cotman CW. NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons. Neurosci Lett 1989;99: 268-73.
14. Brundege JW, Dunwiddie TV. Role of adenosine as a modulator of synaptic activity in the central nervous system. Adv Pharmacol 1997;39:353-91.
15. Bulloch AGM. Sprouting by intact helisoma neurons: role for glutamate. J Neurosci Res 1989;23:384-95.
16. Bulloch AGM, Hauser GC. Sprouting by isolated helisoma neurons: enhancement by glutamate. Int J Dev Neurosci 1990;8:391-8.
17. Burnstock G. P2 purinoceptors: historical perspective and classification. CIBA Found Symp 1996;198:1-28.
18. Burnstock G, Brown CM. An introduction to purinergic receptors. In: Burnstock G, ed. Receptors and recognition. Ser. B. London: Chapman and Hill, 1981:1-45.
19. Caciagli F. mGluRs and purinoceptors cooperate in regulating excitatory amino acid and purine release [Abstract]. Neuropsychopharmacology 1996;35:24.
20. Cantiello HF, Prat AG, Reisin IL, et al. External ATP and its analogs activate the cystic fibrosis transmembrane conductance regulator by a cyclic AMP-independent mechanism. J Biol Chem 1994;269: 11224-32.
21. Casabona G, L'Episcopo MR, Di Iorio P, et al. Interaction between metabotropic receptors and purinergic transmission in rat hippocampal slices. Brain Res 1994;645:13-8.
22. Ciccarelli R, Di Iorio P, Ballerini P, et al. Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes. J Neurosci Res 1994;39:556-66.
23. Ciccarelli R, Di Iorio I, Ballerini P, et al. Guanine-based purines are released from rat astrocytes. Effects of these compounds on astrocyte function. [Abstract]. Drug Dev Res 1998;43:52.
24. Ciccarelli R, Di Iorio P, Giuliani P, et al. Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/ hypoglycemia. Glia 1998;24 [in press].
25. Ciccarelli R, Di Iorio P, Midlemiss PJ, et al. Potential neuroprotective effects of guanine-based purines released from rat cultured astrocytes [Abstract]. Proc II Int EPHAR Meeting 1997;39.
26. Crocker CE, Clark SD, Urschel-Gysbers BA, Glasky AJ, Rathbone MP. Effect of AIT-082 on neurotrophin levels following spinal cord hemisection [Abstract]. Soc Neurosci Abst 1997;23:1149.
27. Cusack NJ, Hourani S. Subtypes of P2 purinoreceptors: studies using analogues of ATP. Ann NY Acad Sci 1990;603:172-81.
28. Di Iorio P, Ballerini P, Caciagli F, Ciccarelli R. Purinoceptor-mediated modulation of purine and neurotransmitter release from hippocampus. Pharmacol Res 1998a;37:169-78.
29. Di Iorio P, Battaglia G, Ciccarelli R, et al. Interaction between A1 adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices. J Neurochem 1996;67:302-9.
30. Di Iorio P, Ciccarelli R, Ballerini P, et al. Effect of guanosine and guanosine-like drugs on NMDA-induced unilateral lesion in rat striatum in vivo [Abstract]. Drug Dev Res 1998b;43:53.
31. Drury AN, Szent-Gyorgyi A. The physiological action of adenine compounds with special reference to their action on the mammalian heart. J Physiol 1929;68:214-37.
32. Fredholm BB. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol 1995a;76:93-101.
33. Fredholm BB. Purinoceptors in the nervous system. Pharmacol Toxicol 1995b;76:228-39.
34. Geiger JD, Fyda D. Adenosine transport in the CNS. In: Stone T, ed. Adenosine in the nervous system. New York: Academic Press, 1991:1-23.
35. Geiger JD, Nagy JI. Adenosine deaminase and [3H]-nitrobenzylthioinosine as markers of adenosine metabolism and transport in central purinergic systems. In: Williams M, ed. Clifton, NJ: Humana Press, 1990:225-88.
36. Giulian D, Baker T. Characterization of ameboid microglia isolated from mammalian brain. J Neurosci 1986;6:2163-78.
37. Gu JG, Nath A, Geiger JD. Characterization of inhibitor-sensitive and -resistant adenosine transporters in cultured human fetal astrocytes. J Neurochem 1996;67:972-7.
38. Gysbers JW, Lamb DP, O'Banion MK, Martzen MR, Rathbone MP. Molecular mechanisms of guanosine and GTP in neurite outgrowth [Abstract]. Soc Neurosci Abst 1993;19:1310.
39. Gysbers JW, Mariggir MA, Pietrangelo T, Fano G, Rathbone MP. Extracellular GTP increases intracellular calcium in PC12 cells [Abstract]. Soc Neurosci Abst 1996;23:737.
40. Gysbers JW, Middlemiss PJ, Hindley S, Rathbone MP. Extracellular guanosine and GTP stimulate NGF and FGF-2 synthesis by astrocytes [Abstract]. Soc Neurosci Abst 1994;20:1314.
41. Gysbers JW, Rathbone MP. Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells. Neuroreport 1992a;3:997-1000.
42. Gysbers JW, Rathbone MP. Guanosine and GTP enhance NGF stimulated neurite outgrowth in PC12 cells [Abstract]. Soc Neurosci Abstr 1992b;18:1000.
43. Gysbers JW, Rathbone MP. Neurite outgrowth in PC12 cells is enhanced by guanosine through both cAMP-dependent and -independent mechanisms. Neurosci Lett 1996a;47:427-39.
44. Gysbers JW, Rathbone MP. GTP and guanosine synergistically enhance NGF-induced neurite outgrowth from PC12 cells. Int J Dev Neurosci 1996b;14:19-34.
45. Hertz L. Dibutyryl cyclic AMP treatment of astrocytes in primary cultures as a substitute for normal morphogenic and "functionogenic" transmitter signals. In: Privat A, Giacobini E, Timiras P, Vernadakis A, eds. Molecular aspects of development and aging in the nervous system. New York: Plenum Press, 1990:227-43.
46. Hertz L, Juurlink BHJ, Formark H, Schousboe A. Methodological appendix: astrocytes in primary culture. In: Pfeiffer SE, ed. Neuroscience approached through tissue culture. Boca Raton, FL: CRC Press, 1982:175-86.
47. Hertz L, Juurlink BHJ, Hertz E, Fosmark H, Schousboe A. Preparation of primary cultures of mouse (rat) astrocytes. In: Shahar A, de Vellis J, Vernadakis A, Haber B, eds. A dissection and tissue culture manual of the nervous system. New York: Alan R Liss, 1989:105-8.
48. Hertz L, Juurlink BHJ, Szuchet S. Cell cultures. In: Lajtha A, ed. Handbook of neurochemistry. New York: Plenum Press, 1985:603-61.
49. Hindley S, Herman MA, Rathbone MP. Stimulation of reactive astrogliosis in vivo by extracellular ADP or an adenosine A2 receptor agonist. J Neurosci Res 1994;38:399-406.
50. Hoffaker T, Corcoran T, Wagner JA. Adenosine inhibits cell division and promotes neurite extension in PC12 cells. J Cell Physiol 1984; 120:188-96.
51. Jarvis MF, Williams M. Adenosine in central nervous system function. In: Williams M, ed. Adenosine and adenosine receptors. Clifton, NJ: Humana Press, 1990:423-74.
52. Juurlink BHJ, Hertz L. Astrocytes. In: Boulton AA, Baker GB, WaIlz W, eds. Neuromethods. Totowa, NJ: Humana Press, 1992:269-321.
53. Juurlink BHJ, Rathbone MP. AIT-082 (a hypoxanthine derivative), guanosine and metabolites stimulate neurite formation in hippocampal neurons [Abstract]. Drug Dev Res 1998;43:55.
54. Kennedy C, Ijzerman A. Adenosine and ATP: from receptor structure to clinical applications. Trends Pharmacol Sci 1994;15:311-2.
55. Kim J-K, Rathbone MP, Middlemiss P, Hughes DW, Smith R. Purinergic stimulation of astroblast proliferation: guanosine and its nucleotides stimulate cell division in chick astroblasts. J Neurosci Res 1991;28:442-55.
56. Latini S, Pazzagli M, Pepeu G, Pedata F. A2 adenosine receptors: their presence and neuromodulatory role in the central nervous system. Gen Pharmacol 1996;27:925-33.
57. Lee CW, Jarvis SM. Nucleoside transport in rat cerebral-cortical synaptosomes. Evidence for two types of nucleoside transporters. Biochem J 1988a;249:557-64.
58. Lee CW, Jarvis SM. Kinetic and inhibitor specificity of adenosine transport in guinea pig cerebral cortical synaptosome: evidence for two nucleoside transporters. Neurochem Int 1988b;12:483-92.
59. Lloyd HGE, Frebholm BB. Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocampal slices. Neurochem Int 1995;26:387-95.
60. Lowry OH, Rosebrough NJ, Farr A, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
61. Meier E, Hertz L, Schousboe A. Neurotransmitters as developmental signals. Neurochem Int 1991;19:1-15.
62. Middlemiss PJ, Gysbers JW, Rathbone MP. Extracellular guanosine and guanosine-5′-triphosphate increase NGF synthesis and release from cultured mouse neopallial astrocytes. Brain Res 1995;677: 152-6.
63. Middlemiss PJ, Rathbone MP, Hooftman E. Purinergic stimulation of astrocyte proliferation: evidence for involvement of P1-A2 and P2Y receptors. Can Coll Neuropsychopharmacol 1990;23.
64. Neary JT, Rathbone MP, Cattabeni F, Abbracchio MP, Burnstock G. Trophics actions of extracellular nucleotides on glial and neuronal cells. Trends Neurosci 1996;19:13-8.
65. North RA, Barnard EA. Nucleotide receptors. Curr Opin Neurobiol 1997;7:346-57.
66. Olano JP, Wolf D, Keherly M, Gelman BB. Quantifying apoptosis in banked human brains using flow cytometry. J Neuropathol Exp Neurol 1996;55:1164-72.
67. Pearce IA, Cambray-Deakin MA, Burgoyne RD. Glutamate acting on NMDA receptors stimulates neunte outgrowth from cerebellar granule cells. FEBS Lett 1987;223:143-7.
68. Pechan PA, Chowdhury K, Gerdes W, Seifert W. Glutamate induces the growth factors NGF, bFGF, the receptor FGF-R1 and c-fos mRNA expression in rat astrocyte culture. Neurosci Lett 1993; 153:111-4.
69. Plagemann PG, Wohlhueter RM. 5′ deoxyadenosine metabolism in various mammalian cell lines. Biochem Pharmacol 1983;32:1433-40.
70. Plagemann PG, Wohlhueter RM, Woffendin C. Nucleoside and nucleobase transport in animal cells. Biochim Biophys Acta 1988; 947:405-43.
71. Rathbone MP. Extracellular purine nucleosides and nucleotides in glial-neuron interactions [Abstract]. Proc 2nd Altschul Symp 1992;24.
72. Rathbone MP, Andrew CM, Ballerini P, Caciagli F, Glasky AJ, Crocker CE. Effects of guanosine and 2-chloroadenosine on C6 glioma cell growth [Abstract]. Soc Neurosci Abst 1997;23:71.
73. Rathbone MP, Christjanson L, DeForge S, et al. Extracellular purine nucleosides stimulate cell division and morphogenesis: pathological and physiological implications. Med Hypotheses 1992a;37: 232-40.
74. Rathbone MP, DeForge S, DeLuca B, et al. Purinergic stimulation of cell division and differentiation: mechanisms and pharmacological implications. Med Hypotheses 1992b;37:213-9.
75. Rathbone MP, Hindley S, Gysbers JW, Gabel B. Purine nucleosides and nucleotides stimulate astrocyte proliferation in vitro and astrogliosis in vivo [Abstract]. Soc Neurosci Abst 1991a;17:550.
76. Rathbone MP, Middlemiss PJ, DeLuca B, Jovetich M. Extracellular guanosine increases astrocyte cAMP: Inhibition by adenosine A2 antagonists. Neuroreport 1991b;2:661-4.
77. Rathbone MP, Middlemiss PJ, Gysbers JW, DeForge S, Costello P, Del Maestro RF. Purine nucleosides and nucleotides stimulate proliferation of a wide range of cell types. In Vitro Cell Dev Biol 1992c; 28A:529-36.
78. Rathbone MP, Middlemiss PJ, Gysbers JW, et al. Trophic effects of purines in neurons and glial cells. Prog Neurobiol [in press].
79. Rathbone MP, Middlemiss PJ, Kim J-K, et al. Adenosine and its nucleotides stimulate proliferation of chick astroblasts and human astrocytoma cells. Neurosci Res 1992d;13:1-17.
80. Ribeiro JA. Purinergic inhibition on neurotransmitter release in the central nervous system. Pharmacol Toxicol 1995;77:299-305.
81. Shinoda I, Furukawa Y, Furukawa S. Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells. Biochem Pharmacol 1990;39:1813-6.
82. Stone TW. Receptors for adenosine and adenine nucleotides. Gen Pharmacol 1991;22:25-31.
83. Tsai SY, McNulty JA. Microglia in the pineal gland of the neonatal rat: characterization and effects on pinealocyte neurite length and serotonin content. Glia 1997;20:243-53.
84. Uemura Y, Miller JM, Matson WR, Beal MF. Neurochemical analysis of focal ischemia in rats. Stroke 1991;22:1548-53.
85. Wakade TD, Palmer KC, McCauley R, Przywara DA, Wakade AR. Adenosine-induced apoptosis in chick embryonic sympathetic neurons: a new physiological role for adenosine. J Physiol 1995; 488:123-38.
86. Williams M. Purine receptors in mammalian tissues: pharmacology and functional significance. Annu Rev Pharmacol Toxicol 1987;27: 315-45.
87. Williams M. Therapeutic opportunities via modulation of cellular purinergic systems [Abstract]. Drug Dev Res 1996;37:175.
88. Wu LG, Saggau P. Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci 1997;20:204-12.
89. Zimmerman H. ATP as a neurotransmitter: its role in synaptic system. Trends Neurosci 1994;17:420-6.