Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia

GLIA

Volumn 25, Issue 1, 1999, Pages 93-98

  Ciccarelli, Renata ^a   Di Iorio, Patrizia ^a   Giuliani, Patricia ^a   D'Alimonte, Iolanda ^a   Ballerini, Patrizia ^a   Caciagli, Francesco ^a   Rathbone, Michel P ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Cultured astrocytes; GTP; Guanosine; Hypoxia hypoglycemia; Release

Indexed keywords

EID: 0032889661     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(19990101)25:1<93::AID-GLIA9>3.0.CO;2-N     Document Type: Article

References (9)

1. Abbracchio MIP, Ceruti S, Barbieri D, Franceschi C, Malorni W, Biondo L, Burnstock G, Cattabeni F. 1995. A novel action for adenosine: Apoptosis of astroglial cells in rat brain primary cultures. Biochem. Biophys Res Comm 213:908-915.
2. Abbracchio MP, Saffrey MJ, Hopker V, Burnstock G. 1994. Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum. Neuroscience 59: 67-76.
3. Berger SJ, Carter JG, Lowry OH. 1985. Distribution of guanine deaminase in mouse brain. J Neurochem 44:1736-1740.
4. Braas KM, Newby AC, Wilson VS, Snyder SH. 1986. Adenosinecontaining neurons in the brain localized by immunocytochemistry. J Neurosci 6:1952-1961.
5. Bradford M. 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 72:248-254.
6. Cascalheira JF, Sebastião AM. 1992. Adenine nucleotides analogues, including γ-phosphate-substituted analogues, are metabolised extracellularly in innervated frog sartorius muscle. Eur J Pharmacol 222:49-59.
7. Ciccarelli R, Di Iorio P, Ballerini P, Ambrosini G, Giuliani P, Tiboni GM, Caciagli F. 1994. Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes. J Neurosci Res 39:556-566.
8. Ciccarelli R, Di Iorio P, Middlemiss PJ, Ballerini P, D'Alimonte I, Rathbone MP, Caciagli F. 1997. Potential neuroprotective effects of guanine-based purines released from rat cultured astrocytes. Proceedings of the II International EPHAR Meeting - "Drug targets in heart and brain ischemia" Florence, July 11-14:39.
9. Craig CG, White TD. 1993. N-Methyl-D-Aspartate- and Non-N-Methyl-D-Aspartate- evoked adenosine release from rat cortical slices: Distinct purinergic sources and mechanisms of release. J Neurochem 60:1073-1080.