Mechanisms of apoptosis induced by purine nucleosides in astrocytes

GLIA

Volumn 38, Issue 3, 2002, Pages 179-190

  Di Iorio, Patrizia ^a   Kleywegt, Sonya ^a,b   Ciccarelli, Renata ^a   Traversa, Ugo ^c   Andrew, Craig M ^b   Crocker, Candice E ^b   Werstiuk, Eva S ^b   Rathbone, Michel P ^b  

^a UNIVERSITY OF CHIETI   (Italy)

^b MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Adenosine; Adenosine A3 receptor; Cell death; Guanosine; SAM SAH ratio

Indexed keywords

2,3 DIETHYL 4,5 DIPROPYL 6 PHENYLPYRIDINE 3 THIOCARBOXYLATE 5 CARBOXYLATE; 2,3-DIETHYL-4,5-DIPROPYL-6-PHENYLPYRIDINE-3-THIOCARBOXYLATE-5-CARBOXYLATE; 9 (2 HYDROXY 3 NONYL)ADENINE; 9-(2-HYDROXY-3-NONYL)ADENINE; ADENINE; ADENOSINE; ADENOSINE A3 RECEPTOR; ADENOSINE DEAMINASE; ADENOSINE RECEPTOR; CARRIER PROTEIN; DRUG DERIVATIVE; ENZYME INHIBITOR; GUANINE; GUANOSINE; HYPOXANTHINE; INOSINE; MESSENGER RNA; PURINE NUCLEOSIDE; PYRIDINE DERIVATIVE;

ANIMAL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL CULTURE; CENTRAL NERVOUS SYSTEM; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; MALE; METABOLISM; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ADENINE; ADENOSINE; ADENOSINE DEAMINASE; ANIMALS; APOPTOSIS; ASTROCYTES; CARRIER PROTEINS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GUANINE; GUANOSINE; HYPOXANTHINE; INOSINE; MALE; PURINE NUCLEOSIDES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RNA, MESSENGER;

EID: 0036560298     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.10055     Document Type: Article

References (65)

1. A novel action for adenosine: Apoptosis of astroglial cells in rat brain primary cultures
2. 3 receptor
3. 3 adenosine receptor mediates cell spreading, reorganization of actin cytoskeleton, and distribution of BCL-xL: Studies in human astroglioma cells
4. 3 receptor and viability of astrocytes
5. Extracellular levels of adenosine and its metabolites in the striatum of awake rats: Inhibition of uptake and metabolism
6. Axon outgrowth is regulated by an intracellular purine-sensitive mechanism in retinal ganglion cells
7. Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury
8. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
9. The neuroprotective activity of guanosine involves the production of trophic factors and the outflow of purines from astrocytes
10. Differential distribution of purine metabolising enzymes between glia and neurons
11. Different pathways of apoptosis revealed by 2-chloro-adenosine and deoxy-D-ribose in mammalian astroglial cells
12. Adenosine- and 2-chloro-adenosine-induced cytopathic effects on myoblastic cells and myotubes: Involvement of different intracellular mechanisms
13. Apoptosis induced by 2-chloro-adenosine and 2-chloro-2′-deoxy-adenosine in a human astrocytoma cell line: Differential mechanisms and possible clinical relevance
14. Effects exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of of rat astrocytes
15. Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycaemia
16. Guanosine and related drugs stimulate the production of neurotrophic factors from rat cultured astrocytes by involving the mitogen-activated protein kinase pathway
17. Cultured astrocye proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia
18. S-adenosylmethionine and methylation
19. Extracellular ATP and adenosine cause apoptosis of pulmonary artery endothelial cells
20. Purine nucleosides protect injured neurons and stimulate neuronal regeneration by intracellular and membrane receptor-mediated mechanisms
21. Correlated flow cytometric analysis of terminal events in apoptosis reveals the absence of some changes in some model systems
22. Activation of glutamate uptake by guanosine in primary astrocyte cultures
23. Characterization of ameboid microglia isolated from developing mammalian brain
24. Characterization of inhibitor-sensitive and -resistant adenosine transporters in cultured human fetal astrocytes
25. Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells
26. Extracellular adenosine, inosine, hypoxanthine, xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia
27. Treatment strategies for neurodegenerative diseases based on trophic factors and cell transplantation techniques
28. 3 receptors: Design of selective ligands and therapeutic prospects
29. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
30. Purinergic stimulation of astroblast proliferation: Guanosine and its nucleotides stimulate cell division in chick astroblasts
31. 3 receptor agonists
32. Adenosine in the central nervous system: Release mechanisms and extracellular concentrations
33. 3 adenosine receptor antagonists
34. Cortical spreading depression activates trophic factor expression in neurons and astrocytes and protects against subsequent focal brain ischemia
35. Signal transduction pathways to apoptosis
36. Adenosine formation and release by embryonic chick neurons and glia in cell culture
37. Storage, release, uptake, and inactivation of purines
38. Extracellular guanosine and guanosine-5′-triphosphate increase NGF synthesis and release from cultured mouse neopallial astrocytes
39. Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells
40. Caspases: Killer proteases
41. Adenosine receptor subtypes: Characterization and therapeutic regulation
42. 3 adenosine receptor
43. Molecular basis for subtype-specific desensitisation of inhibitory adenosine receptors
44. Inhibitory effects of propentofylline on [3H]adenosine influx: A study of three nucleoside transport systems
45. The role of proteases during apoptosis
46. Enzymatic methyl esterfication of erythrocyte membrane proteins is impaired in chronic renal failure
47. Adenosine and neurotrauma: Therapeutic perspectives
48. Purine nucleosides and nucleotides stimulate proliferation of a wide variety of cell types
49. Hippocampal neurons in vitro respond to extracellular guanosine and GTP with neurite outgrowth and branching
50. The trophic effects of purines and purinergic signalling in pathological reactions of astrocytes
51. Trophic effects of purines in neurons and glial cells
52. Localization and characterization of adenosine receptor expression in rat testis
53. Mechanism of extracellular ATP- and adenosine-induced apoptosis of cultured pulmonary artery endothelial cells
54. Neuroprotective roles of adenosine in cerebral ischemia
55. Biochemical and molecular mechanisms regulating apoptosis
56. 2+-mediated mechanisms
57. rRNA complementarity within mRNAs: A possible basis for mRNA-ribosome interactions and translational control
58. Microglia in the pineal gland of the neonatel rat: Characterization and effects on pinealocyte neurite length and serotonin content
59. Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase
60. Neurochemical analysis of focal ischemia in rats
61. 3 receptor stimulation and cerebral ischemia
62. 3 receptor and brain: A culprit, a hero, or merely yet another receptor?
63. Adenosine and cerebral ischemia: Therapeutic future or death of a brave concept?
64. Adenosine-induced apoptosis in chick embryonic sympathetic neurons: A new physiological role for adenosine
65. Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre