T cells and viral persistence: Lessons from diverse infections

Nature Immunology

Volumn 6, Issue 9, 2005, Pages 873-879

  Klenerman, Paul ^a   Hill, Ann ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; HLA ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANTIGEN FUNCTION; CELL SPECIFICITY; CELLULAR IMMUNITY; CYTOMEGALOVIRUS; DISEASE MODEL; EPSTEIN BARR VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMORAL IMMUNITY; IN VIVO STUDY; INNATE IMMUNITY; MEMORY T LYMPHOCYTE; MOLECULAR BIOLOGY; NONHUMAN; PERSISTENT VIRUS INFECTION; PHENOTYPE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; VIRUS IMMUNITY; VIRUS LOAD; VIRUS PATHOGENESIS; ANIMAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; HOST PARASITE INTERACTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; VIRUS INFECTION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HOST-PARASITE RELATIONS; HUMANS; IMMUNOLOGIC MEMORY; VIRAL LOAD; VIRUS DISEASES;

EID: 24944509220     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1241     Document Type: Review

References (98)

1. + T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8, 379-385 (2002).
2. Bachmann, M.F, Hunziker, L., Zinkernagel, R.M., Storni, T. & Kopf, M. Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: Antibodies provide the key. Eur. J. Immunol. 34, 317-326 (2004).
3. Polic, B. et al. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection. J. Exp. Med. 188, 1047-1054 (1998).
4. Doherty, P.C. & Christensen, J.P. Accessing complexity: The dynamics of virus-specific T cell responses. Annu. Rev. Immunol. 18, 561-592 (2000).
5. Kaech, S.M., Wherry, E.J. & Ahmed, R. Effector and memory T-cell differentiation: Implications for vaccine development. Nat. Rev. Immunol. 2, 251-262 (2002).
6. + T-cell homeostasis after infection: setting the 'curve'. Microbes Infect. 4, 441-447 (2002).
7. + T lymphocyte responses. Nat. Immunol. 4, 361-365 (2003).
8. Kaech, S.M. et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4, 1191-1198 (2003).
9. Mongkolsapaya, J. et al. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat. Med. 9, 921-927 (2003).
10. Lechner, F. et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 191, 1499-1512 (2000).
11. Shedlock, D.J. & Shen, H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300, 337-339 (2003).
12. Khanolkar, A., Fuller, M.J. & Zajac, A.J. CD4 T cell-dependent CDB T cell maturation. J. Immunol. 172, 2834-2844 (2004).
13. + T cells after acute infection. Nat. Immunol. 5, 927-933 (2004).
14. + T lymphocytes. Nature 421, 852-856 (2003).
15. + T-cell memory. Nat. Med. 7, 913-919 (2001).
16. Day, C.L. et al. Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J. Clin. Invest. 112, 831-842 (2003).
17. Lucas, M. et al. Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells. J. Virol. 78, 7284-7287 (2004).
18. Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
19. + memory cells in humans defined by HLA and CC chemokine ligand 19 tetramers. J. Immunol. 170, 2461-2468 (2003).
20. Wherry, E.J. et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4, 225-234 (2003).
21. + central and effector memory T cell subsets are largely distinct. Immunity 18, 193-204 (2003).
22. + T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicatioe potential. Blood 100, 933-940 (2002).
23. + T cells during persistent infection Blood 106, 558-565 (2005).
24. + T cells after infection. Nat. Immunol. 3, 619-626 (2002).
25. + T lymphocytes in healthy seropositive donors. J. Virol. 74, 8140-8150 (2000).
26. Khan, N. et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169, 1984-1992 (2002).
27. Komatsu, H. & Sierro, S. A, V.C. & Klenerman, P. Population analysis of antiviral T cell responses using MHC class I-peptide tetramers. Clin. Exp. Immunol. 134, 9-12 (2003).
28. Northfield, J., Lucas, M., Jones, H., Young, N.T. & Klenerman, P. Does memory improve with age? CD85j (ILT2/LIR-1) expression on CD8 T cells correlates with 'memory inflation' in human cytomegalovirus infection. Immunol. Cell Biol. 83, 182-188 (2005).
29. Khan, N. et al. Herpesvirus-specific CD8 T cell immunity mold age: cytomegalovirus impairs the response to a coresident EBV infection. J. Immunol. 173, 7481-7489 (2004).
30. + T lymphocytes depend on infection with CMV. J. Immunol. 170, 4342-4348 (2003).
31. + T cells over time. J. Immunol. 170, 2022-2029 (2003).
32. + T cell populations after murine cytomegalovirus infection. Eur. J. Immunol. 35, 1113-1123 (2005).
33. lo memory-effector cell pool during latent murine cytomegalovirus infection of the lungs. J. Virol. 74, 11495-11503 (2000).
34. Gold, M.C. et al. Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response. J. Immunol. 172, 6944-6953 (2004).
35. + T cell responses after natural primary infection of humans with Epstein-Barr virus. Viral Immunol. 16, 3-16 (2003).
36. Obar, J.J., Crist, S.G., Gondek, D.C. & Usherwood, E.J. Different functional capacities of latent and lytic antigen-specific CD8 T cells in murine gammaherpesvirus infection. J. Immunol. 172, 1213-1219 (2004).
37. Masopust, D., Vezys, V., Marzo, A.L. & Lefrancois, L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291, 2413-2417 (2001).
38. Wherry, E.J., Blattman, J.N., Murali-Krishna, K., van der Most, R. & Ahmed, R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77, 4911-4927 (2003).
39. Wherry, E.J., Barber, D.L., Kaech, S.M., Blattman, J.N. & Ahmed, R. Antigen-independent memory CDB T cells do not develop during chronic viral infection. Proc. Natl. Acad. Sci. USA 101, 16004-16009 (2004).
40. + T-cell immune responses during chronic viral infection. J. Virol. 78, 3578-3600 (2004).
41. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68, 8056-8063 (1994).
42. Ou, R., Zhou, S., Huang, L. & Moskophidis, D. Critical role for α/β and γ interferons in persistence of lymphocyytc choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J. Virol. 75, 8407-8423 (2001).
43. + T cells by regulatory T cells during persistent retroviral infection. Immunity 20, 293-303 (2004).
44. Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
45. + regulatory T cells at the single-cell level. Eur. J. Immunol. 35, 1681-1691 (2005).
46. Rouse, B.T. & Suvas, S. Regulatory cells and infectious agents: Detentes cordiale and contraire. J. Immunol. 173, 2211-2215 (2004).
47. + T cells. J. Exp. Med. 200, 701-712 (2004).
48. Ogg, G.S. et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279, 2103-2106 (1998).
49. + T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat. Immunol. 3, 1061-1068 (2002).
50. + T-cell responses against variable viruses. Proc. R. Soc. Lond. B 271 (Suppl. 3), S53-S56 (2004).
51. Kiepiela, P. et al. Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature 432, 769-775 (2004).
52. Crowe, S.R., Miller, S.C., Shenyo, R.M. & Woodland, D.L. Vaccination with an acidic polymerase epitope of influenza virus elicits a potent antiviral T cell response but delayed clearance of an influenza virus challenge. J. Immunol. 174, 696-701 (2005).
53. + T cells are required for protection from persistent hepatitis C virus infection. J. Exp. Med. 197, 1645-1655 (2003).
54. Grakoui, A. et al. HCV persistence and immune evasion in the absence of memory T cell help. Science 302, 659-662 (2003).
55. + T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained. Eur. J. Immunol. 30, 2479-2487 (2000).
56. Lauer, G.M. et al. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 127, 924-936 (2004).
57. + T lymphocytes within the normal human liver. Eur. J. Immunol. 34, 1526-1531 (2004).
58. + T cell population in chronic hepatitis C virus infection. J. Clin. Invest. 113, 963-972 (2004).
59. Crispe, I.N. Hepatic T cells and liver tolerance. Nat. Rev. Immunol. 3, 51-62 (2003).
60. + T cells during chronic hepatitis C virus infection. J. Virol. 79, 7860-7867 (2005).
61. + T cells during persistent hepatitis C virus infection. J. Virol. 79, 7852-7859 (2005).
62. Sugimoto, K. et al. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 38, 1437-1448 (2003).
63. + regulatory T lymphocytes in hepatitis C virus infection. Hepatology 40, 1062-1071 (2004).
64. Thursz, M., Yallop, R., Goldin, R., Trepo, C. & Thomas, H.C. Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research. Lancet 354, 2119-2124 (1999).
65. McKiernan, S.M. et al. Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. Hepatology 40, 108-114 (2004).
66. + T cell response to Epstein-Barr virus during primary and persistent infection. J. Exp. Med. 198, 903-911 (2003).
67. Sester, M. et al. Sustained high frequencies of specific CD4 T cells restricted to a single persistent virus. J. Virol. 76, 3748-3755 (2002).
68. + T cell mechanisms in the control of respiratory virus infections. Immunol. Rev. 159, 105-117 (1997).
69. + T cells i n protection against CMV disease. Blood 101, 2686-2692 (2003).
70. + T lymphocyte turnover and activation increase upon viral rebound. J. Clin. Invest. 115, 443-450 (2005).
71. + T cells endowed with proliferative capacity. J. Exp. Med. 198, 1909-1922 (2003).
72. + T cells in chronic HCV infection. Hepatology 41, 1019-1028 (2005).
73. MacDonald, A.J. et al. CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons. J. Infect. Dis. 185, 720-727 (2002).
74. + T cells in multiple tissues during acute SIV infection. Nature 434, 1093-1097 (2005),
75. Alcami, A. & Koszinowski, U.H. Viral mechanisms of immune evasion. Immunol. Today 21, 447-455 (2000).
76. Mocarski, E.S., Jr. Immune escape and exploitation strategies of cytomegaloviruses: Impact on and imitation of the major histocompatibility system. Cell. Microbiol. 6, 707-717 (2004).
77. Loewendorf, A. et al. Identification of a mouse cytomegalovirus gene selectively targeting CD86 expression on antigen-presenting cells. J. Virol. 78, 13062-13071 (2004).
78. Holtappels, R. et al. Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissues. J. Exp. Med. 199, 131-136 (2004).
79. Gold, M.C. et al. The murine cytomegalovirus immunomodulatory gene m152 prevents recognition of infected cells by M45-specific CTL but does not alter the immunodominance of the M45-specific CD8 T cell response in vivo. J. Immunol. 169, 359-365 (2002).
80. + cytotoxic T-cell response in natural infection. Blood 104, 1075-1082 (2004).
81. Reddehase, M.J. The immunogenicity of human and murine cytomegaloviruses. Curr. Opin. Immunol. 12, 390-396 (2000).
82. Reddehase, M.J. Antigens and immunoevasins: Opponents in cytomegalovirus immune surveillance. Nat. Rev. Immunol. 2, 831-844 (2002).
83. Bunde, T. et al. Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells. J. Exp. Med. 201, 1031-1036 (2005).
84. Phillips, R.E. et al. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354, 453-459 (1991).
85. Moore, C.B. et al. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science 296, 1439-1443 (2002).
86. Leslie, A.J. et al. HIV evolution: CTL escape mutation and reversion after transmission. Nat. Med. 10, 282-289 (2004).
87. Leslie, A. et al. Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. J. Exp. Med. 201, 891-902 (2005).
88. Erickson, A.L. et al. The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes. Immunity 15, 883-895 (2001).
89. Timm, J. et al. CD8 epitope escape and reversion in acute HCV infection. J. Exp. Med. 200, 1593-1604 (2004).
90. Cox, A.L. et al. Cellular immune selection with hepatitis C virus persistence in humans. J. Exp. Med. 201, 1741-1752 (2005).
91. Ray, S.C. et al. Divergent and convergent evolution after a common-source outbreak of hepatitis C virus. J. Exp. Med. 201, 1753-1759 (2005).
92. + T lymphocytes. J. Viral Hepat. (in the press; doi:10.1111./j1365-2893.2005.00676.x).
93. Collins, K.L., Chen, B.K., Kalams, S.A., Walker, B.D. & Baltimore, D. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391, 397-401 (1998).
94. Swigut, T. et al. Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus. J. Virol. 78, 13335-13344 (2004).
95. Learmont, J.C. et al. Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort. N. Engl. J. Med. 340, 1715-1722 (1999).
96. + T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants. J. Exp. Med. 193, 297-305 (2001).
97. Zinkernagel, R.M. Immunology taught by viruses. Science 271, 173-178 (1996).
98. + T cells specific for influenza A virus M1 display broad expression of maturation-associated phenotypic markers and chemokine receptors. Immunology 115, 239-245 (2005).