Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells

Journal of Virology

Volumn 75, Issue 18, 2001, Pages 8407-8423

  Ou, R ^a   Zhou, S ^a   Huang, L ^a   Moskophidis, D ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; BETA INTERFERON; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEUTRALIZING ANTIBODY;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HOST RESISTANCE; IMMUNE RESPONSE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; SPLEEN CELL; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN;

ACUTE DISEASE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERON-BETA; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEUTRALIZATION TESTS; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERFERON; T-LYMPHOCYTES, CYTOTOXIC; VIRUS LATENCY;

EID: 0034886599     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.18.8407-8423.2001     Document Type: Article

References (73)

1. Persistence of viruses
2. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence
3. Phenotypic analysis of antigen-specific T lymphocytes
4. Formation of functional peptide complexes of class 11 major histocompatibility complex proteins from subunits produced in Escherichia coli
5. Regulation of antigen-specific CD8(+) T cell homeostasis by perforin and interferon-gamma
6. Antibody prevents the establishment of persistent arenavirus infection in synergy with endogenous T cells
7. Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus
8. Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates
9. + T-cell-deficient mice
10. Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells
11. Cytokines in the generation of immune responses to, and resolution of, virus infection
12. Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections
13. Virus-induced immunosuppression: Immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression
14. Cytotoxic T-lymphocyte escape viral variants: How important are they in viral evasion of immune clearance in vivo?
15. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
16. The role of CD4+ T cells in cell-mediated immunity to LCMV: Studies in MHC class I and class II deficient mice
17. Impairment of CD4+ T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants
18. Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection
19. Two roads diverged: Interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection
20. Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains
21. Virus-specific CD8+ T cells in primary and secondary influenza pneumonia
22. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides
23. Enumeration of single IFN-gamma-producing cells in mice during viral and bacterial infection
24. Interferons: Cell signalling, immune modulation, antiviral responses and virus countermeasures
25. Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte
26. Viral clearance without destruction of infected cells during acute HBV infection
27. CD8+ T cell effector mechanisms in resistance to infection
28. Immunopathologic weight loss in intracranial LCMV infection initiated by the anorexigenic effects of IL-1b
29. Immune response in mice that lack the interferon-gamma receptor
30. The duration of antigenic stimulation determines the fate of naive and effector T cells
31. Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells
32. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
33. From TCR engagement to T cell activation: A kinetic view of T cell behavior
34. Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice
35. Subversion of the immune system by pathogens
36. Type I interferons keep activated T cells alive
37. + cytotoxic T-cell responses during chronic viral infection
38. Innate immunity: Impact on the adaptive immune response
39. Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon
40. Role of virus and host variables in virus persistence or immunopathological disease caused by a non-cytolytic virus
41. + T lymphocytes mediate clearance of virus and regulate the antiviral antibody response
42. MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice
43. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
44. The immune response of the mouse to lymphocytic choriomeningitis virus. IV. Enumeration of antibody-producing cells in spleens during acute and persistent infection
45. Immunobiology of cytotoxic T-cell resistant virus variants: Studies on lymphocytic choriomeningitis virus (LCMV)
46. Functional role of type I and type II interferons in antiviral defense
47. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
48. Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus
49. Interferon a/b-mediated inhibition and promotion of interferon g: STAT1 resolves a paradox
50. Restricted expression of viral glycoprotein in cells of persistently infected mice
51. Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection
52. Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated murine infections
53. A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers
54. The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice
55. Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells
56. Antigen-specific regulation of T cell-mediated cytokine production
57. Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice
58. An essential role for type 1 interferon-gamma in terminating persistent viral infection
59. Viral subversion of the immune system
60. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
61. Modulation by gamma interferon of antiviral cell-mediated immune responses in vivo
62. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy
63. Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors
64. Lactate dehydrogenase-elevating virus (LDV): Lifelong coexistence of virus and LDV-specific immunity
65. + T cells and Th1 dominance during lymphocytic choriomeningitis virus infection
66. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge
67. Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction
68. Lymphocyte-dependent 'natural' immunity to virus infections mediated by both natural killer cells and memory T cells
69. Interferons and other cytokines
70. Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus-infected mice with anti-interferon-gamma monoclonal antibody blocks generation of virus-specific cytotoxic T lymphocytes and virus elimination
71. Viral immune evasion due to persistence of activated T cells without effector function
72. Immunology taught by viruses
73. MHC-restricted cytotoxic T cells: Studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness