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Volumn 12, Issue 4, 2000, Pages 390-396

The immunogenicity of human and murine cytomegaloviruses

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIGEN;

EID: 0034131201     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00106-0     Document Type: Review
Times cited : (97)

References (41)
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    • +T cell dependent attenuation of a Δm152 deletion mutant. The work thus provides the first evidence for in vivo relevance of an immunosubversive mechanism of a CMV.
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    • Generation of cytomegalovirus-specific human T-lymphocyte clones by using autologous B-lymphoblastoid cells with stable expression of pp65 or IE1 proteins: A tool to study the fine specificity of the antiviral response
    • In this recent work, several new antigenic peptides were identified for hCMV (see Table 1). Notably, the majority of CTL clones were found to be specific for peptides derived from polymorphic regions of the IE1 protein, indicating that IE1 is a target of immunological selection. The work thus further underscores our new view regarding the relevance of the hCMV IE1 protein for immune control, a relevance that has been experimentally proven for the IE1 protein of mCMV for a long time.
    • Retiere C., Prod'homme V., Imbert-Marcille B.M., Bonneville M., Vie H., Hallet M.M. Generation of cytomegalovirus-specific human T-lymphocyte clones by using autologous B-lymphoblastoid cells with stable expression of pp65 or IE1 proteins: a tool to study the fine specificity of the antiviral response. J Virol. 74:2000;3948-3952. In this recent work, several new antigenic peptides were identified for hCMV (see Table 1). Notably, the majority of CTL clones were found to be specific for peptides derived from polymorphic regions of the IE1 protein, indicating that IE1 is a target of immunological selection. The work thus further underscores our new view regarding the relevance of the hCMV IE1 protein for immune control, a relevance that has been experimentally proven for the IE1 protein of mCMV for a long time.
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    • Retiere, C.1    Prod'homme, V.2    Imbert-Marcille, B.M.3    Bonneville, M.4    Vie, H.5    Hallet, M.M.6
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