Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8+ T lymphocytes in healthy seropositive donors

Journal of Virology

Volumn 74, Issue 17, 2000, Pages 8140-8150

  Gillespie, G M A ^a   Wills, M R ^a   Appay, V ^a   O'Callaghan, C ^a   Murphy, M ^a   Smith, N ^a   Sissons, P ^a   Rowland Jones, S ^a   Bell, J I ^a   Moss, P A H ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN;

ADOPTIVE TRANSFER; ANTIGEN SPECIFICITY; ARTICLE; BLOOD DONOR; CELL KILLING; CYTOMEGALOVIRUS; EFFECTOR CELL; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; SEROCONVERSION; T LYMPHOCYTE ACTIVATION; TARGET CELL;

CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; CYTOTOXICITY, IMMUNOLOGIC; HISTOCOMPATIBILITY TESTING; HUMANS; IMMUNOCOMPETENCE; PHENOTYPE; SEROLOGIC TESTS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033873474     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.17.8140-8150.2000     Document Type: Article

References (52)

1. Phenotypic analysis of antigen-specific T lymphocytes
2. Human cytomegalovirus-specific cytotoxic T cells: Their precursor frequency and stage specificity
3. Human cytomegalovirus-specific cytotoxic T lymphocytes: Requirements for in vitro generation and specificity
4. Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)
5. Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo
6. Evolution of cytotoxic T lymphocyte responses to human immunodeficiency virus type 1 in patients with symptomatic primary infection receiving antiretroviral triple therapy
7. CD57+ T lymphocytes are derived from CD57 - Precursors by differentiation occurring in late immune responses
8. Cutting edge: Rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma
9. HLA-A2-peptide complexes: Refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides
10. Selective interference with class I major histocompatibility complex presentation of the major immediate-early protein following infection with human cytomegalovirus
11. Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product
12. The influence of cytomegalovirus carrier status on lymphocyte subsets and natural immunity
13. Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART)
14. Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells
15. Phenotypic and functional separation of memory and effector human CD8+ T cells
16. High frequency of cytomegalovirus-specific cytotoxic T-effector cells in HLA-A*0201-positive subjects during multiple viral coinfections
17. Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms
18. T-cell epitope mapping by flow cytometry
19. Human cytomegalovirus latent gene expression in granulocyte-macrophage progenitors in culture and in seropositive individuals
20. Immunologic characterization of CD7-deficient mice
21. Abnormally expanded CD8+/Leu-7+ lymphocytes persisting in long-term bone marrow-transplanted patients are resting pre-cytotoxic T-lymphocytes
22. Anergy and apoptosis in CD8+ T cells from HIV-infected persons
23. Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: Correlation with CMV disease and effect of ganciclovir prophylaxis
24. Regulation of CD28 costimulation in human CD8+ T cells
25. Identification of the major late human cytomegalovirus matrix protein /pp65 as a target antigen for CD8+ virus-specific cytotoxic T lymphocytes
26. Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: Human CD8 memory CTLp selectively express CD45RO (UCHL1)
27. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts
28. Clonal populations of T-cells in patients with B-cell malignancies
29. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
30. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
31. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
32. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection
33. Clonal populations of T cells in normal elderly humans: The T cell equivalent to 'benign monoclonal gammapathy.'
34. HLA-restricted cytotoxic T lymphocytes are an early immune response and important defense mechanism in cytomegalovirus infections
35. Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: Pattern of recovery and correlation with cytomegalovirus infection and disease
36. Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression
37. Alveolar CD8+CD57+ lymphocytes in human immunodeficiency virus infection produce an inhibitor of cytotoxic functions
38. Decreased CD7 expression in cutaneous infiltrates of HIV-1+ patients. Military Medical Consortium for the Advancement of Retroviral Research (MMCARR)
39. A reevaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers
40. Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells
41. PCR activity of CMV in healthy CMV-sero-positive individuals: Does latency need redefinition?
42. Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+ T cells from HIV-infected subjects
43. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor
44. CD8high (CD57+) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein-Barr virus-transformed B cell lines
45. Human cytomegalovirus-infected cells have unstable assembly of major histocompatibility complex class I complexes and are resistant to lysis by cytotoxic T lymphocytes
46. Human CD28-CD8+ T cells contain greatly expanded functional virus-specific memory CTL clones
47. The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo
48. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein /pp65: Frequency, specificity, and T-cell receptor usage of /pp65-specific CTL
49. Human virus-specific CD8+ CTL clones revert from CD45ROhigh to CD45RAhigh in vivo: CD45RAhigh CD8+ T cells comprise both naive and memory cells
50. Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific
51. A re-examination of the Epstein-Barr virus carrier state in healthy seropositive individuals