Impairment of CD4+ T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants

Journal of Experimental Medicine

Volumn 193, Issue 3, 2001, Pages 297-305

  Ciurea, Adrian ^a   Hunziker, Lukas ^a   Klenerman, Paul ^a,b   Hengartner, Hans ^a   Zinkernagel, Rolf M ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Humoral responses; Lymphocytic choriomeningitis virus; Persistent infection; T helper cells; Viral evasion

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GLYCOPROTEIN; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; CYTOTOXIC T LYMPHOCYTE; GENE MUTATION; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGENICITY; IMMUNOSURVEILLANCE; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; T LYMPHOCYTE; VIREMIA; VIRUS MENINGITIS; VIRUS NEUTRALIZATION;

ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CHRONIC DISEASE; CRICETINAE; GLYCOPROTEINS; HUMANS; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEUTRALIZATION TESTS; POINT MUTATION; VARIATION (GENETICS); VIRAL PROTEINS;

EID: 0035808786     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.3.297     Document Type: Article

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