Molecular biology of pseudorabies virus: Impact on neurovirology and veterinary medicine

Microbiology and Molecular Biology Reviews

Volumn 69, Issue 3, 2005, Pages 462-500

  Pomeranz, Lisa E ^a,b   Reynolds, Ashley E ^a   Hengartner, Christoph J ^a,c  

^a PRINCETON UNIVERSITY   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c BARRY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTAGLANDIN SYNTHASE; VIRUS GLYCOPROTEIN;

DIAGNOSTIC TEST; DNA REPLICATION; GENE TARGETING; LETHALITY; MEDIATOR RELEASE; MEMBRANE FUSION; MOLECULAR BIOLOGY; NEUROBIOLOGY; NONHUMAN; PSEUDORABIES HERPETOVIRUS; REVIEW; SYNAPTIC TRANSMISSION; TRANSCRIPTION REGULATION; VETERINARY MEDICINE; VIRION; VIROLOGY; VIRUS GENOME; VIRUS INFECTION; VIRUS PARTICLE; VIRUS REACTIVATION; VIRUS REPLICATION; VIRUS VIRULENCE;

ANIMALS; CENTRAL NERVOUS SYSTEM VIRAL DISEASES; DISEASE MODELS, ANIMAL; GENOME, VIRAL; HERPESVIRUS 1, SUID; PSEUDORABIES; SWINE; SWINE DISEASES; VIRUS REPLICATION;

ANIMALIA; HERPESVIRIDAE; SUID HERPESVIRUS 1; SUS SCROFA;

EID: 24944433231     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/MMBR.69.3.462-500.2005     Document Type: Review

References (454)

1. Abmayr, S. M., J. L. Workman, and R. G. Roeder. 1988. The pseudorabies immediate-early protein stimulates in vitro transcription by facilitating TFIID: promoter interactions. Genes Dev. 2:542-553.
2. Adams, R., C. Cunningham, M. D. Davlson, C. A. MacLean, and A. J. Davison. 1998. Characterization of the protein encoded by gene UL49A of herpes simplex virus type 1. J. Gen. Virol. 79:813-823.
3. Adelman, K., B. Salmon, and J. D. Baines. 2001. Herpes simplex virus DNA packaging sequences adopt novel structures that are specifically recognized by a component of the cleavage and packaging machinery. Proc. Natl. Acad. Sci. USA 98:3086-3091.
4. Aleman, N., M. I. Quiroga, M. Lopez-Pena, S. Vazquez, F. H. Guerrero, and J. M. Nieto. 2003. L-particle production during primary replication of pseudorabies virus in the nasal mucosa of swine. J. Virol. 77:5657-5667.
5. Ambagala, A. P., R. S. Gopinath, and S. Srikumaran. 2003. Inhibition of TAP by pseudorabies virus is independent of its vhs activity. Virus Res. 96:37-48.
6. Andries, K., M. B. Pensaert, and J. Vandeputte. 1978. Effect of experimental infection with pseudorabies (Aujeszky's disease) virus on pigs with maternal immunity from vaccinated sows. Am. J. Vet. Res. 39:1282-1285.
7. Angelucci, A., F. Clasca, and M. Sur. 1996. Anterograde axonal tracing with the subunit B of cholera toxin: a highly sensitive immunohistochemical protocol for revealing fine axonal morphology in adult and neonatal brains. J. Neurosci. Methods 65:101-112.
8. Aston-Jones, G., and J. P. Card. 2000. Use of pseudorabies virus to delineate multisynaptic circuits in brain: opportunities and limitations. J. Neurosci. Methods 103:51-61.
9. Aubert, M., and J. A. Blaho. 2001. Modulation of apoptosis during herpes simplex virus infection in human cells. Microbes Infect. 3:859-866.
10. Aujeszky, A. 1902. Ueber eine neue Infektions-krankheit bei Haustieren. Zentralbl. Bakteriol. 32:353-357. (In German.)
11. Avitabile, E., G. Lombardi, T. Gianni, M. Capri, and G. Campadelli-Fiume. 2004. Coexpression of UL20p and gK inhibits cell-cell fusion mediated by herpes simplex virus glycoproteins gD, gH-gL, and wild-type gB or an endocytosis-defective gB mutant and downmodulates their cell surface expression. J. Virol. 78:8015-8025.
12. Babic, N., B. Klupp, A. Brack, T. C. Mettenleiter, G. Ugolini, and A. Flamand. 1996. Deletion of glycoprotein gE reduces the propagation of pseudorabies virus in the nervous system of mice after intranasal inoculation. Virology 219:279-284.
13. Babic, N., B. G. Klupp, B. Makoschey, A. Karger, A. Flamand, and T. C. Mettenleiter. 1996. Glycoprotein gH of pseudorabies virus is essential for penetration and propagation in cell culture and in the nervous system of mice. J. Gen. Virol. 77 (Pt 9):2277-2285.
14. Babic, N., T. C. Mettenleiter, G. Ugolini, A. Flamand, and P. Coulon. 1994. Propagation of pseudorabies virus in the nervous system of the mouse after intranasal inoculation. Virology 204:616-625.
15. Baines, J. D., C. Cunningham, D. Nalwanga, and A. Davison. 1997. The U(L)15 gene of herpes simplex virus type 1 contains within its second exon a novel open reading frame that is translated in frame with the U(L)15 gene product. J. Virol. 71:2666-2673.
16. Baines, J. D., A. P. Poon, J. Rovnak, and B. Roizman. 1994. The herpes simplex virus 1 UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA. J. Virol. 68:8118-8124.
17. Banfield, B. W., J. D. Kaufman, J. A. Randall, and G. E. Pickard. 2003. Development of pseudorabies virus strains expressing red fluorescent proteins: new tools for multisynaptic labeling applications. J. Virol. 77:10106-10112.
18. Banfield, B. W., G. S. Yap, A. C. Knapp, and L. W. Enquist. 1998. A chicken embryo eye model for the analysis of alphaherpesvirus neuronal spread and virulence. J. Virol. 72:4580-4588.
19. Baradaran, K., M. A. Hardwicke, C. E. Dabrowski, and P. A. Schaffen 1996. Properties of the novel herpes simplex virus type 1 origin binding protein. OBPC. J. Virol. 70:5673-5679.
20. Bareyre, F. M., M. Kerschensteiner, O. Raineteau, T. C. Mettenleiter, O. Weinmann, and M. E. Schwab. 2004. The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat. Neurosci. 7:269-277.
21. Barnett, E. M., M. D. Cassell, and S. Perlman. 1993. Two neurotropic viruses, herpes simplex virus type 1 and mouse hepatitis virus, spread along different neural pathways from the main olfactory bulb. Neuroscience 57: 1007-1025.
22. Barnett, E. M., G. D. Evans, N. Sun, S. Perlman, and M. D. Cassell. 1995. Anterograde tracing of trigeminal afferent pathways from the murine tooth pulp to cortex using herpes simplex virus type 1. J. Neurosci. 15:2972-2984.
23. Bartha, A. 1961. Experimental reduction of virulence of Aujeszky's disease virus. Mag. Allatorv. Lapja 16:42-45. (In Hungarian.)
24. Batterson, W., and B. Roizman. 1983. Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes. J. Virol. 46:371-377.
25. Baumeister, J., B. G. Klupp, and T. C. Mettenleiter. 1995. Pseudorabies virus and equine herpesvirus 1 share a nonessential gene which is absent in other herpesviruses and located adjacent to a highly conserved gene cluster. J. Virol. 69:5560-5567.
26. Ben-Porat, T., J. M. Demarchi, and A. S. Kaplan. 1974. Characterization of defective interfering viral particles present in a population of pseudorabies virions. Virology 61:29-37.
27. Ben-Porat, T., J. M. DeMarchi, B. Lomniczi, and A. S. Kaplan. 1986. Role of glycoproteins of pseudorabies virus in eliciting neutralizing antibodies. Virology 154:325-334.
28. Ben-Porat, T., and A. S. Kaplan. 1976. A comparison of two populations of defective, interfering pseudorabies virus particles. Virology 72:471-479.
29. Ben-Porat, T., and A. S. Kaplan. 1985. Molecular biology of pseudorabies virus, p. 105-173. In B. Roizman (ed.), The herpesviruses, vol. 3. Plenum Press, New York, N.Y.
30. Ben-Porat, T., T. Rakusanova, and A. S. Kaplan. 1971. Early functions of the genome of herpesvirus. II. Inhibition of the formation of cell-specific polysomes. Virology 46:890-599.
31. Ben-Porat, T., R. A. Veach, and H. Hampl. 1983. Functions of the major nonstructural DNA binding protein of a herpesvirus (pseudorabies). Virology 124:411-424.
32. Ben-Porat, T., R. A. Veach, and S. Ihara. 1983. Localization of the regions of homology between the genomes of herpes simplex virus, type 1, and pseudorabies virus. Virology 127:194-204.
33. Benetti, L., and B. Roizman. 2004. Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis. Proc. Natl. Acad. Sci. USA 101:9411-9416.
34. Berthomme, H., B. Jacquemont, and A. Epstein. 1993. The pseudorabies virus host-shutoff homolog gene: nucleotide sequence and comparison with alphaherpesvirus protein counterparts. Virology 193:1028-1032.
35. Berthomme, H., S. J. Monahan, D. S. Parris, B. Jacquemont, and A. L. Epstein. 1995. Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: evidence for specificity of interaction. J. Virol. 69:2811-2818.
36. Billig, I., J. P. Card, and B. J. Yates. 2003. Neurochemical phenotypes of MRF neurons influencing diaphragm and reclus abdomin is activity. J. Appl. Physiol. 94:391-398.
37. Boehmer, P. E., and I. R. Lehman. 1997. Herpes simplex virus DNA replication. Annu. Rev. Biochem. 66:347-384.
38. Boldogkoi, Z., A. Braun, and I. Fodor. 2000. Replication and virulence of early protein 0 and long latency transcript deficient mutants of the Aujeszky's disease (pseudorabies) virus. Microbes Infect. 2:1321-1328.
39. Boldogkoi, Z., I. Medveczky, R. Glarits, A. Braun, and I. Fodor. 1996. In vivo studies on Aujeszky's disease virus mutants. Acta Microbiol. Immunol. Hung. 43:307-318.
40. Boldogkoi, Z., and A. Nogradi. 2003. Gene and cancer therapy-pseudorabies virus: a novel research and therapeutic tool? Curr. Gene Ther. 3:155-182.
41. Boldogkoi, Z., A. Sik, A. Denes, A. Reichart, J. Toldi, I. Gerendal, K. J. Kovacs, and M. Palkovits. 2004. Novel tracing paradigms-genetically engineered herpesviruses as tools for mapping functional circuits within the CNS: present status and future prospects. Prog. Neurobiol. 72:417-445.
42. Booy, F. P., W. W. Newcomb, B. L. Trus, J. C. Brown, T. S. Baker, and A. C. Steven. 1991. Liquid-crystalline, phage-like packing of encapsidated DNA in herpes simplex virus. Cell 64:1007-1015.
43. Booy, F. P., B. L. Trus, W. W. Newcomb, J. C. Brown, J. F. Conway, and A. C. Steven. 1994. Finding a needle in a haystack: detection of a small protein (the 12-kDa VP26) in a large complex (the 200-MDa capsid of herpes simplex virus). Proc. Natl. Acad. Sci. USA 91:5652-5656.
44. Brack, A. R., J. M. Dijkstra, H. Granzow, B. G. Klupp, and T. C. Mettenleiter. 1999. Inhibition of virion maturation by simultaneous deletion of glycoproteins E, I, and M of pseudorabies virus. J. Virol. 73:5364-5372.
45. Brack, A. R., B. G. Klupp, H. Granzow, R. Tirabassi, L. W. Enquist, and T. C. Mettenleiter. 2000. Role of the cytoplasmic tail of pseudorabies virus glycoprotein E in virion formation. J. Virol. 74:4004-4016.
46. Bras, F., S. Dezelee, B. Simonet, X. Nguyen, P. Vende, A. Flamand, and M. J. Masse. 1999. The left border of the genomic inversion of pseudorabies virus contains genes homologous to the UL46 and UL47 genes of herpes simplex virus type 1, but no UL45 gene. Virus Res. 60:29-40.
47. Brideau, A. D., J. P. Card, and L. W. Enquist. 2000. Role of pseudorabies virus Us9, a type II membrane protein, in infection of tissue culture cells and the rat nervous system. J. Virol. 74:834-845.
48. Brideau, A. D., M. G. Eldridge, and L. W. Enquist. 2000. Directional transneuronal infection by pseudorabies virus is dependent on an acidic internalization motif in the Us9 cytoplasmic tail. J. Virol. 74:4549-4561.
49. Brideau, A. D., L. W. Enquist, and R. S. Tirabassi. 2000. The role of virion membrane protein endocytosis in the herpesvirus life cycle. J. Clin. Virol. 17:69-82.
50. Brittle, E. E. 2005. Two modes of pseudorabies virus neuroinvasion and lethality in mice. Ph.D. Thesis. Princeton University. Princeton, N.J.
51. Brittle, E. E., A. E. Reynolds, and L. W. Enquist. 2004. Two modes of pseudorabies virus neuroinvasion and lethality in mice. J. Virol. 78:12951-12963.
52. Brockmeier, S. L., K. M. Lager, and W. L. Mengeling. 1993. Comparison of in vivo reactivation, in vitro reactivation, and polymerase chain reaction for detection of latent pseudorabies virus infection in swine. J. Vet. Diagn. Investig. 5:505-509.
53. Brown, T. T., Jr., K. O. Shin, and F. J. Fuller. 1995. Detection of pseudorabies viral DNA in tonsillar epithelial cells of latently infected pigs. Am. J. Vet. Res. 56:587-594.
54. Browne, E. P., B. Wing, D. Coleman, and T. Shenk. 2001. Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs. J. Virol. 75:12319-12330.
55. Calton, C. M., J. A. Randall, M. W. Adkins, and B. W. Banfield. 2004. The pseudorabies virus serine/threonine kinase Us3 contains mitochondrial, nuclear and membrane localization signals. Virus Genes 29:131-145.
56. Campadelli-Fiume, G., M. Arsenakis, F. Farabegoli, and B. Roizman. 1988. Entry of herpes simplex virus 1 in BJ cells that constitutively express viral glycoprotein D is by endocytosis and results in degradation of the virus. J. Virol. 62:159-167.
57. Campbell, M. E., J. W. Palfreyman, and C. M. Preston. 1984. Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription. J. Mol. Biol. 180:1-19.
58. Campbell, M. E., and C. M. Preston. 1987. DNA sequences which regulate the expression of the pseudorabies virus major immediate early gene. Virology 157:307-316.
59. Cano, G., J. P. Card, and A. F. Sved. 2004. Dual viral transneuronal tracing of central autonomic circuits involved in the innervation of the two kidneys in rat. J. Comp. Neurol. 471:462-481.
60. Capua, I., R. Fico, M. Banks, M. Tamba, and G. Calzetta. 1997. Isolation and characterisation of an Aujeszky's disease virus naturally infecting a wild boar (Sus scrofa). Vet. Microbiol. 55:141-146.
61. Card, J. P., J. R. Dubin, M. E. Whealy, and L. W. Enquist. 1995. Influence of infectious dose upon productive replication and transynaptic passage of pseudorabies virus in rat central nervous system. J. Neurovirol. 1:349-358.
62. Card, J. P., L. W. Enquist, and R. Y. Moore. 1999. Neuroinvasiveness of pseudorabies virus injected intracerebrally is dependent on viral concentration and terminal field density. J. Comp. Neurol. 407:438-452.
63. Card, J. P., L. Rinaman, R. B. Lynn, B. H. Lee, R. P. Meade, R. R. Miselis, and L. W. Enquist. 1993. Pseudorabies virus infection of the rat central nervous system: ultrastructural characterization of viral replication, transport, and pathogenesis. J. Neurosci. 13:2515-2539.
64. Card, J. P., L. Rinaman, J. S. Schwaber, R. R. Miselis, M. E. Whealy, A. K. Robbins, and L. W. Enquist. 1990. Neurotropic properties of pseudorabies virus: uptake and transneuronal passage in the rat central nervous system. J. Neurosci. 10:1974-1994.
65. Card, J. P., M. E. Whealy, A. K. Robbins, and L. W. Enquist. 1992. Pseudorabies virus envelope glycoprotein gI influences both neurotropism and virulence during infection of the rat visual system. J. Virol. 66:3032-3041.
66. Card, J. P., M. E. Whealy, A. K. Robbins, R. Y. Moore, and L. W. Enquist. 1991. Two alpha-herpesvirus strains are transported differentially in the rodent visual system. Neuron 6:957-969.
67. Carr, D. B., P. O'Donnell, J. P. Card, and S. R. Sesack. 1999. Dopamine terminals in the rat prefrontal cortex synapse on pyramidal cells that project to the nucleus accumbens. J. Neurosci. 19:11049-11060.
68. Cartier, A., E. Broberg, T. Komai, M. Henriksson, and M. G. Masucci. 2003. The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B. Cell Death Differ. 10: 1320-1328.
69. Cartier, A., T. Komai, and M. G. Masucci. 2003. The Us3 protein kinase of herpes simplex virus 1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad. Exp. Cell Res. 291:242-250.
70. Catalano, C. E. 2000. The terminase enzyme from bacteriophage lambda: a DNA-packaging machine. Cell. Mol. Life Sci. 57:128-148.
71. Ch'ng, T. H., and L. W. Enquist. 2005. Efficient axonal localization of alphaherpesvirus structural proteins in cultured sympathetic neurons requires viral glycoprotein E. J. Virol. 79:8835-8846.
72. Ch'ng, T. H., and L. W. Enquist. Neuron-to-cell spread of pseudorabies virus in a compartmented neuronal culture system. J. Virol., in press.
73. Chang, Y. Y., H. W. Lin, M. L. Wong, and T. J. Chang. 2004. Regulation of the vhs gene promoter of pseudorabies virus by IE180 and EP0, and the requirement of a Sp1 Site for the promoter function. Virus Genes 28:247-258.
74. Chen, S., M. Yang, R. R. Miselis, and G. Aston-Jones. 1999. Characterization of transsynaptic tracing with central application of pseudorabies virus. Brain Res. 838:171-183.
75. Chen, X., M. C. Schmidt, W. F. Coins, and J. C. Glorioso. 1995. Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections. J. Virol. 69:7899-7908.
76. Cheung, A. K. 1991. Cloning of the latency gene and the early protein 0 gene of pseudorabies virus. J. Virol. 65:5260-5271.
77. Cheung, A. K. 1989, Detection of pseudorabies virus transcripts in trigeminal ganglia of latently infected swine. J. Virol. 63:2908-2913.
78. Cheung, A. K. 1989. DNA nucleotide sequence analysis of the immediate-early gene of pseudorabies virus. Nucleic Acids Res. 17:4637-4646.
79. Cheung, A. K. 1988. Fine mapping of the immediate-early gene of the Indiana-Funkhauser strain of pseudorabies virus. J. Virol. 62:4763-4766.
80. Cheung, A. K. 1996. Latency characteristics of an EPO and LLT mutant of pseudorabies virus. J. Vet. Diagn. Investig. 8:112-115.
81. Cheung, A. K., J. Fang, and R. D. Wesley. 1994. Characterization of a pseudorabies virus that is defective in the early protein 0 and latency genes. Am. J. Vet. Res. 55:1710-1716.
82. Cheung, A. K., and T. A. Smith. 1999. Analysis of the latency-associated transcript/UL1-3.5 gene cluster promoter complex of pseudorabies virus. Arch. Virol. 144:381-391.
83. Cheung, P., K. S. Ellison, R. Verity, and J. R. Smiley. 2000. Herpes simplex virus ICP27 induces cytoplasmic accumulation of unspliced polyadenylated alpha-globin pre-mRNA in infected HeLa cells. J. Virol. 74:2913-2919.
84. Chi, J. H., C. A. Harley, A. Mukhopadhyay, and D. W. Wilson. 2005. The cytoplasmic tail of herpes simplex virus envelope glycoprotein D binds to the tegument protein VP22 and to capsids. J. Gen. Virol. 86:253-261.
85. Chien, C. H., J. Y. Shieh, M. H. Liao, E. A. Ling, and C. Y. Wen. 1998. Neuronal connections between the auricular skin and the sympathetic pre- and postganglionic neurons of the dog as studied by using pseudorabies virus. Neurosci. Res. 30:169-175.
86. Chlan, C. A., C. Coulter, and L. T. Feldman. 1987. Binding of the pseudorabies virus immediate-early protein to single-stranded DNA. J. Virol. 61:1855-1860.
87. Ciernik, I. F., J. A. Berzofsky, and D. P. Carbone. 1996. Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes. J. Immunol. 156:2369-2375.
88. Cocchi, F., L. Menotti, P. Mirandola, M. Lopez, and G. Campadelli-Fiume. 1998. The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells. J. Virol. 72:9992-10002.
89. Coe, N. E., and W. L. Mengeling. 1990. Mapping and characterization of neutralizing epitopes of glycoproteins gIII and gp50 of the Indiana-Funkhauser strain of pseudorabies virus. Arch. Virol. 110:137-142.
90. Cohen, G. H., D. Long, J. T. Matthews, M. May, and R. Eisenberg. 1983. Glycopeptides of the type-common glycoprotein gD of herpes simplex virus types 1 and 2. J. Virol. 46:679-689.
91. Cohen, J. I., and S. E. Straus. 2001. Varicella-zoster virus and its replication, p. 2707-2730. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed., vol. 2. Lippincott Williams & Wilkins, Philadelphia, Pa.
92. Corn, J. L., D. E. Stallknecht, N. M. Mechlin, M. P. Luttrell, and J. R. Fischer. 2004. Persistence of pseudorabies virus in feral swine populations. J. Wildl. Dis. 40:307-310.
93. Cromlish, W. A., S. M. Abmayr, J. L. Workman, M. Horikoshi, and R. G. Roeder. 1989. Transcriptionally active immediate-early protein of pseudorabies virus binds to specific sites on class II gene promoters. J. Virol. 63:1869-1876.
94. Crump, C. M., B. Bruun, S. Bell, L. E. Pomeranz, T. Minson, and H. M. Browne. 2004. Alphaherpesvirus glycoprotein M causes the relocalization of plasma membrane proteins. J. Gen. Virol. 85:3517-3527.
95. Dargan, D. J., and J. H. Subak-Sharpe. 1997. The effect of herpes simplex virus type 1 L-particles on virus entry, replication, and the infectivity of naked herpesvirus DNA. Virology 239:378-388.
96. Davies, E. B., and G. W. Beran. 1980. Spontaneous shedding of pseudorabies virus from a clinically recovered postparturient sow. J. Am. Vet. Med. Assoc. 176:1345-1347.
97. Davis-Poynter, N. J., and H. E. Farrell. 1996. Masters of deception: a review of herpesvirus immune evasion strategies. Immunol. Cell Biol. 74: 513-522.
98. Davis, S. F., K. W. Williams, W. Xu, N. R. Glatzer, and B. N. Smith. 2003. Selective enhancement of synaptic inhibition by hypocretin (orexin) in rat vagal motor neurons: implications for autonomic regulation. J. Neurosci. 23:3844-3854.
99. Davison, A. J. 1992. Channel catfish virus: a new type of herpesvirus. Virology 186:9-14.
100. Davison, A. J. 2002. Evolution of the herpesviruses. Vet. Microbiol. 86:69-88.
101. de Groat, W. C., I. Araki, M. A. Vizzard, M. Yoshiyama, N. Yoshimura, K. Sugaya, C. Tai, and J. R. Roppolo. 1998. Developmental and injury induced plasticity in the micturition reflex pathway. Behav. Brain Res. 92:127-140.
102. de Leeuw, P. W., and J. T. van Oirschot. 1985. Vaccines against Aujeszky's disease: evaluation of their efficacy under standardized laboratory conditions. Vet. Q. 7:191-197.
103. de Wind, N., A. Berns, A. Gielkens, and T. Kimman. 1993. Ribonucleotide reductase-deficient mutants of pseudorabies virus are avirulent for pigs and induce partial protective immunity. J. Gen. Virol. 74:351-359.
104. de Wind, N., B. P. Peeters, A. Zuderveld, A. L. Gielkens, A. J. Berns, and T. G. Kimman. 1994. Mutagenesis and characterization of a 41-kilobase-pair region of the pseudorabies virus genome: transcription map, search for virulence genes, and comparison with homologs of herpes simplex virus type 1. Virology 200:784-790.
105. Dean, H. J., and A. K. Cheung. 1993. A 3′ coterminal gene cluster in pseudorabies virus contains herpes simplex virus UL1, UL2, and UL3 gene homologs and a unique UL3.5 open reading frame. J. Virol. 67:5955-5961.
106. DeFalco, J., M. Tomishima, H. Liu, C. Zhao, X. Cai, J. D. Marth, L. Enquist, and J. M. Friedman. 2001. Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science 291:2608-2613.
107. del Rio, T., T. H. Ch'ng, E. A. Flood, S. P. Gross, and L. W. Enquist. 2005. Heterogeneity of a fluorescent tegument component in single pseudorabies virus virions and enveloped axonal assemblies. J. Virol. 79:3903-3919.
108. Del Rio, T., C. J. Decoste, and L. W. Enquist. 2005. Actin is a component of the compensation mechanism in pseudorabies virus virions lacking the major tegument protein VP22. J. Virol. 79:8614-8619.
109. del Rio, T., H. C. Werner, and L. W. Enquist. 2002. The pseudorabies virus VP22 homologue (UL49) is dispensable for virus growth in vitro and has no effect on virulence and neuronal spread in rodents. J. Virol. 76:774-782.
110. Dézélée, S., F. Bras, P. Vende, B. Simonet, X. Nguyen, A. Flamand, and M. J. Masse. 1996. The BamHI fragment 9 of pseudorabies virus contains genes homologous to the UL24, UL25, UL26, and UL 26.5 genes of herpes simplex virus type 1. Virus Res. 42:27-39.
111. Dietz, P., B. G. Klupp, W. Fuchs, B. Kollner, E. Weiland, and T. C. Mettenleiter. 2000. Pseudorabies virus glycoprotein K requires the UL20 gene product for processing. J. Virol. 74:5083-5090.
112. Dijkstra, J. M., W. Fuchs, T. C. Mettenleiter, and B. G. Klupp. 1997. Identification and transcriptional analysis of pseudorabies virus UL6 to UL12 genes. Arch. Virol. 142:17-35.
113. Döhner, K., A. Wolfstein, U. Prank, C. Echeverri, D. Dujardin, R. Vallee, and B. Sodeik. 2002. Function of dynein and dynactin in herpes simplex virus capsid transport. Mol. Biol. Cell 13:2795-2809.
114. Elgadi, M. M., C. E. Hayes, and J. R. Smiley. 1999. The herpes simplex virus vhs protein induces endoribonucleolytic cleavage of target RNAs in cell extracts. J. Virol. 73:7153-7164.
115. Eloit, M., D. Fargeaud, R. L'Haridon, and B. Toma. 1988. Identification of the pseudorabies virus glycoprotein gp50 as a major target of neutralizing antibodies. Arch. Virol. 99:45-56.
116. Enquist, L. W. 2002. Exploiting circuit-specific spread of pseudorabies virus in the central nervous system: insights to pathogenesis and circuit tracers. J. Infect. Dis. 186(Suppl. 2):S209-214.
117. Enquist, L. W. 1994. Infection of the mammalian nervous system by pseudorabies virus (PRV). Semin. Virol. 5:221-231.
118. Enquist, L. W. 1999. Life beyond eradication: veterinary viruses in basic science. Arch. Virol. Suppl. 15:87-109.
119. Enquist, L. W., and J. P. Card. 2003. Recent advances in the use of neurotropic viruses for circuit analysis. Curr. Opin. Neurobiol. 13:603-606.
120. Enquist, L. W., J. Dubin, M. E. Whealy, and J. P. Card. 1994. Complementation analysis of pseudorabies virus gE and gI mutants in retinal ganglion cell neurotropism. J. Virol. 68:5275-5279.
121. Enquist, L. W., P. J. Husak, B. W. Banfield, and G. A. Smith. 1999. Infection and spread of alphaherpesviruses in the nervous system. Adv. Virus Res. 51:237-347.
122. Fabian, R. H., and J. D. Coulter. 1985. Transneuronal transport of lectins. Brain Res. 344:41-48.
123. Farnsworth, A., K. Goldsmith, and D. C. Johnson. 2003. Herpes simplex virus glycoproteins gD and gE/gI serve essential but redundant functions during acquisition of the virion envelope in the cytoplasm. J. Virol. 77: 8481-8494.
124. Farrell, M. J., A. T. Dobson, and L. T. Feldman. 1991. Herpes simplex virus latency-associated transcript is a stable intron. Proc. Natl. Acad. Sci. USA 88:790-794.
125. Favoreel, H. W., H. J. Nauwynck, and M. B. Pensaert. 1999. Role of the cytoplasmic tail of gE in antibody-induced redistribution of viral glycoproteins expressed on pseudorabies-virus-infected cells. Virology 259:141-147.
126. Favoreel, H. W., G. Van Minnebruggen, H. J. Nauwynck, L. W. Enquist, and M. B. Pensaert. 2002. A tyrosine-based motif in the cytoplasmic tail of pseudorabies virus glycoprotein B is important for both antibody-induced internalization of viral glycoproteins and efficient cell-to-cell spread. J. Virol. 76:6845-6851.
127. Feldman, L., F. J. Rixon, J. H. Jean, T. Ben-Porat, and A. S. Kaplan. 1979. Transcription of the genome of pseudorabies virus (a herpesvirus) is strictly controlled. Virology 97:316-327.
128. Field, H. J., and T. J. Hill. 1974. The pathogenesis of pseudorabies in mice following peripheral inoculation. J. Gen. Virol. 23:145-157.
129. Flamand, A., T. Bennardo, N. Babic, B. G. Klupp, and T. C. Mettenleiter. 2001. The absence of glycoprotein gL, but not gC or gK, severely impairs pseudorabies virus neuroinvasiveness. J. Virol. 75:11137-11145.
130. Fort, P., P. H. Luppi, and M. Jouvet. 1994. Afferents to the nucleus reticularis parvicellularis of the cat medulla oblongata: a tract-tracing study with cholera toxin B subunit. J. Comp. Neurol. 342:603-618.
131. Frenkel, N., R. J. Jacob, R. W. Honess, G. S. Hayward, H. Locker, and B. Roizman. 1975. Anatomy of herpes simplex virus DNA. III. Characterization of defective DNA molecules and biological properties of virus populations containing them. J. Virol. 16:153-167.
132. Fuchs, W., C. Ehrlich, B. G. Klupp, and T. C. Mettenleiter. 2000. Characterization of the replication origin (Ori(S)) and adjoining parts of the inverted repeat sequences of the pseudorabies virus genome. J. Gen. Virol. 81:1539-1543.
133. Fuchs, W., H. Granzow, B. G. Klupp, M. Kopp, and T. C. Mettenleiter. 2002. The UL48 tegument protein of pseudorabies virus is critical for intracytoplasmic assembly of infectious virions. J. Virol. 76:6729-6742.
134. Fuchs, W., H. Granzow, and T. C. Mettenleiter. 2003. A pseudorabies virus recombinant simultaneously lacking the major tegument proteins encoded by the UL46, UL47, UL48, and UL49 genes is viable in cultured cells. J. Virol. 77:12891-12900.
135. Fuchs, W., B. G. Klupp, H. Granzow, C. Hengartner, A. Brack, A. Mundt, L. W. Enquist, and T. C. Mettenleiter. 2002. Physical interaction between envelope glycoproteins E and M of pseudorabies virus and the major tegument protein UL49. J. Virol. 76:8208-8217.
136. Fuchs, W., B. G. Klupp, H. Granzow, and T. C. Mettenleiter. 2004. Essential function of the pseudorabies virus UL36 gene product is independent of its interaction with the UL37 protein. J. Virol. 78:11879-11889.
137. Fuchs, W., B. G. Klupp, H. Granzow, and T. C. Mettenleiter. 1997. The UL20 gene product of pseudorabies virus functions in virus egress. J. Virol. 71:5639-5646.
138. Fuchs, W., B. G. Klupp, H. Granzow, N. Osterrieder, and T. C. Mettenleiter. 2002. The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not mature virions. J. Virol. 76:364-378.
139. Fuchs, W., B. G. Klupp, H. Granzow, H. J. Rziha, and T. C. Mettenleiter. 1996. Identification and characterization of the pseudorabies virus UL3.5 protein, which is involved in virus egress. J. Virol. 70:3517-3527.
140. Fujisawa, H., and M. Morita. 1997. Phage DNA packaging. Genes Cells 2:537-545.
141. Garner, J. A., and J. H. LaVail. 1999. Differential anterograde transport of HSV type 1 viral strains in the murine optic pathway. J. Neurovirol. 5:140-150.
142. Geenen, K., H. W. Favoreel, and H. J. Nauwynck. 2005. Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro. J. Gen. Virol. 86:1251-1260.
143. Geenen, K., H. W. Favoreel, L. Olsen, L. W. Enquist, and H. J. Nauwynck. 2005. The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine. Virology 331:144-150.
144. Geerling, J. C., T. C. Mettenleiter, and A. D. Loewy. 2003. Orexin neurons project to diverse sympathetic outflow systems. Neuroscience 122:541-550.
145. Geraghty, R. J., C. R. Jogger, and P. G. Spear. 2000. Cellular expression of alphaherpesvirus gD interferes with entry of homologous and heterologous alphaherpesviruses by blocking access to a shared gD receptor. Virology 268:147-158.
146. Geraghty, R. J., C. Krummenacher, G. H. Cohen, R. J. Eisenberg, and P. G. Spear. 1998. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280:1618-1620.
147. Gerdts, V., A. Jöns, B. Makoschey, N. Visser, and T. C. Mettenleiter. 1997. Protection of pigs against Aujeszky's disease by DNA vaccination. J. Gen. Virol. 78:2139-2146.
148. Gerdts, V., A. Jöns, and T. C. Mettenleiter. 1999. Potency of an experimental DNA vaccine against Aujeszky's disease in pigs. Vet. Microbiol. 66:1-13.
149. Gibson, W., and B. Roizman. 1972. Proteins specified by herpes simplex virus. 8. Characterization and composition of multiple capsid forms of subtypes 1 and 2. J. Virol. 10:1044-1052.
150. Glass, C. M., R. G. McLean, J. B. Katz, D. S. Maehr, C. B. Cropp, L. J. Kirk, A. J. McKeirnan, and J. F. Evermann. 1994. Isolation of pseudorabies (Aujeszky's disease) virus from a Florida panther. J. Wildl. Dis. 30:180-184.
151. Glatzer, N. R., C. P. Hasney, M. D. Bhaskaran, and B. N. Smith. 2003. Synaptic and morphologic properties in vitro of premotor rat nucleus tractus solitarius neurons labeled transneuronally from the stomach. J. Comp. Neurol. 464:525-539.
152. Glazenburg, K. L., B. P. Peeters, J. M. Pol, A. L. Gielkens, and R. J. Moormann. 1995. Construction and properties of pseudorabies virus recombinants with altered control of immediate-early gene expression. J. Virol. 69:189-197.
153. Granzow, H., B. G. Klupp, W. Fuchs, J. Veits, N. Osterrieder, and T. C. Mettenleiter. 2001. Egress of alphaherpesviruses: comparative ultrastructural study. J. Virol. 75:3675-3684.
154. Granzow, H., B. G. Klupp, and T. C. Mettenleiter. 2005. Entry of pseudorabies virus: an immunogold-labding study. J. Virol. 79:3200-3205.
155. Granzow, H., B. G. Klupp, and T. C. Mettenleiter. 2004. The pseudorabies virus US3 protein is a component of primary and of mature virions. J. Virol. 78:1314-1323.
156. Granzow, H., F. Weiland, A. Jöns, B. G. Klupp, A. Karger, and T. C. Mettenleiter. 1997. Ultrastructural analysis of the replication cycle of pseudorabies virus in cell culture: a reassessment. J. Virol. 71:2072-2082.
157. Green, M. R., R. Treisman, and T. Maniatis. 1983. Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. Cell 35:137-148.
158. Gross, S. T., C. A. Harley, and D. W. Wilson. 2003. The cytoplasmic tail of Herpes simplex virus glycoprotein H binds to the tegument protein VP16 in vitro and in vivo. Virology 317:1-12.
159. Grunewald, K., P. Desai, D. C. Winkler, J. B. Heymann, D. M. Belnap, W. Baumeister, and A. C. Steven. 2003. Three-dimensional structure of herpes simplex virus from cryo-electron tomography. Science 302:1396-1398.
160. Gustafson, D. P. 1986. Pseudorabies, p. 209-223. In A. D. Leman, R. D. Clock, W. L. Mengeling, R. H. C. Penny, E. Scholl, and B. Straw (ed.), Diseases of swine, 6th ed. Iowa State University Press, Ames, Iowa.
161. Gutekunst, D. E., E. C. Pirtle, L. D. Miller, and W. C. Stewart. 1980. Isolation of pseudorabies virus from trigeminal ganglia of a latently infected sow. Am. J. Vet. Res. 41:1315-1316.
162. Hagglund, R., and B. Roizman. 2004. Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1. J. Virol. 78:2169-2178.
163. Hahn, E. C., G. R. Page, P. S. Hahn, K. D. Gillis, C. Romero, J. A. Annelli, and E. P. Gibbs. 1997. Mechanisms of transmission of Aujeszky's disease virus originating from feral swine in the USA. Vet. Microbiol. 55:123-130.
164. Hampl, H., T. Ben-Porat, L. Ehrlicher, K. O. Habermehl, and A. S. Kaplan. 1984. Characterization of the envelope proteins of pseudorabies virus. J. Virol. 52:583-590.
165. Hanson, R. P. 1954. The history of pseudorabies in the United States. J. Am. Vet. Med. Assoc. 124:259-261.
166. Hardwicke, M. A., and R. M. Sandri-Goldin. 1994. The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection. J. Virol. 68:4797-4810.
167. Hardy, W. R., and R. M. Sandri-Goldin. 1994. Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect. J. Virol. 68:7790-7799.
168. Harley, C. A., A. Dasgupta, and D. W. Wilson. 2001. Characterization of herpes simplex virus-containing organelles by subcellular fractionation: role for organelle acidification in assembly of infectious particles. J. Virol. 75: 1236-1251.
169. Harper, L., J. Demarchi, and T. Ben-Porat. 1986. Sequence of the genome ends and of the junction between the ends in concatemeric DNA of pseudorabies virus. J. Virol. 60:1183-1185.
170. Harrison, P. J., H. Hultborn, E. Jankowska, R. Katz, B. Storai, and D. Zytnicki. 1984. Labelling of interneurones by retrograde transsynaptic transport of horseradish peroxidase from motoneurones in rats and cats. Neurosci. Lett. 45:15-19.
171. Hassett, D. E., and J. L. Whitton. 1996. DNA immunization. Trends Microbiol. 4:307-312.
172. Hata, A. N., and R. M. Breyer. 2004. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 103:147-166.
173. Hata, S., A. H. Koyama, H. Shiota, A. Adachi, F. Goshima, and Y. Nishiyama. 1999. Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene. Microbes Infect. 1:601-607.
174. Henry, B. E., W. W. Newcomb, and D. J. O'Callaghan. 1979. Biological and biochemical properties of defective interfering particles of equine herpes-virus type 1. Virology 92:495-506.
175. Hill, A. B., B. C. Barnett, A. J. McMichael, and D. J. McGeoch. 1994. HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2. J. Immunol. 152:2736-2741.
176. Ho, T. Y., S. L. Wu, T. J. Chang, C. H. Hsiang, S. H. Chang, and C. Y. Hsiang. 1999. Pseudorabies virus early protein 0 trans-activates the TATA-associated promoter by stimulating the transcription initiation. Virus Res. 61:77-86.
177. Homa, F. L., and J. C. Brown. 1997. Capsid assembly and DNA packaging in herpes simplex virus. Rev. Med. Virol. 7:107-122.
178. Horvath, S., E. Prandovszky, E. Pankotai, Z. Kis, T. Farkas, Z. Boldogkoi, K. Boda, Z. Janka, and J. Toldi. 2005. Use of a recombinant pseudorabies virus to analyze motor cortical reorganization after unilateral facial denervation. Cereb. Cortex 15:378-384.
179. Hsiang, C. Y. 2002. Pseudorabies virus DNA-binding protein stimulates the exonuclease activity and regulates the processivity of pseudorabies virus DNase. Biochem. Biophys. Res. Commun. 293:1301-1308.
180. Hsiang, C. Y., T. Y. Ho, and T. J. Chang. 1996. Identification of a pseudorabies virus UL12 (deoxyribonuclease) gene. Gene 177:109-113.
181. Hsiang, C. Y., T. Y. Ho, C. H. Hsiang, and T. J. Chang. 1998. Recombinant pseudorabies virus DNase exhibits a RecBCD-like catalytic function. Biochem. J. 330:55-59.
182. Huang, C., and C. Y. Wu. 2004. Characterization and expression of the pseudorabies virus early gene UL54. J. Virol. Methods 119:129-136.
183. Huang, C. J., M. K. Rice, G. B. Devi-Rao, and E. K. Wagner. 1994. The activity of the pseudorabies virus latency-associated transcript promoter is dependent on its genomic location in herpes simplex virus recombinants as well as on the type of cell infected. J. Virol. 68:1972-1976.
184. Husak, P. J., T. Kuo, and L. W. Enquist. 2000. Pseudorabies virus membrane proteins gI and gE facilitate anterograde spread of infection in projection-specific neurons in the rat. J. Virol. 74:10975-10983.
185. Ihara, S., L. Feldman, S. Watanabe, and T. Ben-Porat. 1983. Characterization of the immediate-early functions of pseudorabies virus. Virology 131:437-454.
186. Ikenaga, T., Y. Tatecho, T. Nakai, and K. Uematsu. 2002. Betanodavirus as a novel transneuronal tracer for fish. Neurosci. Lett. 331:55-59.
187. Imperiale, M. J., L. T. Feldman, and J. R. Nevins. 1983. Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element. Cell 35:127-136.
188. Irnaten, M., R. A. Neff, J. Wang, A. D. Loewy, T. C. Mettenleiter, and D. Mendelowitz. 2001. Activity of cardiorespiratory networks revealed by transsynaptic virus expressing GFP. J. Neurophysiol. 85:435-438.
189. Jansen, A. S., X. V. Nguyen, V. Karpitskiy, T. C. Mettenleiter, and A. D. Loewy. 1995. Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response. Science 270:644-646.
190. Jerome, K. R., R. Fox, Z. Chen, A. E. Sears, H. Lee, and L. Corey. 1999. Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3. J. Virol. 73:8950-8957.
191. Jin, L., and G. Scherba. 1999. Expression of the pseudorabies virus latency-associated transcript gene during productive infection of cultured cells. J. Virol. 73:9781-9788.
192. Jin, L., W. M. Schnitzlein, and G. Scherba. 2000. Identification of the pseudorabies virus promoter required for latency-associated transcript gene expression in the natural host. J. Virol. 74:6333-6338.
193. Jones, C. 2003. Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Clin. Microbiol. Rev. 16:79-95.
194. Jones, J. O., and A. M. Arvin. 2003. Microarray analysis of host cell gene transcription in response to varicella-zoster virus infection of human T cells and fibroblasts in vitro and SCIDhu skin xenografts in vivo. J. Virol. 77: 1268-1280.
195. Jöns, A., J. M. Dijkstra, and T. C. Mettenleiter. 1998. Glycoproteins M and N of pseudorabies virus form a disulfide-linked complex. J. Virol. 72:550-557.
196. Jöns, A., V. Gerdts, E. Lange, V. Kaden, and T. C. Mettenleiter. 1997. Attenuation of dUTPase-deficient pseudorabies virus for the natural host. Vet. Microbiol. 56:47-54.
197. Jöns, A., H. Granzow, R. Kuchling, and T. C. Mettenleiter. 1996. The UL49.5 gene of pseudorabies virus codes for an O-glycosylated structural protein of the viral envelope. J. Virol. 70:1237-1241.
198. Jöns, A., and T. C. Mettenleiter. 1996. Identification and characterization of pseudorabies virus dUTPase. J. Virol. 70:1242-1245.
199. Justewicz, D. M., M. J. Morin, H. L. Robinson, and R. G. Webster. 1995. Antibody-forming cell response to virus challenge in mice immunized with DNA encoding the influenza virus hemagglutinin. J. Virol. 69:7712-7717.
200. Kaelin, K., S. Dezelee, M. J. Masse, F. Bras, and A. Flamand. 2000. The UL25 protein of pseudorabies virus associates with capsids and localizes to the nucleus and to microtubules. J. Virol. 74:474-482.
201. Kaliman, A. V., Z. Boldogkoi, and I. Fodor. 1994. Large and small subunits of the Aujeszky's disease virus ribonucleotide reductase: nucleotide sequence and putative structure. Biochim. Biophys. Acta 1219:151-156.
202. Katan, M., M. J. McGarvey, W. S. Stevely, and D. P. Leader. 1986. The phosphorylation of ribosomal protein S6 by protein kinases from cells infected with pseudorabies virus. Biochem. J. 239:205-211.
203. Kaufman, G. D., M. J. Mustari, R. R. Miselis, and A. A. Perachio. 1996. Transneuronal pathways to the vestibulocerebellum. J. Comp. Neurol. 370: 501-523.
204. Kelly, R. M., and P. L. Strick. 2003. Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. J. Neurosci. 23:8432-8444.
205. Kelly, R. M., and P. L. Strick. 2000. Rabies as a transneuronal tracer of circuits in the central nervous system. J. Neurosci. Methods 103:63-71.
206. Kim, J. S., L. W. Enquist, and J. P. Card. 1999. Circuit-specific coinfection of neurons in the rat central nervous system with two pseudorabies virus recombinants. J. Virol. 73:9521-9531.
207. Kimman, T. G., G. J. Binkhorst, T. S. van den Ingh, J. M. Pol, A. L. Gielkens, and M. E. Roelvink. 1991. Aujeszky's disease in horses fulfils Koch's postulates. Vet. Rec. 128:103-106.
208. Kit, S., M. Kit, and E. C. Pirtle. 1985. Attenuated properties of thymidine kinase-negative deletion mutant of pseudorabies virus. Am. J. Vet. Res. 46:1359-1367.
209. Kit, S., M. Sheppard, H. Ichimura, and M. Kit. 1987. Second-generation pseudorabies virus vaccine with deletions in thymidine kinase and glycoprotein genes. Am. J. Vet. Res. 48:780-793.
210. Klopfleisch, R., J. P. Teifke, W. Fuchs, M. Kopp, B. G. Klupp, and T. C. Mettenleiter. 2004. Influence of tegument proteins of pseudorabies virus on neuroinvasion and transneuronal spread in the nervous system of adult mice after intranasal inoculation. J. Virol. 78:2956-2966.
211. Kluge, J. P., G. W. Beran, H. T. Hill, and K. B. Platt. 1999. Pseudorabies (Aujeszky's disease), p. 233-46. In B. E. Straw, S. D'Allaire, W. L. Mengeling, and T. J. Taylor (ed.), Diseases of swine, 8th ed. Iowa State University Press, Ames, Iowa.
212. Klupp, B. G., J. Altenschmidt, H. Granzow, W. Fuchs, and T. C. Mettenleiter. 2005. Identification and characterization of the pseudorabies virus UL43 protein. Virology 334:224-233.
213. Klupp, B. G., W. Fuchs, H. Granzow, R. Nixdorf, and T. C. Mettenleiter. 2002. Pseudorabies virus UL36 tegument protein physically interacts with the UL37 protein. J. Virol. 76:3065-3071.
214. Klupp, B. G., H. Granzow, R. Klopfleisch, W. Fuchs, M. Kopp, M. Lenk, and T. C. Mettenleiter. 2005. Functional analysis of the pseudorabies virus UL51 protein. J. Virol. 79:3831-3840.
215. Klupp, B. G., H. Granzow, and T. C. Mettenleiter. 2001. Effect of the pseudorabies virus US3 protein on nuclear membrane localization of the UL34 protein and virus egress from the nucleus. J. Gen. Virol. 82:2363-2371.
216. Klupp, B. G., H. Granzow, and T. C. Mettenleiter. Identification, subviral localization and functional characterization of the pseudorabies virus UL17 protein. J. Virol., in press.
217. Klupp, B. G., H. Granzow, and T. C. Mettenleiter. 2000. Primary envelopment of pseudorabies virus at the nuclear membrane requires the UL34 gene product. J. Virol. 74:10063-10073.
218. Klupp, B. G., H. Granzow, E. Mundt, and T. C. Mettenleiter. 2001. Pseudorabies virus UL37 gene product is involved in secondary envelopment. J. Virol. 75:8927-8936.
219. Klupp, B. G., C. J. Hengartner, T. C. Mettenleiter, and L. W. Enquist. 2004. Complete, annotated sequence of the pseudorabies virus genome. J. Virol. 78:424-440.
220. Klupp, B. G., B. Lomniczi, N. Visser, W. Fuchs, and T. C. Mettenleiter. 1995. Mutations affecting the UL21 gene contribute to avirulence of pseudorabies virus vaccine strain Bartha. Virology 212:466-473.
221. Klupp, B. G., R. Nixdorf, and T. C. Mettenleiter. 2000. Pseudorabies virus glycoprotein M inhibits membrane fusion. J. Virol. 74:6760-6768.
222. Knapp, A. C., P. J. Husak, and L. W. Enquist. 1997. The gE and gI homologs from two alphaherpesviruses have conserved and divergent neuroinvasive properties. J. Virol. 71:5820-5827.
223. Koffa, M. D., J. B. Clements, E. Izaurralde, S. Wadd, S. A. Wilson, I. W. Mattaj, and S. Kuersten. 2001. Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J. 20:5769-5778.
224. Konig, P., K. Giesow, and G. M. Keil. 2002. Glycoprotein M of bovine herpesvirus 1 (BHV-1) is nonessential for replication in cell culture and is involved in inhibition of bovine respiratory syncytial virus F protein induced syncytium formation in recombinant BHV-1 infected cells. Vet. Microbiol. 86:37-49.
225. Kopp, M., H. Granzow, W. Fuchs, B. Klupp, and T. C. Mettenleiter. 2004. Simultaneous deletion of pseudorabies virus tegument protein UL11 and glycoprotein M severely impairs secondary envelopment. J. Virol. 78:3024-3034.
226. Kopp, M., H. Granzow, W. Fuchs, B. G. Klupp, E. Mundt, A. Karger, and T. C. Mettenleiter. 2003. The pseudorabies virus UL11 protein is a virion component involved in secondary envelopment in the cytoplasm. J. Virol. 77:5339-5351.
227. Kopp, M., B. G. Klupp, H. Granzow, W. Fuchs, and T. C Mettenleiter. 2002. Identification and characterization of the pseudorabies virus tegument proteins UL46 and UL47: role for UL47 in virion morphogenesis in the cytoplasm, J. Virol. 76:8820-8833.
228. Koppers-Lalic, D., E. A. Reits, M. E. Ressing, A. D. Lipinska, R. Abele, J. Koch, M. Marcondes Rezende, P. Admiraal, D. van Leeuwen, K. Bienkowska-Szewczyk, T. C. Mettenleiter, F. A. Rijsewijk, R. Tampe, J. Neefjes, and E. J. Wiertz. 2005. Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Proc. Natl. Acad. Sci. USA 102:5144-5149.
229. Koslowski, K. M., P. R. Shaver, X. Y. Wang, D. J. Tenney, and N. E. Pederson. 1997. The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 protein. J. Virol. 71:9118-9123.
230. Koyama, A. H., T. Fukumori, M. Fujita, H. Irie, and A. Adachi. 2000. Physiological significance of apoptosis in animal virus infection. Microbes Infect. 2:1111-1117.
231. Koyano, S., E. C. Mar, F. R. Stamey, and N. Inoue. 2003. Glycoproteins M and N of human herpesvirus 8 form a complex and inhibit cell fusion. J. Gen. Virol. 84:1485-1491.
232. Kozmik, Z., L. Arnold, and V. Paces. 1991. Multiple sets of adjacent mu E1 and oct-1 binding sites upstream of the pseudorabies virus immediate-early gene promoter. Virology 182:239-249.
233. Kritas, S. K., M. B. Pensaert, and T. C. Mettenleiter. 1994. Role of envelope glycoproteins gI, gp63 and gIII in the invasion and spread of Aujeszky's disease virus in the olfactory nervous pathway of the pig. J. Gen. Virol. 75:2319-2327.
234. Krout, K. E., T. C. Mettenleiter, and A. D. Loewy. 2003. Single CNS neurons link both central motor and cardiosympathetic systems: a double-virus tracing study. Neuroscience 118:853-866.
235. Kwong, A. D., and N. Frenkel. 1989. The herpes simplex virus virion host shutoff function. J. Virol. 63:4834-4839.
236. Ladin, B. F., M. L. Blankenship, and T. Ben-Porat. 1980. Replication of herpesvirus DNA. V. Maturation of concatemeric DNA of pseudorabies virus to genome length is related to capsid formation. J. Virol. 33:1151-1164.
237. + temperature-sensitive mutants of pseudorabies virus. Virology 116:544-561.
238. Lake, C. M., S. J. Molesworth, and L. M. Hutt-Fletcher. 1998. The Epstein-Barr virus (EBV) gN homolog BLRF1 encodes a 15-kilodalton glycoprotein that cannot be authentically processed unless it is coexpressed with the EBV gM homolog BBRF3. J. Virol. 72:5559-5564.
239. Lam, Q., C. A. Smibert, K. E. Koop, C. Lavery, J. P. Capone, S. P. Weinheimer, and J. R. Smiley. 1996. Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function. EMBO J. 15:2575-2581.
240. Leader, D. P., A. D. Deana, F. Marchiori, F. C. Purves, and L. A. Pinna. 1991. Further definition of the substrate specificity of the alpha-herpesvirus protein kinase and comparison with protein kinases A and C. Biochim. Biophys. Acta 1091:426-431.
241. Lehman, I. R., and P. E. Boehmer. 1999. Replication of herpes simplex virus DNA. J. Biol. Chem. 274:28059-28062.
242. Leopardi, R., C. Van Sant, and B. Roizman. 1997. The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus. Proc. Natl. Acad. Sci. USA 94:7891-7896.
243. Lin, H. W., Y. Y. Chang, M. L. Wong, J. W. Lin, and T. J. Chang. 2004. Functional analysis of virion host shutoff protein of pseudorabies virus. Virology 324:412-418.
244. Lindberg, A., and J. P. Kreivi. 2002. Splicing inhibition at the level of spliceosome assembly in the presence of herpes simplex virus protein ICP27. Virology 294:189-198.
245. Lomniczi, B., A. S. Kaplan, and T. Ben-Porat. 1987. Multiple defects in the genome of pseudorabies virus can affect virulence without detectably affecting replication in cell culture. Virology 161:181-189.
246. Lomniczi, B., S. Watanabe, T. Ben-Porat, and A. S. Kaplan. 1984. Genetic basis of the neurovirulence of pseudorabies virus. J. Virol. 52:198-205.
247. Lomniczi, B., S. Watanabe, T. Ben-Porat, and A. S. Kaplan. 1987. Genome location and identification of functions defective in the Bartha vaccine strain of pseudorabies virus. J. Virol. 61:796-801.
248. Lundh, B. 1990. Spread of vesicular stomatitis virus along the visual pathways after retinal infection in the mouse. Acta Neuropathol. (Berlin) 79: 395-401.
249. Luxton, G. W., S. Haverlock, K. E. Coller, S. E. Antinone, A. Pincetic, and G. A. Smith. 2005. Targeting of herpesvirus capsid transport in axons is coupled to association with specific sets of tegument proteins. Proc. Natl. Acad. Sci. USA 102:5832-5837.
250. Lyman, M. G., G. L. Demmin, and B. W. Banfield. 2003. The attenuated pseudorabies virus strain Bartha fails to package the tegument proteins Us3 and VP22. J. Virol. 77:1403-1414.
251. Mach, M., B. Kropff, P. Dal Monte, and W. Britt. 2000. Complex formation by human cytomegalovirus glycoproteins M (gpUL100) and N (gpUL73). J. Virol. 74:11881-11892.
252. MacLean, C. A., B. Clark, and D. J. McGeoch. 1989. Gene UL11 of herpes simplex virus type 1 encodes a virion protein which is myristylated. J. Gen. Virol. 70:3147-3157.
253. Maes, R. K., M. D. Sussman, A. Vilnis, and B. J. Thacker. 1997. Recent developments in latency and recombination of Aujeszky's disease (pseudorabies) virus. Vet. Microbiol. 55:13-27.
254. Maga, G., A. Verri, L. Bonizzi, W. Ponti, G. Poli, A. Garbesi, D. Niccolai, S. Spadari, and F. Focher. 1993. Lack of stereospecificity of suid pseudorabies virus thymidine kinase. Biochem. J. 294:381-385.
255. Manickan, E., R. J. Rouse, Z. Yu, W. S. Wire, and B. T. Rouse. 1995. Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes. J. Immunol. 155:259-265.
256. Marchioli, C., R. J. Yancey, Jr., J. G. Timmins, L. E. Post, B. R. Young, and D. A. Povendo. 1988. Protection of mice and swine from pseudorabies virus-induced mortality by administration of pseudorabies virus-specific mouse monoclonal antibodies. Am. J. Vet. Res. 49:860-864.
257. Marchioli, C. C., R. J. Yancey, Jr., E. A. Petrovskis, J. G. Timmins, and L. E. Post. 1987. Evaluation of pseudorabies virus glycoprotein gp50 as a vaccine for Aujeszky's disease in mice and swine: expression by vaccinia virus and Chinese hamster ovary cells. J. Virol. 61:3977-3982.
258. Martin, K. J., J. W. Lillie, and M. R. Green. 1990. Transcriptional activation by the pseudorabies virus immediate early protein. Genes Dev. 4:2376-2382.
259. Masic, M., M. Ercegan, and M. Petrovic. 1965. The significance of the tonsils in the pathogenesis and diagnosis of Aujeszyk's disease in pigs. Zentralbl. Veterinarmed. B. 12:398-405. (In German.)
260. Masse, M. J., A. Jöns, J. M. Dijkstra, T. C. Mettenleiter, and A. Flamand. 1999. Glycoproteins gM and gN of pseudorabies virus are dispensable for viral penetration and propagation in the nervous systems of adult mice. J. Virol. 73:10503-10507.
261. Matsuda Tsuchida, A., S. Katayama, N. Okada, T. Okabe, and N. Sasaki. 1992. Protection from pseudorabies virus challenge in mice by a combination of purified gII, gIII and gVI antigens. J. Vet. Med. Sci. 54:447-452.
262. Maul, G. G., D. Negorev, P. Bell, and A. M. Ishov. 2000. Review: properties and assembly mechanisms of ND10, PML bodies, or PODs. J. Struct. Biol. 129:278-287.
263. McCracken, R. M., J. B. McFerran, and C. Dow. 1973. The neural spread of pseudorabies virus in calves. J. Gen. Virol. 20:17-28.
264. McFerran, J. B., and C. Dow. 1975. Studies on immunisation of pigs with the Bartha strain of Aujeszky's disease virus. Res. Vet. Sci. 19:17-22.
265. McGeoch, D. J., and S. Cook. 1994. Molecular phylogeny of the alphaherpesvirinae subfamily and a proposed evolutionary timescale. J. Mol. Biol. 238:9-22.
266. McGeoch, D. J., M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor. 1988. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69:1531-1574.
267. McGregor, F., A. Phelan, J. Dunlop, and J. B. Clements. 1996. Regulation of herpes simplex virus poly (A) site usage and the action of immediate-early protein IE63 in the early-late switch. J. Virol. 70:1931-1940.
268. McGregor, S., B. C. Easterday, A. S. Kaplan, and T. Ben-Porat. 1985. Vaccination of swine with thymidine kinase-deficient mutants of pseudorabies virus. Am. J. Vet. Res. 46:1494-1497.
269. McLauchlan, J., C. Addison, M. C. Craigie, and F. J. Rixon. 1992. Noninfectious L-particles supply functions which can facilitate infection by HSV-1. Virology 190:682-688.
270. McLauchlan, J., and F. J. Rixon. 1992. Characterization of enveloped tegument structures (L particles) produced by alphaherpesviruses: integrity of the tegument does not depend on the presence of capsid or envelope. J. Gen. Virol. 73:269-276.
271. McMahan, L., and P. A. Schaffer. 1990. The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection. J. Virol. 64:3471-3485.
272. McNabb, D. S., and R. J. Courtney. 1992. Characterization of the large tegument protein (ICP1/2) of herpes simplex virus type 1. Virology 190: 221-232.
273. Mears, W. E., and S. A. Rice. 1996. The RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation. J. Virol. 70:7445-7453.
274. Mettenleiter, T. C. 2000. Aujeszky's disease (pseudorabies) virus: the virus and molecular pathogenesis-state of the art, June 1999. Vet. Res. 31:99-115.
275. Mettenleiter, T. C. 2002. Brief overview on cellular virus receptors. Virus Res. 82:3-8.
276. Mettenleiter, T. C. 2004. Budding events in herpesvirus morphogenesis. Virus Res. 106:167-180.
277. Mettenleiter, T. C. 2002. Herpesvirus assembly and egress. J. Virol. 76: 1537-1547.
278. Mettenleiter, T. C. 1996. Immunobiology of pseudorabies (Aujeszky's disease). Vet. Immunol. Immunopathol. 54:221-229.
279. Mettenleiter, T. C. 2003. Pathogenesis of neurotropic herpesviruses: role of viral glycoproteins in neuroinvasion and transneuronal spread. Virus Res. 92:197-206.
280. Mettenleiter, T. C., B. Lomniczi, L. Zsak, I. Medveczky, T. Ben-Porat, and A. S. Kaplan. 1989. Analysis of the factors that affect virulence of pseudorabies virus, p. 3-11. In J. T. van Oirschot (ed.), Vaccination and control of Aujeszky's disease. Kluwer Academic Publishers, Dordrecht, The Netherlands.
281. Mettenleiter, T. C., N. Lukacs, and H. J. Rziha. 1985. Pseudorabies virus avirulent strains fail to express a major glycoprotein. J. Virol. 56:307-311.
282. Mettenleiter, T. C., A. Saalmuller, and F. Weiland. 1993. Pseudorabies virus protein homologous to herpes simplex virus type 1 ICP18.5 is necessary for capsid maturation. J. Virol. 67:1236-1245.
283. Mettenleiter, T. C., L. Zsak, A. S. Kaplan, T. Ben-Porat, and B. Lomniczi. 1987. Role of a structural glycoprotein of pseudorabies in virus virulence. J. Virol. 61:4030-4032.
284. Milne, R. S., S. A. Connolly, C. Krummenacher, R. J. Eisenberg, and G. H. Cohen. 2001. Porcine HveC, a member of the highly conserved HveC/nectin 1 family, is a functional alphaherpesvirus receptor. Virology 281:315-328.
285. Miranda-Saksena, M., P. Armati, R. A. Boadle, D. J. Holland, and A. L. Cunningham. 2000. Anterograde transport of herpes simplex virus type 1 in cultured, dissociated human and rat dorsal root ganglion neurons. J. Virol. 74:1827-1839.
286. Misra, V., A. C. Bratanich, D. Carpenter, and P. O'Hare. 1994. Protein and DNA elements involved in transactivation of the promoter of the bovine herpesvirus (BHV) 1 IE-1 transcription unit by the BHV alpha gene trans-inducing factor. J. Virol. 68:4898-4909.
287. Moore, R. Y., J. C. Speh, and J. P. Card. 1995. The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells. J. Comp. Neurol. 352:351-366.
288. Moriuchi, H., M. Moriuchi, H. Dean, A. K. Cheung, and J. I. Cohen. 1995. Pseudorabies virus EPO is functionally homologous to varicella-zoster virus ORF61 protein and herpes simplex virus type 1 ICPO. Virology 209:281-283.
289. Moriuchi, H., M. Moriuchi, S. E. Straus, and J. I. Cohen. 1993. Varicella-zoster virus open reading frame 10 protein, the herpes simplex virus VP16 homolog, transactivates herpesvirus immediate-early gene promoters. J. Virol. 67:2739-2746.
290. Morrison, E. E., Y. F. Wang, and D. M. Meredith. 1998. Phosphorylation of structural components promotes dissociation of the herpes simplex virus type 1 tegument. J. Virol. 72:7108-7114.
291. Mossman, K. L., P. F. Macgregor, J. J. Rozmus, A. B. Goryachev, A. M. Edwards, and J. R. Smiley. 2001. Herpes simplex virus triggers and then disarms a host antiviral response. J. Virol. 75:750-758.
292. Mossman, K. L., R. Sherburne, C. Lavery, J. Duncan, and J. R. Smiley. 2000. Evidence that herpes simplex virus VP16 is required for viral egress downstream of the initial envelopment event. J. Virol. 74:6287-6299.
293. Mukamoto, M., I. Watanabe, Y. Kobayashi, F. C. Icatlo, Jr., H. Ishii, and Y. Kodama. 1991. Immunogenicity in Aujeszky's disease virus structural glycoprotein gVI (gp50) in swine. Vet. Microbiol. 29:109-121.
294. Mulder, W., J. Pol, T. Kimman, G. Kok, J. Priem, and B. Peeters. 1996. Glycoprotein D-negative pseudorabies virus can spread transneuronally via direct neuron-to-neuron transmission in its natural host, the pig, but not after additional inactivation of gE or gI. J. Virol. 70:2191-2200.
295. Müller, T., H. J. Bätza, H. Schlüter, F. J. Conraths, and T. C. Mettenleiter. 2003. Eradication of Aujeszky's disease in Germany. J. Vet. Med. B Infect. Dis. Vet. Public Health 50:207-213.
296. Munger, J., A. V. Chee, and B. Roizman. 2001. The U(S)3 protein kinase blocks apoptosis induced by the d120 mutant of herpes simplex virus 1 at a premitochondrial stage. J. Virol. 75:5491-5497.
297. Negroni, J., N. C. Bennett, and H. M. Cooper. 2003. Organization of the arcadian system in the subterranean mole rat, Cryptomys hottentotus (Bathyergidae). Brain Res. 967:48-62.
298. Newcomb, W. W., and J. C. Brown. 1991. Structure of the herpes simplex virus capsid: effects of extraction with guanidine hydrochloride and partial reconstitution of extracted capsids. J. Virol. 65:613-620.
299. Newcomb, W. W., F. L. Homa, D. R. Thomsen, B. L. Trus, N. Cheng, A. Steven, F. Booy, and J. C. Brown. 1999. Assembly of the herpes simplex virus procapsid from purified components and identification of small complexes containing the major capsid and scaffolding proteins. J. Virol. 73: 4239-4250.
300. Newcomb, W. W., R. M. Juhas, D. R. Thomsen, F. L. Homa, A. D. Burch, S. K. Weller, and J. C. Brown. 2001. The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid. J. Virol. 75:10923-10932.
301. Newcomb, W. W., B. L. Trus, F. P. Booy, A. C. Steven, J. S. Wall, and J. C. Brown. 1993. Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes. J. Mol. Biol. 232:499-511.
302. Ng, T. I., W. O. Ogle, and B. Roizman. 1998. UL13 protein kinase of herpes simplex virus 1 complexes with glycoprotein E and mediates the phosphorylation of the viral Fc receptor: glycoproteins E and I. Virology 241:37-48.
303. Nisbiyama, Y., and T. Murata. 2002. Anti-apoptotic protein kinase of herpes simplex virus. Trends Microbiol. 10:105-107.
304. Nixdorf, R., B. G. Klupp, A. Karger, and T. C. Mettenleiter. 2000. Effects of truncation of the carboxy terminus of pseudorabies virus glycoprotein B on infectivity. J. Virol. 74:7137-7145.
305. Nixdorf, R., B. G. Klupp, and T. C. Mettenleiter. 2001. Role of the cytoplasmic tails of pseudorabies virus glycoproteins B, E and M in intracellular localization and virion incorporation. J. Gen. Virol. 82:215-226.
306. Nixdorf, R., J. Schmidt, A. Karger, and T. C. Mettenleiter. 1999. Infection of Chinese hamster ovary cells by pseudorabies virus. J. Virol. 73:8019-8026.
307. Nozawa, N., T. Daikoku, T. Koshizuka, Y. Yamauchi, T. Yoshikawa, and Y. Nishiyama. 2003. Subcellular localization of herpes simplex virus type 1 UL51 protein and role of palmitoylation in Golgi apparatus targeting. J. Virol. 77:3204-3216.
308. Ogg, P. D., P. J. McDonell, B. J. Ryckman, C. M. Knudson, and R. J. Roller. 2004. The HSV-1 Us3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members. Virology 319:212-224.
309. Ono, E., S. Taharaguchi, S. Watanabe, H. Nikami, Y. Shimizu, and H. Kida. 1998. Suppression of pseudorabies virus replication by a mutant form of immediate-early protein IE180 repressing the viral gene transcription. Vet. Microbiol. 60:107-117.
310. Ono, E., S. Watanabe, H. Nikami, T. Tasaki, and H. Kida. 1998. Pseudorabies virus (PRV) early protein 0 activates PRV gene transcription in combination with the immediate-early protein IE180 and enhances the infectivity of PRV genomic DNA. Vet. Microbiol. 63:99-107.
311. Osorio, F. A., and D. L. Rock. 1992. A murine model of pseudorabies virus latency. Microb. Pathog. 12:39-46.
312. Ou, C. J., M. L. Wong, and T. J. Chang. 2002. A TEF-1-element is required for activation of the promoter of pseudorabies virus glycoprotein X gene by IE180. Virus Genes 25:241-253.
313. Ou, C. J., M. L. Wong, C. Huang, and T. J. Chang. 2002. Suppression of promoter activity of the LAT gene by IE180 of pseudorabies virus. Virus Genes 25:227-239.
314. Parkinson, J., and R. D. Everett. 2000. Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 affect cellular structures and proteins. J. Virol. 74:10006-10017.
315. Parkinson, J., and R. D. Everett. 2001. Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 induce the formation of colocalizing, conjugated ubiquitin. J. Virol. 75:5357-5362.
316. Peeters, B., N. de Wind, M. Hooisma, F. Wagenaar, A. Gielkens, and R. Moormann. 1992. Pseudorabies virus envelope glycoproteins gp50 and gII are essential for virus penetration, but only gII is involved in membrane fusion. J. Virol. 66:894-905.
317. Penfold, M. E., P. Armati, and A. L. Cunningham. 1994. Axonal transport of herpes simplex virions to epidermal cells: evidence for a specialized mode of virus transport and assembly. Proc. Natl. Acad. Sci. USA 91:6529-6533.
318. Pensaert, M. B., and J. P. Kluge. 1989. Pseudorabies virus (Aujeszky's disease), p. 39-64. In M. B. Pensaert (ed.), Virus infections of porcines. Elsevier Science Publishers, Amsterdam, The Netherlands.
319. Perdue, M. L., J. C. Cohen, C. C. Randall, and D. J. O'Callaghan. 1976. Biochemical studies of the maturation of herpesvirus nucleocapsid species. Virology 74:194-208.
320. Perez Fontan, J. J., and C. R. Velloff. 1997. Neuroanatomic organization of the parasympathetic bronchomotor system in developing sheep. Am. J. Physiol. 273:R121-33.
321. Petrovskis, E. A., J. G. Timmins, M. A. Armentrout, C. C. Marchioli, R. J. Yancey, Jr., and L. E. Post. 1986. DNA sequence of the gene for pseudorabies virus gp50, a glycoprotein without N-linked glycosylation. J. Virol. 59:216-223.
322. Petrovskis, E. A., J. G. Timmins, T. M. Gierman, and L. E. Post. 1986. Deletions in vaccine strains of pseudorabies virus and their effect on synthesis of glycoprotein gp63. J. Virol. 60:1166-1169.
323. Pickard, G. E., C. A. Smeraski, C. C. Tomlinson, B. W. Banfield, J. Kaufman, C. L. Wilcox, L. W. Enquist, and P. J. Sollars. 2002. Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits. J. Neurosci. 22:2701-2710.
324. Porter, I. M., and N. D. Stow. 2004. Virus particles produced by the herpes simplex virus type 1 alkaline nuclease null mutant ambUL12 contain abnormal genomes. J. Gen. Virol. 85:583-591.
325. Priola, S. A., D. P. Gustafson, E. K. Wagner, and J. G. Stevens. 1990. A major portion of the latent pseudorabies virus genome is transcribed in trigeminal ganglia of pigs. J. Virol. 64:4755-4760.
326. Priola, S. A., and J. G. Stevens. 1991. The 5′ and 3′ limits of transcription in the pseudorabies virus latency associated transcription unit. Virology 182:852-856.
327. Provencio, I., H. M. Cooper, and R. G. Foster. 1998. Retinal projections in mice with inherited retinal degeneration: implications for circadian photoentrainment. J. Comp. Neurol. 395:417-439.
328. Purves, F. C., A. D. Deana, F. Marchiori, D. P. Leader, and L. A. Pinna. 1986. The substrate specificity of the protein kinase induced in cells infected with herpesviruses: studies with synthetic substrates [corrected] indicate structural requirements distinct from other protein kinases. Biochim. Biophys. Acta 889:208-215.
329. Pyles, R. B., and R. L. Thompson. 1994. Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system. J. Virol. 68:4963-4972.
330. Quint, W., A. Gielkens, J. Van Oirschot, A. Berns, and H. T. Cuypers. 1987. Construction and characterization of deletion mutants of pseudorabies virus: a new generation of 'live' vaccines. J. Gen. Virol. 68:523-534.
331. Rajcani, J., V. Andrea, and R. Ingeborg. 2004. Peculiarities of herpes simplex virus (HSV) transcription: an overview. Virus Genes 28:293-310.
332. Rall, G. F., S. Kupershmidt, N. Sugg, R. A. Veach, and T. Ben-Porat. 1992. Functions of the sequences at the ends of the inverted repeats of pseudorabies virus. J. Virol. 66:1506-1519.
333. Ray, N., M. E. Bisher, and L. W. Enquist. 2004. Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. J. Virol. 78: 12964-12974.
334. Ray, N., and L. W. Enquist. 2004. Transcriptional response of a common permissive cell type to infection by two diverse alphaherpesviruses. J. Virol. 78:3489-3501.
335. Raz, E., D. A. Carson, S. E. Parker, T. B. Parr, A. M. Abai, G. Aichinger, S. H. Gromkowski, M. Singh, D. Lew, M. A. Yankauckas, et al. 1994. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91: 9519-9523.
336. Rice, S. A., and D. M. Knipe. 1990. Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27. J. Virol. 64:1704-1715.
337. Richart, S. M., S. A. Simpson, C. Krummenacher, J. C. Whitbeck, L. I. Pizer, G. H. Cohen, R. J. Eisenberg, and C. L. Wilcox. 2003. Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC. J. Virol. 77:3307-3311.
338. Rinaman, L., J. P. Card, and L. W. Enquist. 1993. Spatiotemporal responses of astrocytes, ramified microglia, and brain macrophages to central neuronal infection with pseudorabies virus. J. Neurosci. 13:685-702.
339. Rinaman, L., P. Levitt, and J. P. Card. 2000. Progressive postnatal assembly of limbic-autonomic circuits revealed by central transneuronal transport of pseudorabies virus. J. Neurosci. 20:2731-2741.
340. Rinaman, L., and G. Schwartz. 2004. Anterograde transneuronal viral tracing of central viscerosensory pathways in rats. J. Neurosci. 24:2782-2786.
341. Rixon, F. J., C. Addison, and J. McLauchlan. 1992. Assembly of enveloped tegument structures (L particles) can occur independently of virion maturation in herpes simplex virus type 1-infected cells. J. Gen. Virol. 73:277-284.
342. Rixon, F. J., and T. Ben-Porat. 1979. Structural evolution of the DNA of pseudorabies-defective viral particles. Virology 97:151-163.
343. Rixon, F. J., L. T. Feldman, and T. Ben-Porat. 1980. Expression of the genome of defective interfering pseudorabies virions in the presence or absence of helper functions provided by standard virus. J. Gen. Virol. 46:119-138.
344. Robbins, A. K., D. J. Dorney, M. W. Wathen, M. E. Whealy, C. Gold, R. J. Watson, L. E. Holland, S. D. Weed, M. Levine, J. C. Glorioso, et al. 1987. The pseudorabies virus gII gene is closely related to the gB glycoprotein gene of herpes simplex virus. J. Virol. 61:2691-2701.
345. Robbins, A. K., J. P. Ryan, M. E. Whealy, and L. W. Enquist. 1989. The gene encoding the gIII envelope protein of pseudorabies virus vaccine strain Bartha contains a mutation affecting protein localization. J. Virol. 63:250-258.
346. Roizman, B., R. C. Desrosiers, B. Fleckenstein, C. Lopez, A. C. Minson, and M. J. Studdert. 1992. The family Herpesviridae: an update. Arch. Virol. 123:425-449.
347. Roizman, B., and D. M. Knipe. 2001. Herpes simplex viruses and their replication, p. 2399-2460. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed., vol. 2. Lippincott Williams & Wilkins, Philadelphia, Pa.
348. Roizman, B., and P. E. Pellett. 2001. The family Herpesviridae: a brief introduction, p. 2381-2397. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed., vol. 2. Lippincott Williams & Wilkins, Philadelphia. Pa.
349. 348a.Romero, C. H., P. Meade, J. Santagata, K. Gillis, G. Lollis, E. C. Hahn, and E. P. Gibbs. 1997. Genital infection and transmission of pseudorabies virus in feral swine in Florida, USA. Vet. Microbiol. 55:131-139.
350. Romero, C. H., P. N. Meade, B. L. Homer, J. E. Shultz, and G. Lollis. 2003. Potential sites of virus latency associated with indigenous pseudorabies viruses in feral swine. J. Wildl. Dis. 39:567-575.
351. Romero, C. H., P. N. Meade, J. E. Shultz, H. Y. Chung, E. P. Gibbs, E. C. Hahn, and G. Lollis. 2001. Venereal transmission of pseudorabies viruses indigenous to feral swine. J. Wildl. Dis. 37:289-296.
352. Rouzade-Dominguez, M. L., R. Miselis, and R. J. Valentino. 2003. Central representation of bladder and colon revealed by dual transsynaptic tracing in the rat: substrates for pelvic visceral coordination. Eur. J. Neurosci. 18:3311-3324.
353. Ruda, M., and J. D. Coulter. 1982. Axonal and transneuronal transport of wheat germ agglutinin demonstrated by immunocytochemistry. Brain Res. 249:237-246.
354. Rziha, H.-J., V. F. Ohlinger, D. Lüttiken, and N. Visser. 1989. Latency characteristics of pseudorabies vaccine virus, p. 79-85. In J. T. Van Oirschot (ed.), Vaccination and control of Aujeszky's disease. Kluwer Academic Publishers, Boston, Mass.
355. Rziha, H. J., T. C. Mettenleiter, V. Ohlinger, and G. Wittmann. 1986. Herpesvirus (pseudorabies virus) latency in swine: occurrence and physical state of viral DNA in neural tissues. Virology 155:600-613.
356. Sabin, A. B. 1938. Progression of different nasally installed viruses along different nervous pathways in the same host. Proc. Soc. Exp. Biol. Med. 38:270-275.
357. Sabo, A., and J. Rajcani. 1976. Latent pseudorabies virus infection in pigs. Acta Virol. 20:208-214.
358. Salmon, B., C. Cunningham, A. J. Davison, W. J. Harris, and J. D. Baines. 1998. The herpes simplex virus type 1 U(L)17 gene encodes virion tegument proteins that are required for cleavage and packaging of viral DNA. J. Virol. 72:3779-3788.
359. Sandri-Goldin, R. M. 1998. ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif. Genes Dev. 12:868-879.
360. Sato, H., L. D. Callanan, L. Pesnicak, T. Krogmann, and J. I. Cohen. 2002. Varicella-zoster virus (VZV) ORF17 protein induces RNA cleavage and is critical for replication of VZV at 37 degrees C but not 33 degrees C. J. Virol. 76:11012-11023.
361. Schek, N., and S. L. Bachenheimer. 1985. Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of Vero cells. J. Virol. 55:601-610.
362. Schmidt, J., V. Gerdts, J. Beyer, B. G. Klupp, and T. C. Mettenleiter. 2001. Glycoprotein D-independent infectivity of pseudorabies virus results in an alteration of in vivo host range and correlates with mutations in glycoproteins B and H. J. Virol. 75:10054-10064.
363. Schmiedhofer, J. 1910. Beitraege zur Pathologie der Infektioesen Bulbaer-paralyse (Aujeszkyschen Krankheit). Zeitschr. Infekt. Krkh. Haustiere 8:383-405.
364. Schmitt, B. J., F. A. Osorio, W. W. Stroup, and E. P. Gibbs. 1991. A comparison of differential diagnostic tests to detect antibodies to pseudorabies glycoproteins gX, gI, and gIII in naturally infected feral pigs. J. Vet. Diagn. Investig. 3:344-345.
365. Schwartz, J. A., E. E. Brittle, A. E. Reynolds, L. W. Enquist, and S. J. Silverstein. Pseudorabies virus deleted of UL54 is attenuated in mice, but productively infects cells in culture. J. Virol., submitted for publication.
366. Sherman, G., and S. L. Bachenheimer. 1988. Characterization of intranuclear capsids made by ts morphogenic mutants of HSV-1. Virology 163: 471-480.
367. Shintani, T., A. R. Anker, I. Billig, J. P. Card, and B. J. Yates. 2003. Transneuronal tracing of neural pathways influencing both diaphragm and genioglossal muscle activity in the ferret. J. Appl. Physiol. 95:1453-1459.
368. Shope, R. E. 1931. An experimental study of "mad itch" with especial reference to its relationship to pseudorabies. J. Exp. Med. 54:233-248.
369. Simmons, A., and A. A. Nash. 1984. Zosteriform spread of herpes simplex virus as a model of recrudescence and its use to investigate the role of immune cells in prevention of recurrent disease. J. Virol. 52:816-821.
370. Smeraski, C. A., P. J. Sollars, M. D. Ogilvie, L. W. Enquist, and G. E. Pickard. 2004. Suprachiasmatic nucleus input to autonomic circuits identified by retrograde transsynaptic transport of pseudorabies virus from the eye. J. Comp. Neurol. 471:298-313.
371. Smibert, C. A., B. Popova, P. Xiao, J. P. Capone, and J. R. Smiley. 1994. Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs. J. Virol. 68:2339-2346.
372. Smith, B. N., B. W. Banfield, C. A. Smeraski, C. L. Wilcox, F. E. Dudek, L. W. Enquist, and G. E. Pickard. 2000. Pseudorabies virus expressing enhanced green fluorescent protein: A tool for in vitro electrophysiological analysis of transsynaptically labeled neurons in identified central nervous system circuits. Proc. Natl. Acad. Sci. USA 97:9264-9269.
373. Smith, G. A., and L. W. Enquist. 1999. Construction and transposon mutagenesis in Escherichia coli of a full-length infectious clone of pseudorabies virus, an alphaherpesvirus. J. Virol. 73:6405-6414.
374. Smith, G. A., and L. W. Enquist. 2000. A self-recombining bacterial artificial chromosome and its application for analysis of herpesvirus pathogenesis. Proc. Natl. Acad. Sci. USA 97:4873-4878.
375. Smith, G. A., L. Pomeranz, S. P. Gross, and L. W. Enquist. 2004. Local modulation of plus-end transport targets herpesvirus entry and egress in sensory axons. Proc. Natl. Acad. Sci. USA 101:16034-16039.
376. Sodeik, B. 2000. Mechanisms of viral transport in the cytoplasm. Trends Microbiol. 8:465-472.
377. Sodeik, B., M. W. Ebersold, and A. Helenius. 1997. Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus. J. Cell Biol. 136:1007-1021.
378. Spear, P. G. 2001. A first step toward understanding membrane fusion induced by herpes simplex virus. Mol. Cell 8:2-4.
379. Spear, P. G., R. J. Eisenberg, and G. H. Cohen. 2000. Three classes of cell surface receptors for alphaherpesvirus entry. Virology 275:1-8.
380. Spear, P. G., and R. Longnecker. 2003. Herpesvirus entry: an update. J. Virol. 77:10179-10185.
381. Stark, W. M., M. R. Boocock, and D. J. Sherratt. 1992. Catalysis by site-specific recombinases. Trends Genet. 8:432-439.
382. Stegeman, A., M. C. de Jong, A. van Nes, and A. Bouma. 1997. Dynamics of pseudorabies virus infections in vaccinated pig populations: a review. Vet. Q. 19:117-122.
383. Stegmann, B., H. Zentgraf, A. Ott, and C. H. Schroder. 1978. Synthesis and packaging of herpes simplex virus DNA in the course of virus passages at high multiplicity. Intervirology 10:228-240.
384. Steven, A. C., and P. G. Spear. 1997. Herpesvirus capsid assembly and envelopment, p. 312-351. In W. Chiu, R. Burnett, and R. L. Garcea (ed.), Structural biology of viruses. Oxford University Press, New York, N.Y.
385. Subak-Sharpe, J. H., and D. J. Dargan. 1998. HSV molecular biology: general aspects of herpes simplex virus molecular biology. Virus Genes 16:239-251.
386. Sun, N., M. D. Cassell, and S. Perlman. 1996. Anterograde, transneuronal transport of herpes simplex virus type 1 strain H129 in the murine visual system. J. Virol. 70:5405-5413.
387. Swanson, L. W. 1998-1999. Brain maps: structure of the rat brain, a laboratory guide with printed and electronic templates for data, models and schematics, 2nd revised ed. Elsevier Science, Amsterdam, The Netherlands.
388. Szilagyi, J. F., and C. Cunningham. 1991. Identification and characterization of a novel non-infectious herpes simplex virus-related particle. J. Gen. Virol. 72:661-668.
389. Taddeo, B., A. Esclatine, and B. Roizman. 2002. The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene. Proc. Natl. Acad. Sci. USA 99:17031-17036.
390. Taharaguchi, S., H. Inoue, E. Ono, H. Kida, S. Yamada, and Y. Shimizu. 1994. Mapping of transcriptional regulatory domains of pseudorabies virus immediate-early protein. Arch. Virol. 137:289-302.
391. Taharaguchi, S., T. Kobayashi, S. Yoshino, and E. Ono. 2002. Analysis of regulatory functions for the region located upstream from the latency-associated transcript (LAT) promoter of pseudorabies virus in cultured cells. Vet. Microbiol. 85:197-208.
392. Taharaguchi, S., E. Ono, S. Yamada, Y. Shimizu, and H. Kida. 1995. Mapping of a functional region conferring nuclear localization of pseudorabies virus immediate-early protein. Arch. Virol. 140:1737-1746.
393. Taharaguchi, S., S. Yoshino, K. Amagai, and E. Ono. 2003. The latency-associated transcript promoter of pseudorabies virus directs neuron-specific expression in trigeminal ganglia of transgenic mice. J. Gen. Virol. 84:2015-2022.
394. Takashima, Y., H. Tamura, X. Xuan, and H. Otsuka. 1999. Identification of the US3 gene product of BHV-1 as a protein kinase and characterization of BHV-1 mutants of the US3 gene. Virus Res. 59:23-34.
395. Tanaka, S., T. Imamura, M. Sakaguchi, and K. Mannen. 1998. Acetylcholine reactivates latent pseudorabies virus in mice. J. Virol. Methods 70:103-106.
396. Tanaka, S., T. Imamura, M. Sakaguchi, K. Mannen, and K. Matsuo. 1996. Acetylcholine activates latent pseudorabies virus in pigs. Arch. Virol. 141: 161-166.
397. Tanaka, S., and K. Mannen. 2002. Activation of latent pseudorabies virus infection in mice treated with acetylcholine. Exp. Anim. 51:407-409.
398. Tanaka, S., and K. Mannen. 2003. Effect of mild stress in mice latently infected pseudorabies virus. Exp. Anim. 52:383-386.
399. Tang, D. C., M. DeVit, and S. A. Johnston. 1992. Genetic immunization is a simple method for eliciting an immune response. Nature 356:152-154.
400. Thawley, D. G., R. F. Solorzano, and M. E. Johnson. 1984. Confirmation of pseudorabies virus infection, using virus recrudescence by dexamethasone treatment and in vitro lymphocyte stimulation. Am. J. Vet. Res. 45:981-983.
401. Thomas, J. T., S. T. Oh, S. S. Terhune, and L. A. Laimins. 2001. Cellular changes induced by low-risk human papillomavirus type 11 in keratinocytes that stably maintain viral episomes. J. Virol. 75:7564-7571.
402. Tirabassi, R. S., and L. W. Enquist. 1998. Role of envelope protein gE endocytosis in the pseudorabies virus life cycle. J. Virol. 72:4571-4579.
403. Tirabassi, R. S., R. A. Townley, M. G. Eldridge, and L. W. Enquist. 1997. Characterization of pseudorabies virus mutants expressing carboxy-terminal truncations of gE: evidence for envelope incorporation, virulence, and neurotropism domains. J. Virol. 71:6455-6464.
404. Tirabassi, R. S., R. A. Townley, M. G. Eldridge, and L. W. Enquist. 1998. Molecular mechanisms of neurotropic herpesvirus invasion and spread in the CNS. Neurosci. Biobehav Rev. 22:709-720.
405. Tomishima, M. J., and L. W. Enquist. 2001. A conserved alpha-herpesvirus protein necessary for axonal localization of viral membrane proteins. J. Cell Biol. 154:741-752.
406. Tomishima, M. J., and L. W. Enquist. 2002. In vivo egress of an alphaherpesvirus from axons. J. Virol. 76:8310-8317.
407. Tomishima, M. J., G. A. Smith, and L. W. Enquist. 2001. Sorting and transport of alpha herpesviruses in axons. Traffic 2:429-436.
408. Tonomura, N., E. Ono, Y. Shimizu, and H. Kida. 1996. Negative regulation of immediate-early gene expression of pseudorabies virus by interferon-alpha. Vet. Microbiol. 53:271-281.
409. Trus, B. L., F. L. Homa, F. P. Booy, W. W. Newcomb, D. R. Thomsen, N. Cheng, J. C. Brown, and A. C. Steven. 1995. Herpes simplex virus capsids assembled in insect cells infected with recombinant baculoviruses: structural authenticity and localization of VP26. J. Virol. 69:7362-7366.
410. Tsuda, T., T. Onodera, T. Sugimura, and Y. Murakami. 1992. Induction of protective immunity and neutralizing antibodies to pseudorabies virus by immunization of anti-idiotypic antibodies. Arch. Virol. 124:291-300.
411. Turner, A., B. Bruun, T. Minson, and H. Browne. 1998. Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system. J. Virol. 72: 873-875.
412. Ulmer, J. B., J. J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Felgner, V. J. Dwarki, S. H. Gromkowski, R. R. Deck, C. M. DeWitt, A. Friedman, et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
413. Ulmer, J. B., J. C. Sadoff, and M. A. Liu. 1996. DNA vaccines. Curr. Opin. Immunol. 8:531-536.
414. Van de Walle, G. R., H. W. Favoreel, H. J. Nauwynck, and M. B. Pensaert. 2003. Antibody-induced internalization of viral glycoproteins and gE-gI Fc receptor activity protect pseudorabies virus-infected monocytes from efficient complement-mediated lysis. J. Gen. Virol. 84:939-948.
415. Van Minnebruggen, G., H. W. Favoreel, L. Jacobs, and H. J. Nauwynck. 2003. Pseudorabies virus US3 protein kinase mediates actin stress fiber breakdown. J. Virol. 77:9074-9080.
416. Van Minnebruggen, G., H. W. Favoreel, and H. J. Nauwynck, 2004. Internalization of pseudorabies virus glycoprotein B is mediated by an interaction between the YQRL motif in its cytoplasmic domain and the clathrin-associated AP-2 adaptor complex. J. Virol. 78:8852-8859.
417. van Oirschot, J. T., and A. L. Gielkens. 1984. In vivo and in vitro reactivation of latent pseudorabies virus in pigs born to vaccinated sows. Am. J. Vet. Res. 45:567-571.
418. van Oirschot, J. T., H. J. Rziha, P. J. Moonen, J. M. Pol, and D. van Zaane. 1986. Differentiation of serum antibodies from pigs vaccinated or infected with Aujeszky's disease virus by a competitive enzyme immunoassay. J. Gen. Virol. 67:1179-1182.
419. van Zijl, M., H. van der Gulden, N. de Wind, A. Gielkens, and A. Berns. 1990. Identification of two genes in the unique short region of pseudorabies virus; comparison with herpes simplex virus and varicella-zoster virus. J. Gen. Virol. 71:1747-1755.
420. Visser, N., and D. Lütticken. 1989. Experiences with a gI-/TK-modified live pseudorabies virus vaccine: strain begonia, p. 37-44. In J. T. van Oirschot (ed.), Vaccination and control of Aujeszky's disease. Kluwer Academic Publishers. Dordrecht, The Netherlands.
421. Vlcek, C., Z. Kozmik, V. Paces, S. Schirm, and M. Schwyzer. 1990. Pseudorabies virus immediate-early gene overlaps with an oppositely oriented open reading frame: characterization of their promoter and enhancer regions. Virology 179:365-377.
422. Wagenaar, F., J. M. Pol, B. Peeters, A. L. Gielkens, N. de Wind, and T. G. Kimman. 1995. The US3-encoded protein kinase from pseudorabies virus affects egress of virions from the nucleus. J. Gen. Virol. 76:1851-1859.
423. Wang, J., M. Irnaten, R. A. Neff, P. Venkatesan, C. Evans, A. D. Loewy, T. C. Mettenleiter, and D. Mendelowitz. 2001. Synaptic and neurotransmitter activation of cardiac vagal neurons in the nucleus ambiguus. Ann. N. Y. Acad. Sci. 940:237-246.
424. Watanabe, S., E. Ono, Y. Shimizu, and H. Kida. 1996. Mapping of transregulatory domains of pseudorabies virus early protein 0 and identification of its dominant-negative mutant. Arch. Virol. 141:1001-1009.
425. Watanabe, S., E. Ono, Y. Shimizu, and H. Kida. 1995. Pseudorabies virus early protein 0 transactivates the viral gene promoters. J. Gen. Virol. 76 (Pt 11):2881-2885.
426. Wathen, M. W., and L. M. Wathen. 1984. Isolation, characterization, and physical mapping of a pseudorabies virus mutant containing antigenically altered gp50. J. Virol. 51:57-62.
427. Weeks, B. S., R. S. Ramchandran, J. J. Hopkins, and H. M. Friedman. 2000. Herpes simplex virus type-1 and -2 pathogenesis is restricted by the epidermal basement membrane. Arch. Virol. 145:385-396.
428. Weigel, R. M., W. F. Hall, G. Scherba, A. M. Siegel, E. C. Hahn, and J. R. Lehman. 1992. Evaluation of the sensitivity and specificity of two diagnostic tests for antibodies to pseudorabies virus glycoprotein X. J. Vet. Diagn. Investig. 4:238-244.
429. Wesley, R. D., and A. K. Cheung. 1996. A pseudorabies virus mutant with deletions in the latency and early protein O genes: replication, virulence, and immunity in neonatal piglets. J. Vet. Diagn. Investig. 8:21-24.
430. Whealy, M. E., J. P. Card, A. K. Robbins, J. R. Dubin, H. J. Rziha, and L. W. Enquist. 1993. Specific pseudorabies virus infection of the rat visual system requires both gI and gp63 glycoproteins. J. Virol. 67:3786-3797.
431. Wheeler, J. G., and F. A. Osorio. 1991. Investigation of sites of pseudorabies virus latency, using polymerase chain reaction. Am. J. Vet. Res. 52:1799-1803.
432. White, A. K., J. Ciacci-Zanella, J. Galeota, S. Ele, and F. A. Osorio. 1996. Comparison of the abilities of serologic tests to detect pseudorabies-infected pigs during the latent phase of infection. Am. J. Vet. Res. 57:608-611.
433. White, C. A., N. D. Stow, A. H. Patel, M. Hughes, and V. G. Preston. 2003. Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28. J. Virol. 77:6351-6358.
434. Whitley, R. J. 2001. Herpes simplex viruses, p. 2461-2509. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed., vol. 2. Lippincott Williams & Wilkins, Philadelphia, Pa.
435. Wilkinson, D. E., and S. K. Weller. 2003. The role of DNA recombination in herpes simplex virus DNA replication. IUBMB Life 55:451-458.
436. Wittmann, G., J. Jakubik, and R. Ahl. 1980. Multiplication and distribution of Aujeszky's disease (pseudorabies) virus in vaccinated and non-vaccinated pigs after intranasal infection. Arch. Virol. 66:227-240.
437. Wittmann, G., V. Ohlinger, and H. J. Rziha. 1983. Occurrence and reactivation of latent Aujeszky's disease virus following challenge in previously vaccinated pigs. Arch. Virol. 75:29-41.
438. Wittmann, G., and H.-J. Rziha. 1989. Aujeszky's disease (pseudorabies) in pigs, p. 230-325. In D. M. Knipe and P. M. Howley (ed.), Herpesvirus diseases of cattle, horses and pigs, vol. 9. Kluwer Academic Publishers, Boston, Mass.
439. Wong, M. L., and C. H. Chen. 1998. Evidence for the internal location of actin in the pseudorabies virion. Virus Res. 56:191-197.
440. Wong, M. L., T. Y. Ho, J. H. Huang, C. Y. Hsiang, and T. J. Chang. 1997. Stimulation of type I DNA topoisomerase gene expression by pseudorabies virus. Arch. Virol. 142:2099-2105.
441. Wu, C. A., L. Harper, and T. Ben-Porat. 1986. Molecular basis for interference of defective interfering particles of pseudorabies virus with replication of standard virus. J. Virol. 59:308-317.
442. Wu, C. L., and K. W. Wilcox. 1991. The conserved DNA-binding domains encoded by the herpes simplex virus type 1 ICP4, pseudorabies virus IE180, and varicella-zoster virus ORF62 genes recognize similar sites in the corresponding promoters. J. Virol. 65:1149-1159.
443. Wu, L., and A. J. Berk. 1988. Transcriptional activation by the pseudorabies virus immediate early protein requires the TATA box element in the adenovirus 2 E1B promoter. Virology 167:318-322.
444. Wu, S. L., C. Y. Hsiang, T. Y. Ho, and T. J. Chang. 1998. Identification, expression, and characterization of the pseudorabies virus DNA-binding protein gene and gene product. Virus Res. 56:1-9.
445. Wu, S. X., X. P. Zhu, and G. J. Letchworth. 1998. Bovine herpesvirus 1 glycoprotein M forms a disulfide-linked heterodimer with the U(L)49.5 protein. J. Virol. 72:3029-3036.
446. Yamada, S., and M. Shimizu. 1994. Isolation and characterization of mutants of pseudorabies virus with deletion in the immediate-early regulatory gene. Virology 199:366-375.
447. Yamada, S., and M. Shimizu. 1994. Pseudorabies virus immediate-early regulatory protein IE180 expressed by recombinant baculovirus is functional. Virology 202:491-495.
448. Yang, M., J. P. Card, R. S. Tirabassi, R. R. Miselis, and L. W. Enquist. 1999. Retrograde, transneuronal spread of pseudorabies virus in defined neuronal circuitry of the rat brain is facilitated by gE mutations that reduce virulence. J. Virol. 73:4350-4359.
449. York, I. A., C. Roop, D. W. Andrews, S. R. Riddell, F. L. Graham, and D. C. Johnson. 1994. A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell 77:525-535.
450. Yuan, R., C. Bohan, F. C. Shiao, R. Robinson, H. J. Kaplan, and A. Srinivasan. 1989. Activation of HIV LTR-directed expression: analysis with pseudorabies virus immediate early gene. Virology 172:92-99.
451. Zanin, E., I. Capua, C. Casaccia, A. Zuin, and A. Moresco. 1997. Isolation and characterization of Aujeszky's disease virus in captive brown bears from Italy. J. Wildl. Dis. 33:632-634.
452. Zemanick, M. C., P. L. Strick, and R. D. Dix. 1991. Direction of transneuronal transport of herpes simplex virus 1 in the primate motor system is strain-dependent. Proc. Natl. Acad. Sci. USA 88:8048-8051.
453. Zhou, Z. H., D. H. Chen, J. Jakana, F. J. Rixon, and W. Chiu. 1999. Visualization of tegument-capsid interactions and DNA in intact herpes simplex virus type 1 virions. J. Virol. 73:3210-3218.
454. Zuckermann, F. A., L. Zsak, T. C. Mettenleiter, and T. Ben-Porat. 1990. Pseudorabies virus glycoprotein gIII is a major target antigen for murine and swine virus-specific cytotoxic T lymphocytes. J. Virol. 64:802-812.