The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 protein

Journal of Virology

Volumn 71, Issue 12, 1997, Pages 9118-9123

  Koslowski, Kim M ^a   Shaver, Patti R ^a   Wang, Xiao Yang ^a,c   Tenney, Daniel J ^b   Pederson, Nels E ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN UL 15; VIRUS PROTEIN UL 28;

ARTICLE; CELL NUCLEUS; HERPES SIMPLEX VIRUS; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; PSEUDORABIES HERPETOVIRUS;

EID: 0030731408     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.12.9118-9123.1997     Document Type: Article

References (27)

1. Addison, C., F. J. Rixon, and V. G. Preston. 1990. Herpes simplex virus type 1 UL28 gene product is important for the formation of mature capsids. J. Gen. Virol. 71:2377-2384.
2. Al-Kobaisi, M. F., F. J. Rixon, I. McDougall, and V. G. Preston. 1991. The herpes simplex virus UL33 gene product is required for the assembly of full capsids. Virology 180:380-388.
3. L15 gene product. J. Virol. 71:2666-2673.
4. Baines, J. D., A. P. W. Poon, J. Rovnak, and B. Roizman. 1994. The herpes simplex virus 1 UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA. J. Virol. 68:8118-8124.
5. Cai, W., S. Person, S. C. Warner, J. Zhou, and N. A. DeLuca. 1987. Linker-insertion nonsense and restriction-site deletion mutations of the gB glycoprotein gene of herpes simplex virus type 1. J. Virol. 61:714-721.
6. Cavalcoli, J. D., A. Baghian, F. L. Homa, and K. G. Kousoulas. 1993. Resolution of genotypic and phenotypic properties of herpes simplex virus type 1 temperature-sensitive mutant (KOS) tsZ47: evidence for allelic complementation in the UL28 gene. Virology 197:23-34.
7. DeLuca, N. A., D. J. Bzik, V. C. Bond, S. Person, and W. Snipes. 1982. Nucleotide sequences of herpes simplex virus type 1 (HSV-1) affecting virus entry, cell fusion, and production of glycoprotein gB (VP7). Virology 122: 411-423.
8. Hong, Z., E. Ferrari, J. Wright-Minogue, R. Chase, C. Risano, G. Seelig, C.-G. Lee, and A. D. Kwong. 1996. Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system. J. Virol. 70:4261-4268.
9. Kalderon, D., B. L. Roberts, W. D. Richardson, and A. E. Smith. 1984. A short amino acid sequence able to specify nuclear location. Cell 39:499-509.
10. L21 genes of herpes simplex virus and a putative origin of replication. Virology 191:900-908.
11. Lamberti, C., and S. K. Weller. 1996. The herpes simplex virus type 1 UL6 protein is essential for cleavage and packaging but not for genomic inversion. Virology 226:403-407.
12. McGeoch, D. J., M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor. 1988. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69:1531-1574.
13. McGeoch, D. J., A. Dolan, S. Donald, and F. J. Rixon. 1985. Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1. J. Mol. Biol. 181:1-13.
14. Mettenleiter, T. C., A. Saalmüller, and F. Weiland. 1993. Pseudorabies virus protein homologous to herpes simplex virus type 1 ICP18.5 is necessary for capsid maturation. J. Virol. 67:1236-1245.
15. Mettenleiter, T. C., and P. G. Spear. 1994. Glycoprotein gB (gII) of pseudorabies virus can functionally substitute for glycoprotein gB in herpes simplex virus type 1. J. Virol. 68:500-504.
16. Moriuchi, H., M. Moriuchi, H. Dean, A. K. Cheung, and J. I. Cohen. 1995. Pseudorabies virus EPO is functionally homologous to varicella-zoster virus ORF61 protein and herpes simplex virus type 1 ICP0. Virology 209:281-283.
17. Pancake, B. A., D. P. Aschman, and P. A. Schaffer. 1983. Genetic and phenotypic analysis of herpes simplex virus type 1 mutants conditionally resistant to immune cytolysis. J. Virol. 47:568-585.
18. Patel, A. H., F. J. Rixon, C. Cunningham, and A. J. Davison. 1996. Isolation and characterization of herpes simplex virus type 1 mutants defective in the UL6 gene. Virology 217:111-123.
19. Pederson, N. E., and L. W. Enquist. 1991. Overexpression in bacteria and identification in infected cells of the pseudorabies virus protein homologous to herpes simplex virus type 1 ICP18.5. J. Virol. 65:3746-3758.
20. Pederson, N. E., and K. M. Koslowski. Unpublished data.
21. L15 open reading frame of herpes simplex virus 1. J. Virol. 67:4497-4503.
22. Sherman, G., and S. L. Bachenheimer. 1987. DNA processing in temperature-sensitive morphogenic mutants of HSV-1. Virology 158:427-430.
23. Tengelsen, L. A., N. E. Pederson, P. R. Shaver, M. W. Watben, and F. L. Homa. 1993. Herpes simplex virus type 1 DNA cleavage and encapsidation require the product of the UL28 gene: isolation and characterization of two UL28 deletion mutants. J. Virol. 67:3470-3480.
24. Thompson, J. F., L. S. Hayes, and D. B. Lloyd. 1991. Modulation of firefly luciferase stability and impact on studies of gene regulation. Gene (Amsterdam) 103:171-177.
25. Ward, P. L., W. O. Ogle, and B. Roizman. 1996. Assemblons: nuclear structures defined by aggregation of immature capsids and some tegument proteins of herpes simplex virus 1. J. Virol. 70:4623-4631.
26. L DNA. Virology 161:198-210.
27. Yu, D., A. K. Sheaffer, D. J. Tenney, and S. K. Weller. 1997. Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins. J. Virol. 71:2656-2665.