Pseudorabies virus (PRV) early protein 0 activates PRV gene transcription in combination with the immediate-early protein IE180 and enhances the infectivity of PRV genomic DNA

Veterinary Microbiology

Volumn 63, Issue 2-4, 1998, Pages 99-107

  Ono, Etsuro ^a   Watanabe, Shinji ^b   Nikami, Hideki ^a   Tasaki, Takafumi ^a   Kida, Hiroshi ^b  

^a Inst Immunological Sci   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Genetics; Pseudorabies virus; Transcription

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; THROMBOSPONDIN; THYMIDINE KINASE; VIRUS DNA; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; EXPRESSION VECTOR; GENE CONSTRUCT; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; NONHUMAN; PROMOTER REGION; PSEUDORABIES; VIRION; VIRUS INFECTIVITY; WESTERN BLOTTING;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA, VIRAL; GENE EXPRESSION REGULATION, VIRAL; GENES, REPORTER; HERPESVIRUS 1, SUID; IMMEDIATE-EARLY PROTEINS; KIDNEY; RECOMBINANT FUSION PROTEINS; SWINE; THYMIDINE KINASE; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; VERO CELLS; VIRAL PROTEINS; VIRION;

EID: 0031727135     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1135(98)00236-3     Document Type: Article

References (25)

1. Cheung A.K. DNA nucleotide sequence analysis of the immediate-early gene of pseudorabies virus. Nucleic Acids Res. 17:1989;4637-4646.
2. Cheung A.K. Cloning of the latency gene and the early protein 0 gene of pseudorabies virus. J. Virol. 65:1991;5260-5271.
3. Cheung A.K., Fang J., Wesley R.D. Characterization of a pseudorabies virus that is defective in the early protein 0 and latency genes. Am. J. Vet. Res. 55:1994;1710-1716.
4. Cheung A.K. Latency characteristics of an EP0 and LLT mutant of pseudorabies virus. J. Vet. Diag. Invest. 8:1996;112-115.
5. 4 motif of an alpha herpes virus protein family. J. Mol. Biol. 234:1993;1038-1047.
6. Fraefel C., Zeng J., Choffat Y., Engels M., Schwyzer M., Ackermann M. Identification and zinc dependence of the bovine herpesvirus 1 transactivator protein BICP0. J. Virol. 68:1994;3154-3162.
7. Gutekunst D.E. Latent pseudorabies virus infection in swine detected by RNA-DNA hybridization. Am. J. Vet. Res. 40:1979;1568-1572.
8. Heine J.W., Honess R.W., Cassai E., Roizman B. Proteins specified by herpes simplex virus. XII. The virion polypeptides of type 1 stranis. J. Virol. 14:1974;640-651.
9. Howarth J.A. A serologic study of pseudorabies in swine. J. Am. Vet. Med. Assoc. 154:1969;1583-1589.
10. Ihara S., Feldman L., Watanabe S., Ben-Porat T. Characterization of the immediate-early functions of pseudorabies virus. Virology. 131:1983;437-454.
11. Kida H., Yanagawa R. Isolation and characterization of influenza A viruses from wild free-flying ducks in Hokkaido. Japan. Zbl. Bakt. Hyg., Orig. A 244:1979;135-143.
12. Kit, S., 1994. Pseudorabies virus. In: Webster, R.G., Granoff, A. (Eds.), Encyclopedia of Virology Vol. 3, Academic Press, London, pp. 1173-1179.
13. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London). 227:1970;680-685.
14. Moriuchi H., Moriuchi M., Smith H.A., Straus S.E., Cohen J.I. Varicella-zoster virus open reading frame 61 protein is functionally homologous to herpes simplex virus type 1 ICP0. J. Virol. 66:1992;7303-7308.
15. Nagpal S., Ostrove J.M. Characterization of a potent varicella- zoster virus-encoded trans-repressor. J. Virol. 65:1991;5289-5296.
16. Pellicer A., Wigler M., Axel R., Silverstein S. The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell. 14:1978;133-141.
17. Roizman, B., Furlong, D., 1974. The replication of herpesvirus. In: Fraenkel-Conrat, H.R., Wagner, R. (Eds.), Comprehensive Virology, Plenum Press, New York, pp. 229-403.
18. Sabo A., Rajcani J. Latent pseudorabies virus infection in pigs. Acta Virol. 20:1976;208-214.
19. Sekulovich R.E., Leary K., Sandri-Goldin R.M. The herpes simplex virus type 1 a protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0. J. Virol. 62:1988;4510-4522.
20. Taharaguchi S., Inoue H., Ono E., Kida H., Yamada S., Shimizu Y. Mapping of transcriptional regulatory domains of pseudorabies virus immediate-early protein. Arch. Virol. 137:1994;289-302.
21. Takada A., Kida K. Induction of protective antibody responses against pseudorabies virus by intranasal vaccination with glycoprotein B in mice. Arch. Virol. 140:1995;1629-1635.
22. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some application. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
23. Watanabe S., Ono E., Shimizu Y., Kida H. Pseudorabies virus early protein 0 transactivates the viral gene promoters. J. Gen. Virol. 76:1995;2881-2885.
24. Watanabe S., Ono E., Shimizu Y., Kida H. Mapping of transregulatory domains of pseudorabies virus early protein 0 and identification of its dominant-negative mutant. Arch. Virol. 141:1996;1001-1009.
25. Wesley R.D., Cheung A.K. A pseudorabies virus mutant with deletions in the latency and early protein 0 genes: replication, virulence, and immunity in neonatal piglets. J. Vet. Diag. Invest. 8:1996;21-24.