Orexin neurons project to diverse sympathetic outflow systems

Neuroscience

Volumn 122, Issue 2, 2003, Pages 541-550

  Geerling, J C ^a   Mettenleiter, T C ^b   Loewy, A D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

Blood pressure; Cardiovascular; Catecholamine; Gastrointestinal; Hypothalamus

Indexed keywords

BETA GALACTOSIDASE; GREEN FLUORESCENT PROTEIN; OREXIN;

ADRENAL GLAND; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELIAC GANGLION; CONTROLLED STUDY; FIGHTING; FLIGHT; HYPOTHALAMUS NUCLEUS; MALE; NONHUMAN; PRIORITY JOURNAL; PSEUDORABIES HERPETOVIRUS; RAT; STELLATE GANGLION;

EID: 0242570457     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2003.07.008     Document Type: Article

References (47)

1. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec. 94:1946;239-247.
2. Antunes V.R., Brailoiu G.C., Kwok E.H., Scruggs P., Dun N.J. Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro. Am J Physiol Regul Integr Comp Physiol. 281:2001;R1801-1807.
3. Aston-Jones G., Card J.P. Use of pseudorabies virus to delineate multisynaptic circuits in brain opportunities and limitations . J Neurosci Methods. 103:2000;51-61.
4. Baust W., Weidinger H., Kirchner F. Sympathetic activity during natural sleep and arousal. Arch Ital Biol. 106:1968;379-390.
5. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., Yanagisawa M. Narcolepsy in orexin knockout mice molecular genetics of sleep regulation . Cell. 98:1999;437-451.
6. Craig A.D. Propriospinal input to thoracolumbar sympathetic nuclei from cervical and lumbar lamina I neurons in the cat and the monkey. J Comp Neurol. 331:1993;517-530.
7. Date Y., Mondal M.S., Matsukura S., Nakazato M. Distribution of orexin-A and orexin-B (hypocretins) in the rat spinal cord. Neurosci Lett. 288:2000;87-90.
8. de Lecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett F.S. 2nd, Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins hypothalamus-specific peptides with neuroexcitatory activity . Proc Natl Acad Sci USA. 95:1998;322-327.
9. Eggermann E., Bayer L., Serafin M., Saint-Mleux B., Bernheim L., Machard D., Jones B.E., Muhlethaler M. The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization. J Neurosci. 23:2003;1557-1562.
10. Estabrooke I.V., McCarthy M.T., Ko E., Chou T.C., Chemelli R.M., Yanagisawa M., Saper C.B., Scammell T.E. Fos expression in orexin neurons varies with behavioral state. J Neurosci. 21:2001;1656-1662.
11. Futuro-Neto H.A., Coote J.H. Changes in sympathetic activity to heart and blood vessels during desynchronized sleep. Brain Res. 252:1982;259-268.
12. Grudt T.J., van den Pol A.N., Perl E.R. Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat. J Physiol. 538:2002;517-525.
13. Harrison T.A., Chen C.T., Dun N.J., Chang J.K. Hypothalamic orexin A-immunoreactive neurons project to the rat dorsal medulla. Neurosci Lett. 273:1999;17-20.
14. Hervieu G.J., Cluderay J.E., Harrison D.C., Roberts J.C., Leslie R.A. Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord. Neuroscience. 103:2001;777-797.
15. Jansen A.S., Loewy A.D. Neurons lying in the white matter of the upper cervical spinal cord project to the intermediolateral cell column. Neuroscience. 77:1997;889-898.
16. Jansen A.S., Wessendorf M.W., Loewy A.D. Transneuronal labeling of CNS neuropeptide and monoamine neurons after pseudorabies virus injections into the stellate ganglion. Brain Res. 683:1995;1-24.
17. Jansen A.S., Nguyen X.V., Karpitskiy V., Mettenleiter T.C., Loewy A.D. Central command neurons of the sympathetic nervous system basis of the fight-or-flight response . Science. 270:1995;644-646.
18. Jons A., Mettenleiter T.C. Green fluorescent protein expressed by recombinant pseudorabies virus as an in vivo marker for viral replication. J Virol Methods. 66:1997;283-292.
19. Kayaba Y, Nakamura A, Kasuya Y, Ohuchi T, Yanagisawa M, Komuro I, Fukuda Y, Kuwaki T (2003) Attenuated defense response and low basal blood pressure in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol 285(3): R581-593.
20. Krout K.E., Mettenleiter T.C., Loewy A.D. Single CNS neurons link both central motor and cardiosympathetic systems a double-virus tracing study . Neuroscience. 118:2003;853-866.
21. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 98:1999;365-376.
22. Loewy A.D. Viruses as transneuronal tracers for defining neural circuits. Neurosci Biobehav Rev. 22:1998;679-684.
23. Machado B.H., Bonagamba L.G., Dun S.L., Kwok E.H., Dun N.J. Pressor response to microinjection of orexin/hypocretin into rostral ventrolateral medulla of awake rats. Regul Pept. 104:2002;75-81.
24. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagi-sawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol. 435:2001;6-25.
25. Matsumura K., Tsuchihashi T., Abe I. Central orexin-A augments sympathoadrenal outflow in conscious rabbits. Hypertension. 37:2001;1382-1387.
26. Mettenleiter T.C., Rauh I. A glycoprotein gX-beta-galactosidase fusion gene as insertional marker for rapid identification of pseudorabies virus mutants. J Virol Methods. 30:1990;55-65.
27. Nambu T., Sakurai T., Mizukami K., Hosoya Y., Yanagisawa M., Goto K. Distribution of orexin neurons in the adult rat brain. Brain Res. 827:1999;243-260.
28. Nishino S., Ripley B., Overeem S., Lammers G.J., Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 355:2000;39-40.
29. Oldfield B.J., Giles M.E., Watson A., Anderson C., Colvill L.M., McKinley M.J. The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience. 110:2002;515-526.
30. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci. 18:1998;9996-10015.
31. Peyron C., Faraco J., Rogers W., Ripley B., Overeem S., Charnay Y., Nevsimalova S., Aldrich M., Reynolds D., Albin R., Li R., Hungs M., Pedrazzoli M., Padigaru M., Kucherlapati M., Fan J., Maki R., Lammers G.J., Bouras C., Kucherlapati R., Nishino S., Mignot E. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 6:2000;991-997.
32. Piper D.C., Upton N., Smith M.I., Hunter A.J. The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats. Eur J Neurosci. 12:2000;726-730.
33. Reis D.J., Ruggiero D.A., Morrison S.F. The C1 area of the rostral ventrolateral medulla oblongata a critical brainstem region for control of resting and reflex integration of arterial pressure . Am J Hypertens. 2:1989;363S-374S.
34. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior . Cell. 92:1998;573-585.
35. Shirasaka T., Nakazato M., Matsukura S., Takasaki M., Kannan H. Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol. 277:1999;R1780-1785.
36. Sun M.K., Guyenet P.G. Hypothalamic glutamatergic input to medullary sympathoexcitatory neurons in rats. Am J Physiol. 251:1986;R798-810.
37. Sutcliffe J.G., de Lecea L. The hypocretins setting the arousal threshold . Nat Rev Neurosci. 3:2002;339-349.
38. Swanson L.W. Brain maps structure of the rat brain . 1996;Elsevier, Amsterdam.
39. Thannickal T.C., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., Cornford M., Siegel J.M. Reduced number of hypocretin neurons in human narcolepsy. Neuron. 27:2000;469-474.
40. Torterolo P., Yamuy J., Sampogna S., Morales F.R., Chase M.H. Hypocretinergic neurons are primarily involved in activation of the somatomotor system. Sleep. 26:2003;25-28.
41. Ueyama T., Krout K.E., Nguyen X.V., Karpitskiy V., Kollert A., Mettenleiter T.C., Loewy A.D. Suprachiasmatic nucleus a central autonomic clock . Nat Neurosci. 2:1999;1051-1053.
42. van den Pol A.N. Hypothalamic hypocretin (orexin) robust innervation of the spinal cord . J Neurosci. 19:1999;3171-3182.
43. van den Top M., Nolan M.F., Lee K., Richardson P.J., Buijs R.M., Davies C., Spanswick D. Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurons. J Physiol. 549:(Pt 3):2003;809-821.
44. Vogel V., Sanchez C., Jennum P. EEG measurements by means of radiotelemetry after intracerebroventricular (ICV) cannulation in rodents. J Neurosci Methods. 118:2002;89-96.
45. Westerhaus M.J., Loewy A.D. Sympathetic-related neurons in the preoptic region of the rat identified by viral transneuronal labeling. J Comp Neurol. 414:1999;361-378.
46. Westerhaus M.J., Loewy A.D. Central representation of the sympathetic nervous system in the cerebral cortex. Brain Res. 903:2001;117-127.
47. Yamamoto T., Nozaki-Taguchi N., Chiba T. Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test. Br J Pharmacol. 137:2002;170-176.