Splicing inhibition at the level of spliceosome assembly in the presence of herpes simplex virus protein ICP27

Virology

Volumn 294, Issue 1, 2002, Pages 189-198

  Lindberg, Anette ^a   Kreivi, Jan Peter ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Herpes simplex virus; ICP27; MRNA; Splicing

Indexed keywords

CELL EXTRACT; IMMEDIATE EARLY PROTEIN; MESSENGER RNA; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HELA CELL; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA SPLICING; SPLICEOSOME;

SIMPLEXVIRUS;

EID: 0036067973     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2001.1301     Document Type: Article

References (39)

1. Characterization of herpes simplex virus 1 alpha proteins 0, 4, and 27 with monoclonal antibodies
2. Herpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3′ ends of labile mRNA
3. Herpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic step
4. Splicing of precursors to mRNAs by the spliceosomes
5. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
6. Adenovirus vector designed for expression of toxic proteins
7. The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection
8. Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect
9. Functions of Lsm proteins in mRNA degradation and splicing
10. Selective extraction of polyoma DNA from infected mouse cell cultures
11. Construction and propagation of human adenovirus vectors
12. Immediate early protein IE63 of herpes simplex virus type 1 binds RNA directly
13. Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins
14. Stages in the nuclear association of the herpes simplex virus transcriptional activator protein ICP4
15. Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes
16. Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity
17. Sequences involved in the control of adenovirus L1 alternative RNA splicing
18. TATA-binding protein-associated factor(s) in TFIID function through the initiator to direct basal transcription from a TATA-less class II promoter
19. Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient
20. Regulation of herpes simplex virus poly(A) site usage and the action of immediate-early protein IE63 in the early-late switch
21. Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3′ processing
22. The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection
23. The herpes simplex virus immediate-early protein ICP27 shuttles between nucleus and cytoplasm
24. Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments
25. A novel type of splicing enhancer regulating adenovirus pre-mRNA splicing
26. A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution
27. Herpes simplex virus type 1 immediate early protein IE63 shuttles between nuclear compartments and the cytoplasm
28. Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27
29. Herpes simplex virus and their replication
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31. ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif
32. Interactions between a herpes simplex virus regulatory protein and cellular mRNA processing pathways
33. The herpes simplex virus type 1 regulatory protein ICP27 coimmunoprecipitates with anti-Sm antiserum, and the C terminus appears to be required for this interaction
34. The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for the redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not sufficient to inhibit host cell splicing
35. A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing
36. Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins
37. Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathways
38. The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2
39. Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA