DNA vaccines

Current Opinion in Immunology

Volumn 8, Issue 4, 1996, Pages 531-536

  Ulmer, Jeffrey B ^a   Sadoff, Jerald C ^a   Liu, Margaret A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

CLINICAL TRIAL; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; INFECTION; INFLUENZA; MALARIA; NONHUMAN; REVIEW; VACCINATION; VACCINE PRODUCTION;

EID: 0029742564     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80042-2     Document Type: Article

References (36)

1. Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Felgner PL, Dwarki VJ, Gromkowski SH, Deck RR, Dewitt CM, Friedman A, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science. 259:1993;1745-1749.
2. Donnelly JJ, Friedman A, Martinez D, Montgomery DL, Shiver JW, Motzel S, Ulmer JB, Liu MA. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus. of special interest Nat Med. 1:1995;583-587 These are several important results in this paper: the favorable comparison of a DNA vaccine with a corresponding licensed inactivated whole virus vaccine; the immunogenicity at low doses (10μg per construct) in nonhuman-primates; and the efficacy of a cocktail vaccine designed to induce CTLs active against internal viral proteins and neutralizing antibodies against surface proteins.
3. Sedegah M, Hedstrom R, Hobart P, Hoffman SL. Protection against malaria by immunization with circumsporozoite protein plasmid DNA. Proc Natl Acad Sci USA. 91:1994;9866-9870.
4. + T cell-, interferon γ-, and nitric oxide-dependent immunity. of outstanding interest J Exp Med. 183:1996;1739-1746 Data presented in this paper extends earlier work on malaria DNA vaccines by showing that a combination DNA vaccine can provide protection across a broader spectrum of MHC haplotypes. This paper also investigates in detail some of the underlying mechanisms of protection induced by DNA vaccines using this model.
5. Major ME, Vitvitski L, Mink MA, Schleef M, Whalen RG, Trepo C, Inchauspe G. DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid. J Virol. 69:1995;5798-5805.
6. Lagging LM, Meyer K, Hoft D, Houghton M, Belshe RB, Ray R. Immune responses to plasmid DNA encoding the hepatitis C virus core protein. J Virol. 69:1995;5859-5863.
7. Manickan E, Rouse RJD, Yu Z, Wire WS, Rouse BT. Genetic immunization against herpes simplex virus. J Immunol. 155:1995;259-265.
8. Manickan E, Yu Z, Rouse RJD, Wire WS, Rouse BT. Induction of protective immunity against herpes simlex virus with DNA encoding the immediate early protein ICP 27. Viral Immunol. 8:1995;53-61.
9. Kriesel JD, Spruance SL, Daynes RA, Araneo BA. Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease. J Infect Dis. 173:1996;536-541.
10. Bourne N, Stanberry LR, Bernstein DI, Lew D. DNA immunization against experimental genital herpes simplex virus infection. J Infect Dis. 173:1996;800-807.
11. Donnelly JJ, Martinez D, Jansen KU, Ellis RW, Montgomery DL, Liu MA. Protection against papillomavirus with a polynucleotide vaccine. J Infect Dis. 713:1996;314-320.
12. Zarozinski CC, Fynan EF, Selin LK, Robinson HL, Welsh RM. Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding and internal virion protein. J Immunol. 154:1995;4010-4017.
13. Yokoyama M, Zhang J, Whitton JL. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. J Virol. 69:1995;2684-2688.
14. Pedroz Martins L, Lau LL, Asano MS, Ahmed R. DNA vaccination against persistent viral infection. J Virol. 69:1995;2574-2582.
15. Phillpotts RJ, Venugopal K, Brooks T. Immunisation with DNA polynucleotides protects mice against lethal challenge with St. Louis encephalitis virus. Arch Virol. 141:1996;743-749.
16. Xu D, Liew FY. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major. Immunology. 84:1995;173-176.
17. Yang W, Waine GJ, McManus DP. Antibodies to Schistosoma japonicum (Asian bloodfluke) paramyosin induced by nucleic acid vaccination. Biochem Biophys Res Commun. 212:1995;1029-1039.
18. Huygen K, Content J, Denis O, Montgomery DL, Yawman AM, Randall Deck R, DeWitt CM, Orme IM, Badlwin S, D'Souza C, et al. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. in press Nat Med. 1996.
19. Tascon RE, Colston MJ, Ragno S, Stavropoulos D, Gregory D, Lowrie DB. Vaccination against tuberculosis by DNA injection. in press Nat Med. 1996.
20. Schirmbeck R, Bohm W, Ando K, Chisari FV, Reimann J. Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice. of special interest J Virol. 69:1995;5929-5934 Mice nonresponsive to HBsAg at the CTL level are shown to respond after DNA vaccination, despite the lack of induction of CTLs by recombinant protein or by a recombinant vaccinia virus expressing HBsAg. These data suggest that DNA vaccination results in quantitative and/or qualitative differences in antigen processing or presentation compared with the other modes of vaccination.
21. Davis HL, Michel M-L, Mancini M, Schleef M, Whalen RG. DNA-based immunization overcomes H-2 haplotype-restricted nonresponsiveness to HBsAG in mice. Brown F, Chanock RM, Ginsberg MS, Lerner RA. Vaccines 96. 1996;111-116 Cold Spring Habor Laboratory Press, Cold Spring Harbor, Data presented in this paper demonstrate that vaccination with HBsAG DNA is superior to recombinant protein in a low responder strain of mice, at the antibody level, with respect to protection.
22. Ciernik IF, Berzofsky JA, Carbone DP. Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes. of special interest J Immunol. 156:1996;2369-2375.
23. Donnelly JJ, Ulmer JB, Liu MA. Immunization with DNA. J Immunol Meth. 176:1994;145-152.
24. Nichols WW, Ledwith BJ, Manam SV, Troilo PJ. Potential DNA vaccine integration into host cell genome. of special interest Ann NY Acad Sci. 772:1995;30-39 This detailed study utilized a sensitive PCR approach to address the issue of the potential integration of DNA into the chromosomes of vaccinated animals.
25. Ulmer JB, Deck RR, DeWitt CM, Donnelly JJ, Liu MA. Antigen presentation by non-muscle cells for MHC class I-restricted cytotoxic T lymphocytes following viral protein expression by muscle cells. in press Immunology. 1996.
26. Hengge U, Chan EF, Foster RA, Walker PS, Vogel JC. Cytokine gene expression in epidermis with biological effects following injection of naked DNA. Nat Genet. 10:1995;161-166.
27. Ziang Z, Ertl HC. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity. 2:1995;129-135.
28. Conry RM, Widera G, LoBuglio AF, Fuller JT, Moore SE, Barlow DL, Turner J, Yang N-S, Curiel DT. Selected strategies to augment polynucleotide immunization. Gene Ther. 3:1996;67-74.
29. Irvine KR, Rao JB, Rosenberg S, Restifo NP. Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases. J Immunol. 156:1996;238-245.
30. Messina JP, Gilkeson GS, Pisetsky DS. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J Immunol. 147:1991;1759-1764.
31. Yamamoto S, Yamamoto T, Kataoka T, Kuramoto E, Yano O, Tokunaga T. Unique palindromic sequences in synthetic oligonucleotides are required to induce TNF and augment TNF-mediated natural killer activity. J Immunol. 148:1992;4072-4076.
32. Krieg AM, Yi A-K, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM. CpG motifs in bacterial DNA trigger direct B-cell activation. of special interest Nature. 374:1995;546-549 A detailed analysis of the stimulatory effects of specific DNA sequences on lymphocytes corroborating and extending earlier work [30,31].
33. Gilkeson GS, Pippen AM, Pisetsky DS. Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J Clin Invest. 95:1995;1398-1402.
34. Gilkeson GS, Ruiz P, Pippen AMM, Alexander AL, Lefkowith JB, Pisetsky DS. Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA. of special interest J Exp Med. 183:1996;1389-1397 Demonstration of an unexpected attenuating effect of bacterial DNA on disease and death in a lupus-prone mouse strain.
35. Sizemore D, Branstrom A, Sadoff J. Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunogenicity. of special interest Science. 270:1995;299-302 The recombinant pathogen described in this paper offers the potential for targeting mucosal immune responses with a form of DNA vaccination.
36. Barry MA, Lai WC, Johnston SA. Protection against mycoplasma infection using expression-library immunization. of special interest Nature. 377:1995;632-635 The authors used a clever combination of molecular cloning and DNA vaccination strategies to develop a potential screen for protective antigens. If protective antigens can indeed be identified by this technique, it could accelerate the discovery of vaccine antigens.