The pseudorabies virus VP22 homologue (UL49) is dispensable for virus growth in vitro and has no effect on virulence and neuronal spread in rodents

Journal of Virology

Volumn 76, Issue 2, 2002, Pages 774-782

  Del Rio, T ^a   Werner, H C ^a   Enquist, L W ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; CYTOLOGY; DNA REPLICATION; HERPES VIRUS; IMMUNOFLUORESCENCE; MALE; NERVE CELL; NERVOUS SYSTEM; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PHOSPHORYLATION; PSEUDORABIES HERPETOVIRUS; RAT; VIRAL GENETICS; VIRION; VIROGENESIS; VIRULENCE;

ANIMALS; CELL LINE; CELL NUCLEUS; DNA, RECOMBINANT; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE DELETION; HERPESVIRUS 1, SUID; MALE; NEURONS; PHENOTYPE; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PSEUDORABIES; RATS; RATS, SPRAGUE-DAWLEY; RODENTIA; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; VIRAL STRUCTURAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 0036138814     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.2.774-782.2002     Document Type: Article

References (55)

1. The genome of turkey herpesvirus
2. Molecular biology of pseudorabies virus
3. Role of the cytoplasmic tail of pseudorabies virus glycoprotein E in virion formation
4. A subset of viral transcripts packaged within human cytomegalovirus particles
5. Evaluation of VP22 spread in tissue culture
6. Role of pseudorabies virus Us9, a type II membrane protein, in infection of tissue culture cells and the rat nervous system
7. Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription
8. Two alphaherpesvirus strains are transported differentially in the rodent visual system
9. Pseudorabies virus envelope glycoprotein gI influences both neurotropism and virulence during infection of the rat visual system
10. Varicella-zoster virus (VZV) open reading frame 10 protein, the homolog of the essential herpes simplex virus protein VP16, is dispensable for VZV replication in vitro
11. Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein VP22
12. Marek's disease virus (MDV) homologues of herpes simplex virus type 1 UL49 (VP22) and UL48 (VP16) genes: High-level expression and characterization of MDV-1 VP22 and VP16
13. The herpes simplex virus type 1 tegument protein VP22 is encoded by gene UL49
14. VP16 interacts via its activation domain with VP22, a tegument protein of herpes simplex virus, and is relocated to a novel macromolecular assembly in coexpressing cells
15. Phosphorylation of the herpes simplex virus type 1 tegument protein VP22
16. Intercellular trafficking and protein delivery by a herpesvirus structural protein
17. Herpes simplex virus type 1 tegument protein VP22 induces the stabilization and hyperacetylation of microtubules
18. Identification of phosphorylation sites within the herpes simplex virus tegument protein VP22
19. Live-cell analysis of a green fluorescent protein-tagged herpes simplex virus infection
20. Cytoplasm-to-nucleus translocation of a herpesvirus tegument protein during cell division
21. Proteins specified by herpes simplex virus. Staining and radiolabeling properties of B capsid and virion proteins in polyacrylamide gels
22. Human cytomegalovirus virions differentially incorporate viral and host cell RNA during the assembly process
23. Immunoaffinity purification
24. Synthesis, subcellular localization and VP16 interaction of the herpes simplex virus type 2 UL46 gene product
25. The genome of herpesvirus of turkeys: Comparative analysis with Marek's disease viruses
26. Primary envelopment of pseudorabies virus at the nuclear membrane requires the UL34 gene product
27. Overexpression of the herpes simplex virus type 1 tegument protein VP22 increases its incorporation into virus particles
28. Characterization of bovine herpesvirus 1 UL49 homolog gene and product: Bovine herpesvirus 1 UL49 homolog is dispensable for virus growth
29. Study of immunogenicity and virulence of bovine herpesvirus 1 mutants deficient in the UL49 homolog, UL49.5 homolog and dUTPase genes in cattle
30. Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate alpha-trans-inducing factor-dependent activation of alpha genes
31. Characterization of enveloped tegument structures (L particles) produced by alphaherpesviruses: Integrity of the tegument does not depend on the presence of capsid or envelope
32. A dominant-negative herpesvirus protein inhibits intranuclear targeting of viral proteins: Effects on DNA replication and late gene expression
33. Pseudorabies virus avirulent strains fail to express a major glycoprotein
34. Aujeszky's disease (pseudorabies) virus: The virus and molecular pathogenesis - State of the art, June 1999
35. Differences in the intracellular localization and fate of herpes simplex virus tegument proteins early in the infection of Vero cells
36. Phosphorylation of structural components promotes dissociation of the herpes simplex virus type 1 tegument
37. Evidence that herpes simplex virus VP16 is required for viral egress downstream of the initial envelopment event
38. Intercellular delivery of functional p53 by the herpesvirus protein VP22
39. DNA-binding proteins of herpes simplex virus type 1-infected BHK cell nuclear matrices
40. Modified VP22 localizes to the cell nucleus during synchronized herpes simplex virus type 1 infection
41. Assembly of infectious Herpes simplex virus type 1 virions in the absence of full-length VP22
42. Herpes simplex viruses and their replication
43. Analysis of pseudorabies virus glycoprotein gIII localization and modification by using novel infectious viral mutants carrying unique EcoRI sites
44. Gene contents in a 31-kb segment at the left genome end of bovine herpesvirus-1
45. RNAs extracted from herpes simplex virus 1 virions: Apparent selectivity of viral but not cellular RNAs packaged in virions
46. n-Butyrate, a cell cycle blocker, inhibits the replication of polyomaviruses and papillomaviruses but not that of adenoviruses and herpesviruses
47. Truncation of the C-terminal acidic transcriptional activation domain of herpes simplex virus VP16 produces a phenotype similar to that of the in1814 linker insertion mutation
48. Construction and transposon mutagenesis in Escherichia coli of a full-length infectious clone of pseudorabies virus, an alphaherpesvirus
49. Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion
50. Role of the pseudorabies virus gI cytoplasmic domain in neuroinvasion, virulence, and posttranslational N-linked glycosylation
51. Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites
52. Assemblons: Nuclear structures defined by aggregation of immature capsids and some tegument proteins of herpes simplex virus 1
53. Deletion of the VP16 open reading frame of herpes simplex virus type 1
54. Nucleotide and predicted amino acid sequences of Marek's disease virus homologues of herpes simplex virus major tegument proteins
55. Role of herpes simplex virus type 1 UL46 and UL47 in alpha TIF-mediated transcriptional induction: Characterization of three viral deletion mutants