Latency characteristics of an EPO and LLT mutant of pseudorabies virus

Journal of Veterinary Diagnostic Investigation

Volumn 8, Issue 1, 1996, Pages 112-115

  Cheung, Andrew K ^a  

^a NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY PROTEIN O, PSEUDORABIES VIRUS; PRIMER DNA; VIRUS DNA; VIRUS PROTEIN;

ANIMAL; ARTICLE; GENE DELETION; GENETIC TRANSCRIPTION; GENETICS; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PSEUDORABIES; PSEUDORABIES HERPETOVIRUS; SWINE; TRIGEMINUS GANGLION; VIROLOGY; VIRUS CULTURE; VIRUS GENE; VIRUS LATENCY; VIRUS REPLICATION;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; DNA, VIRAL; GENES, VIRAL; HERPESVIRUS 1, SUID; MOLECULAR SEQUENCE DATA; PLAQUE ASSAY; POLYMERASE CHAIN REACTION; PSEUDORABIES; SEQUENCE DELETION; SWINE; TRANSCRIPTION, GENETIC; TRIGEMINAL GANGLION; VIRAL PROTEINS; VIRUS LATENCY; VIRUS REPLICATION;

EID: 0029679184     PISSN: 10406387     EISSN: None     Source Type: Journal    
DOI: 10.1177/104063879600800119     Document Type: Article

References (19)

1. Cai W, Schaffer PA: 1992, Herpes simplex virus type 1 ICPO regulates expression of immediate-early, early, and late genes in productively infected cells. J Virol 66:2904-2915.
2. Chen J, Silverstein S: 1992, Herpes simplex viruses with mutations in the gene encoding ICPO are defective in gene expression. J Virol 66:2916-2927.
3. Cheung AK: 1989, Detection of pseudorabies virus transcripts in trigeminal ganglia of latently infected swine. J Virol 63:2908-2913.
4. Cheung AK: 1991, Cloning of the latency gene and early protein O gene of pseudorabies virus. J Virol 65:5260-5271.
5. Cheung AK: 1994, Detection of the large latency transcript of pseudorabies virus by RNA-PCR and its potential in diagnosis. J Vet Diagn Invest 6:483-486.
6. Cheung AK, Fang J, Wesley RD: 1994, Characterization of a pseudorabies virus that is defective in the early protein O and latency genes. Am J Vet Res 55:1710-1716.
7. Kluge JP, Beran GW, Hill HT, Platt KB: 1992, Pseudorabies (Aujeszky's disease). In: Diseases of swine, ed. Leman AD, Straw BE, Mengeling WL, et al., 7th ed., pp. 312-323. Iowa State University Press, Ames, IA.
8. Lokensgard JR, Thawley DG, Molitor TW: 1990, Pseudorabies virus latency: restricted transcription. Arch Virol 110:129-136.
9. MacGregor GR, Nolan GP, Fiering S, et al.: 1991, Use of E. coli lacZ (β-galactosidase) as a reporter gene. Methods Mol Biol 7:217-235.
10. Maniatis T, Fritsch EF, Sambrook J: 1982, Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
11. Mengeling WL: 1989, Latent infection and subsequent reactivation of pseudorabies virus in swine exposed to pseudorabies virus while nursing immune dams. Am J Vet Res 50:1658-1666.
12. Mullis KB, Faloona FA: 1987, Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol 155:335-350.
13. Priola SA, Gustafson DP, Wagner EK, Stevens JG: 1990, A major portion of the latent pseudorabies virus genome is transcribed in trigeminal ganglia of pigs. J Virol 64:4755-4760.
14. Priola SA, Stevens JG: 1991, The 5′ and 3′ limits of transcription in the pseudorabies virus latency associated transcription unit. Virology 182:852-856.
15. Robbins AK, Dorney DJ, Wathen MW, et al.: 1987, The pseudorabies virus gII gene is closely related to the gB glycoprotein gene of herpes simplex virus. J Virol 61:2691-2701.
16. Rock DL, Hagemoser WA, Osorio FA, McAllister HA: 1988, Transcription from the pseudorabies virus genome during latent infection. Arch Virol 98:99-106.
17. Southern EM: 1975, Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98: 503-518.
18. Wesley RD, Cheung AK: 1995, A pseudorabies virus mutant with deletions in the latency and early protein O genes: replication, virulence and immunity in neonatal piglets. J Vet Diagn Invest 0:000-000.
19. Zhu X, Chen J, Young CHS, Silverstein S: 1990, Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-O gene products. J Virol 64:4489-4498.