Glycoproteins gM and gN of pseudorabies virus are dispensable for viral penetration and propagation in the nervous systems of adult mice

Journal of Virology

Volumn 73, Issue 12, 1999, Pages 10503-10507

  Masse, Marie Jo ^a   Jöns, Alice ^b   Dijkstra, Johannes M ^b   Mettenleiter, Thomas C ^b   Flamand, Anne ^a  

^a CNRS   (France)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; DELETION MUTANT; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PSEUDORABIES HERPETOVIRUS; REVERTANT; VIRUS REPLICATION; VIRUS VIRULENCE;

EID: 0345504883     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.12.10503-10507.1999     Document Type: Article

References (29)

1. Babic, N., T. C. Mettenleiter, A. Flamand, and G. Ugolini. 1993. Role of essential glycoproteins gII and gp50 in transneuronal transfer of pseudorabies virus from the hypoglossal nerves of mice. J. Virol. 67:4421-4426.
2. Babic, N., T. C. Mettenleiter, G. Ugolini, A. Flamand, and P. Coulon. 1994. Propagation of pseudorabies virus in the nervous system of the mouse after intranasal inoculation. Virology 204:616-625.
3. Babic, N., B. Klupp, A. Brack, T. C. Mettenleiter, G. Ugolini, and A. Flamand. 1996. Deletion of glycoprotein gE reduces the propagation of pseudorabies virus in the nervous system of mice after intranasal inoculation. Virology 219:279-284.
4. Babic, N., B. G. Klupp, B. Makoschey, A. Karger, A. Flamand, and T. C. Mettenleiter. 1996. Glycoprotein gH of pseudorabies virus is essential for penetration and propagation in cell culture and in the nervous system of mice. J. Gen. Virol. 77:2277-2285.
5. Babic, N., and A. Flamand. Unpublished results.
6. Card, J. P., M. E. Whealy, A. K. Robbins, and L. W. Enquist. 1992. Pseudorabies virus envelope glycoprotein gI influences both neurotropism and virulence during infection of the rat visual system. J. Virol. 66:3032-3041.
7. Dijkstra, J. M., N. Visser, T. C. Mettenleiter, and B. G. Klupp. 1996. Identification and characterization of pseudorabies virus glycoprotein gM as a nonessential virion component. J. Virol. 70:5684-5688.
8. Dijkstra, J. M., V. Gerdts, B. G. Klupp, and T. C. Mettenleiter. 1997. Deletion of glycoprotein gM of pseudorabies virus results in attenuation for the natural host. J. Gen. Virol. 78:2147-2151.
9. Enquist, L. W., J. Dubin, M. E. Whealy, and J. P. Card. 1994. Complementation analysis of pseudorabies virus gE and gI mutants in retinal ganglion cell neurotropism. J. Virol. 68:5275-5279.
10. Enquist, L. W., P. J. Husak, B. W. Banfield, and G. A. Smith. 1998. Infection and spread of alphaherpesviruses in the nervous system. Adv. Virus Res. 51:237-347.
11. Jacobs, L., W. A. M. Mulder, J. T. V. Oirschot, A. L. J. Gielkens, and T. J. Kimman. 1993. Deleting two amino acids in glycoprotein gI of pseudorabies virus decreases virulence and neurotropism for pigs, but does not affect immunogenicity. J. Gen. Virol. 74:2201-2206.
12. Jöns, A., J. M. Dijkstra, and T. C. Mettenleiter. 1998. Glycoproteins M and N of pseudorabies virus form a disulfide-linked complex. J. Virol. 72:550-557.
13. Jöns, A., H. Granzow, R. Kuchling, and T. C. Mettenleiter. 1996. The UL49.5 gene of pseudorabies virus codes for an O-glycosylated structural protein of the viral envelope. J. Virol. 70:1237-1241.
14. Karger, A., A. Saalmüller, F. Tufaro, B. W. Banfield, and T. C. Mettenleiter. 1995. Cell surface proteoglycans are not essential for infection by pseudorabies virus. J. Virol. 69:3482-3489.
15. Kimman, T. G., N. de Wind, N. Oei-Lie, J. M. A. Pol, A. J. M. Berns, and A. L. J. Gielkens. 1992. Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpes type 1) to virulence, pathogenesis and immunogenicity. J. Gen. Virol. 73:243-251.
16. Knapp, A. C., P. J. Husak, and L. W. Enquist. 1997. The gE and gI homologs from two alphaherpesviruses have conserved and divergent neuroinvasive properties. J. Virol. 71:5820-5827.
17. Kritas, S. K., H. J. Nauwynck, and M. B. Pensaert. 1995. Dissemination of wild-type and gC-, gE- and gI-deleted mutants of Aujeszky's disease virus in the maxillary nerve and trigeminal ganglion of pigs after intranasal inoculation. J. Gen. Virol. 76:2063-2066.
18. Levine, J. D., X.-S. Zhao, and R. R. Miselis. 1994. Direct and indirect retino-hypothalamic projections to the supraoptic nucleus in the female albino rat. J. Comp. Neurol. 341:214-224.
19. Mettenleiter, T. C. 1993. Pseudorabies (Aujeszky's disease) virus: state of the art. Acta Vet. Hung. 42:153-177.
20. Moore, R. Y., J. C. Speh, and J. P. Card. 1995. The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells. J. Comp. Neurol. 352:351-366.
21. Mulder, W., J. Pol, T. Kimman, G. Kok, J. Priem, and B. Peeters. 1996. Glycoprotein D-negative pseudorabies virus can spread transneuronally via direct neuron-to-neuron transmission in its natural host, the pig, but not after additional inactivation of gE or gI. J. Virol. 70:2191-2200.
22. Mulder, W. A. M., L. Jacobs, J. Priem, G. L. Kok, F. Wagenaar, T. G. Kimman, and J. M. A. Pol. 1994. Glycoprotein gE-negative pseudorabies virus has a reduced capability to infect second- and third-order neurons of the olfactory and trigeminal routes in the porcine central nervous system. J. Gen. Virol. 75:3095-3106.
23. Peeters, B., N. de Wind, M. Hooisma, F. Wagenaar, A. Gielkens, and R. Moormann. 1992. Pseudorabies virus envelope glycoproteins gp50 and gII are essential for virus penetration, but only gII is involved in membrane fusion. J. Virol. 66:894-905.
24. Rauh, I., and T. C. Mettenleiter. 1991. Pseudorabies virus glycoproteins gll and gp50 are essential for virus penetration. J. Virol. 65:5348-5356.
25. Rauh, I., F. Weiland, F. Fehler, G. M. Keil, and T. C. Mettenleiter. 1991. Pseudorabies virus mutants lacking the essential glycoprotein gII can be complemented by glycoprotein gI of bovine herpesvirus 1. J. Virol. 65:621-631.
26. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
27. Sams, J. M., A. S. P. Jansen, T. C. Mettenleiter, and A. D. Loewy. 1995. Pseudorabies virus mutants as transneuronal markers. Brain Res. 687:182-190.
28. Tirabassi, R. S., R. A. Townley, M. G. Eldridge, and L. W. Enquist. 1997. Characterization of pseudorabies virus mutants expressing carboxy-terminal truncations of gE: evidence for envelope incorporation, virulence, and neurotropism domains. J. Virol. 71:6455-6464.
29. Whealy, M. E., J. P. Card, A. K. Robbins, J. R. Dubin, H.-J. Rziha, and L. W. Enquist. 1993. Specific pseudorabies virus infection of the rat visual system requires both gI and gp63 glycoproteins. J. Virol. 67:3786-3797.