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Volumn 1, Issue 2, 2003, Pages 1-12

Angiogenesis as a new target for cancer control

Author keywords

Angiogenesis; Anti angiogenesis Inhibitors; Hypoxia; Trials; VEGF

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 4 DEDIMETHYLAMINOSANCYCLINE; ADRENOMEDULLIN; AE 941; ANGIOGENESIS INHIBITOR; ANGIOGENIC FACTOR; ANGIOZYME; ANTINEOPLASTIC AGENT; CGS 27023A; CILENGITIDE; CM 101; ENDOTHELIN; EPHRIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IM 862; IRINOTECAN; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PRINOMASTAT; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; REBIMASTAT; RECOMBINANT ALPHA INTERFERON; SEMAXANIB; SOLIMASTAT; TANOMASTAT; THROMBOSPONDIN; TNP 70; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR; VATALANIB; ZD 0101; ZK 22584;

EID: 2442447195     PISSN: 13596349     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6349(03)00007-7     Document Type: Article
Times cited : (29)

References (131)
  • 1
    • 0025141337 scopus 로고
    • What is the evidence that tumours are angiogenesis dependent?
    • Folkman J. What is the evidence that tumours are angiogenesis dependent? J. Natl. Cancer Inst. 82:1990;4-6
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 4-6
    • Folkman, J.1
  • 2
    • 0034499732 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and the regulation of angiogenesis
    • Ferrara N. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog. Horm. Res. 55:2000;15-36
    • (2000) Recent Prog. Horm. Res. , vol.55 , pp. 15-36
    • Ferrara, N.1
  • 3
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug-resistance
    • Boehm T., Folkman J., Browder T., Oreilly M.S. Antiangiogenic therapy of experimental cancer does not induce acquired drug-resistance. Nature. 390:1997;404-407
    • (1997) Nature , vol.390 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    Oreilly, M.S.4
  • 4
    • 0035173755 scopus 로고    scopus 로고
    • Overview of angiogenesis: Biologic implications for antiangiogenic therapy
    • Ellis L.M., Liu W.B., Ahmad S.A., et al. Overview of angiogenesis. biologic implications for antiangiogenic therapy Semin. Oncol. 28:2001;94-104
    • (2001) Semin. Oncol. , vol.28 , pp. 94-104
    • Ellis, L.M.1    Liu, W.B.2    Ahmad, S.A.3
  • 5
    • 0034471876 scopus 로고    scopus 로고
    • Genes that regulate metastasis and angiogenesis
    • Webb C.P., Woude G.F.V. Genes that regulate metastasis and angiogenesis. J. Neurooncol. 50:2000;71-87
    • (2000) J. Neurooncol. , vol.50 , pp. 71-87
    • Webb, C.P.1    Woude, G.F.V.2
  • 6
    • 0035379755 scopus 로고    scopus 로고
    • Bioimmunotherapeutic targets on angiogenetic blood vessels in solid malignangies
    • Maio M., Altomonte M., Calabro L., Fonsatti E. Bioimmunotherapeutic targets on angiogenetic blood vessels in solid malignangies. Front Biosci. 6:2001;D776-D784
    • (2001) Front Biosci. , vol.6
    • Maio, M.1    Altomonte, M.2    Calabro, L.3    Fonsatti, E.4
  • 7
    • 0034776405 scopus 로고    scopus 로고
    • Lipid messengers as targets for antiangiogenic therapy
    • Robert E.G., Hunt J.D. Lipid messengers as targets for antiangiogenic therapy. Curr. Pharm. Des. 7:2001;1615-1626
    • (2001) Curr. Pharm. Des. , vol.7 , pp. 1615-1626
    • Robert, E.G.1    Hunt, J.D.2
  • 8
    • 0343673806 scopus 로고    scopus 로고
    • Tumour vasculature as a target for anticancer therapy
    • Eatock M.M., Schatzlein A., Kaye S.B. Tumour vasculature as a target for anticancer therapy. Cancer Treat. Rev. 26:2000;191-204
    • (2000) Cancer Treat. Rev. , vol.26 , pp. 191-204
    • Eatock, M.M.1    Schatzlein, A.2    Kaye, S.B.3
  • 9
    • 0033863589 scopus 로고    scopus 로고
    • Molecular mechanism of angiogenesis - Transcription factors and their therapeutic relevance
    • Sato Y. Molecular mechanism of angiogenesis - transcription factors and their therapeutic relevance. Pharmacol. Ther. 87:2000;51-60
    • (2000) Pharmacol. Ther. , vol.87 , pp. 51-60
    • Sato, Y.1
  • 10
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G., Cohen T., Gengrinovitch S., Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13:1999;9-22
    • (1999) FASEB J. , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 11
    • 0033025957 scopus 로고    scopus 로고
    • Small molecule inhibitors of tumor-promoted angiogenesis, including protein tyrosine kinase inhibitors
    • Hamby J.M., Showalter H.D.H. Small molecule inhibitors of tumor-promoted angiogenesis, including protein tyrosine kinase inhibitors. Pharmacol. Ther. 82:1999;169-193
    • (1999) Pharmacol. Ther. , vol.82 , pp. 169-193
    • Hamby, J.M.1    Showalter, H.D.H.2
  • 12
    • 0032842990 scopus 로고    scopus 로고
    • Anti-integrins as a potential therapeutic target in angiogenesis
    • Mousa S.A. Anti-integrins as a potential therapeutic target in angiogenesis. Expert Opin. Ther. Pat. 9:1999;1237-1248
    • (1999) Expert Opin. Ther. Pat. , vol.9 , pp. 1237-1248
    • Mousa, S.A.1
  • 13
    • 0035866771 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy
    • Geng L., Donnelly E., McMahon G., Lin P.C., et al. Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res. 61:2001;2413-2419
    • (2001) Cancer Res. , vol.61 , pp. 2413-2419
    • Geng, L.1    Donnelly, E.2    McMahon, G.3    Lin, P.C.4
  • 14
    • 0034984740 scopus 로고    scopus 로고
    • VEGF as a mediator of tumor-associated immunodeficiency
    • Ohm J.E., Carbone D.P. VEGF as a mediator of tumor-associated immunodeficiency. Immunol Res. 23:2001;263-272
    • (2001) Immunol Res. , vol.23 , pp. 263-272
    • Ohm, J.E.1    Carbone, D.P.2
  • 15
    • 17944368283 scopus 로고    scopus 로고
    • The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor
    • Ambartsumian N., Klingelhofer J., Grigorian M., et al. The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor. Oncogene. 20:2001;4685-4695
    • (2001) Oncogene , vol.20 , pp. 4685-4695
    • Ambartsumian, N.1    Klingelhofer, J.2    Grigorian, M.3
  • 16
    • 0034695685 scopus 로고    scopus 로고
    • The hemostatic system as a regulator of angiogenesis
    • Browder T., Folkman J., PirieShepherd S. The hemostatic system as a regulator of angiogenesis. J. Biol. Chem. 275:2000;1521-1524
    • (2000) J. Biol. Chem. , vol.275 , pp. 1521-1524
    • Browder, T.1    Folkman, J.2    Pirieshepherd, S.3
  • 17
    • 0035933126 scopus 로고    scopus 로고
    • Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF
    • Cao R.H., Brakenhielm E., Wahlestedt C., Thyberg J., Cao Y.H. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proc. Natl. Acad. Sci. USA. 98:2000;6390-6395
    • (2000) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6390-6395
    • Cao, R.H.1    Brakenhielm, E.2    Wahlestedt, C.3    Thyberg, J.4    Cao, Y.H.5
  • 18
    • 0034816920 scopus 로고    scopus 로고
    • Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility
    • Funasaka T., Haga A., Raz A., Nagase H. Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility. Biochem. Biophys. Res. Commun. 284:2001;1116-1125
    • (2001) Biochem. Biophys. Res. Commun. , vol.284 , pp. 1116-1125
    • Funasaka, T.1    Haga, A.2    Raz, A.3    Nagase, H.4
  • 19
    • 0035897531 scopus 로고    scopus 로고
    • Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells
    • Hu Y.L., Tee M.K., Goetzl E.J., et al. Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells. J. Natl. Cancer Inst. 93:2001;762-768
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 762-768
    • Hu, Y.L.1    Tee, M.K.2    Goetzl, E.J.3
  • 20
    • 0034960583 scopus 로고    scopus 로고
    • The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
    • Pola R., Ling L.E., Silver M., et al. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat. Med. 7:2001;706-711
    • (2001) Nat. Med. , vol.7 , pp. 706-711
    • Pola, R.1    Ling, L.E.2    Silver, M.3
  • 21
    • 0035841946 scopus 로고    scopus 로고
    • Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line
    • Shimo T., Kubota S., Kondo S., et al. Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line. Cancer Lett. 174:2001;57-64
    • (2001) Cancer Lett. , vol.174 , pp. 57-64
    • Shimo, T.1    Kubota, S.2    Kondo, S.3
  • 22
    • 0035504921 scopus 로고    scopus 로고
    • P73 overexpression increases VEGF and reduces thrombospondin-1 production: Implications for tumor angiogenesis
    • Vikhanskaya F., Bani M.R., Borsotti P., et al. p73 overexpression increases VEGF and reduces thrombospondin-1 production. implications for tumor angiogenesis Oncogene. 20:2001;7293-7300
    • (2001) Oncogene , vol.20 , pp. 7293-7300
    • Vikhanskaya, F.1    Bani, M.R.2    Borsotti, P.3
  • 23
    • 85058724162 scopus 로고    scopus 로고
    • AngX/CDT-6, a novel factor that enhances angiogenesis
    • Liu C.Y., Paradis H., Gendron R., et al. AngX/CDT-6, a novel factor that enhances angiogenesis. Mol. Biol. Cell. 11:2000;66A
    • (2000) Mol. Biol. Cell , vol.11
    • Liu, C.Y.1    Paradis, H.2    Gendron, R.3
  • 24
    • 0034848340 scopus 로고    scopus 로고
    • The role of collagen-derived proteolytic fragments in angiogenesis
    • Marneros A.G., Olsen B.R. The role of collagen-derived proteolytic fragments in angiogenesis. Matrix Biol. 20:2001;337-345
    • (2001) Matrix Biol. , vol.20 , pp. 337-345
    • Marneros, A.G.1    Olsen, B.R.2
  • 25
    • 0033888016 scopus 로고    scopus 로고
    • Galectin-3 induces endothetial cell morphogenesis and angiogenesis
    • NangiaMakker P., Honjo Y., Sarvis R., et al. Galectin-3 induces endothetial cell morphogenesis and angiogenesis. Am. J. Pathol. 156:2000;899-909
    • (2000) Am. J. Pathol. , vol.156 , pp. 899-909
    • Nangiamakker, P.1    Honjo, Y.2    Sarvis, R.3
  • 26
    • 0034125929 scopus 로고    scopus 로고
    • Current status of antiangiogenic factors
    • Talks K.L., Harris A.L. Current status of antiangiogenic factors. Br. J. Haematol. 109:2000;477-489
    • (2000) Br. J. Haematol. , vol.109 , pp. 477-489
    • Talks, K.L.1    Harris, A.L.2
  • 27
    • 0035318510 scopus 로고    scopus 로고
    • Tie receptors: New modulators of angiogenic and lymphangiogenic responses
    • Jones N., Iljin K., Dumont D.J., Alitalo K. Tie receptors. New modulators of angiogenic and lymphangiogenic responses Nat. Rev. Mol. Cell. Biol. 2:2001;257-267
    • (2001) Nat. Rev. Mol. Cell. Biol. , vol.2 , pp. 257-267
    • Jones, N.1    Iljin, K.2    Dumont, D.J.3    Alitalo, K.4
  • 29
    • 0035974803 scopus 로고    scopus 로고
    • Identification of an angiogenic mitogen selective for endocrine gland endothelium
    • LeCouter J., Kowalski J., Foster J., et al. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature. 412:2001;877-884
    • (2001) Nature , vol.412 , pp. 877-884
    • Lecouter, J.1    Kowalski, J.2    Foster, J.3
  • 30
    • 0035870271 scopus 로고    scopus 로고
    • Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models
    • Lee M.S., Moon E.J., Lee S.W., Kim H.S., Kim K.W., Kim Y.J. Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models. Cancer Res. 61:2001;3290-3293
    • (2001) Cancer Res. , vol.61 , pp. 3290-3293
    • Lee, M.S.1    Moon, E.J.2    Lee, S.W.3    Kim, H.S.4    Kim, K.W.5    Kim, Y.J.6
  • 31
    • 0035149332 scopus 로고    scopus 로고
    • Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice
    • Lawler J., Miao W.M., Duquette M., Bouck N., Bronson R.T., Hynes R.O. Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am. J. Pathol. 159:2001;1949-1956
    • (2001) Am. J. Pathol. , vol.159 , pp. 1949-1956
    • Lawler, J.1    Miao, W.M.2    Duquette, M.3    Bouck, N.4    Bronson, R.T.5    Hynes, R.O.6
  • 32
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
    • O'Reilly M.S., Boehm T., Shing Y., et al. Endostatin. an endogenous inhibitor of angiogenesis and tumor growth Cell. 88:1997;277-285
    • (1997) Cell , vol.88 , pp. 277-285
    • O'Reilly, M.S.1    Boehm, T.2    Shing, Y.3
  • 33
    • 0027970092 scopus 로고
    • Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • O'Reilly M.S., Holmgren L., Shing Y., et al. Angiostatin. a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma Cell. 79:1994;315-328
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1    Holmgren, L.2    Shing, Y.3
  • 35
    • 0035048449 scopus 로고    scopus 로고
    • Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
    • Kim M.S., Kwon H.J., Lee Y.M., et al. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat. Med. 7:2001;437-443
    • (2001) Nat. Med. , vol.7 , pp. 437-443
    • Kim, M.S.1    Kwon, H.J.2    Lee, Y.M.3
  • 36
    • 0035853699 scopus 로고    scopus 로고
    • A novel anti-angiogenic form of antithrombin with retained proteinase binding ability and heparin affinity
    • Larsson H., Akerud P., Nordling K., Raub S.E., Claesson W.L., Bjork I. A novel anti-angiogenic form of antithrombin with retained proteinase binding ability and heparin affinity. J. Biol. Chem. 276:2001;11996-12002
    • (2001) J. Biol. Chem. , vol.276 , pp. 11996-12002
    • Larsson, H.1    Akerud, P.2    Nordling, K.3    Raub, S.E.4    Claesson, W.L.5    Bjork, I.6
  • 37
    • 12944315074 scopus 로고    scopus 로고
    • Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis
    • Schwarte-Waldhoff I., Volpert O.V., Bouck N.P., et al. Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis. Proc. Natl. Acad. Sci. USA. 97:2000;9624-9629
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9624-9629
    • Schwarte-Waldhoff, I.1    Volpert, O.V.2    Bouck, N.P.3
  • 39
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D., Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 86:1996;353-364
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 40
    • 0028951043 scopus 로고
    • Dormancy of micrometastases- balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren L., Oreilly M.S., Folkman J. Dormancy of micrometastases- balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat. Med. 1:1995;149-153
    • (1995) Nat. Med. , vol.1 , pp. 149-153
    • Holmgren, L.1    Oreilly, M.S.2    Folkman, J.3
  • 41
    • 0030873165 scopus 로고    scopus 로고
    • Pieces of 8- bioactive fragments of extracellular proteins as regulators of angiogenesis
    • Sage E.H. Pieces of 8- bioactive fragments of extracellular proteins as regulators of angiogenesis. Trends Cell Biol. 7:1997;182-186
    • (1997) Trends Cell Biol. , vol.7 , pp. 182-186
    • Sage, E.H.1
  • 42
    • 0035911953 scopus 로고    scopus 로고
    • Angiomotin: An angiostatin binding protein that regulates endothelial cell migration and tube formation
    • Troyanovsky B., Levchenko T., Mansson G., Matvijenko O., Holmgren L. Angiomotin. an angiostatin binding protein that regulates endothelial cell migration and tube formation J. Cell. Biol. 152:2001;1247-1254
    • (2001) J. Cell. Biol. , vol.152 , pp. 1247-1254
    • Troyanovsky, B.1    Levchenko, T.2    Mansson, G.3    Matvijenko, O.4    Holmgren, L.5
  • 43
    • 12644251975 scopus 로고    scopus 로고
    • The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin
    • Gately S., Twardowski P., Stack M.S., et al. The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin. Proc. Natl. Acad. Sci. USA. 94:1997;10868-10872
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10868-10872
    • Gately, S.1    Twardowski, P.2    Stack, M.S.3
  • 44
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial-cell growth-factor, acidic and basic fibroblast growth-factor, tumor-growth factor-beta-1, platelet-derived endothelial-cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M., Lejeune S., Scott P.A.E., et al. Expression of the angiogenic factors vascular endothelial-cell growth-factor, acidic and basic fibroblast growth-factor, tumor-growth factor-beta-1, platelet-derived endothelial-cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res. 57:1997;963-969
    • (1997) Cancer Res. , vol.57 , pp. 963-969
    • Relf, M.1    Lejeune, S.2    Scott, P.A.E.3
  • 46
    • 0034650744 scopus 로고    scopus 로고
    • Oncogenes and tumor angiogenesis: Differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts
    • Rak J., Mitsuhashi Y., Sheehan C., et al. Oncogenes and tumor angiogenesis. differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts Cancer Res. 60:2000;490-498
    • (2000) Cancer Res. , vol.60 , pp. 490-498
    • Rak, J.1    Mitsuhashi, Y.2    Sheehan, C.3
  • 48
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • Ciardiello F., Bianco R., Damiano V., et al. Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin. Cancer Res. 6:2000;3739-3747
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 49
    • 0035174126 scopus 로고    scopus 로고
    • The role of HER2 in angiogenesis
    • Kumar R., Yarmand B.R. The role of HER2 in angiogenesis. Semin. Oncol. 28:2001;27-32
    • (2001) Semin. Oncol. , vol.28 , pp. 27-32
    • Kumar, R.1    Yarmand, B.R.2
  • 50
    • 0035914297 scopus 로고    scopus 로고
    • Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression
    • Sanchez E.T., Botella L.M., Velasco B., Corbi A., Attisano L., Bernabeu C. Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J. Biol. Chem. 276:2001;38527-38535
    • (2001) J. Biol. Chem. , vol.276 , pp. 38527-38535
    • Sanchez, E.T.1    Botella, L.M.2    Velasco, B.3    Corbi, A.4    Attisano, L.5    Bernabeu, C.6
  • 51
    • 0033986273 scopus 로고    scopus 로고
    • Circulating endothelial precursors: Mystery, reality, and promise
    • Rafii S. Circulating endothelial precursors. mystery, reality, and promise J. Clin. Invest. 105:2000;17-19
    • (2000) J. Clin. Invest. , vol.105 , pp. 17-19
    • Rafii, S.1
  • 52
    • 0033529618 scopus 로고    scopus 로고
    • Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    • Asahara T., Masuda H., Takahashi T., et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. 85:1999;221-228
    • (1999) Circ. Res. , vol.85 , pp. 221-228
    • Asahara, T.1    Masuda, H.2    Takahashi, T.3
  • 53
    • 0032528555 scopus 로고    scopus 로고
    • Evidence for circulating bone marrow-derived endothelial cells
    • Shi Q., Rafii S., Wu M.H., et al. Evidence for circulating bone marrow-derived endothelial cells. Blood. 92:1998;362-367
    • (1998) Blood , vol.92 , pp. 362-367
    • Shi, Q.1    Rafii, S.2    Wu, M.H.3
  • 54
    • 0033989026 scopus 로고    scopus 로고
    • Origins of circulating endothelial cells and endothelial outgrowth from blood
    • Lin Y., Weisdorf D.J., Solovey A., Hebbel R.P. Origins of circulating endothelial cells and endothelial outgrowth from blood. J. Clin. Invest. 105:2000;71-77
    • (2000) J. Clin. Invest. , vol.105 , pp. 71-77
    • Lin, Y.1    Weisdorf, D.J.2    Solovey, A.3    Hebbel, R.P.4
  • 55
    • 0034813202 scopus 로고    scopus 로고
    • Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice
    • Davidoff A.M., Ng C.Y.C., Brown P., et al. Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice. Clin. Cancer Res. 7:2001;2870-2879
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2870-2879
    • Davidoff, A.M.1    Ng, C.Y.C.2    Brown, P.3
  • 56
    • 0035849588 scopus 로고    scopus 로고
    • Mobilization of endothelial progenitor cells in patients with acute myocardial infarction
    • Shintani S., Murohara T., Ikeda H., et al. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation. 103:2001;2776-2779
    • (2001) Circulation , vol.103 , pp. 2776-2779
    • Shintani, S.1    Murohara, T.2    Ikeda, H.3
  • 57
    • 0033406794 scopus 로고    scopus 로고
    • Endothelial progenitor cells as putative targets for angiostatin
    • Ito H., Rovira II, Bloom M.L., et al. Endothelial progenitor cells as putative targets for angiostatin. Cancer Res. 59:1999;5875-5877
    • (1999) Cancer Res. , vol.59 , pp. 5875-5877
    • Ito, H.1    Rovira, I.I.2    Bloom, M.L.3
  • 58
    • 0035383784 scopus 로고    scopus 로고
    • Resting and activated endothelial cells are increased in the peripheral blood of cancer patients
    • Mancuso P., Burlini A., Pruneri G., Goldhirsch A., Martinelli G., Bertolini F. Resting and activated endothelial cells are increased in the peripheral blood of cancer patients. Blood. 97:2001;3658-3661
    • (2001) Blood , vol.97 , pp. 3658-3661
    • Mancuso, P.1    Burlini, A.2    Pruneri, G.3    Goldhirsch, A.4    Martinelli, G.5    Bertolini, F.6
  • 59
    • 0033964164 scopus 로고    scopus 로고
    • Intussusceptive angiogenesis - Its role in embryonic vascular network formation
    • Djonov V., Schmid M., Tschanz S.A., Burri P.H. Intussusceptive angiogenesis - its role in embryonic vascular network formation. Circ. Res. 86:2000;286-292
    • (2000) Circ. Res. , vol.86 , pp. 286-292
    • Djonov, V.1    Schmid, M.2    Tschanz, S.A.3    Burri, P.H.4
  • 61
    • 0034769666 scopus 로고    scopus 로고
    • Role of Id proteins in embryonic and tumor angiogenesis
    • Benezra R. Role of Id proteins in embryonic and tumor angiogenesis. Trends Cardiovasc. Med. 11:2001;237-241
    • (2001) Trends Cardiovasc. Med. , vol.11 , pp. 237-241
    • Benezra, R.1
  • 62
    • 0034707595 scopus 로고    scopus 로고
    • Homeobox B3 promotes capillary morphogenesis and angiogenesis
    • Myers C., Charboneau A., Boudreau N. Homeobox B3 promotes capillary morphogenesis and angiogenesis. J. Cell. Biol. 148:2000;343-351
    • (2000) J. Cell. Biol. , vol.148 , pp. 343-351
    • Myers, C.1    Charboneau, A.2    Boudreau, N.3
  • 63
  • 65
    • 0034468383 scopus 로고    scopus 로고
    • Eph receptors and ephrin ligands. Essential mediators of vascular development
    • Adams R.H., Klein R. Eph receptors and ephrin ligands. essential mediators of vascular development. Trends Cardiovasc. Med. 10:2000;183-188
    • (2000) Trends Cardiovasc. Med. , vol.10 , pp. 183-188
    • Adams, R.H.1    Klein, R.2
  • 67
    • 0033669849 scopus 로고    scopus 로고
    • In silico cloning of novel endothelial-specific genes
    • Huminiecki L., Bicknell R. In silico cloning of novel endothelial-specific genes. Genome Res. 10:2000;1796-1806
    • (2000) Genome Res. , vol.10 , pp. 1796-1806
    • Huminiecki, L.1    Bicknell, R.2
  • 68
    • 0035253409 scopus 로고    scopus 로고
    • Angiogenesis: The role of the microenvironment in flipping the switch
    • Giordano F.J., Johnson R.S. Angiogenesis. the role of the microenvironment in flipping the switch Curr. Opin. Genet. Dev. 11:2001;35-40
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 35-40
    • Giordano, F.J.1    Johnson, R.S.2
  • 69
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel M., Vaupel P. Tumor hypoxia. definitions and current clinical, biologic, and molecular aspects J. Natl. Cancer Inst. 93:2001;266-276
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 70
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • Ohh M., Park C.W., Ivan M., et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell. Biol. 2:2000;423-427
    • (2000) Nat. Cell. Biol. , vol.2 , pp. 423-427
    • Ohh, M.1    Park, C.W.2    Ivan, M.3
  • 71
    • 0034641615 scopus 로고    scopus 로고
    • Activation of HIF1 alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
    • Kamura T., Sato S., Iwai K., CzyzykKrzeska M., Conaway R.C., Conaway J.W. Activation of HIF1 alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. USA. 97:2000;10430-10435
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10430-10435
    • Kamura, T.1    Sato, S.2    Iwai, K.3    Czyzykkrzeska, M.4    Conaway, R.C.5    Conaway, J.W.6
  • 72
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell P.H., Wiesener M.S., Chang G.W., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399:1999;271-275
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 73
    • 0033574737 scopus 로고    scopus 로고
    • Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function
    • Stebbins C.E., Kaelin W.G. Jr., Pavletich N.P. Structure of the VHL-ElonginC-ElonginB complex. implications for VHL tumor suppressor function Science. 284:1999;455-461
    • (1999) Science , vol.284 , pp. 455-461
    • Stebbins, C.E.1    Kaelin Jr., W.G.2    Pavletich, N.P.3
  • 74
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks K.L., Turley H., Gatter K.C., et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157:2000;411-421
    • (2000) Am. J. Pathol. , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3
  • 75
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H., De Marzo A.M., Laughner E., et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59:1999;5830-5835
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 76
    • 0035925072 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
    • Bos R., Zhong H., Hanrahan C.F., et al. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J. Natl. Cancer Inst. 93:2001;309-314
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 309-314
    • Bos, R.1    Zhong, H.2    Hanrahan, C.F.3
  • 77
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola P., Mole D.R., Tian Y.M., et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 292:2001;468-472
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1    Mole, D.R.2    Tian, Y.M.3
  • 78
    • 0035917313 scopus 로고    scopus 로고
    • HIF{alpha} targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
    • Ivan M., Kondo K., Yang H., et al. HIF{alpha} targeted for VHL-mediated destruction by proline hydroxylation. implications for O2 sensing Science. 292(5516):2001;449-451
    • (2001) Science , vol.292 , Issue.5516 , pp. 449-451
    • Ivan, M.1    Kondo, K.2    Yang, H.3
  • 79
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 294(5545):2001;1337-1340
    • (2001) Science , vol.294 , Issue.5545 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 80
    • 17944375360 scopus 로고    scopus 로고
    • Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein A.C., Gleadle J.M., McNeill L.A., et al. Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 107:2001;43-54
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1    Gleadle, J.M.2    McNeill, L.A.3
  • 81
    • 0033970086 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment
    • Denko N., Schindler C., Koong A., Laderoute K., Green C., Giaccia A. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin. Cancer Res. 6:2000;480-487
    • (2000) Clin. Cancer Res. , vol.6 , pp. 480-487
    • Denko, N.1    Schindler, C.2    Koong, A.3    Laderoute, K.4    Green, C.5    Giaccia, A.6
  • 82
    • 0034652779 scopus 로고    scopus 로고
    • Candidate genes for the hypoxic tumor phenotype
    • Koong A.C., Denko N.C., Hudson K.M., et al. Candidate genes for the hypoxic tumor phenotype. Cancer Res. 60:2000;883-887
    • (2000) Cancer Res. , vol.60 , pp. 883-887
    • Koong, A.C.1    Denko, N.C.2    Hudson, K.M.3
  • 83
    • 0034649507 scopus 로고    scopus 로고
    • Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
    • Wykoff C.C., Pugh C.W., Maxwell P.H., Harris A.L., Ratcliffe P.J. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene. 19:2000;6297-6305
    • (2000) Oncogene , vol.19 , pp. 6297-6305
    • Wykoff, C.C.1    Pugh, C.W.2    Maxwell, P.H.3    Harris, A.L.4    Ratcliffe, P.J.5
  • 84
    • 0035812284 scopus 로고    scopus 로고
    • Transcriptional response to hypoxia in human tumors
    • Lal A., Peters H., St Croix B., et al. Transcriptional response to hypoxia in human tumors. J. Natl. Cancer Inst. 93:2001;1337-1343
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1337-1343
    • Lal, A.1    Peters, H.2    St Croix, B.3
  • 85
    • 0033924882 scopus 로고    scopus 로고
    • Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor
    • Laderoute K.R., Alarcon R.M., Brody M.D., et al. Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clin. Cancer Res. 6:2000;2941-2950
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2941-2950
    • Laderoute, K.R.1    Alarcon, R.M.2    Brody, M.D.3
  • 86
    • 0035906852 scopus 로고    scopus 로고
    • Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway
    • Clarke K., Smith K., Gullick W.J., Harris A.L. Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway. Br. J. Cancer. 84:2001;1322-1329
    • (2001) Br. J. Cancer , vol.84 , pp. 1322-1329
    • Clarke, K.1    Smith, K.2    Gullick, W.J.3    Harris, A.L.4
  • 87
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H., Chiles K., Feldser D., et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells. implications for tumor angiogenesis and therapeutics Cancer Res. 60:2000;1541-1545
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3
  • 88
    • 0034671256 scopus 로고    scopus 로고
    • Relationship of hypoxia-inducible factor (HIF)-1α and HIF-2α expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines
    • Blancher C., Moore J.W., Talks K.L., Houlbrook S., Harris A.L. Relationship of hypoxia-inducible factor (HIF)-1α and HIF-2α expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. Cancer Res. 60:2000;7106-7113
    • (2000) Cancer Res. , vol.60 , pp. 7106-7113
    • Blancher, C.1    Moore, J.W.2    Talks, K.L.3    Houlbrook, S.4    Harris, A.L.5
  • 89
    • 0034050050 scopus 로고    scopus 로고
    • Loss of PTEN facilitates HIF-1-mediated gene expression
    • Zundel W., Schindler C., Haas-Kogan D., et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14:2000;391-396
    • (2000) Genes Dev. , vol.14 , pp. 391-396
    • Zundel, W.1    Schindler, C.2    Haas-Kogan, D.3
  • 91
    • 0035855668 scopus 로고    scopus 로고
    • Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia
    • Suzuki H., Tomida A., Tsuruo T. Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene. 20:2001;5779-5788
    • (2001) Oncogene , vol.20 , pp. 5779-5788
    • Suzuki, H.1    Tomida, A.2    Tsuruo, T.3
  • 92
    • 0035352721 scopus 로고    scopus 로고
    • Angiogenesis: Pathological prognostic and growth-factor pathways and their link to trial design and anticancer drugs
    • Fox S.B., Gasparini G., Harris A.L. Angiogenesis. pathological prognostic and growth-factor pathways and their link to trial design and anticancer drugs Lancet Oncol. 2:2001;278-289
    • (2001) Lancet Oncol , vol.2 , pp. 278-289
    • Fox, S.B.1    Gasparini, G.2    Harris, A.L.3
  • 93
    • 0036345395 scopus 로고    scopus 로고
    • Second international concensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours
    • Vermeulen P.B., Gasparini G., Fox S.B., et al. Second international concensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. Eur. J. Cancer. 38(12):2002;1564-1579
    • (2002) Eur. J. Cancer , vol.38 , Issue.12 , pp. 1564-1579
    • Vermeulen, P.B.1    Gasparini, G.2    Fox, S.B.3
  • 94
    • 0030920373 scopus 로고    scopus 로고
    • Markers of tumor angiogenesis- clinical-applications in prognosis and anti-angiogenic therapy
    • Fox S.B., Harris A.L. Markers of tumor angiogenesis- clinical- applications in prognosis and anti-angiogenic therapy. Invest. New Drugs. 15:1997;15-28
    • (1997) Invest. New Drugs , vol.15 , pp. 15-28
    • Fox, S.B.1    Harris, A.L.2
  • 95
    • 0034214159 scopus 로고    scopus 로고
    • Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer
    • Koukourakis M.I., Giatromanolaki A., Thorpe P.E., et al. Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer. Cancer Res. 60:2000;3088-3095
    • (2000) Cancer Res. , vol.60 , pp. 3088-3095
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Thorpe, P.E.3
  • 96
    • 0032908133 scopus 로고    scopus 로고
    • Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells
    • Miller D.W., Graulich W., Karges B., et al. Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells. Int. J. Cancer. 81:1999;568-572
    • (1999) Int. J. Cancer , vol.81 , pp. 568-572
    • Miller, D.W.1    Graulich, W.2    Karges, B.3
  • 97
    • 0033557520 scopus 로고    scopus 로고
    • Breast carcinoma: Vascular density determined using CD105 antibody correlates with tumor prognosis
    • Kumar S., Ghellal A., Li C., Byrne G., Haboubi N., Wang J.M., Bundred N. Breast carcinoma. vascular density determined using CD105 antibody correlates with tumor prognosis Cancer Res, 59:1999;856-861
    • (1999) Cancer Res , vol.59 , pp. 856-861
    • Kumar, S.1    Ghellal, A.2    Li, C.3    Byrne, G.4    Haboubi, N.5    Wang, J.M.6    Bundred, N.7
  • 98
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin L.E., Hemo I., Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development. 125:1999;1591-1598
    • (1999) Development , vol.125 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 99
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin L.E., Golijanin D., Itin A., Pode D., Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103:1999;159-165
    • (1999) J. Clin. Invest. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 100
    • 0035187305 scopus 로고    scopus 로고
    • Tissue examination to monitor antiangiogenic therapy: A phase I clinical trial with endostatin
    • Mundhenke C., Thomas J.P., Wilding G., et al. Tissue examination to monitor antiangiogenic therapy. a phase I clinical trial with endostatin Clin. Cancer Res. 7:2001;3366-3374
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3366-3374
    • Mundhenke, C.1    Thomas, J.P.2    Wilding, G.3
  • 101
    • 0033617532 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
    • Bergers G., Javaherian K., Lo K.M., Folkman J., Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science. 284:1999;808-812
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1    Javaherian, K.2    Lo, K.M.3    Folkman, J.4    Hanahan, D.5
  • 102
    • 0035060498 scopus 로고    scopus 로고
    • Pitfalls in the measurement of circulating vascular endothelial growth factor
    • Jelkmann W. Pitfalls in the measurement of circulating vascular endothelial growth factor. Clin. Chem. 47:2001;617-623
    • (2001) Clin. Chem. , vol.47 , pp. 617-623
    • Jelkmann, W.1
  • 103
    • 0032576346 scopus 로고    scopus 로고
    • Involvement of platelets in tumour angiogenesis?
    • Pinedo H.M., Verheul H.M., D'Amato R.J., Folkman J. Involvement of platelets in tumour angiogenesis? Lancet. 352:1998;1775-1777
    • (1998) Lancet , vol.352 , pp. 1775-1777
    • Pinedo, H.M.1    Verheul, H.M.2    D'Amato, R.J.3    Folkman, J.4
  • 104
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
    • Tozer G.M., Prise V.E., Wilson J., et al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent. early effects in tumors and normal tissues Cancer Res. 59:1999;1626-1634
    • (1999) Cancer Res. , vol.59 , pp. 1626-1634
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 106
    • 0034967245 scopus 로고    scopus 로고
    • Tissue-specific gene therapy directed to tumor angiogenesis
    • Varda B.N., Shaish A., Gonen A., et al. Tissue-specific gene therapy directed to tumor angiogenesis. Gene Ther. 8:2001;819-827
    • (2001) Gene Ther. , vol.8 , pp. 819-827
    • Varda, B.N.1    Shaish, A.2    Gonen, A.3
  • 107
    • 0030968939 scopus 로고    scopus 로고
    • Targeting gene-expression to hypoxic tumor-cells
    • Dachs G.U., Patterson A.V., Firth J.D., et al. Targeting gene-expression to hypoxic tumor-cells. Nat. Med. 3:1997;515-520
    • (1997) Nat. Med. , vol.3 , pp. 515-520
    • Dachs, G.U.1    Patterson, A.V.2    Firth, J.D.3
  • 108
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T., Butterfield C.E., Kraling B.M., et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. 60:2000;1878-1886
    • (2000) Cancer Res. , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3
  • 109
    • 0035461919 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of lower dose cancer chemotherapy
    • Gately S., Kerbel R. Antiangiogenic scheduling of lower dose cancer chemotherapy. Cancer J. 7:2001;427-436
    • (2001) Cancer J. , vol.7 , pp. 427-436
    • Gately, S.1    Kerbel, R.2
  • 110
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement G., Baruchel S., Rak J., Man S., Clark K., Hicklin D.J., Bohlen P., Kerbel R.S. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 105:2000;R15-R24
    • (2000) J. Clin. Invest. , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.J.6    Bohlen, P.7    Kerbel, R.S.8
  • 112
    • 0035336732 scopus 로고    scopus 로고
    • Monoclonal antibody strategies to block angiogenesis
    • Hicklin D.J., Witte L., Zhu Z.P., et al. Monoclonal antibody strategies to block angiogenesis. Drug Discov. Today. 6:2001;517-528
    • (2001) Drug Discov. Today , vol.6 , pp. 517-528
    • Hicklin, D.J.1    Witte, L.2    Zhu, Z.P.3
  • 113
    • 0035204128 scopus 로고    scopus 로고
    • Vascular Endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth gactor-induced angiogenesis in vivo and in vitro
    • Tille J.C., Wood J., Mandriota S.J., et al. Vascular Endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth gactor-induced angiogenesis in vivo and in vitro. J. Pharmacol. Exp. Ther. 299:2001;1073-1085
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 1073-1085
    • Tille, J.C.1    Wood, J.2    Mandriota, S.J.3
  • 114
    • 0034798718 scopus 로고    scopus 로고
    • Targeting angiogenic processes by combination rofecoxib and ionizing radiation
    • Dicker A.P., Williams T.L., Grant D.S. Targeting angiogenic processes by combination rofecoxib and ionizing radiation. Am. J. Clin. Oncol. 24:2001;438-442
    • (2001) Am. J. Clin. Oncol. , vol.24 , pp. 438-442
    • Dicker, A.P.1    Williams, T.L.2    Grant, D.S.3
  • 115
    • 0034942982 scopus 로고    scopus 로고
    • Tumor angiogenesis targeting using imaging agents
    • Weber W.A., Haubner R., Vabuliene E., et al. Tumor angiogenesis targeting using imaging agents. Q. J. Nucl. Med. 45:2001;179-182
    • (2001) Q. J. Nucl. Med. , vol.45 , pp. 179-182
    • Weber, W.A.1    Haubner, R.2    Vabuliene, E.3
  • 116
    • 0031756068 scopus 로고    scopus 로고
    • Nmr imaging of changes in vascular morphology due to tumor angiogenesis
    • Dennie J., Mandeville J.B., Boxerman J.L., et al. Nmr imaging of changes in vascular morphology due to tumor angiogenesis. Magn. Reson. Med. 40:1998;793-799
    • (1998) Magn. Reson. Med. , vol.40 , pp. 793-799
    • Dennie, J.1    Mandeville, J.B.2    Boxerman, J.L.3
  • 117
    • 0031946469 scopus 로고    scopus 로고
    • Magnetic-resonance-imaging detects suppression of tumor vascular-permeability after administration of antibody to vascular endothelial growth-factor
    • Pham C.D., Roberts T.P.L., Vanbruggen N., Melnyk O., et al. Magnetic-resonance-imaging detects suppression of tumor vascular-permeability after administration of antibody to vascular endothelial growth-factor. Cancer Invest. 16:1998;225-230
    • (1998) Cancer Invest. , vol.16 , pp. 225-230
    • Pham, C.D.1    Roberts, T.P.L.2    Vanbruggen, N.3    Melnyk, O.4
  • 118
    • 0031862889 scopus 로고    scopus 로고
    • Detection of tumor angiogenesis in-vivo by alpha(v)beta(3)-targeted magnetic-resonance-imaging
    • Sipkins D.A., Cheresh D.A., Kazemi M.R., Nevin L.M., Bednarski M.D., Li K.C.P. Detection of tumor angiogenesis in-vivo by alpha(v)beta(3)-targeted magnetic-resonance-imaging. Nat. Med. 4:1998;623-626
    • (1998) Nat. Med. , vol.4 , pp. 623-626
    • Sipkins, D.A.1    Cheresh, D.A.2    Kazemi, M.R.3    Nevin, L.M.4    Bednarski, M.D.5    Li, K.C.P.6
  • 119
    • 0031883407 scopus 로고    scopus 로고
    • Quantitative assessment of blood-flow, blood-volume and blood oxygenation effects in functional magnetic-resonance-imaging
    • Vanzijl P.C.M., Eleff S.M., Ulatowski J.A., et al. Quantitative assessment of blood-flow, blood-volume and blood oxygenation effects in functional magnetic-resonance-imaging. Nat. Med. 4:1998;159-167
    • (1998) Nat. Med. , vol.4 , pp. 159-167
    • Vanzijl, P.C.M.1    Eleff, S.M.2    Ulatowski, J.A.3
  • 120
    • 0011055479 scopus 로고    scopus 로고
    • Tumor imaging with I-123 labeled angiostatin, a novel anti-angiogenesis targeted radiopharmaceutical
    • Lee K.H., Lee S.Y., Paik J.Y., et al. Tumor imaging with I-123 labeled angiostatin, a novel anti-angiogenesis targeted radiopharmaceutical. J. Nucl. Med. 42:2001;253P
    • (2001) J. Nucl. Med. , vol.42
    • Lee, K.H.1    Lee, S.Y.2    Paik, J.Y.3
  • 121
    • 0028305809 scopus 로고
    • Potentiation of cytotoxic cancer therapies by tnp-470 alone and with other anti-angiogenic agents
    • Teicher B.A., Holden S.A., Ara G., et al. Potentiation of cytotoxic cancer therapies by tnp-470 alone and with other anti-angiogenic agents. Int. J. Cancer. 57:1994;920-925
    • (1994) Int. J. Cancer , vol.57 , pp. 920-925
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3
  • 122
    • 0034975263 scopus 로고    scopus 로고
    • Antiangiogenic agents and their promising potential in combined therapy
    • Burke P.A., DeNardo S.J. Antiangiogenic agents and their promising potential in combined therapy. Crit. Rev. Oncol. Hematol. 39:2001;155-171
    • (2001) Crit. Rev. Oncol. Hematol. , vol.39 , pp. 155-171
    • Burke, P.A.1    Denardo, S.J.2
  • 123
    • 0032818363 scopus 로고    scopus 로고
    • Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival
    • Smith K., Fox S.B., Whitehouse R., Taylor M., et al. Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival. Ann. Oncol. 10:1999;707-713
    • (1999) Ann. Oncol. , vol.10 , pp. 707-713
    • Smith, K.1    Fox, S.B.2    Whitehouse, R.3    Taylor, M.4
  • 124
    • 0030722076 scopus 로고    scopus 로고
    • Non-small-cell-lung carcinoma tumor-growth without morphological evidence of neo-angiogenesis
    • Pezzella F., Pastorino U., Tagliabue E., et al. Non-small-cell-lung carcinoma tumor-growth without morphological evidence of neo-angiogenesis. Am. J. Pathol. 151:1997;1417-1423
    • (1997) Am. J. Pathol. , vol.151 , pp. 1417-1423
    • Pezzella, F.1    Pastorino, U.2    Tagliabue, E.3
  • 125
    • 0034690655 scopus 로고    scopus 로고
    • Evidence for novel non-angiogenic pathway in breast cancer metastasis
    • Pezzella F., Manzotti M., DeBAcco A., et al. Evidence for novel non-angiogenic pathway in breast cancer metastasis. Lancet. 355:2000;1787-1788
    • (2000) Lancet , vol.355 , pp. 1787-1788
    • Pezzella, F.1    Manzotti, M.2    Debacco, A.3
  • 126
    • 0034819711 scopus 로고    scopus 로고
    • Angiogenesis is redundant for tumour growth in lymph node metastases
    • Naresh K.N., Nerurkar A.Y., Borges A.M. Angiogenesis is redundant for tumour growth in lymph node metastases. Histopathology. 38:2001;466-470
    • (2001) Histopathology , vol.38 , pp. 466-470
    • Naresh, K.N.1    Nerurkar, A.Y.2    Borges, A.M.3
  • 127
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • Holash J., Wiegand S.J., Yancopoulos G.D. New model of tumor angiogenesis. dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF Oncogene. 18:1999;5356-5362
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 128
    • 0034513575 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Pro- and anti-angiogenic activities
    • Raza S.L., Cornelius L.A. Matrix metalloproteinases. pro- and anti-angiogenic activities J. Invest. Dermatol. Symp. Proc. 5:2000;47-54
    • (2000) J. Invest. Dermatol. Symp. Proc. , vol.5 , pp. 47-54
    • Raza, S.L.1    Cornelius, L.A.2
  • 129
    • 0032832479 scopus 로고    scopus 로고
    • Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance
    • O'Reilly M.S., Wiederschain D., Stetler-Stevenson W.G., Folkman J., Moses M.A. Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. J. Biol. Chem. 274:1999;29568-29571
    • (1999) J. Biol. Chem. , vol.274 , pp. 29568-29571
    • O'Reilly, M.S.1    Wiederschain, D.2    Stetler-Stevenson, W.G.3    Folkman, J.4    Moses, M.A.5
  • 130
    • 0034993498 scopus 로고    scopus 로고
    • In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects
    • Filleur S., Volpert O.V., Degeorges A., et al. In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects. Genes Dev. 15:2001;1373-1382
    • (2001) Genes Dev. , vol.15 , pp. 1373-1382
    • Filleur, S.1    Volpert, O.V.2    Degeorges, A.3
  • 131
    • 0033027727 scopus 로고    scopus 로고
    • Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat
    • Dawson D.W., Volpert O.V., Pearce S.F., et al. Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat. Mol. Pharmacol. 55:1999;332-338
    • (1999) Mol. Pharmacol. , vol.55 , pp. 332-338
    • Dawson, D.W.1    Volpert, O.V.2    Pearce, S.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.