Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells

Journal of the National Cancer Institute

Volumn 93, Issue 10, 2001, Pages 762-768

  Hu, Yu Long ^a   Tee, Meng Kian ^a   Goetzl, Edward J ^a   Auersperg, Nelly ^b   Mills, Gordon B ^c   Ferrara, Napoleone ^d   Jaffe, Robert B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOPHOSPHATIDIC ACID; MESSENGER RNA; PROTEIN; PROTEIN C FOS; PROTEIN C JUN; RECEPTOR SUBTYPE; TRANSCRIPTION FACTOR AP 1; VASCULOTROPIN; VIRUS T ANTIGEN;

ARTICLE; BINDING SITE; CANCER CELL; CELL IMMORTALIZATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HALF LIFE TIME; HUMAN; HUMAN CELL; ONCOGENE C FOS; ONCOGENE C JUN; OVARY CANCER; PRIORITY JOURNAL; PROMOTER REGION; SIMIAN VIRUS 40; TRANSACTIVATION; TUMOR GROWTH;

EID: 0035897531     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/93.10.762     Document Type: Article

References (37)

1. The bioactive phospholipid lysophosphatidic acid is released from activated platelets
2. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate
3. Lysophosphatidic acid: G-protein signalling and cellular responses
4. Molecular cloning of human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid
5. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
6. Lysophospholipids activate ovarian and breast cancer cells
7. Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients
8. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers
9. 1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation
10. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
11. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
12. Induction of angiogenesis during the transition from hyperplasia to neoplasia
13. Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
14. The biology of vascular endothelial growth factor
15. Vascular endothelial growth factor localization in human ovary and fallopian tubes: Possible role in reproductive function and ovarian cyst formation
16. Vascular permeability factor gene expression in normal and neoplastic human ovaries
17. Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms
18. Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: Correlation with clinicopathology and patient survival, and analysis of serum VEGF levels
19. Role of vascular endothelial growth factor in ovarian cancer: Inhibition of ascites formation by immunoneutralization
20. Characterization of a xenograft model of human ovarian carcinoma which produces ascites and intraabdominal carcinomatosis in mice
21. Simian virus 40-transformed human ovarian surface epithelial cells escape normal growth controls but retain morphogenetic responses to extracellular matrix
22. Characterization of cultured human ovarian surface epithelial cells: Phenotypic plasticity and premalignant changes
23. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: Implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis
24. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
25. Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not from breast or leukemia cells
26. PIK3CA is implicated as an oncogene in ovarian cancer
27. Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
28. Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression
29. Transforming growth factor-α-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation
30. Induction of vascular endothelial growth factor by tumor necrosis factor α in human glioma cells. Possible roles of SP-1
31. Collaborative roles for c-Jun N-terminal kinase, c-Jun, serum response factor, and Sp1 in calcium-regulated myocardial gene expression
32. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
33. AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells
34. Stromelysin in tumor progression and metastasis
35. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
36. Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer
37. Screening for early ovarian cancer