Eph receptors and Ephrin ligands: Essential mediators of vascular development

Trends in Cardiovascular Medicine

Volumn 10, Issue 5, 2000, Pages 183-188

  Adams, Ralf H ^a   Klein, Rüdiger ^a  

^a Developmental Biology Unit   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN; LIGAND; PROTEIN TYROSINE KINASE;

ANGIOGENESIS; CARDIOVASCULAR SYSTEM; DEVELOPMENT; EMBRYO; ENDOTHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ENDOTHELIUM, VASCULAR; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPHA1; RECEPTOR, EPHB4; RECEPTORS, EPH FAMILY; SIGNAL TRANSDUCTION;

EID: 0034468383     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(00)00046-3     Document Type: Review

References (36)

1. Roles of ephrinB ligands and EphB receptors in cardiovascular development; demarcation of arterial/venous domains, vascular morphogenesis and sprouting angiogenesis
2. Signalling by Eph receptors and their ephrin ligands
3. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains
4. Tyrosine phosphorylation of transmembrane ligands for Eph receptors
5. Role of vascular endothelial growth factor and vascular endothelial growth factor receptors in vascular development
6. The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans
7. Fibroblast growth factor receptor-mediated rescue of x-ephrin B1-induced cell dissociation in Xenopus embryos
8. Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family
9. ELK and LERK-2 in developing kidney and microvascular endothelial assembly
10. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity
11. The angiopoietins; Yin and Yang in angiogenesis
12. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion
13. Structure, expression and receptor-binding properties of novel vascular endothelial growth factors
14. The ephrins and Eph receptors in neural development
15. Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis
16. Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases
17. Growth factors acting via endothelial cell-specific receptor tyrosine kinases; VEGFs, angiopoietins, and ephrins in vascular development
18. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrinB2 in cardiovascular development
19. The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis
20. Nuk controls pathfinding of commissural axons in the mammalian central nervous sustem
21. Eph receptors and ephrins; effectors of morphogenesis
22. Bidirectional signaling through the EPH-family receptor Nuk and its transmembrane ligands
23. A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein
24. Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins
25. The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif
26. Ephrin-A1 is expressed at sites of vascular development in the mouse
27. Homeobox B3 promotes capillary morphogenesis and angiogenesis
28. Eph receptors and ephrins in neural development
29. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-α-induced angiogenesis
30. Mechanisms of angiogenesis
31. Vasculogenesis
32. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
33. PDZ proteins bind, cluster and synaptically co-localize with Eph receptors and their ephrin ligands
34. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
35. Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor
36. An Eph receptor regulates integrin activity through R-Ras